Details of a Researcher - TAKAJO Ichiro

Analysis of MRSA Detected in the Expressed Breast Milk of Affected Infants and Their Mothers at the Perinatal Medical Center Reviewed

YAMADA Akiteru, NAKAYAMA Yuki, ANDO Daisuke, HIRABARA Yasutoshi, MORIYAMA Noriyuki, TAKAJO Ichiro

Japanese Journal of Infection Prevention and Control 39 ( 3 ) 64 - 69 2024.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Infection Prevention and Control

Methicillin-resistant Staphylococcus aureus (MRSA) was detected in surveillance cultures from 10 patients in neonatal intensive care units and growing care units (GCU) from January to May 2022. Genetic analysis was conducted using PCR-based open reading frame Typing (POT) to confirm horizontal transmission. Seven POT types were classified. Because MRSA of the same POT type was detected in some affected infants, environmental culture was performed, but MRSA was not detected. The possibility of horizontal transmission could not be ruled out for five isolates, but the route of infection was unknown for the remaining five isolates. Although a concern existed for infection transmission from family members, protective measures were taken during their visit, including the use of gloves and gowns, to prevent direct skin-to-skin contact. In addition, the mothers did not breastfeed.We focused on expressed breast milk, a nonsterile material administered to the affected infants, and conducted culture tests on the expressed breast milk. MRSA was detected in the expressed breast milk of four of the five patients tested. Although the POT types of the four strains were all different, each matched the strains detected in the affected infants. These results indicated vertical transmission through expressed breast milk, leading to guidance on milking methods.

DOI： 10.4058/jsei.39.64

Investigation of Disinfection Effect Using UV-C Ultraviolet Irradiation Robot

ANDO Daisuke, HABU Ryota, MORIYAMA Norifumi, MEGUMI Ryoya, YAMADA Akiteru, RIKITAKE Yuki, HIRABARA Yasutoshi, NAKAYAMA Yuki, KAWASAKI Chiho, TAKAJO Ichiro

Japanese Journal of Infection Prevention and Control 39 ( 2 ) 47 - 52 2024.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Society for Infection Prevention and Control

The University of Miyazaki Hospital established UV-C ultraviolet irradiation robots to strengthen measures against nosocomial infections. In this study, we collected cultures and environmental samples from outpatient examinations and patient rooms before and after UV irradiation and compared the effects of UV-C irradiation time, irradiation distance, and object structure on the disinfection effect of the UV-C irradiation robot, as well as the disinfection effect of the UV-C irradiation robot on patient rooms following their use. As a result, a certain disinfection effect was confirmed by the UV-C irradiation. However, the disinfection effect may be insufficient because of factors such as inadequate irradiation distance, object structure, and the presence of dust. To achieve a higher level of disinfection, it is necessary to complement UV irradiation using a UV-C ultraviolet irradiation robot with regular cleaning practices. Special attention should be paid to areas where objects have complex structures, shadows are easily formed, and dust tends to accumulate. By combining UV irradiation with thorough cleaning of these specific areas, an enhanced disinfection effect can be anticipated.

DOI： 10.4058/jsei.39.47

Human granulocytic anaplasmosis with rash and rhabdomyolysis: A case report Reviewed

Kawaguchi T., Rikitake Y., Rikitake M., Kimura M., Iwao C., Iwao K., Aizawa A., Sumiyoshi M., Kariya Y., Matsuda M., Miyauchi S., Umekita K., Takajo I., Ohashi N., Miyazaki T.

Journal of Infection and Chemotherapy 30 ( 12 ) 1309 - 1314 2024

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy

Human granulocytic anaplasmosis (HGA) is a tick-borne infection caused by Anaplasma phagocytophilum. Only seven cases of HGA have been reported in Japan to date. We report the case of a 61-year-old female farmer who developed HGA with rash and rhabdomyolysis. The patient had fever and erythema covering the entire body, including the palms. An induration with an eschar was observed on the right leg, indicating that the patient had been bitten by a tick. Elevated serum creatinine and creatinine kinase levels and hematuria indicated rhabdomyolysis. We suspected Japanese spotted fever, a tick-borne illness caused by Rickettsia Japonica, and administered minocycline and ciprofloxacin for a week. Transient neutropenia and thrombocytopenia were observed, but the symptoms improved. Polymerase chain reaction (PCR) and antibody tests for R. japonica and Orientia tsutsugamushi, which causes scrub typhus, were both negative. The PCR test for severe fever with thrombocytopenia syndrome virus was also negative. Antibodies against A. phagocytophilum–related proteins were detected by western blotting, indicating seroconversion of IgG with paired serum samples, and the patient was diagnosed with HGA. HGA should be suspected in acute febrile patients with a history of outdoor activity and cytopenia, with or without a rash. A testing system and the accumulation of cases in Japan are necessary for the early diagnosis and appropriate treatment of HGA.

DOI： 10.1016/j.jiac.2024.04.001

Luteibacter jiangsuensis blood stream infection: a first case report. Reviewed

Horiguchi T, Sumiyoshi M, Nagatomo E, Sakamoto K, Ogawa S, Ichinari N, Yamada A, Rikitake Y, Iwao C, Kawaguchi T, Umekita K, Takajo I, Yamamoto S, Miyazaki T.

BMC Infect Dis. 23 ( 1 ) 863 2023.12

Publishing type：Case report

Luteibacter jiangsuensis blood stream infection: a first case report Reviewed

Horiguchi T., Sumiyoshi M., Nagatomo E., Sakamoto K., Ogawa S., Ichinari N., Yamada A., Rikitake Y., Iwao C., Kawaguchi T., Umekita K., Takajo I., Yamamoto S., Miyazaki T.

BMC Infectious Diseases 23 ( 1 ) 863 2023.12

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC Infectious Diseases

Background: Luteibacter jiangsuensis is a gram-negative aerobic bacillus that was first isolated from soil samples at a pesticide factory in China and reported in 2011. Here, we describe the first case of L. jiangsuensis infection in human. Case presentation: A 59-year-old Japanese woman undergoing treatment for Crohn’s disease was admitted to our hospital with fever. Clinical examination indicated catheter-related bloodstream infection. The catheter was removed and meropenem was initiated. Morphologically identical glucose non-fermentative gram-negative bacilli were detected from two sets of aerobic blood culture and catheter-tip cultures. MALDI-TOF mass spectrometry failed to identify the bacterium, which was later identified as L. jiangsuensis by 16 S rRNA gene sequencing. Antimicrobial susceptibility test revealed that the isolate was resistant to carbapenem, therefore meropenem was switched to intravenous levofloxacin (500 mg/day). After 14 days of treatment with levofloxacin, the patient was discharged. Conclusions: This is the first case of L. jiangsuensis infection in human. The strain was identified by 16 S rRNA gene sequence analysis.

DOI： 10.1186/s12879-023-08867-9

Coronavirus disease 2019 in a patient with pulmonary fibrosis and emphysema: An autopsy report Reviewed

Coronavirus disease 2019 in a patient with pulmonary fibrosis and emphysema: An autopsy report. Reviewed

Kudo R, Kawaguchi T, Kimura M, Rikitake Y, Iwao C, Rikitake M, Iwao K, Aizawa A, Kariya Y, Matsuda M, Miyauchi S, Takajo I, Sato Y, Asada Y, Miyazaki T, Umekita K.

Heliyon. 9 ( 11 ) e22221 2023.11

Publishing type：Case report

Kudo R., Kawaguchi T., Kimura M., Rikitake Y., Iwao C., Rikitake M., Iwao K., Aizawa A., Kariya Y., Matsuda M., Miyauchi S., Takajo I., Sato Y., Asada Y., Miyazaki T., Umekita K.

Heliyon 9 ( 11 ) e22221 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Heliyon

Various diseases (e.g., hypertension and diabetes) are risk factors for the exacerbation of coronavirus 2019 (COVID-19). Patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) tend to develop severe COVID-19. Patients with severe COVID-19 present with acute respiratory distress syndrome (ARDS), and many COVID-19-related ARDS survivors eventually develop fibrosis. However, the appropriate management of patients with COVID-19 and ILD and post-COVID-19 ILD remains unclear. Thus, a better understanding of the pathology that exacerbates COVID-19 in patients with ILD is needed. We report the autopsy results of a patient with COVID-19 and combined pulmonary fibrosis and emphysema, whose lung organization and fibrosis progressed after the acute phase of infection. Histopathological findings suggest that fatal pulmonary fibrosis persists after the negative conversion of SARS-CoV-2. Elucidating the cause of death by autopsy may help determine therapeutic strategies in patients with COVID-19 and ILD. Vaccination and early administration of anti-inflammatory drugs or antifibrotic agents may be crucial for preventing disease progression and fatal lung fibrosis. This report aims to clarify the histopathological features of COVID-19 in patients with ILD via autopsy and discuss treatment strategies.

DOI： 10.1016/j.heliyon.2023.e22221

Differences in muscle magnetic resonance imaging findings between anti-signal recognition particle antibody-positive myopathy and anti-aminoacyl-tRNA synthetase antibody-positive myositis.

Kimura M, Aizawa A, Kudou R, Rikitake Y, Iwao C, Rikitake M, Iwao K, Kariya Y, Kawaguchi T, Matsuda M, Miyauchi S, Takajo I, Umekita K

Clinical and experimental rheumatology 42 ( 2 ) 321 - 328 2023.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Clinical and experimental rheumatology

OBJECTIVES: To compare the findings of muscle magnetic resonance imaging (MRI) between anti-signal recognition particle antibody-positive myopathy (anti-SRP myopathy) and anti-aminoacyl-tRNA synthetase antibody-positive myositis (anti-ARS myositis). METHODS: Of the patients newly diagnosed with polymyositis (PM)/dermatomyositis (DM) and immune-mediated necrotising myopathy (IMNM) admitted to our Department between April 2012 and December 2021, those who met the eligibility criteria of positive for anti-SRP or anti-ARS antibodies and thigh MRI at the time of diagnosis were included. We compared the lesion sites and MRI findings of the thigh muscles that were classified into oedema, fascial oedema, fatty replacement, and muscle atrophy between the three groups of anti-SRP myopathy, anti-Jo-1 antibody-positive myositis, and non-Jo-1 antibody-positive myositis. RESULTS: Of the 98 PM/DM and IMNM patients, five anti-SRP myopathy patients and 11 anti-Jo-1-positive and 22 non-Jo-1 antibody-positive patients with myositis were included. The SRP group showed significantly higher blood levels of myogenic enzymes such as serum creatinine kinase (CK) than the other groups (p=0.01). In thigh MRI findings, despite oedema in most cases in anti-SRP and anti-ARS groups, fascial oedema was identified only in the ARS group, frequently in Jo-1 positive patients in particular. Moreover, gluteus maximus muscle lesions occurred more frequently in the SRP group than in the ARS group (p=0.008). CONCLUSIONS: A comparison of thigh MRI between anti-SRP myopathy and anti-ARS myositis showed different findings and lesion sites reflecting the different pathophysiology that may contribute to their diagnosis.

DOI： 10.55563/clinexprheumatol/fjfkfs

特集プライマリケア医に必要な情報をまるっと整理くすりの使い方便利帳第1章　病原微生物に対する薬剤 [抗菌薬] 抗結核薬

Differences in muscle magnetic resonance imaging findings between anti-signal recognition particle antibody-positive myopathy and anti-aminoacyl-tRNA synthetase antibody-positive myositis Reviewed

Kimura M, Aizawa A, Kudou R, Rikitake Y, Iwao C, Rikitake M, Iwao K, Kariya Y, Kawaguchi T, Matsuda M, Miyauchi S, Takajo I, Umekita K

Clin Exp Rheumatol. 42 ( 2 ) doi: 10.55563/clinexprheumatol/fjfkfs 2023.7

Publishing type：Case report

髙城一郎

内科 131 ( 4 ) 554 - 557 2023.4

Publishing type：Research paper (scientific journal) Publisher：南江堂

DOI： 10.15106/j_naika131_554

Neuropsychiatric Systemic Lupus Erythematosus with Cerebral Vasculitis and Lupus Nephritis Successfully Treated with High-dose Glucocorticoids and Mycophenolate Mofetil: A Case Report

Neuropsychiatric Systemic Lupus Erythematosus with Cerebral Vasculitis and Lupus Nephritis Successfully Treated with High-dose Glucocorticoids and Mycophenolate Mofetil: A Case Report. Reviewed

Tanaka S, Kawaguchi T, Kudo R, Kimura M, Rikitake Y, Iwao C, Rikitake M, Iwao K, Aizawa A, Kariya Y, Matsuda M, Miyauchi S, Takajo I, Umekita K.

Intern Med 61 ( 20 ) 3131 - 3135 2022.10

Publishing type：Case report

DOI： 10.2169/internalmedicine.9123-21.

Tanaka Saki, Kawaguchi Takeshi, Kudo Risa, Kimura Masatoshi, Rikitake Yuki, Iwao Chihiro, Rikitake Mao, Iwao Kosho, Aizawa Ayako, Kariya Yimi, Matsuda Motohiro, Miyauchi Shunichi, Takajo Ichiro, Umekita Kunihiko

Internal Medicine advpub ( 0 ) 3131 - 3135 2022.10

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

Neuropsychiatric systemic lupus erythematosus (NPSLE) with cerebral vasculitis is rare, and its prognosis is unfavorable. High-dose glucocorticoids and cyclophosphamide are widely used for the treatment of NPSLE, but cyclophosphamide has a risk of cervical intraepithelial neoplasia and ovarian insufficiency, which may discourage its use in young women. We experienced a case of NPSLE with cerebral vasculitis and lupus nephritis that responded successfully to glucocorticoids and mycophenolate mofetil (MMF). MMF might be a treatment option for NPSLE without concern for reproductive toxicity. However, there are only a few reports on the efficacy of MMF in NPSLE, and further investigations are needed.

DOI： 10.2169/internalmedicine.9123-21

High incidence of serious infections requiring hospitalisation in human T-cell leukaemia virus type 1-positive rheumatoid arthritis: A case-controlled observational study. Reviewed

Hashiba Y, Umekita K, Kimura M, Iwao C, Iwao K, Kariya Y, Kubo K, Miyauchi S, Kudou R, Rikitake Y, Kawaguchi T, Matsuda M, Takajo I, Inoue E, Hidaka T, Okayama A.

Mod Rheumatol 32 ( 5 ) 866 - 874 2022.8

Publishing type：Research paper (scientific journal)

DOI： 10.1093/mr/roab077.

High incidence of serious infections requiring hospitalisation in human T-cell leukaemia virus type 1-positive rheumatoid arthritis: A case-controlled observational study. International journal

Yayoi Hashiba, Kunihiko Umekita, Masatoshi Kimura, Chihiro Iwao, Kosho Iwao, Yumi Kariya, Kazuyoshi Kubo, Shunichi Miyauchi, Risa Kudou, Yuki Rikitake, Takeshi Kawaguchi, Motohiro Matsuda, Ichiro Takajo, Eisuke Inoue, Toshihiko Hidaka, Akihiko Okayama

Modern rheumatology 32 ( 5 ) 866 - 874 2022.8

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: We aimed to assess the clinical features of human T-cell leukaemia virus type 1 (HTLV-1)-positive rheumatoid arthritis (RA) patients. Furthermore, we investigated the impact of HTLV-1 infection on incidences of serious infections requiring hospitalisation (SIH) and malignancies. METHODS: A total of 150 sex- and age-matched HTLV-1-negative and 50 HTLV-1-positive RA patients were enrolled from the HTLV-1 RA Miyazaki Cohort Study. Clinical and laboratory data were collected from this cohort database. The incidence rate (IR) for SIH and malignancies from 2015 to 2020 was analysed. RESULTS: The median age and female ratio in the study population were 70 years old and 80%, respectively. Although no differences were found in inflammatory marker values between the two groups, the patient global assessment and Health Assessment Questionnaire scores were higher in HTLV-1-positive RA patients. In HTLV-1-negative RA patients, the IR for SIH was 6.37/100 person-years (PY) and 1.32/100 PY for malignancies. In HTLV-1-positive RA patients, SIH occurred in 11.1/100 PY and malignancies in 2.46/100 PY. The crude IR ratio comparing SIH between two groups was 1.74 (95% confidence interval, 1.04-2.84), which was a significant increase. CONCLUSIONS: HTLV-1-positive RA patients may worsen RA symptoms. HTLV-1 may be a risk factor for SIH.

DOI： 10.1093/mr/roab077

Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan Reviewed

Oka K., Matsumoto A., Tetsuka N., Morioka H., Iguchi M., Ishiguro N., Nagamori T., Takahashi S., Saito N., Tokuda K., Igari H., Fujikura Y., Kato H., Kanai S., Kusama F., Iwasaki H., Furuhashi K., Baba H., Nagao M., Nakanishi M., Kasahara K., Kakeya H., Chikumi H., Ohge H., Azuma M., Tauchi H., Shimono N., Hamada Y., Takajo I., Nakata H., Kawamura H., Fujita J., Yagi T.

Journal of Global Antimicrobial Resistance 29 247 - 252 2022.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Global Antimicrobial Resistance

Objectives: The dissemination of difficult-to-treat carbapenem-resistant Enterobacterales (CRE) is of great concern. We clarified the risk factors underlying CRE infection mortality in Japan. Methods: We conducted a retrospective, multicentre, observational cohort study of patients with CRE infections at 28 university hospitals from September 2014 to December 2016, using the Japanese National Surveillance criteria. Clinical information, including patient background, type of infection, antibiotic treatment, and treatment outcome, was collected. The carbapenemase genotype was determined using PCR sequencing. Multivariate analysis was performed to identify the risk factors for 28-day mortality. Results: Among the 179 patients enrolled, 65 patients (36.3%) had bloodstream infections, with 37 (20.7%) infections occurring due to carbapenemase-producing Enterobacterales (CPE); all carbapenemases were of IMP-type (IMP-1: 32, IMP-6: 5). Two-thirds of CPE were identified as Enterobacter cloacae complex. Combination therapy was administered only in 46 patients (25.7%), and the 28-day mortality rate was 14.3%. Univariate analysis showed that solid metastatic cancer, Charlson Comorbidity Index ≥3, bloodstream infection, pneumonia, or empyema, central venous catheters, mechanical ventilation, and prior use of quinolones were significant risk factors for mortality. Multivariate analysis revealed that mechanical ventilation (OR: 6.71 [1.42–31.6], P = 0.016), solid metastatic cancers (OR: 5.63 [1.38–23.0], P = 0.016), and bloodstream infections (OR: 3.49 [1.02–12.0], P = 0.046) were independent risk factors for 28-day mortality. Conclusion: The significant risk factors for 28-day mortality in patients with CRE infections in Japan are mechanical ventilation, solid metastatic cancers, and bloodstream infections.

DOI： 10.1016/j.jgar.2022.04.004

Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan. Reviewed

J Glob Antimicrob Resist 29 247 - 252 2022.4

Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jgar.2022.04.004.

Severe Fever with Thrombocytopenia Syndrome Accompanied by Invasive Pulmonary Aspergillosis: An Autopsy Case. International journal

Kosho Iwao, Takeshi Kawaguchi, Masatoshi Kimura, Chihiro Iwao, Mao Rikitake, Ayako Aizawa, Yumi Kariya, Motohiro Matsuda, Syunichi Miyauchi, Ichiro Takajo, Takumi Kiwaki, Tsuyoshi Fukushima, Hiroaki Kataoka, Tadaki Suzuki, Akihiko Okayama, Kunihiko Umekita

Viruses 13 ( 6 ) 2021.6

Language：Japanese Publishing type：Research paper (scientific journal)

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tickborne infectious disease in China, Korea, and Japan caused by the SFTS virus (SFTSV). SFTS has a high mortality rate due to multiorgan failure. Recently, there are several reports on SFTS patients with mycosis. Here, we report a middle-aged Japanese SFTS patient with invasive pulmonary aspergillosis (IPA) revealed by an autopsy. A 61-year-old man with hypertension working in forestry was bitten by a tick and developed fever, diarrhea, and anorexia in 2 days. On day 4, consciousness disorder was appearing, and the patient was transferred to the University of Miyazaki Hospital. A blood test showed leukocytopenia, thrombocytopenia, as well as elevated levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine kinase. The SFTSV gene was detected in serum using a reverse-transcription polymerase chain reaction. On day 5, respiratory failure appeared and progressed rapidly, and on day 7, the patient died. An autopsy was performed that revealed hemophagocytosis in the bone marrow and bleeding of several organs. IPA was observed in lung specimens. SFTSV infection may be a risk factor for developing IPA. Early diagnosis and treatment of IPA may be important in patients with SFTS.

DOI： 10.3390/v13061086

Detection of anti-SFTSV nuclear protein antibody in the acute phase sera of patients using double-antigen ELISA and immunochromatography. Reviewed International journal

Kazumi Umeki, Asato Yasuda, Kunihiko Umekita, Ryoya Megumi, Hajime Nomura, Takeshi Kawaguchi, Motohiro Matsuda, Ichiro Takajo, Masayuki Shimojima, Akihiko Okayama

Journal of virological methods 285 113942 - 113942 2020.11

Language：English Publishing type：Research paper (scientific journal)

Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening febrile illness that is caused by the SFTS virus (SFTSV). The diagnosis of SFTS is usually performed by detecting viral RNA. However, it has been reported that viral RNA is no longer detectable at 6-12 days after the onset of disease. In the current study, we have constructed a plasmid to express the recombinant nuclear protein (NP) based on the Japanese strain of SFTSV (J1). We developed a double-antigen enzyme-linked immunosorbent assay (ELISA) and immunochromatography (IC) assay using recombinant NP to detect antibody against SFTSV-NP. When we tested time-sequential samples from four patients with SFTS, antibody to SFTSV-NP were detectable not only during the recovery phase (days 10-622) but also during the acute phase (days 4-7) of the disease using both of a double-antigen ELISA and IC assay. SFTSV-RNA was detected until 8-11 days after onset, thus suggesting the coexistence of the virus and antibody during the acute phase of SFTS. These data suggest that assays for detecting antibody against SFTS-NP described in the current study may be applicable not only for the epidemiological studies but also for the diagnosis of SFTS.

DOI： 10.1016/j.jviromet.2020.113942

Human T-cell leukemia virus type 1 may invalidate T-SPOT.TB assay results in rheumatoid arthritis patients: A retrospective case-control observational study. Reviewed International journal

Kunihiko Umekita, Yayoi Hashiba, Kosho Iwao, Chihiro Iwao, Masatoshi Kimura, Yumi Kariya, Kazuyoshi Kubo, Shunichi Miyauchi, Risa Kudou, Yuki Rikitake, Katoko Takajo, Takeshi Kawaguchi, Motohiro Matsuda, Ichiro Takajo, Eisuke Inoue, Toshihiko Hidaka, Akihiko Okayama

PloS one 15 ( 5 ) e0233159 2020.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: CD4-positive T cells are the main target of human T-cell leukemia virus type 1 (HTLV-1). Interferon-γ release assays rely on the fact that T-lymphocytes release this cytokine when exposed to tuberculosis-specific antigens and are useful in testing for latent tuberculosis infection before initiating biologic therapy, such as anti-tumor necrosis factor agents. However, the reliability of interferon-γ release assays in detecting tuberculosis infection among HTLV-1-positive patients with rheumatoid arthritis (RA) remains unclear. The present study aimed to evaluate the use of the T-SPOT.TB assay in HTLV-1-positive RA patients. METHODS: Overall, 29 HTLV-1-positive RA patients and 87 age- and sex-matched HTLV-1-negative RA patients (controls) were included from the HTLV-1 RA Miyazaki Cohort Study. Results of the T-SPOT.TB assay for latent tuberculosis infection screening were collected from medical records of patients. RESULTS: Approximately 55% of the HTLV-1-positive RA patients showed invalid T-SPOT.TB assay results (odds ratio: 108, 95% confidence interval: 13.1-890, p < 0.0001) owing to a spot count of >10 in the negative controls. HTLV-1 proviral load values were significantly higher in patients with invalid results compared with those without invalid results (p = 0.003). CONCLUSION: HTLV-1 infection affects T-SPOT.TB assay results in RA patients. Assay results in HTLV-1 endemic regions should be interpreted with caution when screening for latent tuberculosis infection before initiation of biologic therapy.

DOI： 10.1371/journal.pone.0233159

Effective Treatment with Tocilizumab in a Rheumatoid Arthritis Patient Complicated with Human T-cell Leukemia Virus Type 1-associated Myelopathy: A Case Report. Reviewed

Chihiro Iwao, Kunihiko Umekita, Shunichi Miyauchi, Masatoshi Kimura, Yuki Rikitake, Koushou Iwao, Mao Rikitake, Ayako Aizawa, Takeshi Kawaguchi, Yumi Kariya, Motohiro Matsuda, Ichiro Takajo, Kazutaka Shiomi, Akihiko Okayama

Internal medicine (Tokyo, Japan) 59 ( 15 ) 1891 - 1897 2020.4

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

A 61-year-old woman with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and interstitial pneumonia (IP) was admitted to our hospital. She complained of sicca symptoms, polyarthralgia, and swollen joints. She was diagnosed with rheumatoid arthritis (RA) and Sjogren's syndrome. Methotrexate and anti-tumor necrosis factor therapy were not utilized because of the inclusion of severe respiratory disorders among the complications and the neurological symptoms of HAM/TSP. Tocilizumab monotherapy improved the RA disease activity without exacerbating HAM/TSP. The present case suggests that tocilizumab might be a suitable treatment option in patients with RA and HAM/TSP.

DOI： 10.2169/internalmedicine.4455-20

Pseudo-outbreak of Mycobacterium paragordonae in a hospital: possible relation to the aerator/rectifier connected to the faucet of the water supply system. Reviewed

Takajo I, Iwao C, Aratake M, Nakayama Y, Yamada A, Takeda N, Saeki Y, Umeki K, Toyama T, Hirabara Y, Fukuda M, Okayama A

J Hosp Infect. 104 ( 4 ) 545 - 551 2020.4

Language：English Publishing type：Research paper (scientific journal)

Pseudo-outbreak of Mycobacterium paragordonae in a hospital: possible role of the aerator/rectifier connected to the faucet of the water supply system

Takajo I., Iwao C., Aratake M., Nakayama Y., Yamada A., Takeda N., Saeki Y., Umeki K., Toyama T., Hirabara Y., Fukuda M., Okayama A.

Journal of Hospital Infection 104 ( 4 ) 545 - 551 2020.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Hospital Infection

Background: Pseudo-outbreaks of non-tuberculous mycobacteria (NTM) in association with the water supply system in hospitals have been previously reported. We found that the frequency of NTM isolation in clinical samples increased after the reconstruction and renovation of a hospital in Japan in 2014. Aim: To analyse NTM, their possible relationship with the hospital water supply system, and outcomes of preventive measures. Methods: Environmental samples obtained from the water supply in hospital wards were tested for NTM. On obtaining positive results, the bacteria were further analysed using polymerase chain reaction (PCR). Findings: The PCR products of NTM showed that most samples tested positive for Mycobacterium paragordonae. Because none of the analysed patients developed any disease due to these bacteria, this event was considered a pseudo-outbreak. Investigation of the water supply system revealed that samples obtained from the recently attached aerators/rectifiers during hospital renovation tested positive for these bacteria. Therefore, measures to remove aerators/rectifiers and prevent patients from drinking tap water in the hospital were introduced. Thereafter, the frequency of NTM-positive samples significantly decreased in the hospital. Conclusion: This study is one of the few reports which reveal the possibility of pseudo-outbreaks of M. paragordonae in hospitals, hence raising the question whether aerators/rectifiers should be used in hospitals at all, because their mesh structure may promote NTM proliferation in supplied water. The importance of surveillance of bacteria derived from the environment, particularly after hospital reconstruction/renovation, is re-emphasized.

DOI： 10.1016/j.jhin.2019.11.014

TNF阻害療法経過中に肺 Mycobacterium avium complex 感染症を発症したHTLV-1陽性関節リウマチ患者への生物学的製剤治療経験. Reviewed

木村賢俊, 梅北邦彦, 工藤理紗, 岩尾千紘, 力武雄幹, 力武真央, 岩尾浩昭, 相澤彩子, 川口剛, 仮屋裕美, 松田基弘, 宮内俊一, 高城佳人子, 高城一郎, 岡山昭彦.

九州リウマチ 40 ( 1 ) 34 - 40 2020.3

Language：Japanese Publishing type：Research paper (scientific journal)

Long-Term Outcome of Infection Control for Methicillin-Resistant Staphylococcus Aureus and Kaizen Approach with Problem-Solving. Reviewed

Ayabe T, Tomita M, Takajo I, Nakayama Y, Maeda R, Okumura M, Nakamura K.

Open Journal of Safety Science and Technology. 10 ( 1 ) 1 - 23 2020.3

Publishing type：Research paper (scientific journal)

DOI： 10.4236/ojsst.2020.101001

The time-sequential changes of risk factors for adult T-cell leukemia development in human T-cell leukemia virus-positive patients with rheumatoid arthritis: a retrospective cohort study. Reviewed

Umekita K., Hashiba Y., Kariya Y., Kubo K., Miyauchi S., Aizawa A., Umeki K., Nomura H., Kawaguchi T., Matsuda M., Takajo I., Hidaka T., Okayama A.

Modern Rheumatology 29 ( 5 ) 795 - 801 2019.9

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1080/14397595.2018.1519890

IgG4関連涙腺・唾液腺炎に認められた回腸末端部の隆起性病変. Reviewed

岩尾浩昭, 梅北邦彦, 岩尾千紘, 力武雄幹, 力武真央, 相澤彩子, 川口剛, 松田基弘, 宮内俊一, 高城一郎, 長安真由美, 秋山裕, 片岡寛章, 前川和也, 浅田祐士郎, 岡山昭彦.

九州リウマチ 39 ( 1 ) 40 - 48 2019.3

Language：Japanese Publishing type：Research paper (scientific journal)

Detection of microbial genes in a single leukocyte by polymerase chain reaction following laser capture microdissection. Reviewed

Yamada A, Umeki K, Saeki Y, Hashikura Y, Nomura H, Yamamoto I, Umekita K, Takajo I, Koshimoto C, Okayama A.

Journal of Microbiological Methods. 155 42 - 48 2018.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.mimet.2018.11.005

Multi-step genomic dissection of a suspected intra-hospital Helicobacter cinaedi outbreak. Reviewed

Gotoh Y, Taniguchi T, Yoshimura D, Katsura K, Saeki Y, Hirabara Y, Fukuda M, Takajo I, Tomida J, Kawamura Y, Ogura Y, Itoh T, Misawa N, Okayama A, Hayashi T.

Microb Genom. 4 ( 12 ) e000236 - e000236 2018.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1099/mgen.0.000236

Development of a simple and practical method of discrimination between Vibrio furnissii and V. fluvialis based on single-nucleotide polymorphisms of 16S rRNA genes observed in V. furnissii but not in V. fluvialis. Reviewed

Takajo, I., Yamada, A., Umeki, K., Saeki, Y., Hashikura, Y., Yamamoto, I., Umekita, K., Urayama-Kawano, M., Yamasaki, S., Taniguchi, T., Misawa, N., Okayama, A.

Journal of Microbiological Methods 144 22 - 28 2018.10

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.mimet.2017.10.014

Infliximab as an alternative therapy for refractory adult onset Kawasaki disease A case report Reviewed

Kawaguchi T., Rikitake Y., Tsuruda T., Kawata C., Rikitake M., Iwao K., Aizawa A., Kariya Y., Matsuda M., Miyauchi S., Umekita K., Takajo I., Okayama A.

Medicine (United States) 97 ( 40 ) e12720 - e12720 2018.10

Language：English Publishing type：Research paper (scientific journal)

© The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. Objective. The aim of this study was to clarify the mechanism of leucocytapheresis (LCAP) in patients with RA. Methods. Protein profiles of blood samples from two patients with RA obtained via LCAP column inlet and outlet lines were analysed by two-dimensional fluorescence difference gel electrophoresis and mass spectrometry. The lactoferrin (LTF) levels of peripheral and circulating blood samples from seven patients obtained via the LCAP column blood circuit were then determined by ELISA. Peripheral blood samples from 14 patients with RA were exposed to unwoven polyester fibre filters and the LTF level was determined. In addition, morphological changes in neutrophils after exposure to the filter were examined by optical microscopy, electronic microscopy and LTF immunostaining. Results. LTF levels were increased in both samples from the LCAP column outlet and peripheral blood at the end of LCAP treatment. Furthermore, peripheral blood samples exposed to the filter revealed a decreased number of neutrophils and an increased level of LTF. Morphological analysis of the exposed neutrophils showed vacuolization of the cytoplasm and degranulation of LTF-positive granules. These data suggest that LTF stored in the granules of neutrophils is released from the neutrophils caught in the LCAP column. Conclusion. Because LTF has been reported to have multiple anti-inflammatory properties, increased levels of LTF may contribute to the clinical effect of LCAP in patients with RA.

DOI： 10.1097/MD.0000000000012720

Adult T-cell Leukemia/Lymphoma as a Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis - A Case Report. Reviewed

Takajo Ichiro, Umekita Kunihiko, Ikei Yoshihiko, Oshima Koichi, Okayama Akihiko

Internal Medicine 57 ( 14 ) 2071 - 2075 2018.7

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2169/internalmedicine.0308-17

病院大規模再整備に伴うアスペルギルス感染予防対策. Reviewed

岡山昭彦, 福田真弓, 佐伯裕二, 高城一郎, 平原康寿.

環境感染誌. 33 ( 4 ) 161 - 168 2018.7

Language：Japanese Publishing type：Research paper (scientific journal)

C.DIFF QUIK CHEK COMPLETE®にてクロストリジウム・ディフィシル抗原（グルタミン酸デヒドロゲナーゼ(GDH)）陽性・トキシン陰性を示した検体におけるBDマックスCDIFF®を用いた遺伝子検査の有用性. Reviewed

松浦成美, 佐伯裕二, 梅木一美, 武田展幸, 山田明輝, 山本成郎, 高城一郎, 岡山昭彦.

医学検査. 67 ( 4 ) 451 - 455 2018.7

Language：Japanese Publishing type：Research paper (scientific journal)

母児結核感染例の院内感染対策. Reviewed

高城一郎, 荒武舞, 福田真弓, 平原康寿, 佐伯裕二, 岡山昭彦.

環境感染誌. 33 ( 2 ) 81 - 86 2018.3

Language：Japanese Publishing type：Research paper (scientific journal)

多発脳梗塞を来した治療抵抗性巨細胞性動脈炎の1例. Reviewed

力武真央, 梅北邦彦, 楠元規生, 岩尾浩昭, 相澤彩子, 松田基弘, 久保和義, 仮屋裕美, 宮内俊一, 高城一郎, 長友安弘, 岡山昭彦.

九州リウマチ. 37 ( 2 ) 125 - 131 2017.9

Language：Japanese Publishing type：Research paper (scientific journal)

筋ジストロフィーとの鑑別を要し、経口ステロイドおよびタクロリムス併用療法が奏功した抗SRP抗体陽性ミオパチーの2例. Reviewed

河野彩子, 梅北邦彦, 小村真央, 岩尾浩昭, 松田基弘, 久保和義, 宮内俊一, 高城一郎, 長友安弘, 塩見一剛, 西野一三, 岡山昭彦.

九州リウマチ. 37 ( 1 ) 72 - 79 2017.3

Language：Japanese Publishing type：Research paper (scientific journal)

関節リウマチ治療中に発症したウエステルマン肺吸虫症.

小村真央, 宮内俊一, 岩尾浩昭, 河野彩子, 松田基弘, 久保和義, 梅北邦彦, 高城一郎, 長友安弘, 岡山昭彦, 丸山治彦.

宮崎県内科医会誌. ( 91 ) 11 - 15 2017.3

Language：Japanese Publishing type：Research paper (scientific journal)

Possible Case of Novel Spotted Fever Group Rickettsiosis in Traveler Returning to Japan from India. Reviewed

Takajo I, Sekizuka T, Fujita H, Kawano A, Kawaguchi T, Matsuda M, Kubo K, Miyauchi S, Umekita K, Nagatomo Y, Kuroda M, Takasaki T, Okayama A, Ando S.

Emerging Infectious Diseases. 2016.6

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3201/eid2206.151985.

The pathogenic potential of Helicobacter cinaedi isolated from non-human sources: adherence, invasion and translocation ability in polarized intestinal epithelial Caco-2 cells in vitro. Reviewed

Taniguchi T, Yamazaki W, Saeki Y, Takajo I, Okayama A, Hayashi T, Misawa N.

The Journal of Veterinary Medical Science. 78 ( 4 ) 627 - 632 2016.3

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1292/jvms.15-0595.

Use of anti-tumor necrosis factor biologics in the treatment of rheumatoid arthritis does not change human T-lymphotropic virus type 1 markers: a case series. Reviewed

Umekita K, Umeki K, Miyauchi S, Ueno S, Kubo K, Kusumoto N, Takajo I, Nagatomo Y, Okayama A.

Modern Rheumatology. 2013.11

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3109/14397595.2013.844389

Treatment with anti-tumor necrosis factor biologics in human T-lymphotropic virus type 1 positive patients with rheumatoid arthritis. Reviewed

Umekita K, Hidaka T, Miyauchi S, Ueno S, Kubo K, Takajo I, Hashiba Y, Kai Y, Nagatomo Y, Okayama A.

Arthritis Care Res (Hoboken). 68 ( 5 ) 788 - 792 2013.10

Language：English Publishing type：Research paper (scientific journal)

In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,866 clinical isolates obtained from 72 centers in 2010

Yamaguchi K., Ohno A., Ishii Y., Tateda K., Iwata M., Akizawa K., Shimizu C., Hayashi T., Kaku M., Kunishima H., Kitagawa M., Miki M., Kawamura C., Yasujima M., Tashiro H., Horiuchi H., Katayama Y., Suwabe A., Kurota M., Kikuchi K., Kuroki S., Hirayama K., Takahashi T., Gotou T., Morikane K., Ota R., Nakagawa T., Moriya K., Murata M., Yoneyama A., Kondou S., Misawa S., Sekine I., Shiotani J., Nakayama T., Yagoshi M., Horiuchi H., Tazawa Y., Kanno H., Aihara M., Yamazaki K., Okamoto H., Haruki K., Yazawa J., Nagano E., Okada M., Fukuda Y., Ikari H., Maesaki S., Hashikita G., Sumitomo M., Miyajima E., Saito T., Taniguchi N., Hishinuma A., Yamamoto Y., Okamoto Y., Yamane N., Maruyama R., Kawashima C., Murakami M., Yomoda S., Machida T., Ozaki Y., Uchida T., Baba H., Sugiura Y., Kondo K., Yamada T., Gonda H., Yamaguchi I., Akahori T., Uemura K., Maekawa M., Yoshimura H., Nakatani K., Matsushima Y., Nobori T., Fujimoto Y., Asano Y., Morinaga A., Fujita S., Senda Y., Hida Y., Yamashita M., Yoshida H., Ichiyama S., Okabe H., Shigeta M., Shimizu K., Masaki H., Heijyou H., Nakaya H., Takubo T., Kusakabe T., Higashiyama T., Yoshida H., Morishita H., Matsuo S., Kono H.

Japanese Journal of Antibiotics 65 ( 3 ) 181 - 206 2012.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Antibiotics

Postmarketing surveillance of levofloxacin (LVFX) has been conducted continuously since 1992. The present survey was performed to investigate in vitro susceptibility of recent clinical isolates in Japan to 30 selected antibacterial agents, focusing on fluoroquinolones (FQs). The common respiratory pathogens Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae continue to show a high susceptibility to FQs. In contrast, widely-prevailing resistance to macrolides was markedly noted among S. pneumoniae and S. pyogenes. Regarding H. influenzae, the prevalence of β-lactamase-negative ampicillin-resistant isolates has been increasing year by year (25.8% in 2002, 40.0% in 2004, 50.1% in 2007, and 57.9% in 2010). Enterobacteriaceae showed high susceptibility to FQs, however, prevalence of LVFX-resistant Escherichia coli, including intermediate resistance, was 29.3%, showing an increase over time. Nevertheless, the increase in the prevalence of LVFX-resistant E. coli isolates has slowed since 2007 (8.2% in 2000, 11.8% in 2002, 18.8% in 2004, 26.2% in 2007, and 29.3% in 2010), suggesting the influence of LVFX 500 mg tablets since its approval in 2009. Another Enterobacteriaceae member, Klebsiella pneumoniae, showed low resistance to FQs, in contrast with E. coli. In methicillin-resistant Staphylococcus aureus (MRSA), the percentage of FQ-susceptible isolates was low, at 51.6% for susceptibility to sitafloxacin, and at only around 10% for susceptibility to other FQs. However, methicillin-susceptible S. aureus (MSSA) isolates were highly susceptible to FQs, with the percentage ranging from 88.5% to 99.1%. The prevalence of FQs-resistant isolates in methicillin-resistant coagulase-negative staphylococci was higher than that in methicillin-susceptible coagulase-negative staphylococci, although it was lower than the prevalence of FQ-resistance in MRSA. The prevalence of FQs-resistant Pseudomonas aeruginosa isolates derived from urinary tract infections (UTIs) was 15.4-21.3%, higher than the prevalence of 6.1-12.3% in P. aeruginosa isolates from respiratory tract infections (RTIs). While this trend was consistent with the results of previous surveillance, gradual decreases were noted in the prevalence of FQ-resistant P. aeruginosa isolates derived from UTIs. The prevalence of multidrug-resistant P. aeruginosa was 2.3% among isolates derived from UTIs and 0.3% among isolates from RTIs, a decrease from the results of 2007, Acinetobacter spp. showed high susceptibility to FQs. Imipenem-resistant Acinetobacter baumannii, which is currently an emerging issue, was detected at a prevalence of 2.4% (13 isolates). Neisseria gonorrhoeae showed a high resistance of 81.3-82.5%, to FQs. Ceftriaxone (CTRX) continued to show 100% susceptibility until 2007, but the present survey revealed the advent of resistance to CTRX in some clinical isolates. The result of the present survey indicated that although methicillin-resistant staphylococci, Enterococcus faecium, P. aeruginosa from UTIs, N. gonorrhoeae, and E. coli showed resistance of about 20% or more (19.5-89.2%) against the FQs which have been used clinically for over 17 years, the trends observed were similar to the results of previous surveillance. While FQ resistance has been prevailing in E. coli, E. coli still shows more than 70% susceptibility to FQs. The other bacterial species maintained high susceptibility rates of greater than 80%, against FQs.

膠原病患者に合併した細菌感染症診断におけるプロカルシトニン測定の有用性. Reviewed

高城一郎, 山本成郎, 梅木一美, 岡山昭彦.

臨床病理 60 ( 4 ) 294 - 299 2012.4

Language：Japanese Publishing type：Research paper (scientific journal)

Usefulness of serum procalcitonin measurement in the diagnosis of bacterial infection in patients with systemic autoimmune diseases.

Takajo I, Yamamoto I, Umeki K, Okayama A

Rinsho byori. The Japanese journal of clinical pathology 60 ( 4 ) 294 - 9 2012.4

Language：English Publishing type：Research paper (scientific journal)

A case of intubation granuloma treated with steroid inhalation

Proviral loads of human T-lymphotropic virus type 1 in asymptomatic carriers with different infection routes. Reviewed

Ueno S, Umeki K, Takajo I, Nagatomo Y, Kusumoto N, Umekita K, Morishita K, Okayama A.

International Journal of Cancer 130 ( 10 ) 2318 - 2326 2011.8

Language：English Publishing type：Research paper (scientific journal)

Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers. Reviewed

Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, Okayama A.

International Journal of Cancer 128 ( 6 ) 1335 - 1343 2011.3

Language：English Publishing type：Research paper (scientific journal)

MIYAUCHI Shun-ichi, NAGATOMO Yasuhiro, KUBO Kazuyoshi, UMEKITA Kunihiko, UENO Shirou, TAKAJOU Ichirou, KAI Yasufumi, OKAYAMA Akihiko

48 ( 7 ) 488 - 491 2010.7

Language：Japanese Publishing type：Research paper (scientific journal)

Diagnosis of Bacterial Infection Using Procalcitonin Reviewed

TAKAJO Ichiro, OKAYAMA Akihiko

The Official journal of Japanese Society of Laboratory Medicine 58 ( 5 ) 517 - 522 2010.5

Language：Japanese Publishing type：Research paper (scientific journal)

Multiple Integrations of Human T-Lymphotropic Virus Type 1 Proviruses in the Engrafted Cells from the Asymptomatic Carriers in NOD/SCID/γcnull Mice. Reviewed

Yamamoto I, Takajo I, Umeki K, Morishita K, Hatakeyama K, Kataoka H, Nomura H, Okayama A.

Intervirology 53 ( 4 ) 229 - 239 2010.3

Language：English Publishing type：Research paper (scientific journal)

炎症マーカー・プロカルシトニンを中心に Reviewed

高城一郎

臨床化学 38 2009.7

Language：Japanese Publishing type：Research paper (scientific journal)

Overwhelming Postsplenectomy Infection 22 Years After Splenectomy Reviewed

KUSUMOTO Norio, KUROKI Masayuki, UMEKITA Kunihiko, UENO Shiro, TAKAJO Ichiro, KAI Yasufumi, NAGATOMO Yasuhiro, SHIMADA Masami, HIDAKA Tomonori, KUBO Kazuyoshi, MIYAUCHI Syunnichi, OKAYAMA Akihiko

Kansenshogaku Zasshi 83 ( 3 ) 261 - 265 2009.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Infectious Diseases

A 25-year-old man undergoing splenectomy at 3 years of age to treat idiopathic thrombocytopenic purpura but no history of Streptococcus pneumonia vaccination, and reporting high fever, nausea, and headache developed purpura, confusion, and hypotension the next day and was admitted. Detailed examination showed disseminated intravascular coagulation and multiple-organ dysfunction. Chest X-ray and computed tomography (CT) showed pneumonia and pleural effusion. Blood culture was positive for S. pneumoniae. Gram staining of sputa yielded numerous white blood cells and gram-negative rods, and sputa culture was positive for Pasteurella multocida and Haemophilus influenzae. The medical history and presence of these organisms yielded a diagnosis of overwhelming postsplenectomy infection (OPSI), and the patient responded to treatment with a combination of benzylpenicillin, cefotaxime, and meropenem. This case suggests that patients with a history of splenectomy may benefit from vaccination for S. pneumoniae and adequate education on OPSI.

DOI： 10.11150/kansenshogakuzasshi.83.261

Successful treatment with corticosteroid to the complete atrioventricular block associated with an adult systemic lupus erythematosus Reviewed

KUSUMOTO Norio, KAI Yasufumi, KUBO Kazuyoshi, MIYAUCHI Syunnichi, UMEKITA Kunihiko, UENO Shiro, TAKAJO Ichiro, NAGATOMO Yasuhiro, OKAYAMA Akihiko, KAMEDA Takuro, SHIMODA Kazuya

Nihon Naika Gakkai Zasshi 98 ( 4 ) 859 - 861 2009.4

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

DOI： 10.2169/naika.98.859

白血球除去療法(LCAP)が長期間有効であった慢性C型肝炎合併関節リウマチの1例(一般論文,日本アフェレシス学会第14回九州地方会抄録) Reviewed

Leukocytapheresis (LCAP) decreases the level of platelet-derived microparticles (MPs) and increases the level of granulocytes-derived MPs: a possible connection with the effect of LCAP on rheumatoid arthritis. Reviewed

Umekita K, Hidaka T, Ueno S, Takajo I, Kai Y, Nagatomo Y, Sawaguchi A, Suganuma T, Okayama A.

Modern Rheumatology 19 ( 3 ) 265 - 272 2009.4

Language：English Publishing type：Research paper (scientific journal)

Activation of complement system in adult T-cell leukemia (ATL) occurs mainly through lectin pathway: A serum proteomic approach using mass spectrometry. Reviewed

Yo-ichi Ishida, Kiyoshi Yamashita, Hidenori Sasaki, Ichirou Takajou, Yoko Kubuki, Kazuhiro Morishita, Hirohito Tsubouchi, Akihiko Okayama

Cancer Letters 271 ( 1 ) 167 - 177 2008.11

Language：English Publishing type：Research paper (scientific journal)

大学病院検査部における技師・学生教育

梅木一美、緒方陽一、島田雅巳、野村創、高城一郎、岡山昭彦

宮崎県臨床検査技師会会誌 88 38 - 40 2008.1

Language：Japanese Publishing type：Research paper (scientific journal)

梅北邦彦, 荻野展永, 楠元規生, 上野史朗, 高城一郎, 甲斐泰文, 黒木昌幸, 長友安弘, 岡山昭彦

日本アフェレシス学会雑誌 27 ( 3 ) 250 - 251 2008

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本アフェレシス学会

Engraftment of peripheral blood mononuclear cells from human T-lymphotropic virus Type 1 carriers in NOD/SCID/gammac(null) (NOG) mice. Reviewed

Ichiro Takajo, Kazumi Umeki, Kazuhiro Morishita, Ikuo Yamamoto, Yoko Kubuki, Kinta Hatakeyama, Hiroaki Kataoka, Akihiko Okayama

International Journal of Cancer 121 ( 10 ) 2205 - 2211 2007.11

Language：English Publishing type：Research paper (scientific journal)

[18F]fluorodeoxyglucose positron emission tomography is a useful tool to diagnose the early stage of Takayasu’s arteritis and to evaluate the activity of the disease. Reviewed

Umekita K, Takajo I, Miyauchi S, Tsurumura K, Ueno S, Kusumoto N, Kai Y, Kuroki M, Sasaki T, Okayama A

Mod Rheumatol. 16 ( 4 ) 243 - 247 2006.8

Language：English Publishing type：Research paper (scientific journal)

Search for Serum Markers of Adult T-cell leukemia (ATL) ; Identification of C3f, Thymosin beta 4, and Cystatin A Reviewed

Ishida Yo-ichi, Yamashita Kiyoshi, Sasaki Hidenori, Takajou Ichirou, Kubuki Yoko, Morishita Kazuhiro, Tsubouchi Hirohito, Okayama Akihiko

Abstracts for Annual Meeting of Japanese Proteomics Society 2006 ( 0 ) 56 - 56 2006

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Proteomics Society (Japan Human Proteome Organisation)

DOI： 10.14889/jhupo.2006.0.56.0

Protein-losing gastropathy associated with autoimmune disease: successful treatment with prednisolone. Reviewed

Aoki T, Noma N, Takajo I, Yamaga JI, Otsuka M, Yuchi H, Ishikawa N, Inatsu H, Sakata JI, Asada Y, Eto T

J Gastroenterol 37 204 - 209 2002.1

Language：English Publishing type：Research paper (scientific journal)

A case with symptomatic epilepsy and mirror movement due to unilateral schizencephaly

Takajo I., Ohi T., Shiomi K., Sugimoto S., Matsukura S.

Brain and Nerve 52 ( 7 ) 617 - 620 2000.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Brain and Nerve

Schizencephaly is an extremely rare congenital disease caused by abnormal neuronal migration. The etiology of schizencephaly is not established but vascular disturbance in early childhood could cause this condition. We have cared of a patient with schizencephaly. The patient was 47 year old male. He had focal motor seizure with secondary generalization. Neurological examination revealed, mild left hemiparesis, left pyramidal signs with no sensory impairment, left hemiatrophy, and mirror movement. MRI findings showed schizencephaly, open lip type (type II) in right cerebral hemisphere. His epileptic seizure was controlled by administration of sodium valproate. The possible mechanism of this mirror movement in his left hand and leg could be reorganization of non-affected brain and disinhibition on homolateral pyramidal tract in non-affected left cerebral hemisphere by the transcallosal inhibitory pathway from affected right cerebral hemisphere. Sodium valpronate can not suppress this mirror movement.