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Faculty of Medicine College Hospital Radiation part |
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Assistant Professor |
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SAKAE Tatefumi
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Papers 【 display / non-display 】
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Comparison of Conventional Fast SpinEcho,Single-Shot Two-Dimensional and Three-Dimensional Half-Fourier RARE for T2-Weighted Female Pelvic Imaging. Reviewed
杉村 宏,山口 健一郎,古小路 英二,田村 正三,榮 建文,古賀 治幸,町田 好男,喜種 慎一
Journal of Magnetic Resonance Imaging 19 349 - 355
Language：English Publishing type：Research paper (scientific journal)
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深部静脈血栓症における一時的下大静脈フィルターの肺塞栓症に対する予防効果と問題点 Reviewed
榮 建文,古賀 治幸,古小路 英二,山口 健一郎,杉村 宏,田村 正三,落合 礼次
IVR会誌 19 ( 4 ) 383 - 387
Language：Japanese Publishing type：Research paper (scientific journal)
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Oguri N., Gi T., Nakamura E., Maekawa K., Furukoji E., Okawa H., Kouyama S., Horiuchi S., Sawaguchi A., Sakae T., Azuma M., Asada Y., Yamashita A.
Research and Practice in Thrombosis and Haemostasis 9 ( 2 ) 2025.2
Publishing type：Research paper (scientific journal) Publisher：Research and Practice in Thrombosis and Haemostasis
Background: Novel anticoagulants targeting coagulation factor (F)XI/activated FXI (FXIa) are currently under development. However, whether FXI is present in human deep vein thrombosis (DVT) and whether FXIa and activated FX (FXa) play different roles in venous thrombus formation and hemostasis remain unclear. Objectives: To determine the presence of FXI in DVT and the effects of direct oral FXIa and FXa inhibitors on venous thrombus formation and hemostasis in rabbits and on in vitro thrombus formation. Methods: We immunohistochemically assessed FXI localization in human-aspirated DVT (n = 15). Additionally, we compared thrombus formation induced by endothelial denudation and stenosis or stasis in the jugular vein and skin bleeding time and volume between rabbits treated with direct FXIa inhibitors (ONO-1600586) and FXa inhibitors (rivaroxaban). Ex vivo rabbit and human blood were perfused in a flow chamber under low-shear rates (70/s). Results: FXI was localized in all DVT, predominantly in fibrin-rich areas. The FXI immunopositive area in the nonorganizing area was greater than that in the organizing area. Although FXIa and FXa inhibitors comparably inhibited venous thrombus formation, FXIa inhibitors did not affect bleeding time or volume in rabbits. FXIa or FXa inhibitors mildly or strongly inhibited fibrin formation at low-shear rates, respectively. Furthermore, the FXIa inhibitor suppressed human FXIa activity, thrombin generation, and fibrin formation during perfusion. Conclusion: The pathologic findings of human DVT suggest FXI's role in human DVT. FXIa inhibitors may inhibit less fibrin formation than FXa inhibitors and may explain the minor role of FXIa in hemostasis.
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Expression of fibroblast activation protein-α in human deep vein thrombosis Reviewed
Oguri N., Gi T., Nakamura E., Furukoji E., Goto H., Maekawa K., Tsuji A.B., Nishii R., Aman M., Moriguchi-Goto S., Sakae T., Azuma M., Yamashita A.
Thrombosis Research 241 109075 2024.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Thrombosis Research
Background: Fibroblast activation protein-α (FAP), a type-II transmembrane serine protease, is associated with wound healing, cancer-associated fibroblasts, and chronic fibrosing diseases. However, its expression in deep vein thrombosis (DVT) remains unclear. Therefore, this study investigated FAP expression and localization in DVT. Methods: We performed pathological analyses of the aspirated thrombi of patients with DVT (n = 14), classifying thrombotic areas in terms of fresh, cellular lysis, and organizing reaction components. The organizing reaction included endothelialization and fibroblastic reaction. We immunohistochemically examined FAP-expressed areas and cells, and finally analyzed FAP expression in cultured dermal fibroblasts. Results: All the aspirated thrombi showed a heterogeneous mixture of at least two of the three thrombotic areas. Specifically, 83 % of aspirated thrombi showed fresh and organizing reaction components. Immunohistochemical expression of FAP was restricted to the organizing area. Double immunofluorescence staining showed that FAP in the thrombi was mainly expressed in vimentin-positive or α-smooth muscle actin-positive fibroblasts. Some CD163-positive macrophages expressed FAP. FAP mRNA and protein levels were higher in fibroblasts with low-proliferative activity cultured under 0.1 % fetal bovine serum (FBS) than that under 10 % FBS. Fibroblasts cultured in 10 % FBS showed a significant decrease in FAP mRNA levels following supplementation with hemin, but not with thrombin. Conclusions: The heterogeneous composition of venous thrombi suggests a multistep thrombus formation process in human DVT. Further, fibroblasts or myofibroblasts may express FAP during the organizing process. FAP expression may be higher in fibroblasts with low proliferative activity.
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The Japanese Urological Association's clinical practice guidelines for urotrauma 2023 Reviewed
Horiguchi A., Shinchi M., Ojima K., Iijima K., Inoue K., Inoue T., Kaneko N., Kanematsu A., Saito D., Sakae T., Sugihara T., Sekine K., Takao T., Tabei T., Tamura Y., Funabiki T., Yagihashi Y., Yanagi M., Takahashi S., Nakajima Y.
International Journal of Urology 31 ( 2 ) 98 - 110 2024.2
Publishing type：Research paper (scientific journal) Publisher：International Journal of Urology
The Japanese Urological Association's guidelines for the treatment of renal trauma were published in 2016. In conjunction with its revision, herein, we present the new guidelines for overall urotrauma. Its purpose is to provide standard diagnostic and treatment recommendations for urotrauma, including iatrogenic trauma, to preserve organ function and minimize complications and fatality. The guidelines committee comprised urologists with experience in urotrauma care, selected by the Trauma and Emergency Medicine Subcommittee of the Specialty Area Committee of the Japanese Urological Association, and specialists recommended by the Japanese Association for the Surgery of Trauma and the Japanese Society of Interventional Radiology. The guidelines committee established the domains of renal and ureteral, bladder, urethral, and genital trauma, and determined the lead person for each domain. A total of 30 clinical questions (CQs) were established for all domains; 15 for renal and ureteral trauma and five each for the other domains. An extensive literature search was conducted for studies published between January 1, 1983 and July 16, 2020, based on the preset keywords for each CQ. Since only few randomized controlled trials or meta-analyses were found on urotrauma clinical practice, conducting a systematic review and summarizing the evidence proved challenging; hence, the grade of recommendation was determined according to the 2007 “Minds Handbook for Clinical Practice Guidelines” based on a consensus reached by the guidelines committee. We hope that these guidelines will be useful for clinicians in their daily practice, especially those involved in urotrauma care.
DOI： 10.1111/iju.15331
Books 【 display / non-display 】
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泌尿器外傷診療ガイドライン 2022年版
榮 建文
日本泌尿器科学会 2022.8
Language：Japanese Book type：Scholarly book
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Recent Advances in the Diagnosis in the Diagnosis and treatment of Small Intestinal Diseases
（ Role： Joint author）
2013.5
Language：Japanese Book type：Scholarly book
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麻酔科医に必要な局所解剖
榮 建文，田村正三（ Role： Joint author , 大腿静脈からのカテーテ. ル挿入に必要な解剖 130-131）
文光堂 2002.10
Language：Japanese Book type：Scholarly book
MISC 【 display / non-display 】
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胆道腫瘍診断におけるワークステーションの有用性
杉村 宏,山口 健一郎,榮 建文,古賀 治幸,田村 正三,甲斐 眞弘,大内田 次郎,牧野 一郎,千々岩 一男,村中 貴浩
INNERVISION 19 ( 7 ) 92 - 93
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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次世代の画像解析ソフトウェア 胆道腫瘍診断におけるワークステーションの有用性
杉村 宏,山口 健一郎,榮 建文,古賀 治幸,田村 正三,甲斐 眞弘,大内田 次郎,牧野 一郎,千々岩 一男,村中 貴浩
INNERVISION 19 ( 7 ) 92 - 93
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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Inferior Vena Cava Filter Placement and Removal
Sakae Tatefumi, Furukoji Eiji, Masuda Rie
The Official Journal of the Japanese Society of Interventional Radiology 34 ( 4 ) 284 - 289 2020.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
DOI： 10.11407/ivr.34.284
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TMPマイクロカテーテルCarnelinSiの使用経験 Invited
榮 建文
TMPマイクロカテーテルCarnelinSiの使用経験 1 - 6 2016.6
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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FathomTm0.016
榮 建文
Rad Fan 13 ( 12 ) 22 - 23 2015.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：メディカルアイ
Presentations 【 display / non-display 】
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腹腔動脈瘤切除術後のバイパス吻合部に形成された仮性動脈瘤に対しcovered-stentを用いて治療を行った1例
原 卓也、古小路 英二、増田 梨絵、榮 建文、東 美菜子
第44回九州IVR研究会
Event date： 2022.12.17
Language：Japanese Presentation type：Oral presentation (general)
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AFXを用いた腹部大動脈瘤治療戦略
榮 建文
Miyazaki Aortic Conference
Event date： 2022.6.17
Language：Japanese Presentation type：Symposium, workshop panel (nominated)
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腫瘍出血を繰り返す転移性肺腫瘍に対して塞栓術でコントロールしている1例
増田梨絵、古小路英二、榮 建文
南九州IVR講演会
Event date： 2021.3.11
Language：Japanese Presentation type：Oral presentation (general)
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リンパ腫様肉芽腫症の診断に至ったメトトレキサート関連リンパ増殖性疾患の1例
今田真希、下村 明、中田 博、榮 建文、川口 剛、魏 峻洸
第192回日本医学放射線学会九州地方会
Event date： 2021.2.7
Language：Japanese Presentation type：Oral presentation (general)
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去勢抵抗性前立腺癌骨転移患者におけるRa-223投与後の生存期間に関連するパラメータの検討
木村 綾、寺田珠沙、水谷陽一、榮 建文、岡部 洸、寺田直樹
第192回日本医学放射線学会九州地方会
Event date： 2021.2.7
Language：Japanese Presentation type：Oral presentation (general)