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Faculty of Medicine School of Nursing Life and basic nursing study course |
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Sawada Hirotake
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Degree 【 display / non-display 】
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Doctor (Medicine) ( 2006.3 University of Miyazaki )
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学士（医学） ( 1995.3 宮崎医科大学 )
Research Areas 【 display / non-display 】
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Life Science / Clinical pharmacy
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Life Science / Physiology
Papers 【 display / non-display 】
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ガラクトース高値を認め、蛋白質加水分解MCT乳を使用したシトリン欠損症. Reviewed
明利聡瑠, 松山美靜代, 澤田浩武, 神田一夫、盛武浩.
特殊ミルク情報 60 ( 1 ) 49 - 52 2025.2
Language：Japanese Publishing type：Case report
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Strategies Used by Left-Handed Nurses in the Process of Acquiring Nursing Skills Reviewed
Kawanishi Yukihiro, Nomaguchi Chikaho, Sawada Hirotake
Japanese Journal of Nursing Art and Science 23 ( 0 ) 150 - 157 2024.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society of Nursing Art and Science
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Yamaguchi F., Inomata C., Yoshinaga N., Sawada H., Shimamoto K., Haruta-Tsukamoto A.
Psychiatry and Clinical Neurosciences Reports 3 ( 4 ) e70021 2024.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Psychiatry and Clinical Neurosciences Reports
Aim: This study aimed to evaluate a team-based systematic prevention and management program for delirium (a multicomponent intervention addressing potentially modifiable risk factors based on the DELirium Team Approach [DELTA]) in older patients undergoing orthopedic surgery within a real-world clinical setting. The DELTA program was initiated at our hospital in January 2019. Methods: A retrospective before–after study was conducted during a preintervention period (January 1, 2017 to December 31, 2018) and a postintervention period (January 1, 2020 to December 31, 2021) at orthopedic wards of an advanced acute care hospital in Japan. A total of 787 inpatients were evaluated before the preintervention period, and 833 inpatients were evaluated after the postintervention period. Results: After the DELTA program's implementation, a significant decrease in benzodiazepine receptor agonist prescriptions (odds ratio [OR], 0.39; 95% confidence interval [CI], 0.29–0.53) and an increase in prescriptions of either melatonin receptor agonists or dual orexin receptor antagonists (OR, 3.83; 95% CI, 2.49–5.88) were observed. However, no significant difference was observed in the incidence of falls, self-extubation, or required level of medical and nursing care, including risky behavior and inability to follow medical or care instructions following the intervention, despite a reduction in the length of hospital stay and institutionalization. Conclusion: Implementing the DELTA program for older patients undergoing orthopedic surgery contributed to optimizing the prescription of hypnotics; however, the impact on other patient outcomes, such as falls, self-extubation, and required level of medical and nursing care was limited.
DOI： 10.1002/pcn5.70021
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Yamaguchi Fumitake, Nakashima Chiho, Kiyonaga Takumi, Kawasaki Chiho, Kawaguchi Tsubasa, Miyazaki Shigeaki, Hombu Amy, Fujii Yoshinori, Tsuruta Kurumi, Chosa Etsuo, Sawada Hirotake
Journal of International Nursing Research 3 ( 2 ) e2023-0028 - e2023-0028 2024.8
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本看護研究学会
<b>Objective: </b>This study evaluated new indices for quantitative assessment of mobility in orthopedic patients who underwent total hip and knee arthroplasties. <b>Methods: </b>This observational study evaluated three new indices, the 5-m walker gait, sitting-rising, and supine-to-sitting and sitting-to-supine times, for assessing the ambulatory function of 33 orthopedic patients after total hip and knee arthroplasties in the immediate postoperative period. The validity of these indices was verified using the functional independence measure, and their effectiveness was examined by comparing them with previously reported indices. <b>Results: </b>The 5-m walker gait time had the highest sensitivity, and Youden's index was the most valid model fit. These new indices demonstrate greater sensitivities and specificities than previously reported indices. <b>Conclusions: </b>The 5-m walker gait time is a clinically valid and effective index of independent mobility.
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Hasuike S., Ozono Y., Uchida K., Ogawa S., Tamura H., Uchiyama N., Hatada H., Komaki Y., Nakamura K., Iwakiri H., Sueta M., Nagata K., Toyoki Nishimura , Matsuyama M., Sawada H., Oguri T., Sato Y., Kawakami H.
Medicine (United States) 103 ( 22 ) 2024.5
Publishing type：Research paper (scientific journal) Publisher：Medicine (United States)
Background: Nonalcoholic steatohepatitis (NASH) is an important etiology of hepatocellular carcinoma (HCC), and there is no established therapy for this syndrome. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor (ROHHAD(NET)) is an extremely rare syndrome considered to be life-threatening, with death occurring around 10 years of age. We present the oldest known autopsy case of this syndrome that developed HCC. This case provided important information on not only improving the course of this syndrome, but also understanding the natural history and therapeutic modalities of NASH and HCC. Methods: The patient was diagnosed with ROHHAD(NET) syndrome in childhood, and liver cirrhosis due to NASH was diagnosed at age 17. HCC was detected at age 20, and embolization and irradiation were performed. At age 21, she died from accidental acute pancreatitis and subsequent liver failure and pulmonary hemorrhage. Results: Rapid onset of obesity, hypoventilation, and hypothalamic disturbance appeared in childhood and was diagnosed as this syndrome. At age 17, liver cirrhosis due to NASH was diagnosed by liver biopsy, and at age 20, HCC was diagnosed by imaging. Transarterial chemoembolization and irradiation were performed, and the HCC was well controlled for a year. Conclusion: At age 21, she died from accidental acute pancreatitis, subsequent liver failure and pulmonary hemorrhage. Autopsy revealed that the HCC was mostly necrotized. This case was valuable not only for other ROHHAD(NET) syndrome cases, but also in improving our understanding of the natural history of NASH and HCC.
Books 【 display / non-display 】
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歯科からの紹介患者の治療成果および医科歯科連携への期待について
澤田浩武（ Role： Sole author）
小児歯科臨床 2018.11
Language：Japanese
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総説：小腸・胎盤におけるカルシウム吸収調節
澤田浩武（ Role： Sole author）
宮崎県医師会医学会誌 2018.2
Language：Japanese
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新しい新生児マススクリーニングの課題
澤田浩武（ Role： Sole author）
日本遺伝看護学会誌 2018.2
Language：Japanese
MISC 【 display / non-display 】
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【GPCR研究の最前線】カルシトニン受容体刺激ペプチド
澤田浩武,片渕剛,南野直人
内分泌・糖尿病科 22 ( 4 ) 445 - 450 2006.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：科学評論社
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Boyden E., Campos-Xavier A., Kalamajski S., Cameron T., Suarez P., Tanackovic G., Andria G., Ballhausen D., Briggs M., Hartley C., Cohn D., Davidson H., Hall C., Ikegawa S., Jouk P., König R., Megarbané A., Nishimura G., Lachman R., Mortier G., Rimoin D., Rogers R., Rossi M., Sawada H., Scott R., Unger S., Valadares E., Bateman J., Warman M., Superti-Furga A., Bonafé L.
American Journal of Human Genetics 90 ( 1 ) 2012.1
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：American Journal of Human Genetics
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第26回ヤングフェニックスサマーキャンプ
澤田浩武,栗林忠信
プラクティス 21 ( 5 ) 578 - 579 2004.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：医歯薬出版
Presentations 【 display / non-display 】
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RARS2変異により橋小脳低形成6型を呈した日本人2家系
味原さや香 野々宮瑞紀 娼佐かおり 武者育麻 荒尾正人 齋藤恵 澤田浩武 村山圭 岡崎康司 大竹明
第61回日本先天代謝異常学会
Event date： 2019.10.24 - 2019.10.26
Language：Japanese Presentation type：Poster presentation
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学校検尿での尿糖強陽性緊急受診システムの現状と問題点：九州沖縄地区における調査
山本幸代 香月きょう子 徳永剛 木下英一 長谷川宏 松本志郎 是松聖悟 澤田浩武 鮫島幸二 鹿島直子 吉田朝秀 宮里善次
第53回日本小児内分泌学会学術集会
Event date： 2019.9.26 - 2019.9.28
Language：Japanese Presentation type：Poster presentation
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胎盤カルシウムイオンチヤネルTRPV6遺伝子異常による新生児一過性副甲状腺機能充進症
山下純英 澤田浩武 鈴木喜郎 水本洋 秦大資
第53回日本小児内分泌学会学術集会
Event date： 2019.9.26 - 2019.9.28
Language：Japanese Presentation type：Poster presentation
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高チロシン血症１型の１例並びに移植後のニチシノン投与について
松本志郎 吉田敬伸 河崎達也 坂本理恵子 城戸淳 山本英和 澤田浩武 字藤山麻衣子 盛武浩 猪股裕紀洋 遠藤文夫 中村公俊
第60回日本先天代謝異常学会
Event date： 2018.11.8 - 2018.11.10
Language：Japanese Presentation type：Oral presentation (general)
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横紋筋融解を契機に判明したcPT2欠損症の兄弟例
麻田智子 宇藤山麻衣子 松山美静代 盛武浩 瀧田浩武 原圭一 但馬剛
第60回日本先天代謝異常学会
Event date： 2018.11.8 - 2018.11.10
Language：Japanese Presentation type：Poster presentation
Grant-in-Aid for Scientific Research 【 display / non-display 】
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新規疾患の新生児マススクリーニングに求められる実施体制の構築に関する研究
Grant number：23DA0801 2023.04 - 2026.03
厚生労働省 厚生科研 成育疾患克服等次世代育成基盤研究事業
Authorship：Coinvestigator(s)
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舌色を活用した栄養状態自己管理システムの構築
Grant number：22K11088 2022.04 - 2026.03
日本学術振興会 科学研究費基金 基盤研究(C)
竹山 ゆみ子, 永松 有紀, 澤田 浩武, 原口 直樹, 大川 百合子
Authorship：Coinvestigator(s)
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舌の色構成を活用した高齢者の栄養評価指標の開発
Grant number：18K10574 2018.04 - 2023.03
日本学術振興会 科学研究費助成事業 基盤研究(C) 基盤研究(C)
竹山 ゆみ子, 永松 有紀, 澤田 浩武, 甲斐 由紀子
Authorship：Principal investigator
本研究の目的は、介護老人保健施設を利用している65歳以上の女性と地域在住の65歳以上の女性に対して、舌色撮影と血液生化学検査、身体計測、舌圧測定を実施し、高齢者に対する簡便で非侵襲的な栄養評価システム構築に向けた、「舌色」の栄養評価指標としての有用性を検証することである。現在、地域在住女性高齢者50名のデータ収集を行っている。対象者の平均年齢は73.84±5.25歳であり、前期高齢者70.28±3.14歳（29名）、後期高齢者78.81±3.14歳（21名）であった。舌圧と握力は相関したが、上腕筋面積や全身の骨格筋量とは相関しなかった。本研究はWorld Dysphagia Summitで発表した。介護老人保健施設の入所女性高齢者は、新型コロナウイルス感染症の影響で、データ収集できていない。そのため、前回収集した介護老人保健施設女性高齢者のデータと、今回の地域在住女性高齢者のデータの傾向を分析した。舌圧は、栄養状態を反映する血液検査値・身体計測値は有意差がみられたが、上腕筋面積とは有意な差はみられなかった。本研究の分析結果は、学会で発表予定である。
今後は、舌色についても前回収集した介護老人保健施設女性高齢者のデータと地域在住女性高齢者のデータの傾向を確認し、良好な舌色の色構成の特定にむけて検証する。 -
Effects of DHA in the brain on energy homeostasis in Mfsd2 KO mice
Grant number：16K09971 2016.04 - 2020.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
Sawada Hirotake
Authorship：Principal investigator
Behavioral analysis of Mfsd2 KO mice in free-living and 8-way radial maze tests revealed attention deficits, cognitive impairment, memory loss, poor concentration, and anxiety disorders. These disorders were thought to be caused by the lack of DHA in the brain. This suggests that lack of DHA in the brain may cause developmental delay and developmental problems in humans as well as mice. DHA in the brain is important for neurodevelopment in infancy and childhood.
Impaired balance in motor function was also seen in Mfsd2 KO mice, indicating cerebellar dysfunction. This implies that DHA in the brain is also important for motor function.
Histologically, brain atrophy of KO mice was detected. In addition, KO mice may also have olfactory abnormalities. -
Mfsd2遺伝子KOマウスを用いた、脳内ＤＨＡによるエネルギー代謝調節機構の解明
Grant number：16K09971 2016.04 - 2019.03
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
Mfsd2 (Major facilitator superfamily domain containing 2) はDHA(ドコサヘキサエン酸）のトランスポーターとして末梢から脳内へのDHA供給に重要な役割を果たし、脳内エネルギー代謝、神経発達、神経活動に重要な役割を果たしている。申請者のグループは、Mfsd2遺伝子ノックアウトマウス(KOマウス)を作出し、発育・発達・栄養・内分泌について評価してきた。本研究は、末梢のDHAが十分であるにもかかわらず、脳内のDHAが欠如するMfsd2 KOマウスの解析を通じて、脳内DHAがエネルギー代謝調節機構および食物選択行動調節機構にどのような影響を及ぼしているかを解明する。この研究は中枢を介した臓器間ネットワークにおける脳内DHAの役割について新たな知見を提供できるものと考えている。計画している具体的な研究項目は以下のとおりである。
① DHAとMfsd2 の発現・分布部位と成長に伴う発現量・分布量の検討
② Mfsd2 KOマウスの摂食行動およびエネルギー代謝特性
③ Mfsd2 KOマウスの代謝関連遺伝子発現