TAKAJO Ichiro

写真a

Affiliation

Faculty of Medicine College Hospital Center for Infection Control

Title

Associate Professor

External Link

Degree 【 display / non-display

  • 博士(医学) ( 2008.3   宮崎大学 )

Research Areas 【 display / non-display

  • Life Science / Connective tissue disease and allergy

 

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  • Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan

    Oka K., Matsumoto A., Tetsuka N., Morioka H., Iguchi M., Ishiguro N., Nagamori T., Takahashi S., Saito N., Tokuda K., Igari H., Fujikura Y., Kato H., Kanai S., Kusama F., Iwasaki H., Furuhashi K., Baba H., Nagao M., Nakanishi M., Kasahara K., Kakeya H., Chikumi H., Ohge H., Azuma M., Tauchi H., Shimono N., Hamada Y., Takajo I., Nakata H., Kawamura H., Fujita J., Yagi T.

    Journal of Global Antimicrobial Resistance   29   247 - 252   2022.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Global Antimicrobial Resistance  

    Objectives: The dissemination of difficult-to-treat carbapenem-resistant Enterobacterales (CRE) is of great concern. We clarified the risk factors underlying CRE infection mortality in Japan. Methods: We conducted a retrospective, multicentre, observational cohort study of patients with CRE infections at 28 university hospitals from September 2014 to December 2016, using the Japanese National Surveillance criteria. Clinical information, including patient background, type of infection, antibiotic treatment, and treatment outcome, was collected. The carbapenemase genotype was determined using PCR sequencing. Multivariate analysis was performed to identify the risk factors for 28-day mortality. Results: Among the 179 patients enrolled, 65 patients (36.3%) had bloodstream infections, with 37 (20.7%) infections occurring due to carbapenemase-producing Enterobacterales (CPE); all carbapenemases were of IMP-type (IMP-1: 32, IMP-6: 5). Two-thirds of CPE were identified as Enterobacter cloacae complex. Combination therapy was administered only in 46 patients (25.7%), and the 28-day mortality rate was 14.3%. Univariate analysis showed that solid metastatic cancer, Charlson Comorbidity Index ≥3, bloodstream infection, pneumonia, or empyema, central venous catheters, mechanical ventilation, and prior use of quinolones were significant risk factors for mortality. Multivariate analysis revealed that mechanical ventilation (OR: 6.71 [1.42–31.6], P = 0.016), solid metastatic cancers (OR: 5.63 [1.38–23.0], P = 0.016), and bloodstream infections (OR: 3.49 [1.02–12.0], P = 0.046) were independent risk factors for 28-day mortality. Conclusion: The significant risk factors for 28-day mortality in patients with CRE infections in Japan are mechanical ventilation, solid metastatic cancers, and bloodstream infections.

    DOI: 10.1016/j.jgar.2022.04.004

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  • Neuropsychiatric Systemic Lupus Erythematosus with Cerebral Vasculitis and Lupus Nephritis Successfully Treated with High-dose Glucocorticoids and Mycophenolate Mofetil: A Case Report

    Tanaka Saki, Kawaguchi Takeshi, Kudo Risa, Kimura Masatoshi, Rikitake Yuki, Iwao Chihiro, Rikitake Mao, Iwao Kosho, Aizawa Ayako, Kariya Yimi, Matsuda Motohiro, Miyauchi Shunichi, Takajo Ichiro, Umekita Kunihiko

    Internal Medicine   advpub ( 0 )   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japanese Society of Internal Medicine  

    DOI: 10.2169/internalmedicine.9123-21

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  • High incidence of serious infections requiring hospitalisation in human T-cell leukaemia virus type 1-positive rheumatoid arthritis: A case-controlled observational study. International journal

    Yayoi Hashiba, Kunihiko Umekita, Masatoshi Kimura, Chihiro Iwao, Kosho Iwao, Yumi Kariya, Kazuyoshi Kubo, Shunichi Miyauchi, Risa Kudou, Yuki Rikitake, Takeshi Kawaguchi, Motohiro Matsuda, Ichiro Takajo, Eisuke Inoue, Toshihiko Hidaka, Akihiko Okayama

    Modern rheumatology   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/mr/roab077

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  • Severe Fever with Thrombocytopenia Syndrome Accompanied by Invasive Pulmonary Aspergillosis: An Autopsy Case. International journal

    Kosho Iwao, Takeshi Kawaguchi, Masatoshi Kimura, Chihiro Iwao, Mao Rikitake, Ayako Aizawa, Yumi Kariya, Motohiro Matsuda, Syunichi Miyauchi, Ichiro Takajo, Takumi Kiwaki, Tsuyoshi Fukushima, Hiroaki Kataoka, Tadaki Suzuki, Akihiko Okayama, Kunihiko Umekita

    Viruses   13 ( 6 )   2021.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tickborne infectious disease in China, Korea, and Japan caused by the SFTS virus (SFTSV). SFTS has a high mortality rate due to multiorgan failure. Recently, there are several reports on SFTS patients with mycosis. Here, we report a middle-aged Japanese SFTS patient with invasive pulmonary aspergillosis (IPA) revealed by an autopsy. A 61-year-old man with hypertension working in forestry was bitten by a tick and developed fever, diarrhea, and anorexia in 2 days. On day 4, consciousness disorder was appearing, and the patient was transferred to the University of Miyazaki Hospital. A blood test showed leukocytopenia, thrombocytopenia, as well as elevated levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine kinase. The SFTSV gene was detected in serum using a reverse-transcription polymerase chain reaction. On day 5, respiratory failure appeared and progressed rapidly, and on day 7, the patient died. An autopsy was performed that revealed hemophagocytosis in the bone marrow and bleeding of several organs. IPA was observed in lung specimens. SFTSV infection may be a risk factor for developing IPA. Early diagnosis and treatment of IPA may be important in patients with SFTS.

    DOI: 10.3390/v13061086

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  • Detection of anti-SFTSV nuclear protein antibody in the acute phase sera of patients using double-antigen ELISA and immunochromatography Reviewed

    Umeki K., Yasuda A., Umekita K., Megumi R., Nomura H., Kawaguchi T., Matsuda M., Takajo I., Shimojima M., Okayama A.

    Journal of Virological Methods   285   113942   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Virological Methods  

    © 2020 Elsevier B.V. Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening febrile illness that is caused by the SFTS virus (SFTSV). The diagnosis of SFTS is usually performed by detecting viral RNA. However, it has been reported that viral RNA is no longer detectable at 6–12 days after the onset of disease. In the current study, we have constructed a plasmid to express the recombinant nuclear protein (NP) based on the Japanese strain of SFTSV (J1). We developed a double-antigen enzyme-linked immunosorbent assay (ELISA) and immunochromatography (IC) assay using recombinant NP to detect antibody against SFTSV-NP. When we tested time-sequential samples from four patients with SFTS, antibody to SFTSV-NP were detectable not only during the recovery phase (days 10–622) but also during the acute phase (days 4–7) of the disease using both of a double-antigen ELISA and IC assay. SFTSV-RNA was detected until 8–11 days after onset, thus suggesting the coexistence of the virus and antibody during the acute phase of SFTS. These data suggest that assays for detecting antibody against SFTS-NP described in the current study may be applicable not only for the epidemiological studies but also for the diagnosis of SFTS.

    DOI: 10.1016/j.jviromet.2020.113942

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MISC 【 display / non-display

  • Abdominal paragonimiasis after consumption of wild boar meat

    Nakashima S., Takajo I., Maruyama H., Nagayasu E.

    International Journal of Infectious Diseases   105   40 - 41   2021.4

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    Language:Japanese   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:International Journal of Infectious Diseases  

    DOI: 10.1016/j.ijid.2021.02.012

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  • 新型コロナ時代の抗菌薬適正使用. Reviewed

    岡山昭彦, 高城一郎.

    宮崎県内科医会誌.   96   4 - 8   2020.10

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    Language:Japanese   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

  • 麻疹とその対策.

    岡山昭彦, 高城一郎.

    宮崎県内科医会誌.   94   8 - 13   2018.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 重症熱性血小板減少症候群(Severe fever with thrombocytopenia syndrome : SFTS)について. Reviewed

    高城一郎

    宮崎県内科医会誌.   2017.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

  • 筋ジストロフィーとの鑑別を要し、経口ステロイドおよびタクロリムス併用療法が奏功した抗SRP抗体陽性ミオパチーの1例. Reviewed

    河野彩子, 梅北邦彦, 小村真央, 岩尾浩昭, 松田基弘, 久保和義, 宮内俊一, 高城一郎, 長友安弘, 塩見一剛, 西野一三, 岡山昭彦.

    九州リウマチ.   37 ( 1 )   72 - 79   2017.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations 【 display / non-display

  • 当科における免疫抑制療法中に発生したノカルジア感染症5例の臨床的検討.

    工藤理紗, 梅北邦彦, 木村賢俊, 力武雄幹, 岩尾浩昭, 力武真央, 相澤彩子, 仮屋裕美, 川口剛, 松田基弘, 宮内俊一, 高城佳人子, 高城一郎, 岡山昭彦.

    第61回九州リウマチ学会.  ( LIVE配信)) 

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    Event date: 2021.3.20 - 2021.3.21

    Language:Japanese  

    Venue: LIVE配信)  

  • ステロイド開始後に難治性心室頻拍が出現したサルコイドーシスの1例.

    岩尾浩昭, 松田基弘, 力武雄幹, 川口剛, 宮内俊一, 梅北邦彦, 高城一郎, 岡山昭彦.

    第332回日本内科学会九州地方会.  (Web開催)) 

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    Event date: 2021.1.9

    Language:Japanese  

    Venue:Web開催)  

  • SLEを基礎疾患とし繰り返す肺炎の後に診断された肺放線菌症.

    木村賢俊, 川口剛, 工藤理紗, 力武雄幹, 岩尾浩昭, 松田基弘, 宮内俊一, 梅北邦彦, 高城一郎, 岡山昭彦.

    第331回日本内科学会九州地方会.  (Web開催)) 

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    Event date: 2020.11.29

    Language:Japanese  

    Venue:Web開催)  

  • 肺病変、関節炎を呈した播種性非結核性抗酸菌感染症の1例.

    力武雄幹, 川口剛, 工藤理紗, 木村賢俊, 岩尾千紘, 岩尾浩昭, 力武真央, 仮屋裕美, 松田基弘, 宮内俊一, 梅北邦彦, 高城佳人子, 高城一郎, 岡山昭彦.

    第90回日本感染症学会西日本地方会学術集会 第63回日本感染症学会中日本地方会学術集会 第68回日本化学療法学会西日本支部総会.  (福岡県福岡市, アクロス福岡) 現地開催・WEB中継(ハイブリッド開催) ) 

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    Event date: 2020.11.5 - 2020.11.7

    Language:Japanese  

    Venue:福岡県福岡市, アクロス福岡) 現地開催・WEB中継(ハイブリッド開催)  

  • 成人スティル病の治療中に発症したNocardia arthritidisによる肺炎.

    工藤理紗, 川口剛, 木村賢俊, 力武雄幹, 岩尾千紘, 岩尾浩昭, 仮屋裕美, 松田基弘, 宮内俊一, 梅北邦彦, 高城佳人子, 高城一郎, 矢口貴志, 岡山昭彦.

    第90回日本感染症学会西日本地方会学術集会 第63回日本感染症学会中日本地方会学術集会 第68回日本化学療法学会西日本支部総会.  (福岡県福岡市, アクロス福岡) 現地開催・WEB中継(ハイブリッド開催)) 

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    Event date: 2020.11.5 - 2020.11.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡県福岡市, アクロス福岡) 現地開催・WEB中継(ハイブリッド開催)  

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Works 【 display / non-display

  • 「話題の感染症」デング熱について.

    2014.12

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    醫友しののめ.

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  • 届出制に基づいたダプトマイシンの使用状況の検討.

    2014.10

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    記録集 第88回日本感染症学会学術講演会 第62回日本化学療法学会総会.

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Awards 【 display / non-display

  • 日本感染症学会西日本地方会感染症優秀論文賞

    2008.12   日本感染症学会  

    高城一郎

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

Grant-in-Aid for Scientific Research 【 display / non-display

  • The establishment of diagnostic tool for causative microorganisms using laser capture microdissection

    Grant number:17K08988  2017.04 - 2020.03

    Japan Society for the Promotion of Science  Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

    Ichiro Takajo

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    Authorship:Principal investigator 

    To detect causative microorganisms is important to select accuracy treatments in daily clinical practice of infectious diseases. Gram staining is a common technique to estimate causative microorganisms. However, sometimes, it is difficult to distinguish bacterial contamination of clinical samples in this method. In the present study, we tried to establish a novel method to detect "true" causative microorganisms using laser capture microdissection (LCM). Bacteria-phagocytized neutrophils were targeted and were collected by LCM. After nucleic acid extraction from these neutrophils, the bacteria-specific 16S ribosomal RNA was analyzed. In peritonitis model mice, a causative microorganism was detected by this method. Therefore, LCM method may be a useful tool to detect causative microorganism which was phagocytized by neutrophils. In future study, it is necessary to evaluate the sensitivity and specificity of this method in clinical samples.

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  • 膠原病における新規疾患特異的マーカーの検索

    2007.04 - 2009.03

    科学研究費補助金 

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    Authorship:Principal investigator 

    膠原病における新規疾患特異的マーカーの検索

Other research activities 【 display / non-display

  • 「話題の感染症」デング熱について.

    2014.12

     More details

    醫友しののめ.

  • 届出制に基づいたダプトマイシンの使用状況の検討.

    2014.10

     More details

    記録集 第88回日本感染症学会学術講演会 第62回日本化学療法学会総会.