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Affiliation |
Faculty of Medicine College Hospital Center for Infection Control |
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Associate Professor |
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Related SDGs |
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TAKAJO Ichiro
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Research Areas 【 display / non-display 】
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Life Science / Connective tissue disease and allergy
Papers 【 display / non-display 】
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Kita T, Ohmagari N, Saito S, Mukae H, Takazono T, Nakada TA, Shimada T, Hirai Y, Shindo Y, Komiya K, Saito A, Yamato M, Homma K, Okamoto M, Yamamoto Y, Mutoh Y, Hasegawa C, Mori N, Nakamura-Uchiyama F, Honda M, Tomii K, Ishii H, Takajo I, Watanabe K, Kitamura K
Viruses 17 ( 7 ) 982 2025.7
Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI
Adrenomedullin (AM) is a bioactive peptide that is strongly induced during severe inflammation, including pneumonia and sepsis, and serves as an organ-protective factor. The plasma concentration of AM is markedly increased in the novel coronavirus disease COVID-19 and is closely related to the severity of the disease and prognosis of patients. We performed two investigator-initiated trials to evaluate the efficacy and safety of AM in patients with moderate-to-severe COVID-19. This multicenter, double-blind, placebo-controlled phase-2a trial evaluated COVID-19 patients with severe (n = 33) and moderate (n = 31) pneumonia in Japan. Patients were randomly assigned to receive either 15 ng/kg/min AM or placebo. The primary endpoint was the duration of mechanical ventilation (MV) for severe pneumonia and oxygen support for moderate pneumonia. The main secondary endpoint was clinical status up to 30 days after the intervention. No differences in primary or secondary endpoints were observed between the AM and placebo groups in patients with severe or moderate pneumonia. In the severe pneumonia group, three patients in the placebo group died due to respiratory failure, and one patient in the AM group died due to respiratory failure. The respiratory function test at 30 days in the moderate pneumonia group tended to be better than that in the AM group and approached significance (p = 0.073). Although mild adverse events caused by the vasodilatory effects of AM were noted, the safety of AM for treating pneumonia was confirmed. In these trials, we did not observe a definitive efficacy of AM in moderate to severe pneumonia. Alternative strategies for the treatment of AM in pneumonia require further research.
DOI： 10.3390/v17070982
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Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan. Reviewed
Oka K, Matsumoto A, Tetsuka N, Morioka H, Iguchi M, Ishiguro N, Nagamori T, Takahashi S, Saito N, Tokuda K, Igari H, Fujikura Y, Kato H, Kanai S, Kusama F, Iwasaki H, Furuhashi K, Baba H, Nagao M, Nakanishi M, Kasahara K, Kakeya H, Chikumi H, Ohge H, Azuma M, Tauchi H, Shimono N, Hamada Y, Takajo I, Nakata H, Kawamura H, Fujita J, Yagi T, on behalf of Japan Infection Prevention and Control Conference for National and Public University Hospitals.:
J Glob Antimicrob Resist 29 247 - 252 2022.4
Publishing type：Research paper (scientific journal)
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HTLV-1陽性全身性強皮症の臨床的特徴. Reviewed
宮内俊一, 工藤理紗, 木村賢俊, 岩尾千紘, 力武雄幹, 岩尾浩昭, 力武真央, 相澤彩子, 川口剛, 仮屋裕美, 松田基弘, 梅北邦彦, 高城佳人子, 高城一郎, 岡山昭彦.
九州リウマチ 41 ( 1 ) 37 - 42 2022.3
Publishing type：Research paper (scientific journal)
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Neuropsychiatric Systemic Lupus Erythematosus with Cerebral Vasculitis and Lupus Nephritis Successfully Treated with High-dose Glucocorticoids and Mycophenolate Mofetil: A Case Report. Reviewed
Tanaka S, Kawaguchi T, Kudo R, Kimura M, Rikitake Y, Iwao C, Rikitake M, Iwao K, Aizawa A, Kariya Y, Matsuda M, Miyauchi S, Takajo I, Umekita K.
Intern Med 2022.3
Publishing type：Research paper (scientific journal)
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High incidence of serious infections requiring hospitalisation in human T-cell leukaemia virus type 1-positive rheumatoid arthritis: A case-controlled observational study. Reviewed
Hashiba Y, Umekita K, Kimura M, Iwao C, Iwao K, Kariya Y, Kubo K, Miyauchi S, Kudou R, Rikitake Y, Kawaguchi T, Matsuda M, Takajo I, Inoue E, Hidaka T, Okayama A.
Mod Rheumatol 16 2021.10
Publishing type：Research paper (scientific journal)
DOI： 10.1093/mr/roab077.
Books 【 display / non-display 】
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日本病院薬剤師会雑誌 別刷
髙城一郎、宮崎泰可（ Role： Contributor , 【話題のくすり】イサブコナゾール）
日本神経内科学会 2024.2
Responsible for pages：60(2): 178-180 Book type：Scholarly book
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INFECTION CONTROL
髙城一郎（ Role： Contributor , 水回りに潜む微生物と感染リスク. ）
メディカ出版 2024.1
Responsible for pages：33(1): 94-97 (2024) Book type：Scholarly book
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臨床雑誌内科 増刊号 プライマリケア医に必要な情報を まるっと整理 くすりの使い方便利帳
髙城一郎（ Role： Contributor , 病原微生物に対する薬剤 [抗菌薬] 抗結核薬）
南江堂 2023.4
Responsible for pages：131(4):554-557 Book type：Scholarly book
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日州医事
髙城一郎（ Role： Contributor , 診療メモ「新型コロナウイルス感染症診療について」）
宮崎県医師会 2024.1
Responsible for pages：893(1):116-117 Book type：Scholarly book
MISC 【 display / non-display 】
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新型コロナ時代の抗菌薬適正使用. Reviewed
岡山昭彦, 高城一郎.
新型コロナ時代の抗菌薬適正使用. 2020.10
Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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Abdominal paragonimiasis after consumption of wild boar meat
Nakashima S., Takajo I., Maruyama H., Nagayasu E.
International Journal of Infectious Diseases 105 40 - 41 2021.4
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：International Journal of Infectious Diseases
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新型コロナ時代の抗菌薬適正使用. Reviewed
岡山昭彦, 高城一郎.
宮崎県内科医会誌. 96 4 - 8 2020.10
Language：Japanese Publishing type：Rapid communication, short report, research note, etc. (scientific journal)
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麻疹とその対策.
岡山昭彦, 高城一郎.
宮崎県内科医会誌. 94 8 - 13 2018.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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重症熱性血小板減少症候群(Severe fever with thrombocytopenia syndrome : SFTS)について. Reviewed
高城一郎
宮崎県内科医会誌. 2017.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
Presentations 【 display / non-display 】
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重症熱性血小板減少症候群（SFTS）に侵襲性肺アスペルギルス症が合併した 1 剖検例
住吉誠、木村賢俊、力武雄幹、岩尾千紘、力武真央、岩尾浩昭、仮屋裕美、川口剛、 松田基弘、宮内俊一、梅北邦彦、髙城一郎、宮崎泰可
第89回九州真菌懇話会・第4回日本医真菌学会九州・中四国支部会
Event date： 2022.7.31
Presentation type：Oral presentation (general)
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Bacillus cereus血流感染予防のための介入～院内洗濯機及び乾燥機管理、CVルート管理を通して～
中山雄貴、安藤大介、森山徳文、山田明輝、 平原康寿、岩尾千紘、髙城一郎
第36回日本環境感染学会
Event date： 2022.6.16 - 2022.6.18
Presentation type：Oral presentation (general)
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カルバペネム系抗菌薬適正使用推進のためのClinical Questionと今後の取り組み
平原康寿、森山徳文、髙城一郎、宮崎泰可
第70回日本科学療法学会総会
Event date： 2022.6.3 - 2022.6.5
Presentation type：Oral presentation (general)
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低用量ステロイド治療が継続可能であったあ皮膚筋炎/多発性筋炎の臨床的特徴
木村賢俊、相澤彩子、工藤理紗、力武雄幹、岩尾千紘、力武真央、岩尾浩昭、仮屋裕美、川口剛、松田基弘、宮内俊一、髙城一郎、梅北邦彦
第66回日本リウマチ学会総会・学術集会
Event date： 2022.4.25 - 2022.4.27
Presentation type：Oral presentation (general)
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乳児入院後に母親の活動性肺結核罹患が判明した事例と院内感染対策について
髙城一郎、岩尾千紘、力武雄幹、宮崎泰可
第88回日本呼吸器学会・日本結核非結核性抗酸菌症病学会九州支部秋季各術講演会
Event date： 2022.3.19
Presentation type：Oral presentation (general)
Works 【 display / non-display 】
Awards 【 display / non-display 】
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日本感染症学会西日本地方会感染症優秀論文賞
2008.12 日本感染症学会
高城一郎
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
Grant-in-Aid for Scientific Research 【 display / non-display 】
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医療施設における水道蛇口整流器の取り扱い標準化の確立
Grant number：23K04092 2023.04 - 2027.03
独立行政法人日本学術振興会 科学研究費基金 基盤研究(C)
Authorship：Principal investigator
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Grant number：17K08988 2017.04 - 2020.03
Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
Ichiro Takajo
Authorship：Principal investigator
To detect causative microorganisms is important to select accuracy treatments in daily clinical practice of infectious diseases. Gram staining is a common technique to estimate causative microorganisms. However, sometimes, it is difficult to distinguish bacterial contamination of clinical samples in this method. In the present study, we tried to establish a novel method to detect "true" causative microorganisms using laser capture microdissection (LCM). Bacteria-phagocytized neutrophils were targeted and were collected by LCM. After nucleic acid extraction from these neutrophils, the bacteria-specific 16S ribosomal RNA was analyzed. In peritonitis model mice, a causative microorganism was detected by this method. Therefore, LCM method may be a useful tool to detect causative microorganism which was phagocytized by neutrophils. In future study, it is necessary to evaluate the sensitivity and specificity of this method in clinical samples.
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膠原病における新規疾患特異的マーカーの検索
Grant number：19659257 2007.04 - 2009.03
独立行政法人日本学術振興会 科学研究費補助金 萌芽研究
Authorship：Principal investigator
膠原病における新規疾患特異的マーカーの検索
Other research activities 【 display / non-display 】
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「話題の感染症」デング熱について.
2014.12
醫友しののめ.
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届出制に基づいたダプトマイシンの使用状況の検討.
2014.10
記録集 第88回日本感染症学会学術講演会 第62回日本化学療法学会総会.