Details of a Researcher - AYABE Takanori

Video-assisted thoracoscopic left upper lobectomy in a patient with situs inversus totalis

臨床倫理コンサルテーションにおいて倫理支援を行うメンバーに求められるコンピテンシー Reviewed

三浦由香里、板井孝壱郎、綾部貴典、深谷基裕

臨床倫理 ( 11 ) 66 - 78 2023.9

Language：Japanese Publishing type：Research paper (scientific journal)

Kuroki Shoei, Inomata Mayu, Ayabe Takanori, Maeda Ryo

The Journal of the Japanese Association for Chest Surgery 37 ( 2 ) 146 - 151 2023.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Chest Surgery

Complete situs inversus is a rare abnormality of autosomal recessive inheritance. The surgical management of this entity is complex because the viscus anatomy mirrors the normal anatomy. Here, we report a patient with complete situs inversus, who underwent lobectomy using video-assisted thoracic surgery for lung cancer of the left upper lobe. The procedure was successfully performed despite the patient's atypical anatomy, which mirrored the normal anatomy. Before the surgical intervention, we created a virtual image of left upper lobectomy in a patient with complete situs inversus by horizontally reversing a typical video of right upper lobectomy.

DOI： 10.2995/jacsurg.37.146

Pulmonary torsion after resuscitative thoracotomy: a case report

Hara Daisuke, Hamahiro Tomoka, Maeda Ryo, Ayabe Takanori, Tomita Masaki

Japanese Journal of Acute Care Surgery 13 ( 0 ) 62 - 66 2023

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for the Acute Care Surgery

The patient was a 30-year-old woman with a history of schizophrenia. She was transferred to our department due to abdominal trauma caused by suicide. She was undergone aortic clamping and cardiac massage by resuscitative thoracotomy for hemorrhagic shock and cardiac arrest. Subsequently, damage control surgery was performed for intraabdominal hemorrhage. On the second postoperative day, reoperation was scheduled for gauze depacking and gastrointestinal reconstruction, but a preoperative chest x-ray and chest CT showed decreased permeability of the left upper lobe. Postoperative pneumonia was diagnosed and reoperation was performed as scheduled. After that, a CT scan showed the same abnormality in the left lung, and left upper lobe pulmonary torsion was diagnosed by thoracic surgeon. Emergency operation was performed and the twisted upper lobe was removed. We report a rare case of pulmonary torsion that may be caused by resuscitative thoracotomy. The pulmonary torsion is required careful treatment.

DOI： 10.50840/jjacs.13-06

Competencies required for members who provide ethical support in clinical ethics consultations Reviewed

Miura Yukari, Itai Koichiro, Ayabe Takanori, Fukaya Motohiro

Journal of Clinical Ethics 11 ( 0 ) 66 - 78 2023

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Association for Clinial Ethics

In clinical ethics consultations in Japan, activities are carried out to provide appropriate advice in order to assist concerned parties in resolving anxieties and conflicts, such as withholding or discontinuing treatment, supporting patient decision-making, and so on. The purpose of this study is to conduct semi-structured interviews with senior clinical ethicists to clarify their competencies. The participants were 38 people from 20 medical institutions. Using theme analysis, 49 subcategories, 11 categories, and 4 themes were extracted from the verbatim transcripts. Clinical ethicists listens to the client’s anxieties regardless of their own perspective, sees through to the essence of the problem, and builds ethical reasoning. They support the discussion process itself in order to activate the exchange of opinions among participants through conferences and derive concrete measures for resolution. Above all, it is important to divide roles and promote cooperation within the ethics consulting team in order to demonstrate individual abilities. It was deduced from the narrative that they used a wide variety of competencies to support medical staff facing ethical issues.

DOI： 10.34329/jce.11.0_66

Promotion of Patient Safety Through an Enhanced Awareness of Clinical Ethics. Attempts to Collaborate between Safety Management and Clinical Ethics. Reviewed

Koichiro Itai, Yukari Miura , Takanori Ayabe

Journal of Philosophy and Ethics in Health Care and Medicine 16 64 - 70 2022.12

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

「医療安全・質の向上」を改善し、レジリエント・ヘルスケアで医療を変革する Invited Reviewed

綾部貴典

宮崎県医師会雑誌 46 107 - 127 2022.9

Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)

A spontaneous reduction in tumor size of a thymic carcinoma: a case report.

Kuroki S, Ayabe T, Tanaka H, Nakada H, Maeda R

Surgical case reports 8 ( 1 ) 154 2022.8

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s40792-022-01510-w

Intrapulmonary solitary fibrous tumor coexisting with lung adenocarcinomas.

Kuroki S, Ayabe T, Gi T, Sato Y, Nakada H, Maeda R

Surgical case reports 8 ( 1 ) 150 2022.8

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s40792-022-01508-4

Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells. Reviewed

Approach to seamless pre- and post-graduation medical safety education (1): Questionnaire survey regaring near-miss experiences of Japanse medical students Reviewed

Yukiko Kai, Takanori Ayabe, Taro Funamoto, Yamamoto Emiko, Yumiko Takeyama, Amy Hombu

Journal of Medical Safety 2022 17 - 24 2022.6

Language：English Publishing type：Research paper (scientific journal)

Approach to seamless pre- and post-graduation medical safety education (2): Comparative survey regarding near-miss experience of Japanese medical students and residents Reviewed

Yukiko Kai, Takanori Ayabe, Taro Funamoto, Emiko Yamamoto, Yumiko Takeyama, Amy Hombu

Journal of Medical Safety 2022 25 - 36 2022.6

Language：English Publishing type：Research paper (scientific journal)

Okumura, M., Iwakiri, T., Yoshikawa, N., Nagatomo, T., Ayabe, T. Tsuneyoshi, I., Ikeda, R.,

Int. J. Mol. Sci. 23 ( 16 ) 9108 2022.6

Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Molecular Sciences

Aberrant activation of hepatocyte growth factor (HGF) and its receptor c-Met axis promotes tumor growth. Therefore, many clinical trials have been conducted. A phase 3 trial investigating a monoclonal antibody targeting HGF in combination with fluoropyrimidine-based chemotherapy had to be terminated prematurely; however, the reason behind the failure remains poorly defined. In this study, we investigated the influence of HGF on the antineoplastic effects of 5-fluorouracil (5-FU), a fluoropyrimidine, in HepG2 cells. HGF suppressed the proliferative activity of cells concomitantly treated with 5-FU more robustly as compared to that of cells treated with 5-FU alone, and markedly increased the expression of uridine phosphorylase 1 (UPP1). Intracellular concentration of 5-fluorouridine, an initial anabolite of 5-FU catalyzed by UPP1, was increased by HGF. Interestingly, erlotinib enhanced HGF-induced increase in UPP1 mRNA; in contrast, gefitinib suppressed it. Furthermore, erlotinib suppressed HGF-increased phosphorylation of the epidermal growth factor receptor at the Tyr1173 site involved in downregulation of extracellular signal-regulated kinase (Erk) activation, and enhanced the HGF-increased phosphorylation of Erk. Collectively, these findings suggest that inhibition of the HGF/c-Met axis diminishes the effects of fluoropyrimidine through downregulation of UPP1 expression. Therefore, extreme caution must be exercised in terms of patient safety while offering chemotherapy comprising fluoropyrimidine concomitantly with inhibitors of the HGF/c-Met axis.

DOI： 10.3390/ijms23169108

Characteristics of Consultation Cases Related to Patient Decision-Making Support in Clinical Ethics Consultation Reviewed

A spontaneous reduction in tumor size of a thymic carcinoma: A case report. Reviewed

Shoei Kuroki; Takanori Ayabe; Hioyuki Tanaka; Hiroshi Nakada; Ryo Maeda.

Surgical Case Reports 12 154 2022.6

Language：English Publishing type：Case report

DOI： 10.1186/s40792-022-01510-w.

Intrapulmonary solitary fibrous tumor coexisting with lung adenocarcinomas. Reviewed

Shoei Kuroki, Takanori Ayabe, Toshihiro Gi, Yuchiro Sato, Hioshi Nakada, Ryo Maeda.

Surgical Case Reports 8 ( 1 ) 150 2022.6

Language：English Publishing type：Case report

DOI： 10.1186/s40792-022-01508-4.

第122回日本外科学会定期学術集会、特別企画(6)「医療安全を支えるNon-Technical Skills」　6. 「大学病院における多職種ノンテクニカルスキルの実践」安全管理確保のための質改善向上の取り組み Reviewed

綾部貴典、奥村　学、神田久美子、中村小夜子、小田浩美、山本亜矢、甲斐由紀子、恒吉勇男

日本外科学会雑誌 123 ( 6 ) 633 - 635 2022.6

Authorship：Lead author Language：Japanese Publishing type：Research paper (other academic)

MIURA Yukari, ITAI Koichiro, AYABE Takanori, FUKAYA Motohiro

Journal of Humanities in Medicine 12 ( 0 ) 19 - 32 2022

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Philosophical and Ethical Researches in Medicine (Kyushu)

DOI： 10.51031/itetsuq.12.0_19

Approach to seamless pre-and post-graduation medical safety education (2)：：Comparative survey regarding near-miss experiences of Japanese medical students and residents Reviewed

甲斐由紀子, 綾部貴典, 舩元太郎, 竹山ゆみ子, 山本恵美子

International Association of Risk Management in Medicine 1 2022

Publishing type：Research paper (scientific journal)

Approach to seamless pre-and post-graduation medical safety education (1)：Questionnaire survey regarding near-miss experiences of Japanese medical students Reviewed

甲斐由紀子, 綾部貴典, 舩元太郎, 竹山ゆみ子, 山本恵美子

International Association of Risk Management in Medicine 1 3 - 8 2022

Publishing type：Research paper (scientific journal)

Primary mucinous adenocarcinoma of the thymus: A case report

第121回日本外科学会定期学術集会、特別企画（2）「高難度新規医療技術導入に対する取り組み」、6.特能病院間相互ピアレビュー実施状況の報告「高難度新規医療技術を用いた医療の提供の適否等を決定する部門の運用状況」

綾部貴典*、後信、工藤篤、北村温美、西塔拓郎、中村京太、中島和江

日本外科学会雑誌 122 ( 5 ) 546 - 548 2021.9

Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)

「高難度新規医療技術」管理体制の現状と医療事故防止に向けた取り組み　-医療安全と臨床倫理双方の観点からの考察- Reviewed

三浦由佳里、板井孝壱郎、綾部貴典

人間と医療 11 4 - 17 2021.9

Language：Japanese Publishing type：Research paper (scientific journal)

Hamahiro Tomoka, Maeda Ryo, Ayabe Takanori, Sato Yuichiro, Tomita Masaki

Respiratory Medicine Case Reports 34 2021.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier

Recurrent solitary fibrous tumor of the pleura with malignant transformation: a case report.

Sakamoto R, Hamahiro T, Maeda R, Ayabe T, Tomita M, Tanaka H

Journal of surgical case reports 2021 ( 7 ) rjab283 2021.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Surgical Case Reports

We report a rare case of recurrent solitary fibrous tumor (SFT) of the pleura with suspicious malignant transformation. A 78-year-old man had undergone prior surgical resection of the primary and recurrent SFT tumors at 11 and 2 years before the current presentation. Although his primary tumor had a round shape and did not show invasive growth, the current recurrent tumor extended through the neural foramen and had an osteoclastic progression into the thoracic spine. A computed tomography (CT) guided needle biopsy was performed and the pathological diagnosis of the tumor was confirmed as the recurrence of SFT. Immunohistochemically, the MIB-1 proliferation index (Ki-67) of the primary tumor and the current tumor was 1.74 and 30.00%, respectively. These clinical and immunohistochemical findings were strongly suspected the malignant transformation of SFT from benign. He was treated with radiotherapy, and a response was observed.

DOI： 10.1093/jscr/rjab283

Pulmonary torsion after resuscitative thoracotomy: a case report.

Hara D, Hamahiro T, Maeda R, Ayabe T, Tomita M

Journal of surgical case reports 2021 ( 7 ) rjab313 2021.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Surgical Case Reports

We report a rare case of pulmonary torsion after nonpulmonary thoracotomy. A 38-year-old woman with schizophrenia committed suicide by a self-infliction of sharp force into the chest and abdomen. During emergent abdominal damage control surgery, a left-sided resuscitative thoracostomy was also performed due to hemorrhagic shock. Although abnormal shadow was detected on postoperative chest roentgenogram and computed tomography, the diagnosis of pulmonary torsion was delayed. Seven days after initial surgery, pulmonary torsion was diagnosed and managed by left upper lobectomy. To our knowledge, this is the first report of pulmonary torsion after resuscitative thoracotomy.

DOI： 10.1093/jscr/rjab313

Primary mucinous adenocarcinoma of the thymus: A case report

第120回日本外科学会定期学術集会、特別企画（4）「希望と安心をもたらす医療安全管理―無過失補償制度の可能性も含めて―」、3.外科医がリードする大学病院の医療安全管理の現状と課題 Invited Reviewed

綾部貴典、中村都英

日本外科学会雑誌 122 ( 1 ) 105 - 107 2021.1

Language：Japanese Publishing type：Research paper (scientific journal)

Hamahiro T., Maeda R., Ayabe T., Sato Y., Tomita M.

Respiratory Medicine Case Reports 34 101497 2021.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Respiratory Medicine Case Reports

Primary thymic mucinous adenocarcinoma is extremely rare; to our knowledge, only 16 cases have been reported to date. A 68-year-old man presented to a previous hospital due to massive pericardial effusion. Cytological examination of the pericardial effusion revealed the presence of adenocarcinoma, and computed tomography showed an anterior mediastinal mass lesion invading the pericardium. Because systemic examination failed to detect other lesions, except for liver metastasis, mediastinal lymph node swelling, and pleural dissemination, a thoracoscopic biopsy of the mediastinal and pleural tumor was performed. The pathological diagnosis was thymic mucinous adenocarcinoma. Although he received chemotherapy, he died due to cancer 6 months after the biopsy.

DOI： 10.1016/j.rmcr.2021.101497

Current status of "high-difficulty new medical technology" management system and efforts to prevent medical accidents

MIURA Yukari, ITAI Koichiro, AYABE Takanori

Journal of Humanities in Medicine 11 ( 0 ) 4 - 17 2021

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Philosophical and Ethical Researches in Medicine (Kyushu)

DOI： 10.51031/itetsuq.11.0_4

第120回日本外科学会定期学術集会、特別企画（4）「希望と安心をもたらす医療安全管理―無過失補償制度の可能性も含めて―」、3.外科医がリードする大学病院の医療安全管理の現状と課題

綾部貴典

日本外科学会雑誌 122(1) 105 - 107 2021

Publishing type：Research paper (scientific journal)

Prognostic impact of a novel tumor marker and inflammation index for patients with non-small-cell lung cancer

Development of a System to Support Surgical Safety-I and Safety-II. Implementation of Resilient Surgical Healthcare for Bleeding Incidents in Thoracic Surgery Reviewed

Ayabe T., Tomita M., Maeda R., Okumura M., Nakamura K.

Surgical Science 11 405 - 427 2020.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4236/ss.2020.1112043

Implementation of Resilience Engineering for Operating Room. Unveiling the Hidden Interactions among Multi-professionals in Surgical Team. Reviewed

Ayabe T., Tomita M.，Maeda R.，Okumura M., Nakamura K., Nakajima S., Nakajima K.

Surgical Science 11 242 - 256 2020.9

Language：English Publishing type：Research paper (scientific journal)

Implementation of Resilience Engineering for Thoracic Surgery. Reconciling Work-As-Imagined and Work-As-Done. Reviewed

Ayabe T.，Tomita M.，Maeda R.，Okumura M., Nakamura K., Nakajima K.

Surgical Science 11 257 - 273 2020.9

Language：English Publishing type：Research paper (scientific journal)

Randomized control trial on the efficacy of dual bronchodilator of glycopyrronium/indacaterol for lung cancer surgery: Improvement of postoperative pulmonary function in both patients with chronic obstructive pulmonary disease and normal pulmonary function. Reviewed

Ayabe T., Tomita M., Maeda R., Ochiai K., Hamahiro T., Nakamura K.

Surgical Science 11 133 - 165 2020.7

Language：English Publishing type：Research paper (scientific journal)

Tomita M., Maeda R., Ayabe T., Nakamura K.

Anticancer Research 40 ( 7 ) 4023 - 4027 2020.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

© 2020 International Institute of Anticancer Research. All rights reserved. Background/Aim: Different tumor markers and systemic inflammation have been linked with cancer development and poor outcome. We aimed to establish a novel non-invasive prognostic index for patients with resectable non-small cell lung cancer (NSCLC) based on serum carcinoembryonic antigen (CEA) and C-reactive protein (CRP). Patients and Methods: Four hundred and sixty-two patients curatively resected for NSCLC between 2008 and 2014 were included. All patients with a follow-up period of less than 5 years were omitted. The geometric mean of the normalized serum CEA and CRP levels was used as a novel tumor marker and inflammation index (TMII). The cut-off value of TMII was determined by receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were used to identify the relative risk factors for survival. Results: ROC curve analysis revealed a TMII cut-off value of 0.46. The group with high TMII displayed more adverse clinical characteristics. Furthermore, compared to patients with low TMII, the group with high TMII had significantly poorer survival. On multivariate analysis, TMII was independently associated with survival. Conclusion: We established a novel prognostic index (TMII) based on serum CEA and CRP. Preoperative TMII may predict poor outcomes in patients with NSCLC.

DOI： 10.21873/ANTICANRES.14397

臨床経験胸痛で発見され自然縮小した胸腺腫

千代反田顕, 前田亮, 富田雅樹, 綾部貴典, 佐藤勇一郎, 中村都英

胸部外科 73 ( 5 ) 358 - 361 2020.5

Publishing type：Research paper (scientific journal) Publisher：南江堂

DOI： 10.15106/j_kyobu73_358

[Preoperative Spontaneous Regression of Thymoma].

Chiyotanda T, Maeda R, Tomita M, Ayabe T, Sato Y, Nakamura K

Kyobu geka. The Japanese journal of thoracic surgery 73 ( 5 ) 358 - 361 2020.5

Language：Japanese Publishing type：Research paper (scientific journal)

Classification of Contents in Clinical Ethics Consultation Requests::Based on Clinical Indicators of University of Miyazaki Hospital

Long-Term Outcome of Infection Control for Methicillin-Resistant Staphylococcus Aureus and Kaizen Approach with Problem-Solving. Reviewed

Ayabe T., Tomita M., Takajo I., Nakayama Y., Maeda R., Okumura M., Nakamura, K.

Open Journal of Safety Science and Technology 10 1 - 23 2020.2

Language：English Publishing type：Research paper (scientific journal)

第119回日本外科学会定期学術集会、特別企画（7）「医療安全―患者と医師が信頼しあえる外科医療を目指して」、３．外科医療における患者第一の医療安全と臨床倫理のスキルとエッセンス Invited

綾部貴典、富田雅樹、前田亮、中村都英

日本外科学会雑誌 121 ( 1 ) 120 - 122 2020.1

Language：Japanese Publishing type：Research paper (scientific journal)

Prognostic Impact of a Novel Tumor Marker and Inflammation Index for Patients With Non-small-cell Lung Cancer. Reviewed

Tomita M., Maeda R., Ayabe T., Nakamura K.

Anticancer Research 40 4023 - 4027 2020.1

Language：English Publishing type：Research paper (scientific journal)

MIURA Yukari, ITAI Koichiro, AYABE Takanori

Bioethics 30 ( 1 ) 40 - 49 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Association for Bioethics

　　In this paper, 437 clinical ethics consultation cases handled at our hospital in the past 6 years were subjected to 4-step coding by referencing the SCAT method, a qualitative research method. We focused on the themes and concepts shared across various cases and defined these as "key terms." The following 9 key terms were extracted: "off-label medical treatment" (207 cases), "use of unapproved drugs" (33 cases), "conflicting treatment strategies" (32 cases), "interacting with patients who have no relatives" (14 cases), "withholding treatment" (11 cases), "mental support for physicians" (10 cases), "withdrawing treatment" (9 cases), "support for family" (7 cases), and "protection of personal information" (6 cases). While the 7 classifications created based on explanations of the Japan Council for Quality Health Care in "Approaches to Evaluation" set external scenarios in which ethical problems are expected to be encountered, the present 9 key terms are thought to present a part of the internal dilemmas faced by medical professionals.

DOI： 10.20593/jabedit.30.1_40

第119回日本外科学会定期学術集会、特別企画（7）「医療安全―患者と医師が信頼しあえる外科医療を目指して」、３．外科医療における患者第一の医療安全と臨床倫理のスキルとエッセンス Reviewed

綾部貴典

日本外科学会雑誌 121 120 - 122 2020

Publishing type：Research paper (scientific journal)

Resected thymic large cell neuroendocrine carcinoma: a case report and review of the literature. Reviewed

第11章　レジリエンス・エンジニアリングの外科手術への展開　—外科手術チームのメンバー間の隠された相互作用 Invited Reviewed

綾部貴典、中島伸

レジリエント・ヘルスケア入門医学書院 125 - 132 2019.12

Language：Japanese Publishing type：Research paper (scientific journal)

The Prognostic Values of a Novel Preoperative Inflammation-Based Score in Japanese Patients With Non-Small Cell Lung Cancer Reviewed

Masaki Tomita, Takanori Ayabe, Ryo Maeda, Kunihide Nakamura

World journal of oncology 10 ( 4-5 ) 176 - 180 2019.10

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.14740/wjon1222

Ogata S,_Maeda R,_Tomita M,_Sato Y,_Ayabe T,_Nakamura K

International journal of surgery case reports 60 53 - 57 2019.6

Language：English Publishing type：Research paper (scientific journal)

© 2019 Introduction: Large cell neuroendocrine carcinoma (LCNEC) of the thymus is an extremely rare neoplasm. Presentation of case: We report a rare case of LCNEC of the thymus in a 55-year-old woman. Her chest roentgenogram during a routine checkup revealed an abnormal shadow in the mediastinal left upper lung field. Chest computed tomography showed an anterior mediastinal mass measuring 4.8 × 4.0 cm. Positron emission tomography with 18F-fluorodeoxyglucose (FDG) showed high FDG accumulation at the lesion. To obtain a definitive diagnosis and achieve complete resection, a surgery was performed. The postoperative diagnosis was thymic LCNEC; it was classified as a Masaoka stage III tumor due to the invasion of tumor cells into the left lung. Postoperatively, the patient received adjuvant chemotherapy and survived without any signs of recurrence for 30 months after surgery. Discussion/conclusion: The detailed clinical features of thymic LCNEC remain unknown because of its rarity. In total, 20 cases of resection for LCNEC, including the present case, have been reported in the English language literature; we have presented a review of these cases and discussed the optimal therapy for this rare and virulent tumor of the thymus.

DOI： 10.1016/j.ijscr.2019.05.057

Resected thymic large cell neuroendocrine carcinoma: A case report and review of the literature

Emergent Completion Pneumonectomy for Postoperative Hemorrhage from Rupture of the Infected Pulmonary Artery in Lung Cancer Surgery. Invited Reviewed

Takanori Ayabe, Masaki Tomita, Tetsuhiro Shimizu, MitsuhiroYano, Kunihide Nakamura and Toshio Onitsuka:

Top 25 Contributions on Surgery Research. 4 2 - 4 2019.4

Language：English Publishing type：Research paper (scientific journal)

2017年の宮崎県における呼吸器外科手術の現状報告 Reviewed

能勢直弘、富田雅樹、綾部貴典、別府樹一郎、市成秀樹、枝川正雄、巻幡聡、森山裕一、中村都英

宮医誌 43, 35-39. (2019) 43 35 - 39 2019.3

Language：Japanese Publishing type：Research paper (scientific journal)

Ogata S., Maeda R., Tomita M., Sato Y., Ayabe T., Nakamura K.

International Journal of Surgery Case Reports 60 53 - 57 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：International Journal of Surgery Case Reports

Primary ectopic mediastinal goiter

Maeda R., Tomita M., Oguri N., Ayabe T., Nakamura K.

Chirurgia (Turin) 32 ( 5 ) 263 - 266 2019

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Chirurgia (Turin)

© 2018 Edizioni Minerva Medica We herein report a rare case of primary ectopic mediastinal goiter in a 45-year-old woman. a chest roentgenogram at a regular checkup revealed an abnormal shadow in the mediastinal right upper lung field. Chest computed tomography showed a hypervascular mass in the anterior mediastinum with compression of the left brachiocephalic vein, which extended to the right middle mediastinum. an operation was performed to obtain a definitive diagnosis and achieve complete resection. The tumor with tight adhesion to the great vessels was successfully resected by L-shaped mini-sternotomy combined with right-sided video-assisted thoracic surgery (VaTS). The postoperative diagnosis was primary ectopic mediastinal goiter. Right-sided VATS and an L-shaped mini-sternotomy approach allowed tumor resection with sufficient surgical exposure and a good cosmetic outcome. We discuss the surgical approach for resection of this rare anterior mediastinal tumor extending to the middle mediastinum.

DOI： 10.23736/S0394-9508.18.04889-1

Fiberoptic Bronchoscopic Removal of Dental Crown Dropped in Bronchus During Dental Treatment. Reviewed

Ayabe, T., Tomita, M., Maeda, R., Mori, K., Nakamura, K.

Biomed J Sci & Tech Res 11 ( 5 ) MS.ID.002167. 2018.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.26717/ BJSTR.2018.11.002167.

Evaluation and Outcomes of Multidisciplinary-Reported Incidents Regarding Patient Safety Management at Special Functioning Hospital in Japan. Reviewed

Takanori Ayabe, Masaki Tomita, Manabu Okumura, Shigeko Shimizu, Eiko Uchida, Yukari Miura, Koichiro Itai, Kunihide Nakamura

Open Journal of Safety Science and Technology ( 8 ) 107 - 136 2018.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4236/ojsst.2018.84007

Serum Carcinoembryonic Antigen Level Predicts Cancer-Specific Outcomes of Resected Non-Small Cell Lung Cancer With Interstitial Pneumonia.

Tomita M, Ayabe T, Maeda R, Nakamura K

World journal of oncology 9 136 - 140 2018.11

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.14740/wjon1163

The inflammatory prognostic index predicts cancer-specific outcomes of patients with resected non-small cell lung cancer Reviewed

Tomita M., Ayabe T., Maeda R., Nakamura K.

Asian Pacific Journal of Cancer Prevention 19 2867 - 2870 2018.10

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.22034/APJCP.2018.19.10.2867

Systemic Immune-inflammation Index Predicts Survival of Patients After Curative Resection for Non-small Cell Lung Cancer. Reviewed

A case of spontaneous hemopneumothorax in which the condition worsened after chest drainage. Reviewed

Naohiro Nose, Hiroki Mori, Akihiro Yonei, Ryo Maeda, Takanori Ayabe, Masaki Tomita, Kunihide Nakamura

Journal of Surgical Case Reports 8 rjy217 2018.8

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/jscr/rjy217

Intrathoracic scapular dislocation following lung cancer resection.

Tomita M, Iwasaki A, Ayabe T, Maeda R, Nakamura K

Journal of Surgical Case Reports 7 1 - 3 2018.7

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1093/jscr/rjy178

Tomita M., Ayabe T., Maeda R., Nakamura K.

In Vivo 32 ( 3 ) 663 - 667 2018.6

Language：Japanese Publishing type：Research paper (scientific journal)

Background: The systemic immune-inflammation index (SII) is reported to be associated with clinical outcomes and has been proven to be a promising prognostic indicator in several solid tumor types. To the best of our knowledge, however, no studies regarding SII in patients with resectable non-small cell lung cancer (NSCLC) are available. Materials and Methods: Three hundred forty-one patients with NSCLC who underwent surgery at our Institution between 2008 and 2012 were included. The SII was calculated using the formula: platelet count × neutrophil/lymphocyte count. The optimal cutoff value was calculated using the Cutoff Finder (http://molpath.charite.de/cutoff). Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model. Results: The optimal cut-off value was 471.2×109/l for SII. A low SII was associated with female gender, never smoking status, adenocarcinoma histology, higher pathological TNM stage and low level of serum C-reactive protein, but not age, serum carcinoembryonic antigen or cytokeratin 19 fragment level. Patients of the low SII group had a significantly better 5-year overall survival than those with high SII (83.61% vs. 60.39%, p<0.001). Multivariate analysis revealed that the SII was a significant independent predictive indicator for cancer-specific survival (p=0.007). Conclusion: This is the first study to demonstrate that the SII could represent an independent prognostic factor for patients with resectable NSCLC.

DOI： 10.21873/invivo.11291

Fluorodeoxyglucose positron emission tomography can provide useful information for differentiating thymic epithelial tumors

Fluorodeoxyglucose Positron Emission Tomography Can Provide Useful Information for Differentiating Thymic Epithelial Tumors.

Tomita M., Ayabe T., Tsuchiya K., Nakamura K.

Thorac Cardiovasc Surg. ( 66 ) 345- - 349 2018.6

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1055/s-0037-1604208.

Tomita M., Ayabe T., Tsuchiya K., Nakamura K.

Thoracic and Cardiovascular Surgeon 66 ( 4 ) 345 - 349 2018.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Thoracic and Cardiovascular Surgeon

© 2018 Georg Thieme Verlag KG. Background We examined the usefulness of fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting the World Health Organization (WHO) histologic type and Masaoka stage of thymic epithelial tumors. Methods A total of 73 patients with thymic epithelial tumors who underwent preoperative FDG-PET were included. Relationships between the maximum standardized uptake value (SUVmax) and WHO histologic type and the Masaoka stage of the tumor were examined. Differences in SUVmax between the various groups were calculated. To avoid the effect of the tumor size on SUVmax, the ratio of SUVmax to tumor size (SUVmax/T) was also examined. Results There was a significant relationship between SUVmax and WHO histologic type. SUVmax of high-risk thymomas (types B2 and B3) was significantly higher than that of low-risk thymomas (types A, AB, and B1). SUVmax of thymic carcinomas was also significantly higher than those of the low-risk and high-risk groups. The relationship between the SUVmax/T and WHO histologic type showed more significant results. SUVmax and SUVmax/T showed higher values in patients with advanced Masaoka stage disease than in those with early-stage disease. Conclusions FDG-PET can provide useful information for differentiating thymic epithelial tumors. The SUVmax/T is more useful than the SUVmax for differentiating between low-risk and high-risk thymomas.

DOI： 10.1055/s-0037-1604208

Systemic immune-inflammation index predicts survival of patients after curative resection for non-small cell lung cancer

Comparison of Inflammation-Based Prognostic Scores in Patients undergoing Curative Resection for Non-small Cell Lung Cancer.

Tomita M, Ayabe T, Maeda R, Nakamura K

World journal of oncology 9 85 - 90 2018.6

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.14740/wjon1097w

Evaluation and Outcome of Surgeon-Reported Incidents regarding Surgical Patient Safety. Reviewed

Ayabe, T., Tomita, M., Okumura, M., Maeda, R. and Nakamura, K.

Surgical Science ( 9 ) 422 - 445 2018.5

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4236/ss.2018.911049

Tomita M., Ayabe T., Maeda R., Nakamura K.

In Vivo 32 ( 3 ) 663 - 667 2018.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：In Vivo

The advanced lung cancer inflammation index is an independent prognostic factor after surgical resection in patients with non-small-cell lung cancer Reviewed

Tomita M., Ayabe T., Nakamura K.

Interactive CardioVascular and Thoracic Surgery 26 ( 2 ) 288 - 292 2018.2

Language：English Publishing type：Research paper (scientific journal)

© 2017 The Author. OBJECTIVES The usefulness of a recently developed advanced lung cancer inflammation index (ALI) has been reported in advanced non-small-cell lung cancer (NSCLC) and small-cell lung cancer. However, no previous studies have examined the prognostic significance of ALI in patients with operable NSCLC. Therefore, the aim of this study was to explore the relationship between ALI and the prognosis of resected NSCLC. METHODS Three hundred and forty-three patients with NSCLC who underwent surgery at our institution between 2008 and 2012 were included. The ALI score was calculated as body mass index × serum albumin/neutrophil to lymphocyte ratio. A Web-based software programme [Cutoff Finder (http://molpath.charite.de/cutoff/)] was used to determine the optimal cut-off value for ALI. The Kaplan-Meier methods and a multivariable Cox proportional hazards model were used to evaluate the potential prognostic factors. RESULTS The optimal cut-off value of ALI was defined as 37.66. The low-ALI group (ALI < 37.66) displayed more adverse clinical characteristics. Furthermore, compared with patients in the high-ALI group (ALI > 37.66), those in the low-ALI group had significantly poorer survival rates. On multivariable analysis, gender, histological diagnosis, pN status, serum carcinoembryonic antigen level, serum C-reactive protein level and ALI were associated independently with cancer-specific survival. CONCLUSIONS This study is the first to investigate whether ALI is useful for predicting postoperative survival in patients with NSCLC. Preoperative ALI might serve as a potentially clinically valuable marker of the prognosis for patients with operable NSCLC.

DOI： 10.1093/icvts/ivx329

The advanced lung cancer inflammation index is an independent prognostic factor after surgical resection in patients with non-small-cell lung cancer

Tomita M., Ayabe T., Nakamura K.

Interactive Cardiovascular and Thoracic Surgery 26 ( 2 ) 288 - 292 2018.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Interactive Cardiovascular and Thoracic Surgery

Low body mass index is an independent predictive factor after surgical resection in patients with non-small cell lung cancer. Reviewed

Tomita M., Ayabe T., Nakamura K.

Asian Pacific Journal of Cancer Prevention 18 ( 12 ) 3353 - 3356 2017.12

Language：English Publishing type：Research paper (scientific journal)

Background: The effect of body mass index (BMI) on postoperative survival in non-small cell lung cancer (NSCLC) has been controversial. We retrospectively analysed the effect of preoperative BMI on postoperative outcomes of NSCLC surgery. Methods: Consecutive 384 NSCLC patients were enrolled. Patients were subdivided into 3 groups: low BMI group (BMI < 18.5 kg/m2), normal BMI group (BMI=18.5-24.0 kg/m2) and high BMI group (BMI > 24.0 kg/m2). The prognostic significance of BMI was examined retrospectively. Results: The 5-year survival of patients with low, normal and high BMI groups were 46.3%, 74.3% and 84.3%, respectively. The low BMI group had a poorer prognosis than the other groups (p < 0.001). The survival of high BMI group had a more favorable trend than that of normal BMI group, but this did not reach statistical significance (p=0.057). On multivariate analysis, significant risk factors for cancer-specific survival were male gender (p=0.0061), non-adenocarcinoma histology (p=0.0003), pN1-2 status (p=0.0007), high serum CEA level (p < 0.0001) and low BMI (low vs. others: p < 0.0001). Conclusions: Preoperative BMI is an independent prognostic factor for NSCLC patients after surgical resection, with low BMI patients having an unfavorable prognosis.

DOI： 10.22034/APJCP.2017.18.12.3353

Low body mass index is an independent predictive factor after surgical resection in patients with non-small cell lung cancer

Tomita M., Ayabe T., Nakamura K.

Asian Pacific Journal of Cancer Prevention 18 ( 12 ) 3353 - 3356 2017.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asian Pacific Journal of Cancer Prevention

Combination of Advanced Lung Cancer Inflammation Index and C-Reactive Protein Is a Prognostic Factor in Patients With Operable Non-Small Cell Lung Cancer.

Tomita M, Ayabe T, Maeda R, Nakamura K

World journal of oncology 8 ( 6 ) 175 - 179 2017.12

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.14740/wjon1076w

Combination of Advanced Lung Cancer Inflammation Index and C-Reactive Protein Is a Prognostic Factor in Patients With Operable Non-Small Cell Lung Cancer.

Tomita M, Ayabe T, Maeda R, Nakamura K

World journal of oncology 8 ( 6 ) 175 - 179 2017.12

Language：Japanese Publishing type：Research paper (scientific journal)

2016年の宮崎県における呼吸器外科手術の現状報告 Reviewed

富田雅樹、綾部貴典、別府樹一郎、市成秀樹、能勢直弘、枝川正雄、巻幡聡、森山裕一、中村都英

宮崎県医師会医学会誌 41 154 - 158 2017.10

Language：Japanese Publishing type：Research paper (scientific journal)

Unexpected Postoperative Paraplegia after Thoracotomy in Lung Cancer: Incidental Migration of Oxidized Regenerated Cellulose Used for Hemostasis of Intercostal Space Bleeding Reviewed

Takanori Ayabe, Masaki Tomita, Shigeko Shimizu, Etsuko Yokoyama, Manabu Okumura, Koichiro Itai, Kunihide Nakamura

Surgical Science 8 365 - 374 2017.8

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4236/ss.2017.88040

Influence of smoking status and mass body index on serum carcinoembryonic antigen concentration in patients with thoracic disease. Reviewed

Tomita, M., Ayabe, T., Tsuchiya, K. and Nakamura, K.

Surgical Science 8 279 - 286 2017.7

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4236/ss.2017.87030.

Patient-Reported Outcomes of Chemotherapy Involving Non Small Cell Lung Cancer: Evaluation by Questionnaires of Quality of Life Regarding Anti-Aging and Anti-Cancer Drugs. Advances in Lung Cancer Reviewed

Ayabe, T., Tomita, M., Asada, T., Tsuchiya, K., Nemoto, M. and Nakamura, K.

Advances in Lung Cancer 6 13 - 35 2017.6

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4236/alc.2017.62002

Does Obesity-Related Hemodilution of Carcinoembryonic Antigen Exist in Non-Small Cell Lung Cancer Patients?

Tomita M, Ayabe T, Nakamura K

World journal of oncology 8 ( 2 ) 41 - 44 2017.5

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.14740/wjon1026w

Prognostic Significance of a Tumor Marker Index Based on Preoperative Serum Carcinoembryonic Antigen and Krebs von den Lungen-6 Levels in Non-Small Cell Lung Cancer. Reviewed

Patient-Reported Outcomes of Surgery of Non-Small Cell Lung Cancer: Evaluation Based on the Questionnaires of Anti-Aging Quality of Life and the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Reviewed

Ayabe, T., Tomita, M., Nose, N., Asada, T. and Nakamura, K.

Surgical Science 8 203 - 219 2017.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4236/ss.2017.85024

Tomita M., Ayabe T., Chosa E., Nose N., Nakamura K.

Asian Pacific Journal of Cancer Prevention 18 ( 1 ) 287 - 291 2017.4

Language：English Publishing type：Research paper (scientific journal)

Background: We retrospectively analysed the prognostic significance of a tumor marker index (TMI) based on preoperative serum carcinoembryonic antigen (CEA) and Krebs von den Lungen-6 (KL-6) levels in nonsmall cell lung cancer (NSCLC) patients. Materials and Methods: We enrolled 176 NSCLC patients who had preoperative serum CEA and KL-6 level measurements and had undergone curative surgery between 2009 and 2011. Results: The 5-year disease-specific survival of patients with high serum CEA levels was significantly poorer compared with that of patients with normal levels. The value for patients with high serum KL-6 levels was also poor. Patients with both normal serum CEA and KL-6 levels had a favourable prognosis, whereas those with both high serum CEA and KL-6 levels had a poor outcome. The5-year disease-specific survival rate was 82.9% for patients in the low TMI group compared to 47.5% in the high TMI group (p < 0.01). Both univariate and multivariate analyses revealed prognostic significance for TMI. Conclusions: TMI based on preoperative serum CEA and KL-6 levels might be useful for the prediction of the prognosis of NSCLC patients.

DOI： 10.22034/APJCP.2017.18.1.287

Thymoma (World Health Organization type B3) with neuroendocrine differentiation in multiple endocrine neoplasia type 1 Reviewed

Tomita M, Ichiki N, Ayabe T, Tanaka H, Kataoka H, Nakamura K

Journal of Surgical Case Reports 4 1 - 3 2017.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/jscr/rjx071

Prognostic significance of a tumor marker index based on preoperative serum carcinoembryonic antigen and Krebs von den Lungen-6 levels in non-small cell lung cancer

Preoperative Serum Krebs Von Den Lungen-6 and Surfactant Protein-D Levels in Non-Small Cell Lung Cancer Patients with Interstitial Pneumonia Reviewed

Tomita, M., Ayabe, T., Chosa, E., Asada, T., Tsuchiya, K. and Nakamura, K.

Open Journal of Thoracic Surgery 7 1 - 7 2017.4

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4236/ojts.2017.71001

Does Obesity-Related Hemodilution of Carcinoembryonic Antigen Exist in Non-Small Cell Lung Cancer Patients?

Tomita M, Ayabe T, Nakamura K

World journal of oncology 8 ( 2 ) 41 - 44 2017.4

Language：Japanese Publishing type：Research paper (scientific journal)

Thymoma (World Health Organization type B3) with neuroendocrine differentiation in multiple endocrine neoplasia type 1.

Tomita M, Ichiki N, Ayabe T, Tanaka H, Kataoka H, Nakamura K

Journal of surgical case reports 2017 ( 4 ) rjx071 2017.4

Language：Japanese Publishing type：Research paper (scientific journal)

Changes in Safety Attitude and Improvement of Multidisciplinary Teamwork by Implementation of the WHO Surgical Safety Checklist in University Hospital Reviewed

Ayabe, T., Shinpuku, G., Tomita, M., Nakamura, S., Yokoyama, E., Shimizu, S., Okumura, M., Itai, K., Tsuneyoshi, I., Takeshima, H., and Nakamura, K.

Open Journal of Safety Science and Technology 7 22 - 41 2017.2

Language：English Publishing type：Research paper (scientific journal)

DOI： https://doi.org/10.4236/ojsst.2017.71003.

Tomita M., Ayabe T., Chosa E., Nose N., Nakamura K.

Asian Pacific Journal of Cancer Prevention 18 ( 1 ) 287 - 291 2017

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asian Pacific Journal of Cancer Prevention

Prognostic significance of preoperative serum Krebs von den Lungen-6 level in non-small cell lung cancer

Tomita M., Ayabe T., Chosa E., Nose N., Nakamura K.

General Thoracic and Cardiovascular Surgery 64 ( 11 ) 657 - 661 2016.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：General Thoracic and Cardiovascular Surgery

© 2016, The Japanese Association for Thoracic Surgery. Objectives: We retrospectively analyzed the prognostic significance of preoperative serum Krebs von den Lungen-6 (KL-6) level in non-small cell lung cancer (NSCLC) patients. Methods: We enrolled 175 NSCLC patients who underwent curative surgery between 2009 and 2011. We subdivided the patients into 2 groups: with and without interstitial lung disease (ILD). Prognostic significance of serum KL-6 level was examined. Results: The 5-year survival of patients with high serum KL-6 level was poor. Multivariate analysis also revealed the prognostic significance of serum KL-6 level. Serum KL-6 level was also a prognostic factor for patients without ILD. Although the number of patients with ILD was small, in patients with ILD, there was a trend towards an association between serum KL-6 level and patients’ prognosis but this did not reach statistical significance. Conclusions: Serum KL-6 level is a prognostic factor for resected NSCLC patients, especially patients without ILD. There is a possibility that serum KL-6 level is a prognostic marker regardless of the presence of ILD.

DOI： 10.1007/s11748-016-0706-4

外科医師が報告したインシデントレポート Reviewed

綾部貴典、富田雅樹、帖佐英一、中村都英

宮崎県医師会雑誌 - 5 2016.10

Language：Japanese Publishing type：Research paper (scientific journal)

Port-site implantation of Type A Masaoka Stage I thymoma after video-assisted thoracic surgery: a case report.

Nose N, Higuchi K, Chosa E, Ayabe T, Tomita M, Nakamura K

Journal of surgical case reports 2016 ( 9 ) 2016.9

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1093/jscr/rjw164

A Case Report of Resection of a Giant Desmoid Tumor 16 cm in Longer Diameter of the Chest Wall Probably Enlarged after Getting Pregnant

Severity of Chronic Obstructive Pulmonary Disease and the Prognosis of Non-Small Cell Lung Cancer Patients Reviewed

Tomita, M., Ayabe, T., Chosa, E., Nose, N., Tsuchiya, K., Nakamura, K.

Advances in Lung Cancer 5 13 - 20 2016.9

Language：English Publishing type：Research paper (scientific journal)

DOI： http://dx.doi.org/10.4236/alc.2016.52002

Port-site implantation of Type A Masaoka Stage I thymoma after video-assisted thoracic surgery: a case report. Reviewed

Nose, N., Higuchi, K., Chosa, E., Ayabe, T., Tomita, M., and Nakamura,

Journal of Surgical Case Reports 9 1 - 3 2016.9

Language：English Publishing type：Research paper (scientific journal)

DOI： http://dx.doi.org/10.1093/jscr/rjw164

二期的に手術を行った両側巨大肺嚢胞症の1例 Reviewed

綾部貴典、富田雅樹、中村都英

日気嚢疾会誌 15 1 - 5 2016.9

Language：Japanese Publishing type：Research paper (scientific journal)

Prognostic significance of preoperative serum Krebs von den Lungen-6 level in non-small cell lung cancer. Reviewed

Tomita, M., Ayabe, T., Chosa, E., Nose,N., Nakamura, K.

Gen Thorac Cardiovasc Surg 64 657 - 661 2016.8

Language：English Publishing type：Research paper (scientific journal)

DOI： http://dx.doi.org/10.1007/s11748-016-0706-4

Unexpected Intraoperative Resecting of Common Trunk of Pulmonary Vein Resulted in an Incidental Pneumonectomy from Left Upper Lobectomy Reviewed

Ayabe, T., Tomita, M, Nose, N, Chosa, E, Higuchi, K., Nakamura, K.

Open Journal of Thoracic Surgery 6 18 - 24 2016.8

Language：English Publishing type：Research paper (scientific journal)

DOI： http://dx.doi.org/10.4236/ojts.2016.63004.

妊娠を契機に増大したと推測される長径16cm胸壁デスモイド腫瘍の1例 Reviewed

帖佐英一、綾部貴典、森　浩貴、富田雅樹、中村都英

日本臨床外科学会雑誌 77 41 - 47 2016.6

Language：Japanese Publishing type：Research paper (scientific journal)

ポータブル型胸腔ドレナージ装置トパーズの臨床的有用性の検討 Reviewed

富田雅樹, 綾部貴典, 帖佐英一, 能勢直弘, 中村都英

宮崎医会誌 40 140 - 146 2016.5

Language：Japanese Publishing type：Research paper (scientific journal)

巨大肺嚢胞の2切除例 Reviewed

綾部貴典、富田雅樹、帖佐英一、川越勝也、中村都英

宮崎医会誌 40 41 - 46 2016.4

Language：Japanese Publishing type：Research paper (scientific journal)

Clinical Outcomes, Safety and Efficacy of Intrapleural Hyperthermic Chemotherapy for Thoracic Malignant Diseases with Pleural Effusion Reviewed

Ayabe, T., Tomita, M., Chosa, E., Mori, H. and Nakamura, K.

Journal of Cancer Therapy 7 203 - 215 2016.4

Language：English Publishing type：Research paper (scientific journal)

DOI： http://dx.doi.org/10.4236/jct.2016.73021

Outcomes of Quality of Life Regarding the Next-Generation Thoracoscopic Intrapleural Hyperthermic Chemotherapy of Non-Small Cell Lung Cancer with Dissemination Reviewed

Ayabe, T., Tomita, M., Chosa, E., Mori, K. and Nakamura, K.

Journal of Cancer Therapy 7 203 - 215 2016.3

Language：English Publishing type：Research paper (scientific journal)

DOI： http://dx.doi.org/10.4236/jct.2016.73021

CHOSA Eiichi, AYABE Takanori, MORI Hiroki, TOMITA Masaki, NAKAMURA Kunihide

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 77 ( 3 ) 545 - 551 2016

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Surgical Association

A 29-year-old pregnant woman was admitted to the hospital because of dyspnea and left chest pain. We preferentially considered the maternal safety and performed artificial abortion. Chest computed tomographic (CT) scan and magnetic resonance imaging (MRI) revealed a 15×8×16cm tumor on the left anterior chest wall, which had compressed the heart. The pathological diagnosis of ultrasonography- guided biopsy specimen was desmoid tumor. Tumor resection was done. The left chest wall including the 7th to the 10th ribs was resected with the pericardium and diaphragm. A wide defect of the chest wall was reconstructed with mesh. However, the patient developed wound infection, and the infected mesh had to be removed. The defect of the chest wall was reconstructed with a free tensor fascia lata musculocutaneous flap. No evidence of recurrence has been found for 6 years after the resection. Desmoid tumors during pregnancy are rare and the courses of treatment are controversial. Further accumulation of cases is necessary.

DOI： 10.3919/jjsa.77.545

妊娠中に胸腔鏡下肺切除術を施行した自然気胸の2例 Reviewed

米井彰洋，市成秀樹、峯一彦、綾部貴典、富田雅樹、中村都英

日呼外会誌２９８７５ - ８７９ 2015.11

Language：Japanese Publishing type：Research paper (scientific journal)

Postoperative Serum CEA Level is a More Significant Prognostic Factor than Post/Preoperative Serum CEA Ratio in Non-small Cell Cancer Patients. Reviewed

Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Kunihide Nakamura,

Asian Pacific Journal of Cancer Prevention 16 7809 - 7812 2015.10

Language：English Publishing type：Research paper (scientific journal)

DOI： DOI:http://dx.doi.org/10.7314/APJCP.2015.16.17.7809

Unusual cystic hamartomatous lung lesion with clinical manifestation of subpleural bullae in a woman of reproductive age: A case report

Yorita K., Ayabe T., Chosa E., Uchino N., Nagatomo Y., Yamaguchi T., Nakatani Y., Kataoka H.

Pathology International 65 ( 10 ) 558 - 562 2015.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Pathology International

© 2015 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd. Pulmonary hamartoma is a common benign lung disorder, and most cases show solid nodules. Here, we documented the clinicopathological features of a growing, bulla-like, multilocular hamartomatous lung lesion in a woman of reproductive age. To the best of our knowledge, this disorder has not been reported in the literature to date. An asymptomatic 29-year-old Japanese woman with no significant past medical history was referred to our institution for surgical treatment of a bullous lesion in the right upper lobe because the pulmonary lesion had enlarged to multilocular cysts, including a giant bulla, within 1 year, leading to compression of the right lung. The bullous lesion, which was projected from the apex of the lung via a narrow stalk, showed nonemphysematous, multiloculated tissue. The wall mimicked a bronchiolar structure with ciliated, nonatypical epithelium and layers of nonatypical spindle cells that were positive for smooth muscle markers and sex steroid hormone receptors. No cartilage was included in the lesion. We believe that this may be a novel form of hamartoma. This disorder may be included in a differential diagnosis of subpleural bullous diseases in women of reproductive age.

DOI： 10.1111/pin.12342

Impact of smoking on outcome of resected lung adenocarcinoma

Impact of smoking on outcome of resected lung adenocarcinoma. Reviewed

Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Kunihide Nakamura

Gen Thorac Cardiovasc Surg ６３６０８ - ６１２ 2015.9

Language：English Publishing type：Research paper (scientific journal)

DOI： DOI 10.1007/s11748-015-0579-y

Unusual cystic hamartomatous lung lesion with clinical manifestation of subpleural bullae in a woman of reproductive age: A case report. Reviewed

Kenji Yorita, Takanori Ayabe, Eiichi Chosa, Noriko Uchino, Yasuhiro Nagatomo, Tetsuro Yamaguchi, Yukio Nakatani, and Hiroaki Kataoka,

Pathology International 65 558 - 562 2015.8

Language：English Publishing type：Research paper (scientific journal)

Tomita M., Ayabe T., Chosa E., Nakamura K.

General Thoracic and Cardiovascular Surgery 63 ( 11 ) 608 - 612 2015.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：General Thoracic and Cardiovascular Surgery

© 2015, The Japanese Association for Thoracic Surgery. Objective: Smoking is a well-known causative factor of lung cancer and the association of smoking with adenocarcinoma is considered to be the weakest. We investigated the influence of smoking on postoperative prognosis in patients with lung adenocarcinoma. Methods: One hundred and eighty-one consecutive patients of resected lung adenocarcinoma were studied retrospectively. The histologic subtype was subdivided into 2 groups: lepidic dominant histologic subtype, including adenocarcinoma in situ, minimally invasive adenocarcinoma, and lepidic predominant invasive adenocarcinoma versus other subtypes. Results: The 5-year survival of ever smokers was significantly unfavorable than that of never smokers. Similarly, there was also a relationship between the patients’ survival and Brinkman index (BI), with unfavorable survival found in patients with greater smoking histories. Based on a multivariable analysis, pN status and BI were significant factors affecting the postoperative prognosis of patients undergoing surgery. However, gender, serum carcinoembryonic antigen (CEA) level, lepidic dominant histologic subtype and pure/mixed ground-glass opacity (GGO) were not prognostic factors although previous reports showed prognostic significance. These factors that we failed to find the prognostic significance were significantly associated with smoking. Conclusion: The smoking was significantly predictive of an unfavorable prognosis after surgery for lung adenocarcinoma. It is suggested that smoking is associated with serum CEA level, histologic subtype and GGO, resulting in unfavorable outcome.

DOI： 10.1007/s11748-015-0579-y

Correlation between serum carcinoembryonic antigen level and histologic subtype in resected lung adenocarcinoma

“Isolated Renal Metastasis from Non-Small-Cell Lung Cancer: Report of 2 Cases,” Reviewed

Masaki Tomita, Takanori Ayabe, Eiichi Chosa, and Kunihide Nakamura

Case Reports in Surgery ３ 357481 2015.7

Language：English Publishing type：Research paper (scientific journal)

DOI： doi:10.1155/2015/357481

胸膜播種・悪性胸水を伴う肺癌に対する次世代型胸腔内温熱化学療法 Reviewed

綾部貴典、富田雅樹、帖佐英一、土屋和代、森浩貴、七島篤志、中村都英

宮崎医会誌３９ 152 - 162 2015.6

Language：Japanese Publishing type：Research paper (scientific journal)

A Resection of the Giant First Left Rib Tumor and Chest Wall Reconstruction by Transmanubrial Osteomuscular Sparing Approach. Reviewed

Ayabe, T., Tomita, M., Mori, H., Chosa, E., and Nakamura, K.

Open Journal of Thoracic Surgery ５３５ - ４２ 2015.4

Language：English Publishing type：Research paper (scientific journal)

DOI： doi: 10.4236/ojts.2015.53008.

Correlation between Serum Carcinoembryonic Antigen Level and Histologic Subtype in Resected Lung Adenocarcinoma. Reviewed

Tomita M., Ayabe T, Chosa E., Nakamura K.

Asian Pacific Journal of Cancer Prevention 16 3857 - 3860 2015.3

Language：English Publishing type：Research paper (scientific journal)

DOI： DOI:http://dx.doi.org/10.7314/APJCP.2015.16.9.3857

Pneumonectomy of Primary Pulmonary Angiosarcoma with Malignant Effusion and Intrapleural Hypotonic Hyperthermic Chemotherapy: Case Report and Review of the Literature. Reviewed

Ayabe, T., Tomita, M., Chosa, E., Kawagoe, K. and Nakamura, K.

Journal of Cancer Therapy ６２２７ - ２３６ 2015.2

Language：English Publishing type：Research paper (scientific journal)

DOI： doi: 10.4236/jct.2015.62025

Tomita M., Ayabe T., Nakamura E.C.K.

Asian Pacific Journal of Cancer Prevention 16 ( 9 ) 3857 - 3860 2015

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asian Pacific Journal of Cancer Prevention

Background: Recent studies revealed a relationship between ground-glass opacity (GGO) ratio on computed tomography (CT) and serum carcinoembryonic antigen (CEA) level in lung adenocarcinoma. Since an association between lepidic histologic pattern and GGO is well accepted, we investigated the link between histologic subtype and serum CEA level in resected lung adenocarcinoma. Materials and Methods: One hundred and eighty-one consecutive patients with resected lung adenocarcinoma were studied retrospectively. The histologic subtype was subdivided into 2 groups: lepidic dominant histologic subtype, including adenocarcinoma in situ, minimally invasive adenocarcinoma and lepidic predominant invasive adenocarcinoma versus other subtypes. Results: The 5-year survival of patients with s high serum CEA level was significantly more unfavorable than that with normal levels. Similarly, there was also a relationship between the patient survival and histologic subtype, with favorable survival found in patients with the lepidic dominant histologic subtype. There was a significant relationship between serum CEA level and lepidic dominant histologic subtype overall and in p-stage I patients. Conclusions: Lung adenocarcinomas with non-lepidic dominant histologic subtype are associated with high serum CEA levels.

DOI： 10.7314/APJCP.2015.16.9.3857

Postoperative serum CEA level is a more significant prognostic factor than post/preoperative serum CEA ratio in non-small cell cancer patients

Tomita M., Ayabe T., Chosa E., Nakamura K.

Asian Pacific Journal of Cancer Prevention 16 ( 17 ) 7809 - 7812 2015

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asian Pacific Journal of Cancer Prevention

Background: In non-small cell lung cancer (NSCLC) patients with preoperative high serum carcinoembryonic antigen (CEA) level, patients with a persistently high serum CEA level after surgery have been reported to have a poor prognosis. In addition, in other cancers, the post/preoperative serum CEA ratio has been reported as a useful parameter. Materials and Methods: We enrolled 123 NSCLC patients with preoperative high CEA levels (≥5 ng/mL) who underwent curative surgery between 2004 and 2011. Prognostic significance of postoperative serum CEA level and the CEA ratio was examined. Results: The 5-year survival of patients with persistently high serum CEA level after surgery was poor. On the other hand, patients with normal postoperative serum CEA levels had significant favorable prognosis. The patients with CEA ratio > 1 had poor prognosis, however the number was only 7 (5.7%). The 5-year survival rates of patients with other subgroup based on the CEA ratio (0.5≤CEA ratio and 0.5≤CEA ratio≤1) was similar. Multivariate analysis revealed prognostic significance for the postoperative serum CEA level but not the CEA ratio. Conclusions: For NSCLC patients with preoperative high serum CEA level, their postoperative serum CEA levels is a more significant prognostic factor than the post/preoperative serum CEA ratio.

DOI： 10.7314/APJCP.2015.16.17.7809

Isolated Renal Metastasis from Non-Small-Cell Lung Cancer: Report of 2 Cases.

Tomita M, Ayabe T, Chosa E, Nakamura K

Case reports in surgery 2015 357481 2015

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1155/2015/357481

Two cases of spontaneous pneumothorax during pregnancy

Yonei Akihiro, Ichinari Hideki, Mine Kazuhiko, Ayabe Takanori, Tomita Masaki, Nakamura Kunihide

The Journal of the Japanese Association for Chest Surgery 29 ( 7 ) 875 - 879 2015

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Chest Surgery

We encountered two surgical cases of spontaneous pneumothorax that developed during pregnancy, which are reported as follows. Case 1 was a 28-year-old female. Left pneumothorax developed six months prior to natural conception and at the eighth week of pregnancy, both of which were resolved by thoracic drainage. Left pneumothorax recurred for the third time at the 11th week of pregnancy and persistent pulmonary fistula was noted for four weeks or longer; therefore, video-assisted thoracoscopic surgery (VATS) was performed at the 16th week of pregnancy. The postoperative course was favorable, and a healthy baby was born at full term. Case 2 was a 21-year-old female. Right pneumothorax was diagnosed at the 20th week of pregnancy, which improved with thoracic drainage. Right pneumothorax recurred at the 24th week of pregnancy. Thoracic drainage was performed again; however, she was admitted for surgery since the air leak persisted. The Department of Obstetrics and Gynecology cooperated with the Department of Anesthesiology during the perioperative period, and VATS was performed at the 25th week of pregnancy. The postoperative course was favorable, and a healthy baby was born at full term. Although pneumothorax during pregnancy is rare, recurrence is common once it has developed, due to factors involving ventilation; therefore, regular VATS may be possible based on surgical indications in consideration of the gestational age.

DOI： 10.2995/jacsurg.29.875

Posterior mediastinal ganglioneuroma with peripheral replacement by white and brown adipocytes resulting in diagnostic fallacy from a false-positive 18F-2-fluoro-2-deoxyglucose-positron emission tomography finding: a case report. Reviewed

Kenji Yorita, Akihiro Yonei, Takanori Ayabe, Hiroshi Nakada, Ken Nakashima, Tsuyoshi Fukushima, Hiroaki Kataoka

Journal of Medical Case Reports 8 345 2014.9

Language：English Publishing type：Research paper (scientific journal)

Effect of Inhaled Tiotropium as the Perioperative Management of Patients Undergoing Pulmonary Resection for Primary Lung Cancer Invited

Takanori Ayabe, Masaki Tomita, Eiichi Chosa, Katsuya Kawagoe, Kunihide Nakamura

Journal of Cancer Therapy 5 845 - 859 2014.8

Language：English Publishing type：Research paper (scientific journal)

DOI： doi: 10.4236/jct.2014.59093.

Epidermal Growth Factor Receptor Mutations in Japanese Men with Lung Adenocarcinomas Reviewed

Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Katsuya Kawagoe, Kunihide Nakamura

Asian Pacific Journal of Cancer Prevention 15 10627 - 10630 2014.8

Language：English Publishing type：Research paper (scientific journal)

原発性肺癌術後再発診断におけるFDG-PET/CT所見の検討 Reviewed

寺田珠沙、長町茂樹、西井龍一、水谷陽一、中田　博、田村正三、清水哲哉、綾部貴典、富田雅樹、中村都英

臨床放射線 59 165 - 172 2014.8

Language：Japanese Publishing type：Research paper (scientific journal)

末梢型肺腫瘤影を呈した肺梗塞の２切除例と１非切除例 Reviewed

富田雅樹、綾部貴典、帖佐英一、中村都英

宮崎医会誌 38 88 - 92 2014.6

Language：Japanese Publishing type：Research paper (scientific journal)

Prognostic significance of pre-and postoperative glasgow prognostic score for patients with non-small cell lung cancer

Tomita M., Ayabe T., Chosa E., Nakamura K.

Anticancer Research 34 ( 6 ) 3137 - 3140 2014.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Background: Our previous study showed the prognostic impact of preoperative Glasgow prognostic score (GPS) in patients who underwent resection for non-small cell lung cancer (NSCLC). In the present study, the relationship between postoperative GPS and prognosis was also examined in patients with NSCLC with preoperative GPS 1 or 2. Patients and Methods: Three hundred and twelve consecutive patients resected for NSCLC with a follow-up period of more than five years were enrolled. The GPS was calculated as follows: patients with elevated C-reactive protein level (>1.0 mg/dl) and hypoalbuminemia (<3.5 g/dl) were assigned to GPS 2. Patients with one or no abnormal value were assigned to GPS 1 or GPS 0. Results: Study patients were allocated as follows: 264 (84.62%) to GPS 0; 31 (9.94%) to GPS 1; and 17 (5.45%) to GPS 2. The prognosis of the patients with preoperative GPS 2 was significantly poorer. Postoperative GPS was also examined for 48 patients with preoperative GPS 1 or 2. In 30/48 patients, postoperative GPS was improved to GPS 0, however, the postoperative GPS of the remaining 18 patients did not change to GPS 0. The 5-year survival of patients with postoperative GPS 0 and 1-2 were 73.02% and 11.11%, respectively. Conclusion: Preoperative GPS may be useful for postoperative prognosis of patients with NSCLC. Furthermore, persistently high GPS after surgery indicates poor prognosis in patients with NSCLC.

Prognostic significance of pre- and postoperative glasgow prognostic score for patients with non-small cell lung cancer.

Tomita M, Ayabe T, Chosa E, Nakamura K

Anticancer research 34 ( 6 ) 3137 - 40 2014.6

Language：Japanese Publishing type：Research paper (scientific journal)

The usefulness of FDG-PET/CT in diagnosing recurrence of post-operative primary lung cancer

Usefulness of the Glasgow prognostic score for predicting survival in patients with resected non-small cell lung cancer Reviewed

Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Kunihide Nakamura

Journal of Cancer Research & Therapy 2 ( 2 ) 36 - 39 2014.5

Language：English Publishing type：Research paper (scientific journal)

Five-Year Survivors of Non-Small Cell Lung Cancer Paqtients with Positive Pleural Lavage Cytology Reviewed

Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Kunihide Nakamura

Advances in Lung Cancer 3 21 - 25 2014.3

Language：English Publishing type：Research paper (scientific journal)

Chemotherapy (Gemcitabine plus Carboplatin versus Paclitaxel plus Carboplatin)　in Elderly Patients with Non-Small Cell Lung Cancer. Journal of Cancer Therapy, 5, 281-296, (2014).

1. Takanori Ayabe, Masaki Tomita, Makoto Ikenoue, Yukie SHirasaki, Kunihide Nakamura

Journal of Cancer Therapy 2014.3

Language：English Publishing type：Research paper (scientific journal)

Prognostic Significance of Pre- and Postoperative Glasgow　Prognostic Score for Patients with Non-small Cell Lung Cancer. Reviewed

Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Kunihide Nakamura,

Anticancer Research 34 3137 - 3140 2014.2

Language：English Publishing type：Research paper (scientific journal)

Terada T., Nagamachi S., Nisii R., Mizutani Y., Nakada H., Tamura S., Shimizu T., Ayabe T., Tomita M., Nakamura K.

Japanese Journal of Clinical Radiology 59 ( 1 ) 165 - 172 2014.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Clinical Radiology

Differential diagnosis by the FDG PET/CT between recurrence of primary lung cancer and the postoperative change is difficult. The results of our study, favorable diagnostic accuracy as higher 70% were obtained by setting the optimal cutoff value of SUVmax except for pleural lesions. Diagnostic performance was further improved by adding delayed image. The usefulness of FDG PET/CT was confirmed in diagnosing recurrence of NSCLC after surgery.

Yorita K., Yonei A., Ayabe T., Nakada H., Nakashima K., Fukushima T., Kataoka H.

Journal of Medical Case Reports 8 ( 1 ) 345 2014

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Medical Case Reports

© 2014 Al-Kandari et al.; licensee BioMed Central Ltd. Introduction: Ganglioneuroma is a rare tumor in the posterior mediastinum; fat-containing ganglioneuromas are rarely reported. The present case report documents a brown fat-containing, posterior mediastinal ganglioneuroma, which has not been reported previously. Radiological examination, in particular 18F-2-fluoro-2-deoxyglucose-positron emission tomography, suggested that the tumor had low-grade malignant potential. This led to uncertainty at preoperative diagnosis. Case presentation: An asymptomatic 66-year-old Japanese woman with no significant past medical history was referred for the evaluation of a posterior mediastinal mass. Although its size had not changed in the past 5 years, a malignant lipomatous tumor could not be excluded due to the presence of intratumoral fat and increased 18F-2-fluoro-2-deoxyglucose uptake observed by positron emission tomography imaging. A computed tomography-guided core-needle biopsy revealed a mixture of mature adipocytes, spindle-shaped cells, and fibrotic stroma. Definite diagnosis was not possible, and surgical resection was performed. Three years after the surgery, she remains disease-free. Conclusions: Histological diagnosis of the surgically resected mass confirmed ganglioneuroma with substantial amounts of white and brown adipose tissues in peripheral areas. The existence of both ganglion cells and brown fat tissue intensified the accumulation of 18F-2-fluoro-2-deoxyglucose, resulting in a false-positive result by positron emission tomography. Considering this, ganglioneuroma should not be excluded either clinically or pathologically in fat-containing, posterior mediastinal tumors.

DOI： 10.1186/1752-1947-8-345

Epidermal growth factor receptor mutations in Japanese men with lung adenocarcinomas

Tomita M., Ayabe T., Chosa E., Kawagoe K., Nakamura K.

Asian Pacific Journal of Cancer Prevention 15 ( 24 ) 10627 - 10630 2014

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asian Pacific Journal of Cancer Prevention

Background: Epidermal growth factor receptor (EGFR) mutations play a vital role in the prognosis of patients with lung adenocarcinoma. Such somatic mutations are more common in women who are non-smokers with adenocarcinoma and are of Asian origin. However, to our knowledge, there are few studies that have focused on men. Materials and Methods: One hundred and eighty-four consecutive patients (90 men and 94 women) of resected lung adenocarcinoma were studied retrospectively. Results: EGFR mutations were positive in 48.9% and negative (wild type) in 51.1%. Overall mutation was significant in women (66.0% vs. 32.2%) compared with men (p < 0.001). For overall patients, EGFR mutation status was associated with gender, pStage, pT status, lepidic dominant histologic subtype, pure or mixed ground-glass nodule type on computed tomography and smoking status. However, in men, EGFR mutation status was only associated with lepidic dominant histologic subtype and not the other variables. Interestingly, the Brinkman index of men with mutant EGFR also did not differ from that for the wild type (680.0±619.3 vs. 813.1±552.1 p=0.1077). Conclusions: The clinical characteristics of men with lung adenocarcinoma related to EGFR mutation are not always similar to that of overall patients. Especially we failed to find the relationship between EGFR mutations and smoking status in men.

DOI： 10.7314/APJCP.2014.15.24.10627

Figure-L unilateral mini-sternotomy for cervico-thoracic neurofibroma originating from vagus nerve with neurofibromatosis type 1

AYABE Takanori, TOMITA Masaki, MARUTSUKA Kosuke, SHIMIZU Tetsuya, NAKAMURA Kunihide

The Journal of the Japanese Association for Chest Surgery 27 ( 6 ) 712 - 718 2013.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Chest Surgery

A neurogenic tumor in the cervico-thoracic region is rare. To remove such a tumor, a supraclavicular approach, mini-sternotomy, video-assisted thoracic surgery, or a combination of these procedures is performed in consideration of minimally invasive surgery. A 25-year-old male was pointed out by others as showing a left cervical swelling 6 months previously. He was diagnosed with a cervico-thoracic tumor of 5.5×4.5 cm by chest computed-tomographic scanning, originating from the vagus nerve and passing to the level of the aortic arch. Physical examination showed café-au-lait macules, Lisch nodules, and scoliosis, and the patient was diagnosed with neurofibromatosis type 1 (NF-1). We incised the skin from the left cervical region to median anterior thorax. A figure-L unilateral mini-sternotomy at the left first intercostal space was performed. The tumor originating from the vagus nerve was resected by 22 cm in its longitudinal length, and pathological examination showed neurofibroma. A type I thyroplasty for hoarseness from the left recurrent nerve palsy was performed. A combination of the figure-L unilateral mini-sternotomy and supraclavicular approach is considered an effective and useful minimally invasive approach for a cervico-thoracic tumor.

DOI： 10.2995/jacsurg.27.712

Adjuvant Chemotherapy of Gemcitabine plus Carboplatin versus Paclitaxel plus Carboplatin in Patients with Resected Non-Small Lung Cancer Reviewed

Takanori Ayabe, Masaki Tomita, Kunihide Nakamura

Journal of Cancer Therapy 4 15 - 23 2013.9

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4236/jct.2013.48A003

メチシリン耐性黄色ブドウ球菌(MRSA)アウトブレイク時の感染対策とチーム医療 Reviewed

綾部貴典、西村征憲、幸森千晶、上森しのぶ、福田真弓、富田雅樹、岡山昭彦、中村都英

宮崎医会誌 37 187 - 194 2013.9

Language：Japanese Publishing type：Research paper (scientific journal)

胸腔鏡下緊急手術を施行した特発性血気胸の3例 Reviewed

阪口修平、富田雅樹、白崎幸枝、綾部貴典、清水哲哉、中村都英

宮崎県医師会医学会会誌 37 160 - 163 2013.9

Language：Japanese Publishing type：Research paper (scientific journal)

肺癌術後再発・転移に対する化学療法(GEM+CBDCA vs PTX+CBDCA) Reviewed

綾部貴典、富田雅樹、原政樹、鬼塚敏男、中村都英

宮崎医会誌 37 97 - 105 2013.9

Language：Japanese Publishing type：Research paper (scientific journal)

Neurofibromatosis type 1に合併した迷走神経由来の頚胸部発生神経線維腫の1切除例 Reviewed

綾部貴典、富田雅樹、丸塚浩助、清水哲哉、中村都英

日本呼吸器外科学会雑誌 27 ( 6 ) 44 - 50 2013.6

Language：Japanese Publishing type：Research paper (scientific journal)

Is There a Relationship Between Serum Carcinoembryonic Antigen Level and Epidermal Growth Factor Receptor Mutations in Resected Lung Adenocarcinomas?

Tomita M., Ayabe T., Chosa E., Nakamura K.

Annals of Cancer Research and Therapy 21 ( 1 ) 31 - 35 2013

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Cancer Research and Therapy

Some previous studies reported the relationship between the mutation status of epidermal growth factor receptor (EGFR) gene and serum carcinoembryonic antigen (CEA) level in advanced or recurrent lung adenocarcinomas. In the present study, this relationship was examined in resected lung adenocarcinomas. One hundred thirty five resected lung adenocarcinoma patients were reviewed retrospectively. Mutations of the EGFR gene were detected in 64 of the 135 patients, the most common being deletions in exon 19 and the L858R mutations in exon 21. The patients with normal serum CEA level had favorable prognosis, whereas those with high had poor prognosis. The 5-year survival of the patients with EGFR mutation-negative was significantly worse than that of the patients with EGFR mutation-positive. Both univariate and multivariate analyses indicated an independent prognostic impact of the combined use of serum CEA level and the status of EGFR mutation. There was no difference in the rate of EGFR gene mutations according to the serum CEA level. Furthermore we also failed to find the differences in the serum CEA level based on the EGFR mutation status. The rate of deletions in exon 19 and/or the L858R mutation in exon 21 was not also related to the serum CEA level. In conclusions we failed to find the relationship between the serum CEA level and the EGFR mutation status in resected lung adenocarcinomas. © 2013, The Japanese Society of Strategies for Cancer Research and Therapy. All rights reserved.

DOI： 10.4993/acrt.21.31

Preoperative Total Serum Cholesterol and Patients' Survival in Resected Nonsmall Cell Lung Cancer Reviewed

Masaki Tomita, Takanori Ayabe, Tetsuya Shimizu, and Kunihide Nakamura

Lung Cancer International 2012 ( 463520 ) 4 2012.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1155/2012/463520

(Anticancer Research 32, 8 (3535))

Tomita M., Shimizu T., Ayabe T., Nakamura K., Onitsuka T.

Anticancer Research 32 ( 12 ) 2012.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Salvage surgery of nonremovable metallic stent for adenoid cystic carcinoma and the subsequent difficulty of airway management Reviewed

Takanori Ayabe, Tetsuya Shimizu, Masaki Tomita, Masaki Hara, Mitsuhiro Yano, and Kunihide Nakamura

Ann. Cancer Res. Ther. 20 ( 1 ) 24 - 31 2012.9

Language：English Publishing type：Research paper (scientific journal)

非小細胞肺癌術後のCBDCA＋GEM化学療法の検討 Reviewed

綾部貴典、富田雅樹、原政樹、清水哲哉、中村都英、鬼塚敏男

宮崎医会誌 36 116 - 124 2012.9

Language：Japanese Publishing type：Research paper (scientific journal)

(Anticancer Research 32, 8, (3535))

Tomita M., Shimizu T., Ayabe T., Nakamura K., Onitsuka T.

Anticancer Research 32 ( 9 ) 2012.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Maximum SUV on positron emission tomography and serum CEA level as prognostic factors after curative resection for non-small cell lung cancer

Tomita M., Shimizu T., Ayabe T., Onitsuka T.

Asia-Pacific Journal of Clinical Oncology 8 ( 3 ) 244 - 247 2012.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asia-Pacific Journal of Clinical Oncology

Aims: The relationship between the maximum standardized uptake values (SUVmax) on positron emission tomography (PET) and serum carcinoembryonic antigen (CEA) level in non-small cell lung cancer (NSCLC) patients was investigated. Methods: Consecutively, 197 surgically resected NSCLC patients with preoperative staging including serum CEA and PET were reviewed retrospectively. Results: When patients were subdivided into two groups based on the median value of the SUVmax (6.6), the 5-year survival of patients with a high SUVmax was 63.20%, which was significantly worse than patients with a low SUVmax (87.29%, P=0.0004). The 5-year survival of patients with normal and high serum CEA level was 82.70 and 51.08%, respectively (P<0.0001). Univariate and multivariate analyses indicated the independent prognostic impact of the SUVmax and serum CEA level. Patients with both low SUVmax and normal serum CEA level had favorable prognosis, whereas those with both high SUVmax and high serum CEA level had poor prognosis. Conclusion: Preoperative SUVmax and serum CEA level are independent prognostic factors for survival in NSCLC. The combined use of preoperative SUVmax and serum CEA level might be a better prognostic indicator. © 2012 Wiley Publishing Asia Pty Ltd.

DOI： 10.1111/j.1743-7563.2012.01549.x

Maximum SUV on positron emission tomography and serum CEA level as prognostic factors after curative resection for non-small cell lung cancer. Reviewed

Elevated Preoperative Inflammatory Markers Based on Neutrophil-to-Lymphocyte Ratio and C-Reactive Protein Predict Poor Survival in Resected Non-small Cell Lung Cancer. Reviewed

Tomita M, Shimizu T, Ayabe T, Onitsuka T.

Anticancer Res 32 ( 8 ) 3535 - 3538 2012.8

Language：English Publishing type：Research paper (scientific journal)

Tomita M, Shimizu T, Ayabe T, Onitsuka T.

Asia Pac J Clin Oncol. 8 244 - 247 2012.8

Language：English Publishing type：Research paper (scientific journal)

DOI： doi:10.1111/j.1743-7563.2012.01549.x

Elevated preoperative inflammatory markers based on neutrophil-to-lymphocyte ratio and C-reactive protein predict poor survival in resected non-small cell lung cancer.

Tomita M, Shimizu T, Ayabe T, Nakamura K, Onitsuka T

Anticancer research 32 ( 8 ) 3535 - 8 2012.8

Language：Japanese Publishing type：Research paper (scientific journal)

Elevated preoperative inflammatory markers based on,neutrophil-to- lymphocyteratio and C-reactive protein predict poor survival in resected non-small cell lung cancer

Tomita M., Shimizu T., Ayabe T., Onitsuka T.

Anticancer Research 32 ( 8 ) 3535 - 3538 2012.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Background: Previous studies showed the prognostic impact of inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP), in resected non-small cell lung cancer (NSCLC). However, there are no studies that examined both of these markers simultaneously. Patients and Methods: Three hundred and one consecutive cases of resected NSCLC with a follow-up period of more than 5 years were reviewed retrospectively. Results: A significant association was only observed between NLR and patients ' survival (p<0.0001). High CRP also led to a higher 5-year survival rate than low CRP (38.71% vs. 70.71%, p<0.0001). We evaluated the prognostic significance of the use of NLR and CRP combined. The 5-year survival of patients with both low NLR and low CRP was 74.18%. On the other hand, that of patients with both of these at a low level was significantly poor (20.00%, p<0.0001). Univariate and multivariate analyses of the clinicopathological factors affecting survival revealed that the combined use of preoperative NLR and CRP was an independent prognostic determinant. Conclusion: The combined use of preoperative NLR and CRP might be useful to predict the prognosis of patients with NSCLC.

[Parasternal approach for anterior apical lung cancer with invasion of the first rib].

前領域肺尖部第1 肋骨浸潤肺癌に対する傍胸骨アプローチ Reviewed

清水哲哉,，富田雅樹，綾部貴典，米井彰洋，中尾大伸，中村都英，鬼塚敏男

胸部外科 65 ( 7 ) 555 - 558 2012.7

Language：Japanese Publishing type：Research paper (scientific journal)

Shimizu T., Tomita M., Ayabe T., Yonei A., Nakao H., Nakamura K., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 65 ( 7 ) 555 - 558 2012.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

For complete resection of anterior apical invasive lung cancer, it is of clinical significance to select the appropriate surgical approaches based on the anatomic location of the tumor and extent of invasion of adjacent anatomic structures. However, patients with anterior apical lung cancer without vessel invasion are occasionally burdened with unnecessarily excessive surgical invasion. We present 2 cases of anterior apical lung cancer invading the 1st rib but not subclavian vein, who underwent complete resection through the parasternal approach. We also discuss the feasibility of this approach.

Surgical resection of pulmonary basaloid carcinoma with contralateral metastasis

肺癌に対するCBDCA＋weekly PTX化学療法 Reviewed

綾部貴典、富田雅樹、原政樹、清水哲哉、中村都英、鬼塚敏男

宮崎県医師会医学会会誌 36 108 - 115 2012.6

Language：Japanese Publishing type：Research paper (scientific journal)

術前診断が困難であった対側肺転移を伴う肺類基底細胞癌の1切除例 Reviewed

綾部貴典、富田雅樹、盛口淸香、丸塚浩助、清水哲哉

日本呼吸器外科学会雑誌 26 ( 4 ) 77 - 81 2012.6

Language：Japanese Publishing type：Research paper (scientific journal)

左胸膜外肺全摘術を施行した悪性胸膜中皮腫の１例 Reviewed

清水哲哉、富田雅樹、綾部貴典、米井彰洋、中尾大伸、中村都英、鬼塚敏男

宮崎県医師会医学会会誌 36 143 - 147 2012.6

Language：Japanese Publishing type：Research paper (scientific journal)

精神疾患を有する乳癌手術症例の臨床的検討 Reviewed

綾部貴典、清水哲哉、富田雅樹、米井彰洋、中尾大伸、中村都英、鬼塚敏男

宮崎県医師会医学会会誌 36 131 - 137 2012.6

Language：Japanese Publishing type：Research paper (scientific journal)

AYABE Takanori, TOMITA Masaki, MORIGUCHI Sayaka, MARUTSUKA Kousuke, SHIMIZU Tetsuya

The Journal of the Japanese Association for Chest Surgery 26 ( 4 ) 439 - 443 2012.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Chest Surgery

A 76-year-old female who underwent surgery for breast cancer (T1N0M0, stage I) presented with bilateral lung tumors (lt., B9, B10, endobronchial growing tumor, 30×14 mm rt., S8, nodule, 10 mm). Preoperatively, transbronchial lung biopsy from the left lung tumor disclosed a pleomorphic adenoma. The right lung tumor was resected by wedge resection under video-assisted thoracic surgery, and the left tumor was resected with basal segmentectomy via open thoracotomy. Both tumors were eventually diagnosed as pulmonary basaloid carcinoma based on immunohistochemical results positive for AE1/AE3 and negative for Synaptophysin and Chromogranin A. Clinically, the right tumor was deemed a metastasis from the left one, and she was diagnosed with T1bNxM1, p-stage IV. Neither distant metastasis nor local recurrence was noted at the 17th postoperative month. Pulmonary basaloid carcinoma has been reported as an uncommon variant of large cell carcinoma, for which the preoperative diagnosis is difficult; however, aggressive surgical resection and close immunohistochemical examination should be performed.

DOI： 10.2995/jacsurg.26.439

内分泌療法（アナストロゾール）が奏功した胸水貯留・胸膜転移を伴う転移性進行乳癌の１例 Reviewed

綾部貴典、清水哲哉、富田雅樹、米井彰洋、鬼塚敏男

宮崎県医師会雑誌 36 35 - 43 2012.3

Language：Japanese Publishing type：Research paper (scientific journal)

限局性気管支拡張症を呈した35年の経過をもつ気道異物の1例 Reviewed

久保和義、長友安弘、宮内俊一、楠元規生、上野史朗、松本紫朗、綾部貴典、富田雅樹、清水哲哉、岡山昭彦

日本呼吸器内視鏡学会誌 34 ( 3 ) 242 - 245 2012.3

Language：Japanese Publishing type：Research paper (scientific journal)

A surgical intervention followed by adjuvant treatment of erlotinib for a 85-year-old elderly advanced lung cancer. Reviewed

Takanori Ayabe, Testuya Shimizu, Masaki Tomita, and Toshio Onitsuka.

Ann. Cancer Res. Therap 20 ( 1 ) 1 - 6 2012.2

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4993/acrt.20.01

Preoperative Total Serum Cholesterol and Patients' Survival in Resected Nonsmall Cell Lung Cancer Reviewed

Tomita M., Ayabe T., Shimizu T., and Nakamura K

Lung Cancer International ( 2012 ) 463520 - 4 pages 2012.2

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1155/2012/463520.

精神健康不全者に対し大学カウンセリング・ルームで奏功した心身医療に他のCAMを加えた統合医療的治療の試み Reviewed

秋坂真史、綾部貴典、山口昌俊、本部暢子、富田賢一、森　憲正、土屋利紀

日本統合医療学会誌 5 49 - 54 2012.2

Language：Japanese Publishing type：Research paper (scientific journal)

A case of advanced lung cancer treated by surgery followed by adjuvant combination therapy of gefitinib and interleukin-2 lymphokine-activated killer cell immunotherapy. Reviewed

Ayabe T., Shimizu T., Tomita M., Kushima Y., Onitsuka T.

Ann. Cancer Res. Therap. 20 ( 1 ) 11 - 16 2012.2

Language：English Publishing type：Research paper (scientific journal)

A case of long-term survival of gefitinib-induction therapy for advanced N2-multistation lung cancer without epidermal growth factor receptor gene mutation. Reviewed

Taknori Ayabe, Tstsuya Shimizu, Masaki Tomita, Masaki Hara, and Toshio Onitsuka.

Ann. Cancer Res. Therap 19 ( 2 ) 62 - 65 2012.2

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4993/acrt.19.62

A case of advanced lung cancer treated by surgery followed by adjuvant combination therapy of gefitinib and interleukin-2 lymphokine-activated killer cell immunotherapy. Reviewed

Ayabe T., Shimizu T., Tomita M., Kushima Y., Onitsuka T.

Ann. Cancer Res. Therap. 20 ( 1 ) 11 - 16 2012.2

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4993/acrt.20.11

Salvage surgery of nonremovable metallic stent for adenoid cystic carcinoma and the subsequent difficulty of airway management

Ayabe T., Shimizu T., Tomita M., Hara M., Yano M., Nakamura K.

Annals of Cancer Research and Therapy 20 ( 1 ) 24 - 31 2012

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Cancer Research and Therapy

In 1999, a 60-year-old female diagnosed with tracheobronchial adenoid cystic carcinoma, was rejected due to the high risk reconstruction surgery of the carina. Our interventional radiological doctor implanted metallic stents for bilateral bronchial stenosis (right: Ultraflex, left: Spiral Z stent) to prevent endobronchial edematous asphyxia during radiation therapy. Radiotherapy showed that the tumor had decreased in size. The migrated right metallic stent was removed but the left one remained because it could not be removed. She had been unevenful for 3 years after the metallic stent implantation. In the 4th year, bronchoscopic balloon dilatation therapy had been performed for the produced dyspnea due to the exuberant granulation once every year for 4 years. The left lung had been destroyed by resuscitate pneumonia, thus we performed a pneumonectomy as salvage surgery using a cardiopulmonary bypass. The postpneumonectomy syndrome, dysphagia and dyspnea had confused her. Bronchoscopic balloon dilatation therapy had been continued for the right single airway stenosis every three months for 2 years. Eventually, she died of respiratory failure due to the recurrence of the disease after 12 years of treatment. We should require use of a silicone stent for the low grade malignancy of tracheobronchial airway stenosis. Eventual open thoracotomic removal should be done for management of the long-term complications of nonremovable metallic stents. © 2012, The Japanese Society of Strategies for Cancer Research and Therapy. All rights reserved.

DOI： 10.4993/acrt.20.24

A Case of a Bronchial Foreign Body, Undiagnosed for 35 Years, Causing a Focal Bronchiectasia

Kubo Kazuyoshi, Okayama Akihiko, Nagatomo Yasuhiro, Miyauchi Shunichi, Kusumoto Norio, Ueno Shirou, Matsumoto Shiro, Ayabe Takanori, Tomita Masaki, Shimizu Tetsuya

The Journal of the Japan Society for Respiratory Endoscopy 34 ( 3 ) 242 - 245 2012

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society for Respiratory Endoscopy

Background. Bronchial foreign bodies can cause the bronchiectasis. However, a long interval (35 years) from the absorption of a foreign body at age of 5 years old was implicated in the present case. Case. A 40-year-old woman with wet cough and low grade fever was given a diagnosis of bronchiectasis. She was admitted to our hospital in May 2008 because of exacerbation of symptoms. She had right precordial crackles. Computed tomography (CT) showed bronchiectatic changes confined to the right upper lobe. Bronchoscopy revealed stenosis of the right main bronchus, orifice of the right upper lobe bronchus, and right truncus intermedius. The patient underwent right upper lobectomy and tracheobronchoplasty. When the right upper lobe was resected, a plastic body (12 mm in size) was found. Her bronchiectasis was considered caused by bronchial obstruction due to this foreign body. Her symptoms disappeared and her pulmonary function was improved after the surgical treatment. Detailed history taking revealed an episode of a foreign body (a plastic flower) aspiration at age 5. The plastic foreign body was difficult to detect by chest X-ray and CT. Conclusion. This case suggested that an intrabronchial foreign body can cause long-term obstruction of bronchus resulting in atypical bronchiectasis.

DOI： 10.18907/jjsre.34.3_242

Persistently High Neutrophil to Lymphocyte Ratio after Surgery Indicate Reviewed

Masaki Tomita, Tetsuya Shimizu, Takanori Ayabe, Toshio Onitsuka

Ann. Cancer Res. Therap 19 ( 2 ) 54 - 56 2011.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.4993/acrt.19.54

Preoperative neutrophil to lymphocyte ratio as a prognostic predictor after curative resection for non-small cell lung cancer

Tomita M., Shimizu T., Ayabe T., Yonei A., Onitsuka T.

Anticancer Research 31 ( 9 ) 2995 - 2998 2011.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Background: The prognostic impact of neutrophil to lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) was examined using patients with a follow-up period more than 5 years. Patients and Methods: Two hundred and eighty four consecutive resected NSCLC patients were reviewed retrospectively. In this study, patients who were treated with a follow-up period less than 5 years were omitted, Results: The mean value of NLR was 2.44±2.22 (range: 0.56-29.44). The 5-year survival of the patients with a high NLR (≥2.5) was significantly worse than that of the patients with a low NLR (47.06% vs. 67.84%, p<0.0001). Univariate analysis of the clinicopathological factors affecting survival revealed that age, gender, histology, pT status, pN status, high serum CEA level, positive findings of pleural lavage cytology and high NLR were significant risk factors for reduced survival. On multivariate analysis, a high NLR was an independent risk factor for reduced survival. Conclusion: A high preoperative NLR may be a convenient biomarker to identify patients with a poor prognosis after resection for NSCLC.

Preoperative neutrophil to lymphocyte ratio as a prognostic predictor after curative resection for non-small cell lung cancer.

Tomita M, Shimizu T, Ayabe T, Yonei A, Onitsuka T

Anticancer research 31 ( 9 ) 2995 - 8 2011.9

Language：Japanese Publishing type：Research paper (scientific journal)

Emergent Completion Pneumonectomy for Postoperative Hemorrhage from Rupture of the Infected Pulmonary Artery in Lung Cancer Surgery Reviewed

Case Reports in Surgery 2011 4 pages 2011.7

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1155/2011/902062

根治的化学放射線療法後の遺残・再発食道癌に対する救済手術（Salvage手術）の長期成績 Reviewed

綾部貴典、松崎泰憲、清水哲哉、原政樹、富田雅樹、鬼塚敏男

宮崎県医師会雑誌 35 100 - 107 2011.7

Language：Japanese Publishing type：Research paper (scientific journal)

Bronchoscopic Removal of Staple-Line Reinforcement Material Reviewed

Journal of Bronchology & Interventional Pulmonology 18 ( 3 ) 274 - 277 2011.7

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1097/LBR.0b013e31822846a7

Bronchial Flap Closure of the Lower Membranous Trachea Reviewed

Tomita M, Shimizu T, Ayabe T, Yonei A, and Onitsuka T

Ann Thorac Surg 91 935 - 937 2011.5

Language：English Publishing type：Research paper (scientific journal)

Preoperative Neutrophil to Lymphocyte Ratio as a Prognostic Predictor after Curative Resection for Non-small Cell Lung Cancer Reviewed

MASAKI TOMITA, TETSUYA SHIMIZU, TAKANORI AYABE, AKIHIRO YONEI, and TOSHIO ONITSUKA

ANTICANCER RESEARCH 31 2995 - 2998 2011.5

Language：English Publishing type：Research paper (scientific journal)

アンスラサイクリン系抗癌剤の術前化学療法による薬剤性心筋症合併乳癌の１切除例 Reviewed

綾部貴典、富田雅樹、原政樹、清水哲哉、松崎泰憲、鬼塚敏男

宮崎県医師会雑誌 35 108 - 115 2011.5

Language：Japanese Publishing type：Research paper (scientific journal)

Bronchial flap closure of the lower membranous trachea

Tomita M., Shimizu T., Ayabe T., Yonei A., Onitsuka T.

Annals of Thoracic Surgery 91 ( 3 ) 935 - 937 2011.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic Surgery

A novel method for closure of the lower membranous trachea after right pneumonectomy using a flap derived from the cartilaginous portion of the right main bronchus is described in this study. This technique was used successfully in patients with tracheal stenosis due to a giant posterior mediastinal tumor known as schwannoma. Because of the severe tracheobronchial stenosis and destroyed right lung, tumor resection combined with resection of the lower membranous trachea and right pneumonectomy was carried out. We closed the defect in the membranous lower trachea with the flap derived from the right main bronchus. The clinical course was uneventful. © 2011 The Society of Thoracic Surgeons.

DOI： 10.1016/j.athoracsur.2010.08.014

Prognostic significance of the combined use of preoperative platelet count and serum carcinoembryonic antigen level in non-small-cell lung cancer

TOMITA Masaki, SHIMIZU Tetsuya, AYABE Takanori, ONITSUKA Toshio

General thoracic and cardiovascular surgery 58 ( 11 ) 573 - 576 2010.11

Language：Japanese Publishing type：Research paper (scientific journal)

Prognostic significance of the combined use of preoperative platelet count and serum carcinoembryonic antigen level in non-small-cell lung cancer

Tomita M., Shimizu T., Ayabe T., Onitsuka T.

General Thoracic and Cardiovascular Surgery 58 ( 11 ) 573 - 576 2010.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：General Thoracic and Cardiovascular Surgery

Purpose: The prognostic significance of the combined use of preoperative platelet count and serum carcinoembryonic antigen (CEA) level in non-small-cell lung cancer patients was investigated. Methods: Consecutive 289 non-small-cell lung cancer patients were reviewed retrospectively. Thrombocytosis was defined as a platelet count of at least 40 × 104/mm3. Results: The frequency of preoperative thrombocytosis was 4.5% (13/289). The 5-year survival of patients with thrombocytosis was 30.77%, which was significantly poorer than that of patients with normal counts (68.65%, P = 0.0010). The 5-year survivals of patients with a normal CEA level and those with an elevated serum CEA level were 74.18% and 55.78%, respectively (P = 0.0019). Patients with both a normal platelet count and a normal serum CEA level had a favorable prognosis, whereas those with both thrombocytosis and elevated serum CEA level had a poor prognosis. The prognostic impact of the combined use of the platelet count and the serum CEA level was more significant than that of the platelet count or the serum CEA level alone. Both univariate and multivariate analyses indicated an independent prognostic impact of the combined use of platelet count and serum CEA levels. Conclusion: The combined use of preoperative platelet count and serum CEA levels might be useful for predicting the prognosis of non-small-cell lung cancer patients. © 2010 The Japanese Association for Thoracic Surgery.

DOI： 10.1007/s11748-010-0647-2

Carcinoembryonic antigen level in serum and pleural lavage fluid in non-small cell lung cancer

Tomita M., Shimizu T., Ayabe T., Yonei A., Onitsuka T.

Thoracic and Cardiovascular Surgeon 58 ( 6 ) 350 - 353 2010.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Thoracic and Cardiovascular Surgeon

Background: This study evaluates the tumor marker index (TMI) based on carcinoembryonic antigen (CEA) levels in serum and pleural lavage fluid as a potential prognostic determinant for patients with non-small cell lung cancer (NSCLC). Materials and Methods: Three hundred and eighty-three consecutive NSCLC patients were reviewed retrospectively. Results: The 5-year survival of patients with normal and high serum CEA levels was 71.78% and 51.38%, respectively (p<0.0001). The 5-year survival of patients with high CEA levels in pleural lavage fluid was 25.0%, which was significantly poorer compared with that of patients with normal lavage CEA levels (78.23%, p<0.0001). There was a 5-year survival rate of 73.75% in patients with a TMI less than or equal to 1.0 compared to a rate of only 55.12% in patients with a TMI greater than 1.0 (p<0.001). Both univariate and multivariate analyses indicated the independent prognostic impact of the TMI. Conclusions: The TMI based on serum and lavage CEA levels might be useful for predicting the prognosis of NSCLC patients. © Georg Thieme Verlag KG Stuttgart - New York.

DOI： 10.1055/s-0030-1250025

Prognostic significance of tumour marker index based on preoperative CEA and CYFRA 21-1 in non-small cell lung cancer

Tomita M., Shimizu T., Ayabe T., Yonei A., Onitsuka T.

Anticancer Research 30 ( 7 ) 3099 - 3102 2010.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Background: Prognostic impact of tumour marker index (TMI) based on preoperative serum carcinoembryonic antigen (CEA) and CYFRA 21-1 in non-small cell lung cancer (NSCLC) was examined using patients with a follow-up period more than 5 years. Patients and Methods: Two hundred and ninety-three consecutive NSCLC patients were reviewed retrospectively, and any patients with follow-up periods less than 5 years were omitted. Results: The 5-year survival of the patients with normal and high serum CEA levels was 7152% and 48.41%, respectively (p<0.0001). The 5-year survival of the patients with a high serum CYFRA 21-1 level was 39.66%, which was significantly poorer compared with that of the patients with a normal serum CYFRA 21-1 level (66.95%, p<0.0001). There was a 5-year-survival rate of 72.28% in patients with a TMI less than or equal to 1.0 compared to only 37.08% in patients with a TMI greater than 1.0 (p<0.0001). Both univariate and multivariate analyses indicated the independent prognostic impact of TMI. Conclusions: TMI may be useful for predicting the prognosis of NSCLC patients.

Prognostic significance of tumour marker index based on preoperative CEA and CYFRA 21-1 in non-small cell lung cancer.

Tomita M, Shimizu T, Ayabe T, Yonei A, Onitsuka T

Anticancer research 30 ( 7 ) 3099 - 102 2010.7

Language：Japanese Publishing type：Research paper (scientific journal)

Postoperative Serum C-Reactive Protein Levels in Non-Small Cell Lung Cancer Patients

HARA Masaki, YONEI Akihiro, AYABE Takanori, TOMITA Masaki, NAKAMURA Kunihide, ONITSUKA Toshio

Annals of thoracic and cardiovascular surgery 16 ( 2 ) 85 - 90 2010.4

Language：Japanese Publishing type：Research paper (scientific journal)

Prognostic significance of the combined use of preoperative platelet count and serum carcinoembryonic antigen level in non-small-cell cancer Reviewed

Tomita M, Shimizu T, Ayabe T, and Onitsuka T

Gen Thorac Cardiovasc Surg 58 573 - 576 2010.4

Language：English Publishing type：Research paper (scientific journal)

Carcinoembryonic Antigen Level in Serum and Pleural Lavage Fluid in Non-Small Lung Cancer Reviewed

Tomita M, Shimizu T, Ayabe T, Yonei T, and Onitsuka T

Thorac Cardiovasc Surg 58 350 - 353 2010.4

Language：English Publishing type：Research paper (scientific journal)

"Postoperative Serum C-Reactive Protein Level in Non-Small Cell Lung Cancer Patients Reviewed

Hara M, Yonei A, Ayabe T, Tomita M, Nakamura K, and Onitsuka T

Ann Thorac Cardiovasc Surg 16 85 - 90 2010.4

Language：English Publishing type：Research paper (scientific journal)

Prognostic Significance of Tumour Marker Index Based on Preoperative CEA and CYFRA 21-1 in Non-small Cell Lung Cancer Reviewed

Tomita M, Shimizu T, Ayabe T, Yonei A, and Onitsuka T

Anticancer Research 30 3099 - 3102 2010.4

Language：English Publishing type：Research paper (scientific journal)

Postoperative serum C-reactive protein levels in non-small cell lung cancer patients

Hara M., Yonei A., Ayabe T., Tomita M., Nakamura K., Onitsuka T.

Annals of Thoracic and Cardiovascular Surgery 16 ( 2 ) 85 - 90 2010.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic and Cardiovascular Surgery

Purpose: The significance of the postoperative serum C-reactive protein (CRP) level as a prognosis indicator was evaluated in patients with non-small cell lung cancer (NSCLC). Patients and Methods: A total of 276 patients who had undergone a curative resection of NSCLC were retrospectively reviewed.&Results: The overall and disease-specific survival rates in the postoperative CRP/high group (≥ 0.5 mg/dL at 30 days postoperation: n = 130) were significantly lower than those in the postoperative CRP/low group (< 0.5 mg/dL at 30 days postoperation: n = 146). However, based on a multivariate analysis, the postoperative CRP level was not among the unfavorable indicators regarding survival. The patients were divided into two groups, namely, the preop-erative CRP/low group (n = 231) and the CRP/high group (n = 45). The proportion of the postoperative CRP/low group (60.2%) in the preoperative CRP/low group was significantly lower than that in the preoperative CRP/low group (15.6%; p <0.0001). No significant difference was observed in the disease-specific survival rates in the postoperative CRP/high group and the postoperative CRP/low group in either the preoperative high/group or low/group. Conclusions: The overall and disease-specific survival rates in the postoperative CRP/high group were significantly lower than that in the postoperative CRP/low group. This difference may be associated with the relationship between the pre- and postoperative CRP levels.

Postoperative serum C-reactive protein levels in non-small cell lung cancer patients.

Hara M, Yonei A, Ayabe T, Tomita M, Nakamura K, Onitsuka T

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 16 ( 2 ) 85 - 90 2010.4

Language：Japanese Publishing type：Research paper (scientific journal)

Preoperative leukocytosis, anemia and thrombocytosis are associated with poor survival in non-small cell lung cancer

Tomita M., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Anticancer Research 29 ( 7 ) 2687 - 2690 2009.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Background: Previous studies have reported any prognostic impact of preoperative leukocytosis, anemia and thrombocytosis in non-small cell lung cancer (NSCLC). The significance of the combined use of these 3 abnormal blood cell counts was investigated. Patients and Methods: Two hundred and eighty-nine consecutive NSCLC patients were reviewed retrospectively. Results: The patients with leukocytosis, anemia and thrombocytosis had significantly worse prognosis. The 5-year survival of the patients with all three of these abnormal blood cell counts was 25.0%, which was significantly poorer compared with that of the patients without any of these abnormal cell counts (78.23%). The 5-year survival of the patients with 1 or 2 out of the three abnormal blood cell counts was an intermediate value. Both univariate and multivariate analyses indicated the independent prognostic impact of the use of these three abnormal blood cell counts combined. Conclusion: The use of leukocytosis, anemia and thrombocytosis combined might be useful for predicting the prognosis of NSCLC patients.

Preoperative leukocytosis, anemia and thrombocytosis are associated with poor survival in non-small cell lung cancer.

Tomita M, Shimizu T, Hara M, Ayabe T, Onitsuka T

Anticancer research 29 ( 7 ) 2687 - 90 2009.7

Language：Japanese Publishing type：Research paper (scientific journal)

Serum carcinoembryonic antigen level in non-small-cell lung cancer patients with preoperative normal serum level

TOMITA Masaki, SHIMIZU Tetsuya, HARA Masaki, AYABE Takanori, ONITSUKA Toshio

General thoracic and cardiovascular surgery 57 ( 6 ) 303 - 306 2009.6

Language：Japanese Publishing type：Research paper (scientific journal)

Pulmonary Metastasis from Renal Cell Carcinoma 17 Years after Nephrectomy : Report of Two Cases

TOMITA Masaki, SHIMIZU Tetsuya, HARA Masaki, AYABE Takanori, MATSUZAKI Yasunori, ONITSUKA Toshio

Annals of thoracic and cardiovascular surgery 15 ( 3 ) 189 - 191 2009.6

Language：Japanese Publishing type：Research paper (scientific journal)

Pulmonary metastasis from renal cell carcinoma 17 years after nephrectomy: Report of two cases

Tomita M., Shimizu T., Hara M., Ayabe T., Matsuzaki Y., Onitsuka T.

Annals of Thoracic and Cardiovascular Surgery 15 ( 3 ) 189 - 191 2009.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic and Cardiovascular Surgery

We herein report two cases of pulmonary metastasis from renal cell carcinoma with 17-year disease-free intervals. Despite long disease-free intervals, their clinical course after pulmonary resection was different. An 82-year-old man (case 1) and a 73-year-old man (case 2), with histories of having undergone left nephrectomy for clear-cell-type renal cell carcinoma 17 years ago, were found to have right pulmonary nodules, which were detected incidentally by chest roentgenograms. A chest computed tomography revealed the presence of nodules in the right lung. They underwent surgical pulmonary resection 17 years after nephrectomy. These tumors were diagnosed as metastatic renal cell carcinoma. Currently, the case 1 patient is doing well with no signs of recurrence 42 months after pulmonary metastasectomy; however, the case 2 patient was found to have multiple tumor recurrences 11 months after metastasectomy. Their clinical courses indicate that a longer disease-free interval does not always imply a favorable prognosis. (Ann Thorac Cardiovasc Surg 2009; 15: 189-191) © 2009 The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery.

Pulmonary metastasis from renal cell carcinoma 17 years after nephrectomy: report of two cases.

Tomita M, Shimizu T, Hara M, Ayabe T, Matsuzaki Y, Onitsuka T

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 15 ( 3 ) 189 - 91 2009.6

Language：Japanese Publishing type：Research paper (scientific journal)

Serum carcinoembryonic antigen level in non-small-cell lung cancer patients with preoperative normal serum level

Tomita M., Shimizu T., Hara M., Ayabe T., Onitsuka T.

General Thoracic and Cardiovascular Surgery 57 ( 6 ) 303 - 306 2009.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：General Thoracic and Cardiovascular Surgery

Objective: The prognostic significance of serum carcinoembryonic antigen (CEA) levels in non-small-cell lung cancer (NSCLC) patients with a normal serum CEA level (<5.0 ng/ml) was examined. Methods: A total of 220 consecutive NSCLC patients with preoperative normal serum CEA levels were included. Patients were subdivided into two groups: preoperative serum CEA level ≥2.5 and <2.5 ng/ml. Results: The 5-year survival of patients with preoperative serum CEA level less and more than 2.5 ng/ml were 79.62% and 62.0%, respectively (P = 0.0036). Multivariate analysis indicated that a preoperative serum CEA level of ≥2.5 ng/ml was an independent prognostic factor. Similar results were found in patients with adenocarcinoma but not found in others. Conclusion: NSCLC patients with a high serum CEA level, especially adenocarcinoma patients, had poorer prognosis even if their serum CEA levels were within the normal upper limit. © 2009 The Japanese Association for Thoracic Surgery.

DOI： 10.1007/s11748-008-0397-6

Serum carcinoembryonic antigen level and pleural lavage cytology in woman with non-small cell lung cancer

Serum carcinoembryonic antigen level in non-small cell lung cancer patients with preoperative normal serum level. Reviewed

Tomita M, Shimizu T, Hara M, Ayabe T, and Onitsuka T

General Thoracic Cardiovasc Surg 57 303 - 306 2009.4

Language：English Publishing type：Research paper (scientific journal)

Preoperative Leukocytosis, Anemia and Thrombocytosis Are Associated with Poor Survival in Non-small Cell Lung Cancer Reviewed

Tomita M, Shimizu T, Hara M, Ayabe T and Onitsuka T

Anticancer Research 29 2687 - 2690 2009.4

Language：English Publishing type：Research paper (scientific journal)

Pulmonary Metastasis from Renal Cell Carcinoma 17 Years after nephrectomy: report of Two Cases Reviewed

Tomita M, Shimizu T, Hara M, Ayabe T, Matsuzaki Y, and Onitsuka T

Ann Thorac Cardiovasc Surg 15 189 - 191 2009.4

Language：English Publishing type：Research paper (scientific journal)

Serum carcinoembryonic antigen level and pleural lavage cytology in woman with non-small cell lung cancer

Tomita M, Shimizu T, Hara M, Ayabe T, and Onitsuka T

Thorac Cardiovasc Surg 56 422 - 425 2008.10

Language：English Publishing type：Research paper (scientific journal)

肺癌病期診断目的以外に縦隔鏡検査を施行した症例の検討

富田雅樹、清水哲哉、原　政樹、綾部貴典、米井彰洋、鬼塚敏男

宮崎医誌 32 108 - 110 2008.10

Language：English Publishing type：Research paper (scientific journal)

Tomita M., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Thoracic and Cardiovascular Surgeon 56 ( 7 ) 422 - 425 2008.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Thoracic and Cardiovascular Surgeon

Background: The prognostic impact of serum carcinoembryonic antigen (CEA) levels and pleural lavage cytology (PLC) in female patients with non-small cell lung cancer (NSCLC) were examined. Methods: A consecutive series of 122 women with NSCLC who underwent surgical resection and PLC were included in the study. Results: The 5-year survival rate of patients with preoperative serum normal and elevated CEA levels was 86.79% and 58.46%, respectively (p = 0.0032). Positive PLC was present in 9/122 (7.38%) of patients. The 5-year survival rate of patients with positive PLC findings was 33.33%, which was significantly poor compared with that of patients with negative findings (83.16%, p = 0.0010). Multivariate analysis indicated that pN status, preoperative serum CEA levels and PLC findings were independent prognostic factors. Conclusions: Preoperative serum CEA level and PLC findings were independent prognostic factors for female patients with NSCLC. © Georg Thieme Verlag KG Stuttgart.

DOI： 10.1055/s-2008-1038781

Malignant Peripheral Nerve Sheath Tumor with Horner's Syndrome : A Case Report

Malignant Peripheral Nerve Sheath Tumor with Horner's Syndromer: A Case Report

Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Enomoto Y, Wada S, Tanaka H, Kataoka H, Nabeshima K, and Onitsuka T

Ann Thorac Cardiovasc Surg 14 246 - 248 2008.9

Language：English Publishing type：Research paper (scientific journal)

HARA Masaki, MATSUZAKI Yasunori, SHIMIZU Tetsuya, TOMITA Masaki, AYABE Takanori, ENOMOTO Yusuke, WADA Shunsuke, TANAKA Hiroyuki, KATAOKA Hiroaki, NABESHIMA Kazuki, ONITSUKA Toshio

Annals of thoracic and cardiovascular surgery 14 ( 4 ) 246 - 248 2008.8

Language：Japanese Publishing type：Research paper (scientific journal)

Squamous Cell Carcinoma of the Hilar Lymph Node with Unknown Primary Tumor : A Case Report

TOMITA Masaki, MATSUZAKI Yasunori, SHIMIZU Tetsuya, HARA Masaki, AYABE Takanori, ENOMOTO Yusuke, ONITSUKA Toshio

Annals of thoracic and cardiovascular surgery 14 ( 4 ) 242 - 245 2008.8

Language：Japanese Publishing type：Research paper (scientific journal)

Malignant peripheral nerve sheath tumor with Horner's syndrome: a case report.

Hara M, Matsuzaki Y, Shimizu T, Tomita M, Ayabe T, Enomoto Y, Wada S, Tanaka H, Kataoka H, Nabeshima K, Onitsuka T

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 14 ( 4 ) 246 - 8 2008.8

Language：Japanese Publishing type：Research paper (scientific journal)

Prognostic impact of thrombocytosis in resectable non-small cell lung cancer

Tomita M., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Interactive Cardiovascular and Thoracic Surgery 7 ( 4 ) 613 - 615 2008.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Interactive Cardiovascular and Thoracic Surgery

Relationship between thrombocytosis and poor prognosis has been reported in lung cancer. However, the majority of previous studies included many advanced stage and small cell lung cancer patients. Few studies focused on resectable non-small cell lung cancer patients. In the present study, therefore, consecutive 240 non-small cell lung cancer patients who received surgical resection were reviewed retrospectively, and investigated the survival impact of preoperative platelet count. In our results, the frequency of preoperative thrombocytosis was only 5.83% (14/240). The 5-year survival of patients with and without thrombocytosis was 28.87% and 63.73%, respectively. Both univariate and multivariate analyses indicated the independent prognostic impact of thrombocytosis. The present study is the first evaluation of prognostic effect of thrombocytosis in patients with resectable non-small cell lung cancer. Preoperative platelet count was a prognostic factor for resectable non-small cell lung cancer patients.

DOI： 10.1510/icvts.2007.174391

Malignant peripheral nerve sheath tumor with horner's syndrome: A case report

Hara M., Matsuzaki Y., Shimizu T., Tomita M., Ayabe T., Enomoto Y., Wada S., Tanaka H., Kataoka H., Nabeshima K., Onitsuka T.

Annals of Thoracic and Cardiovascular Surgery 14 ( 4 ) 246 - 248 2008.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic and Cardiovascular Surgery

We report on a 42-year-old woman with malignant peripheral nerve sheath tumor (MPNST) arising from the cervical sympathetic nerve. A collar incision and partial sternotomy were performed at the second intercostal space. The mass was spindle shaped and connected to the sympathetic trunk on the cranial and caudal sides, and it compressed the left carotid sheath on the median side. After the patient's uneventful recovery from surgery, adjuvant radiotherapy was administered to the area of resection. The patient remains well 5 years after surgery with no evidence of recurrence. (Ann Thorac Cardiovasc Surg 2008; 14: 246-248).

Squamous cell carcinoma of the hilar lymph node with unknown primary tumor: A case report

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Enomoto Y., Onitsuka T.

Annals of Thoracic and Cardiovascular Surgery 14 ( 4 ) 242 - 245 2008.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic and Cardiovascular Surgery

We herein report a rare case of squamous cell carcinoma (SCC) located in the hilar nodes with unknown primary tumor. A 56-year-old man underwent a thoracotomy under the clinical diagnosis of lung cancer with hilar nodes involvement. The tumor was found at the hilus and resected without pulmonary resection. The pathological diagnosis of this tumor was metastatic SCC in hilar lymph nodes. Examinations of the whole body failed to detect a primary site of the SCC. The patient is doing well with no clinical sign of recurrence 32 months after surgery. (Ann Thorac Cardiovasc Surg 2008; 14: 242-245).

Squamous cell carcinoma of the hilar lymph node with unknown primary tumor: a case report.

Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Enomoto Y, Onitsuka T

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 14 ( 4 ) 242 - 5 2008.8

Language：Japanese Publishing type：Research paper (scientific journal)

Induction of Apoptosis by Intrapleural Perfusion Hyperthermo-Chemotherapy for Malignant Pleural Mesothelioma

Squamous Cell Carcinoma of the Hilar Lymph Node with Unknown Primary Tumor: A Case Report Reviewed

Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Enomoto Y, and Onitsuka T

Ann Thorac Cardiovasc Surg 14 242 - 245 2008.7

Language：English Publishing type：Research paper (scientific journal)

MATSUZAKI Yasunori, TOMITA Masaki, SHIMIZU Tetsuya, HARA Masaki, AYABE Takanori, ONITSUKA Toshio

Annals of thoracic and cardiovascular surgery 14 ( 3 ) 161 - 165 2008.6

Language：Japanese Publishing type：Research paper (scientific journal)

Prognostic impact of thrombocytosis in resectable non-small cell lung cancer

Tomita M, Shimizu T, Hara M, Ayabe T, and Onitsuka T

Interact Cardiovasc Thorac Surg 7 613 - 615 2008.6

Language：English Publishing type：Research paper (scientific journal)

Induction of apoptosis by intrapleural perfusion hyperthermo-chemotherapy for malignant pleural mesothelioma

Matsuzaki Y., Tomita M., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Annals of Thoracic and Cardiovascular Surgery 14 ( 3 ) 161 - 165 2008.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic and Cardiovascular Surgery

Purpose: Despite extensive clinical research, no effective therapy for advanced malignant pleuralmesothelioma has been established. In this study, we induced apoptosis in patients with this disease, using intrapleural perfusion hyperthermo-chemotherapy, a new procedure developed in our surgical department. We then measured the tumorcidal effect. Material and Methods: Our study included 6 consecutive patients with malignant pleural mesothelioma (stage III: 5; stage IV: 1). Because of the advanced stage of the disease, none of the patients underwent tumor resection or pleurectomy. All patients, however, received perfusion treatment. Tumor cells collected from pleural effusions pre- and at 0, 24, and 48 h postperfusion were examined using an immunocytochemical stain to determine apoptosis. The percentage of positively stained cells was expressed as the apoptotic index. Results: Preperfusion, the apoptotic index was 3.8% ± 2.0%, indicating spontaneous apoptosis of untreated tumor cells. Postperfusion, the apoptotic index at 0, 24, and 48 h was 22.8% ± 5.15%, 63.8% ± 8.2%, and 47.8% ± 6.9%, respectively. The patients had a median survival time of 30 months. No patient morbidity was associated with the perfusion treatment. Conclusion: In patients with malignant pleural mesothelioma, intrapleural perfusion hyperthermo-chemotherapy induced potent apoptosis of tumor cells, increasing immediately postperfusion and peaking at 24 h. (Ann Thorac Cardiovasc Surg 2008; 14: 161-165).

Induction of apoptosis by intrapleural perfusion hyperthermo-chemotherapy for malignant pleural mesothelioma.

Matsuzaki Y, Tomita M, Shimizu T, Hara M, Ayabe T, Onitsuka T

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 14 ( 3 ) 161 - 5 2008.6

Language：Japanese Publishing type：Research paper (scientific journal)

Impact of preoperative hemoglobin level on survival of non-small cell lung cancer patients

Impact of Preoperative Hemoglobin Level on Survival of Non-small Cell Lung Cancer Patients

Tomita M, Shimizu T, Hara M, Ayabe T, and Onitsuka T

Anticancer Research 28 1947 - 1950 2008.5

Language：English Publishing type：Research paper (scientific journal)

Tomita M., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Anticancer Research 28 ( 3 B ) 1947 - 1950 2008.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Background: Only a few studies have reported any prognostic impact of the preoperative hemoglobin level itself in resectable non-small cell lung cancer (NSCLC). The survival impact of preoperative hemoglobin level and the relationship between hemoglobin and serum CEA level were investigated. Patients and Methods: Two hundred and forty consecutive NSCLC patients were reviewed retrospectively. Results: The 5-year survival of patients with low and those with a normal hemoglobin level was 42.99% and 73.47%, respectively. Both univariate and multivariate analyses indicated the independent prognostic impact of the hemoglobin level. The result for stage I patients was identical. Patients with normal hemoglobin could be subdivided into 2 groups based on their serum CEA level; the 5-year survival of patients with normal and those with elevated CEA was 81.72% and 57.24%, respectively. Conclusion: The preoperative hemoglobin level was a prognostic factor for NSCLC patients. The combined use of hemoglobin and CEA levels might be useful to predict the prognosis of patients.

Impact of preoperative hemoglobin level on survival of non-small cell lung cancer patients.

Tomita M, Shimizu T, Hara M, Ayabe T, Onitsuka T

Anticancer research 28 ( 3B ) 1947 - 50 2008.5

Language：Japanese Publishing type：Research paper (scientific journal)

DP-067-6 非小細胞肺癌切除例において血中CRP値は独立予後因子である(第108回日本外科学会定期学術集会)

原政樹, 松崎泰憲, 清水哲哉, 富田雅樹, 綾部貴典, 仙波速見, 鬼塚敏男

日本外科学会雑誌 109 ( 2 ) 2008.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人日本外科学会

Induction of apoptosis by intrapleural perfusion hyperthermo-chemotherapy for malignant pleural mesothelioma Reviewed

Matsuzaki Y, Tomita M, Shimizu T, Hara M, Ayabe T, and Onitsuka T

Ann Thorac Cardiovasc Surg 14 161 - 165 2008.4

Language：English Publishing type：Research paper (scientific journal)

Preoperative Peripheral Naive / Memory Ratio and Prognosis of Nonsmall-Cell Lung Cancer Patients

HARA Masaki, MATSUZAKI Yasunori, SHIMIZU Tetsuya, TOMITA Masaki, AYABE Takanori, ENOMOTO Yusuke, ONITSUKA Toshio

Annals of thoracic and cardiovascular surgery 13 ( 6 ) 384 - 390 2007.12

Language：Japanese Publishing type：Research paper (scientific journal)

Preoperative peripheral naïve / memory ratio and prognosis of nonsmall-cell lung cancer patients.

Hara M, Matsuzaki Y, Shimizu T, Tomita M, Ayabe T, Enomoto Y, Onitsuka T

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 13 ( 6 ) 384 - 90 2007.12

Language：Japanese Publishing type：Research paper (scientific journal)

Preoperative peripheral naïve/memory ratio and prognosis of nonsmall-cell lung cancer patients

Hara M., Matsuzaki Y., Shimizu T., Tomita M., Ayabe T., Enomoto Y., Onitsuka T.

Annals of Thoracic and Cardiovascular Surgery 13 ( 6 ) 384 - 390 2007.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic and Cardiovascular Surgery

Purpose: This study focused on the relationship between preoperative peripheral blood CD4 + naïve/memory ratio and prognosis following surgery for patients with nonsmall-cell lung cancer. Methods: After measuring CD3, CD4, CD8, CD45RA, CD45RO, CD25, and intracellular CTLA4 levels, CD4 + naïve/memory ratios were determined for 13 controls and 38 patients. Results: Although we observed no significant difference in the ratios, the patients exhibited a wider range of values than the controls. Of the 38 patients, 24 subsequently underwent surgery and were divided into three groups based on their preoperative CD4 + naïve/memory ratio: Group I: <0.3; Group II: 0.3-0.8; and Group III: >0.8. Survival times were then evaluated. Group II survival was significantly better than Groups I and III. Conclusion: Our data suggest that the preoperative CD4 + naïve/memory ratio may serve as a prognostic factor for nonsmall-cell lung cancer patients.

Preoperative serum C-reactive protein level in non-small cell lung cancer

縦隔鏡下生検を施行した非小細胞肺癌46症例の検討. Reviewed

綾部貴典、松崎泰憲、清水哲哉、原　政樹、富田雅樹、鬼塚敏男

宮崎県医師会医学会会誌 31 21 - 28 2007.8

Language：Japanese Publishing type：Research paper (scientific journal)

Hara M., Matsuzaki Y., Shimuzu T., Tomita M., Ayabe T., Enomoto Y., Onitsuka T.

Anticancer Research 27 ( 4 C ) 3001 - 3004 2007.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

We evaluated the significance of the preoperative serum C-reactive protein (CRP) level as a prognostic indicator in patients with non-small cell lung cancer (NSCLC). Patients and Methods: Two hundred and three patients who had undergone a curative resection of NSCLC were retrospectively reviewed. Results: The proportion of the tumor size over 3 cm per patient in the CRP-positive group (≥0.5 mg/dL: n=38) was significantly higher than that in the CRP-negative group (<0.5 mg/dL: n=165). The proportion of the adenocarcinoma in CRP-positive group was significantly lower than that in CRP-negative group. The overall and disease specific survival rates in the CRP-positive group were significantly lower than the rates in the CRP-negative group. Based on a multivariate analysis, the preoperative serum CRP level was selected as one of the unfavorable indicators regarding survival. Conclusion: The preoperative serum CRP level is an independent and significant indicator predictive of a poor prognosis in patients with NSCLC.

Preoperative serum C-reactive protein level in non-small cell lung cancer.

Hara M, Matsuzaki Y, Shimuzu T, Tomita M, Ayabe T, Enomoto Y, Onitsuka T

Anticancer research 27 ( 4C ) 3001 - 4 2007.7

Language：Japanese Publishing type：Research paper (scientific journal)

Retrograde tube drainage for esophageal anastomotic leaks and perforation

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Diseases of the Esophagus 20 ( 3 ) 247 - 250 2007.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Diseases of the Esophagus

The mortality and morbidity of esophageal anastomotic leaks or perforations remain high. We performed retrograde transanastomotic esophageal sump tube drainages for esophageal anastomotic leak or perforation in three patients. Our method is a modified procedure of the T-tube drainage. The Levin gastric tube was simply inserted into the esophagus via anastomotic leak or perforation to develop a defined fistula. All three patients were treated with a satisfactory outcome. An advantage of this method is that it is technically easy, and available for patients whose diseases are difficult to treat with standard T-tube drainage. In addition, one of our patients was successfully managed non-operatively by fluoroscopical guidance. This retrograde esophageal sump tube drainage was technically very easy, safe and useful for esophageal anastomotic leaks or perforations. © 2007 The Authors Journal compilation © 2007 The International Society for Diseases of the Esophagus.

DOI： 10.1111/j.1442-2050.2007.00680.x

Inflammatory myofibroblastic tumor detected by positron emission tomography

18FDG-PETで高度の集積を認めた炎症性筋線維芽細胞腫の1例. Reviewed

今井光一、芦谷淳一、小玉剛士、京楽由佳、佐野ありさ、松元信弘、中里雅光、綾部貴典、松崎泰憲、鬼塚敏男、山下　篤

日本胸部臨床 66 259 - 263 2007.5

Language：Japanese Publishing type：Research paper (scientific journal)

Imai K., Ashitani J., Kodama T., Kyoraku Y., Sano A., Matsumoto N., Nakazato M., Ayabe T., Matsuzaki Y., Onitsuka T., Yamashita A.

Japanese Journal of Chest Diseases 66 ( 3 ) 259 - 263 2007.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Chest Diseases

A 33 year-old female was admitted to our hospital with a pulmonary nodule in the right upper lung field. Examinations including bronchofiberscopy revealed no clear diagnosis. Because of strongly positive detection by positron emission tomography, the nodule was removed surgically and diagnosed as inflammatory myofibroblastic tumor pathologically.

Lung cancer patients with postoperative normalization of serum carcinoembryonic antigen level: Predictive factors for re-elevation

Preoperative serum C-reactive protein level in non-small cell lung cancer. Reviewed

Hara M., Matsuzaki Y., Shimizu T., Tomita M., Ayabe T., Enomoto Y., Onitsuka T.

Anticancer Research 27 ( 4C ) 3001 - 3004 2007.4

Language：English Publishing type：Research paper (scientific journal)

胸腔内温熱灌流化学療法を含めた集学的治療が奏効した悪性胸膜中皮腫の１例. Reviewed

綾部貴典, 松崎泰憲, 清水哲哉, 原　政樹, 富田雅樹, 鬼塚敏男

宮崎県医師会医学会会誌 31 ( 1 ) 51 - 56 2007.4

Language：Japanese Publishing type：Research paper (scientific journal)

生着癌組織に対する抗体を用いた拒絶反応の誘導

渡邉章, 原政樹, 帖佐英一, 松崎泰憲, 清水哲哉, 富田雅樹, 綾部貴典, 榎本雄介, 関屋亮, 中村都英, 鬼塚敏男

日本外科学会雑誌 108 2007.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人日本外科学会

Preoperative peripheral naive / memory ratio and prognosis of nonsmall-cell lung cancer patients. Reviewed

Hara M., Matsuzaki Y., Shimizu T., Tomita M., Ayabe T., Enomoto Y., Onitsuka T.

Annals of Thoracic and Cardiovascular Surgery 13 ( 6 ) 384 - 390 2007.3

Language：English Publishing type：Research paper (scientific journal)

Retrograde tube drainage for esophageal anastomotic leaks and perforation. Reviewed

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Diseases of the Esophagus 20 ( 3 ) 247 - 250 2007.2

Language：English Publishing type：Research paper (scientific journal)

弓部大動脈置換と肺摘除により完全切除しえた浸潤型胸腺腫. Reviewed

綾部貴典, 松崎泰憲, 清水哲哉, 原　政樹, 富田雅樹, 矢野義和, 矢野光洋, 中村都英, 鬼塚敏男, 伊藤浩史, 長池幸樹

胸部外科 59 ( 9 ) 804 - 808 2006.12

Language：Japanese Publishing type：Research paper (scientific journal)

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Asia-Pacific Journal of Clinical Oncology 2 ( 3 ) 132 - 136 2006.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asia-Pacific Journal of Clinical Oncology

Background: Postoperative normalization of serum carcinoembryonic antigen (CEA) level has been reported to be a favorable prognostic predictor in lung cancer. However, serum CEA levels of some patients' groups re-elevate during their postoperative course. The aim of study was to find predictors of CEA re-elevation in patients with preoperative high and postoperative normal CEA. Methods: Sixty-one consecutive lung cancer patients with preoperative high serum CEA level (>5 ng/mL) and postoperative normal level were reviewed retrospectively. Among these patients, serum CEA levels of 23 patients re-elevated during their postoperative course. We compared patients with and without re-elevation of serum CEA levels. Results: Th e 5-year survival of patients with and without re-elevation of serum CEA level was 13.20% and 88.68%, respectively (P < 0.0001). There are significant differences in pN2 status and CEA level in pleural lavage fluid between patients with and without re-elevation of serum CEA level. Conclusions: Our results showed that pN2 status and lavage CEA level were related to the re-elevation of serum CEA level. © 2006 The Authors; Journal Compilation © Blackwell Publishing Asia Pty Ltd.

DOI： 10.1111/j.1743-7563.2006.00061.x

Relationship between serum carcinoembryonic antigen level and T status in non-small cell lung cancer.

Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Onitsuka T

Anticancer research 26 ( 5B ) 3845 - 8 2006.9

Language：Japanese Publishing type：Research paper (scientific journal)

Relationship between serum carcinoembryonic antigen level and T status in non-small cell lung cancer

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Anticancer Research 26 ( 5 B ) 3845 - 3848 2006.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Background: Controversy exists regarding the relationship between serum carcinoembryonic antigen (CEA) level and T status in non-small cell lung cancer. Materials and Methods: Two hundred and forty-seven lung cancer patients with pN0 disease were included in the study and the relationship between serum CEA level and T status, tumor size and degree of local extension was investigated. Results: Patients with tumors 0 to 1.5 cm in diameter had significantly low serum CEA level. However, there were no significant differences in serum CEA level among other tumor size groups. Serum CEA level was not related to the degree of local extension. The 5-year survival of patients with both normal serum CEA levels and T1 disease was significantly better than that of patients with high serum CEA level and T2-4 disease. Conclusion: Serum CEA levels do not always relate to T status. The combined use of these factors might be useful in predicting the prognosis of pN0 non-small cell lung cancer patients.

[pN0 stage IA lung cancer downstaged from pN2 IIIA by induction therapy; report of a case].

Ayabe T, Matsuzaki Y, Shimizu T, Hara M, Tomita M, Onitsuka T

Kyobu geka. The Japanese journal of thoracic surgery 59 ( 10 ) 955 - 7 2006.9

Language：Japanese Publishing type：Research paper (scientific journal)

pN0 stage IA lung cancer downstaged from pN2 IIIA by induction therapy; report of a case

Ayabe T., Matsuzaki Y., Shimizu T., Hara M., Tomita M., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 59 ( 10 ) 955 - 957 2006.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

A 75-year-old male of adenocarcinoma in non-small cell lung cancer (NSCLC) was diagnosed to be p-staged IIIA by a preoperative mediastinoscopy. After the induction chemotherapy of cisplatin (80 mg/m2, day 1, 4 weeks, 2 cycles) plus docetaxel hydrate (60 mg/m2, day 1, 4 weeks, 2 cycles), we performed lobectomy and lymph nodes dissection. The postoperative pathological results showed no metastasis of the resected lymph nodes. The postoperative stage has been down to be pN0 IA from pN2 IIIA. After the adjuvant therapy of docetaxel hydrate (60 mg/m2, day 1, 4 weeks, 2 cycles), the postoperative serum carcinoembryonic antigen level has been normalized without a recurrence for more than 2 years. A pathological staging with a mediastinoscopic diagnosis for the suspected clinical IIIA-staged NSCLC should bring us a good assessment of the induction therapy.

Complete resection of the invasive thymoma combined with replacement of aortic arch and pneumonectomy

気管管状切除再建を行った気管原発 Schwannoma の１例. Reviewed

室内健志, 松崎泰憲, 清水哲哉, 原　政樹, 富田雅樹, 綾部貴典, 田代耕盛, 鬼塚敏男

宮崎県医師会医学会会誌 30 ( 2 ) 86 - 89 2006.8

Language：Japanese Publishing type：Research paper (scientific journal)

Ayabe T., Matsuzaki Y., Shimizu T., Hara M., Tomita M., Yano Y., Yano M., Nakamura K., Ito H., Nagaike K., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 59 ( 9 ) 804 - 808 2006.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

A 68-year-old male was found an abnormal shadow on chest X-ray and was diagnosed as thymoma by computed tomography (CT)-guided needle biopsy. As the tumor invaded the aortic arch, left main pulmonary artery and the lung, thymectomy combined resection of the surrounding tissues was performed for the complete resection. The aortic arch was replaced with cardiovascular graft under cardiopulmonary bypass, with the aid of selective cerebral perfusion. The left pneumonectomy was performed because the tumor invaded to the left main pulmonary artery and to the lung parenchyma. Masaoka stage III and histologic type B2 were diagnosed according to the World Health Organization classification. The patient has been well without recurrence or metastasis after the surgery for 2 years. A complete resection of the thymoma invaded to great vessels should be performed to expect for the good curability and prognosis.

New method for localization of the small ground-glass opacity lesion in resected lung

Lung cancer patients with postoperative normalization of serum carcinoembryonic antigen level: Predictive factors for re-elevation. Reviewed

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Asia. Pac. J. Clin. Oncol., 2(3)：132-136, (2006) 2 ( 3 ) 132 - 136 2006.7

Language：English Publishing type：Research paper (scientific journal)

pN2-IIIA期小細胞肺癌に対する術前化学療法によりpN0 へ down-stageした１症例. Reviewed

綾部貴典, 松崎泰憲, 清水哲哉, 原　政樹, 富田雅樹, 鬼塚敏男

宮崎県医師会医学会会誌, 30(2): 95-99, (2006) 30 ( 2 ) 95 - 99 2006.7

Language：Japanese Publishing type：Research paper (scientific journal)

右大動脈弓とpostaortic left innominate veinを伴う右上葉肺癌の１手術例. Reviewed

原　政樹, 松崎泰憲, 清水哲哉, 富田雅樹, 綾部貴典, 鬼塚敏男

日本呼吸器外科学会雑誌 20 ( 2 ) 166 - 170 2006.7

Language：Japanese Publishing type：Research paper (scientific journal)

術前導入療法によりpN0IA期へダウンステージしたpN2IIIA期非小細胞肺癌の１例. Reviewed

綾部貴典, 松崎泰憲, 清水哲哉, 原　政樹, 富田雅樹, 鬼塚敏男

胸部外科 59 ( 10 ) 955 - 957 2006.7

Language：Japanese Publishing type：Research paper (scientific journal)

遺伝子からタンパク質まで　-アデニル酸キナーゼ、その構造と機能を探る-、pp359-373、「遺伝子の窓から見た動物たち―, フィールドと実験室をつないで」、竹中修企画、村山美穂、渡邊邦夫、竹中晃子編、京都大学学術出版会 Reviewed

綾部貴典

「遺伝子の窓から見た動物たち―, フィールドと実験室をつないで」 359 - 373 2006.5

Language：Japanese Publishing type：Research paper (other academic)

Ayabe T., Matsuzaki Y., Shimizu T., Hara M., Tomita M., Enomoto Y., Nakata H., Kuroki M., Ito H., Kataoka H., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 59 ( 5 ) 377 - 382 2006.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

A small lesion showing ground-glass opacity (GGO) by preoperative computed tomography (CT) is sometimes difficult to detect after lobectomy when it locates in the central part of the lobe. In order to facilitate to identify the lesion for marking pathological specimen, we developed a new method using CT. After surgery, the resected pulmonary lobe was expanded with airflow through the bronchial stump and the target lesion was examined with CT. The laser beam of the CT on the surface of the lung is used as a guiding line for cutting. Through the application of this method for 2 clinical cases, it was found to be possible to exactly identify the GGO lesion from the surface of the resected lung enabling to visualize a fresh surface of the lesion like a CT image with minimal destruction of the structure.

Preoperative Prognostic Factors for pN2 Non-small Cell Lung Cancer

肺癌すりガラス状陰影の部位同定の工夫. Reviewed

綾部貴典, 松崎泰憲, 清水哲哉, 原　政樹, 富田雅樹, 榎本雄介, 中田　博, 黒木正臣, 伊藤浩史, 片岡寛晃, 鬼塚敏男

胸部外科 59 ( 5 ) 377 - 382 2006.3

Language：Japanese Publishing type：Research paper (scientific journal)

TOMITA Masaki, MATSUZAKI Yasunori, SHIMIZU Tetsuya, HARA Masaki, AYABE Takanori, ONITSUKA Toshio

Annals of thoracic and cardiovascular surgery 12 ( 1 ) 15 - 20 2006.2

Language：Japanese Publishing type：Research paper (scientific journal)

Relationship between serum carcinoembryonic antigen level and T status in non-small cell lung cancer. Reviewed

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Anticancer Res., 26(5B)：3845-3848, (2006) 26 ( 5B ) 3845 - 3848 2006.2

Language：English Publishing type：Research paper (scientific journal)

Preoperative prognostic factors for pN2 non-small cell lung cancer.

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 12 ( 1 ) 15 - 20 2006.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

PURPOSE: The prognosis of non-small cell lung cancer (NSCLC) with pathologic mediastinal lymph node involvement (pN2) is poor in general. The majority of previously reported prognostic factors of pN2 disease are not available preoperatively. When we perform preoperative induction chemotherapy, we should undertake therapeutic planning according to preoperative factors. METHODS: We focused on preoperative clinicopathologic factors, and investigated the prognosis in 78 patients with pN2 NSCLC who received complete resection. RESULTS: Age, gender, histologic subtype, tumor location, smoking status and cT status were not related to patients' survival. On the other hand patients with cN0 disease and normal serum carcinoembryonic antigen (CEA) level had a significant favorable survival (p = 0.038 and p = 0.019, respectively). In addition, comorbidity had a significant survival impact (p = 0.031). Despite there being no independent prognostic factors by multivariate analysis, the patients without all of cN1-2 disease, elevated serum CEA level and comorbidity had a significant favorable prognosis (p = 0.008). CONCLUSION: Among the preoperative factors examined, pN2 patients with all cN0 disease, normal serum CEA level and no comorbidities might have a favorable prognosis. Combined use of these might be a useful prognostic determinant, and even in the presence of pN2 disease, patients without these unfavorable 3 factors might have a favorable prognosis when treated with surgery alone.

Preoperative prognostic factors for pN2 non-small cell lung cancer.

Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Onitsuka T

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 12 ( 1 ) 15 - 20 2006.2

Language：Japanese Publishing type：Research paper (scientific journal)

Right lung cancer with right aortic arch and posterior aortic left innominate vein

Preoperative prognostic factors for pN2 non-small cell lung cancer. Reviewed

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Ann. Thorac. Cardiovasc. Surg. 12 ( 1 ) 15 - 20 2006.1

Language：English Publishing type：Research paper (scientific journal)

Hara Masaki, Matsuzaki Yasunori, Shimizu Tetsuya, Tomita Masaki, Ayabe Takanori, Onitsuka Toshio

The Journal of the Japanese Association for Chest Surgery 20 ( 2 ) 166 - 170 2006

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Chest Surgery

A 61-year-old woman was admitted to our hospital for surgical treatment of a right upper lobe adenocarcinoma. The patient had a right aortic arch with an aberrant left subclavian artery and a posterior left aortic innominate vein. Right upper lobectomy with mediastinal lymphadenectomy was performed via right thoracotomy. Although paratracheal and tracheobronchial lymph nodes were easily resected, there was difficulty resecting the superior mediastinal and pretracheal lymph nodes because of the aortic arch, aortic diverticulum and posterior left aortic innominate vein compression. Preoperative MDCT and FDG-PET are useful in planning the operative approach and likelihood of success.

DOI： 10.2995/jacsurg.20.166

von Recklinghausen 病に合併した胸部外科疾患. Reviewed

綾部貴典, 松崎泰憲, 枝川正雄, 清水哲哉, 原　政樹, 二宮浩範, 緒方克己, 鬼塚敏男

胸部外科 58 ( 3 ) 219 - 225 2005.12

Language：Japanese Publishing type：Research paper (scientific journal)

Vascular endothelial growth factor expression in pN2 non-small cell lung cancer: Lack of prognostic value. Reviewed

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Respirology, 10(1): 31-35, (2005) 10 ( 1 ) 31 - 35 2005.12

Language：English Publishing type：Research paper (scientific journal)

Chemotherapy and Surgical Resection for Solitary Bone Metastasis of Lung Cancer Resulting in Long-term Survival

HARA Masaki, MATSUZAKI Yasunori, SHIMIZU Tetsuya, TOMITA Masaki, AYABE Takanori, ONITSUKA Toshio

Haigan 45 ( 7 ) 829 - 832 2005.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Lung Cancer Society

Background. Distant metastatic lesions of lung cancer are generally regarded as inoperable. This case report describes long-term survival achieved with surgical resection of primary and metastatic lesions in combination with perioperative chemotherapy. Case. A 62-year old man was referred to our institution with an irregularly shaped right upper lobe nodule in October 1999. Intraoperative frozen section of the nodule at the time of right upper lobectomy and mediastinal lymph node dissection confirmed adenocarcinoma of the lung. A left humeral head lesion identified by bone scintigraphy in January 2000 was confirmed to be metastatic adenocarcinoma by biopsy. Following 2 courses of chemotherapy (CDDP & TXT) the patient underwent left humeral head resection and reconstruction in April 2000. The final pathologic examination failed to demonstrate any malignant cells in the specimen, which was interpreted to indicate a complete histologic response to chemotherapy. Five years later, the patient is well without evidence of recurrence. Conclusion. Long term survival in a patient with primary lung cancer and a solitary bone metastasis was achieved through lobectomy, perioperative chemotherapy, and resection of the metastatic lesion.

DOI： 10.2482/haigan.45.829

Surgery for the thymoma combined with pure red cell aplasia and myasthenia gravis

Ayabe T., Matsuzaki Y., Edagawa M., Shimizu T., Hara M., Tomita M., Akiyama Y., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 58 ( 12 ) 2005.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

Pure red cell aplasia (PRCA) and myasthenia gravis (MG) are respectively combined with thymoma, however, these 3 complications are extremely rare coexisted as a clinical triad. A 73-year-old female with mediastinal tumor found in 2000 was pointed out anemia in June 2002. As PRCA was diagnosed by the bone marrow examination, blood transfusion had been performed. By a chest computed tomography (CT), a thymoma in size of 7 x 5 cm in diameter was recognized in the anterior mediastinum. The serum level of anti-acetylcholine receptor antibody was elevated to be 35 nmol/l. MG was simultaneously diagnosed with a decreased power of neck muscle. The extended thymectomy was performed in August 2002, and pathological diagnosis disclosed a 'type AB' by World Health Organization (WHO) classification. After the operation, the decreased power of neck muscle had been improved, however, PRCA had not been remitted in the early-postoperative term. Blood transfusion had been required (2-4 units/1-2 weeks) for the postoperative 7 months' term. A cyclosporin (250 mg/day) as an adjuvant therapy was administered in April 2003. One month later, the patient's serum level of Hb had been over 10 g/dl without blood transfusion. The patient has been followed up with reducing the dose of cyclosporin. Conclusions: Surgery for a thymoma combined with PRCA and MG was effective for MG but not for PRCA in an early-postoperative term, however, a multimodality therapy with immunosuppressant as a postoperative adjuvant should bring a favorable outcome to patient's clinical data, and the postoperative long-observation must be critical in this case.

Prognostic determinants for lung cancer patients with preoperative high serum carcinoembryonic antigen levels

Prognostic significance of carcinoembryonidc antigen level in pleural lavage fluid for patients with lung adenocarcinoma. Reviewed

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Ann. Thorac. Surg. 80 ( 1 ) 276 - 281 2005.10

Language：English Publishing type：Research paper (scientific journal)

原発性肺癌外科切除例の臨床的検討. Reviewed

綾部貴典, 松崎泰憲, 枝川正雄, 清水哲哉, 原　政樹, 富田雅樹, 鬼塚敏男

宮崎県医師会医学会会誌 29 ( 2 ) 85 - 93 2005.10

Language：Japanese Publishing type：Research paper (scientific journal)

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Thoracic and Cardiovascular Surgeon 53 ( 5 ) 300 - 304 2005.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Thoracic and Cardiovascular Surgeon

Background: Several reports have indicated that preoperative high serum carcinoembryonic antigen (CEA) levels are associated with poor survival after surgical resection in lung cancer. Methods: 82 consecutive lung cancer patients with preoperative high serum CEA levels (> 5 ng/mL) were included in this study. Postoperative serum CEA level was also measured. Prognostic indicators were evaluated. Results: Among patients with a preoperative high serum CEA level, a serum CEA level higher than 10 ng/mL, pT status, pN status, and positive pleural lavage cytology findings were unfavorable prognostic indicators, whereas age, gender, smoking status, histologic subtype were not. Postoperative serum CEA levels of all but 2 patients decreased, however those of 28 patients did not return to normal range. Our result showed that patients with postoperative high serum CEA level had poor prognosis. Multivariate analysis demonstrated that pT status, pN status, and postoperative high serum CEA level was an independent prognostic determinant. Conclusions: In lung cancer patients with preoperative high serum CEA levels, pT status, pN status, and normalization of serum CEA level after surgery are significant prognostic determinants. © Georg Thieme Verlag KG · Stuttgart.

DOI： 10.1055/s-2005-865671

Serum carcinoembryonic antigen level in pN1 non-small cell lung cancer patients

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Anticancer Research 25 ( 5 ) 3601 - 3605 2005.9

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research

Background: Although the prognostic significance of the serum carcinoembryonic antigen (CEA) level in non-small cell lung cancer has been reported in several studies, it is unknown whether the serum CEA level is a prognostic determinant for pN1 disease or not. Materials and Methods: Seventy patients with pN1 non-small cell lung cancer who received complete resection were reviewed. The preoperative serum CEA level was measured in all patients. Results: The pN1 patients with pT2-4 disease, hilar node involvement, multiple N1 station and elevated serum CEA level (>5 ng/mL) had a significantly unfavorable prognosis. Although a serum CEA level higher than 5 ng/mL was not an independent prognostic determinant, more than 10 ng/mL was an independent factor by multivariate analysis. In patients with pT1-2N1 disease, a serum CEA level more than 10 ng/mL was also a prognostic determinant. Conclusion: An elevated serum CEA level, especially higher than 10 ng/mL, is a significant prognostic determinant for pN1 lung cancer patients.

Serum carcinoembryonic antigen level in pN1 non-small cell lung cancer patients.

Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Onitsuka T

Anticancer research 25 ( 5 ) 3601 - 5 2005.9

Language：Japanese Publishing type：Research paper (scientific journal)

Prognostic significance of carcinoembryonic antigen level in pleural lavage fluid for patients with lung adenocarcinoma

Tomita M., Shimizu T., Matsuzaki Y., Hara M., Ayabe T., Onitsuka T.

Annals of Thoracic Surgery 80 ( 1 ) 276 - 281 2005.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic Surgery

Background. Prognostic indicators for non-small cell lung cancer patients traditionally include TNM staging, pleural lavage cytology, and serum carcinoembryonic antigen levels. This prospective study evaluates carcinoembryonic antigen levels in pleural lavage fluid as a potential determinant for patients with lung adenocarcinoma. Methods. One hundred and fifty patients underwent thoracotomy. Pleural lavage fluid was collected, and pleural lavage cytology and lavage carcinoembryonic antigen levels were determined. The control group included 40 patients with nonmalignant disease. Results. Sixteen patients (10.7%) had positive pleural lavage cytologies. These patients and those with elevated serum carcinoembryonic antigen levels generally had a poor prognosis. Thirty-seven patients (24.7%), however, showed elevated lavage carcinoembryonic antigen levels, and a significant correlation with patient survival was demonstrated. Multivariate analysis confirmed these results. We also found a correlation between positive pleural lavage cytologies and serum carcinoembryonic antigen levels and patient survival in patients with pN0 disease but not in those with pN1-2 disease. Elevated lavage carcinoembryonic antigen levels, however, correlated significantly with survival rates in patients with pN1-2 disease. Conclusions. An elevated lavage carcinoembryonic antigen level is an independent prognostic determinant for patients with lung adenocarcinoma, even with advanced disease, and may be a more useful marker of subclinical microdissemination than pleural lavage cytology. © 2005 by The Society of Thoracic Surgeons.

DOI： 10.1016/j.athoracsur.2005.01.028

Primary lung cancer; assessment of the disclosed 5-year survival rate by the Internet website

Prognostic determinants for lung cancer patients with preoperative high serum carcinoembryonic antigen levels. Reviewed

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Thorac. cardiovasc. Surg. 53 300 - 304 2005.6

Language：English Publishing type：Research paper (scientific journal)

Serum carcinoembryonic antigen level in pN1 Non-small cell lung cancer patients. Reviewed

Tomita M., Matsuzaki Y., Shimizu T, Hara M, Ayabe T., Onitsuka T

Anticancer Research 25 ( 5 ) 3601 - 3606 2005.6

Language：English Publishing type：Research paper (scientific journal)

Ayabe T., Matsuzaki Y., Edagawa M., Shimizu T., Hara M., Tomita M., Ninomiya H., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 58 ( 6 ) 451 - 459 2005.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

The disclosed 5-year survival rate for lung cancer in the Internet website represents a various difference by each institution. The better inferiority of the survival has been listed in a table to compare with other institutions and has been reported in magazines and media with a lack of an enough inspection, i.e., with a sufficient considering of a risk adjustment such as patient's background, operative policy, postoperative adjuvant therapy, and statistical background. We report our outcome of the surgical treatment for primary lung cancer. Of 875 patients treated for lung cancer in our department for 23 years between January 1980 and December 2002, 115 patients containing of 42 cases in 1997 and of 48 ones in 1992 and of 25 ones in 1987 were selected and the accumulated survival analysis was treated by Kaplan-Meier method. Eighty males and 35 females were between 15 and 80-year-old (average 63.2 +/- 11.4). The pathological classification was adenocarcinoma (n=69), squamous cell carcinoma (n=32), and others (n=14). The operative procedures were pneumonectomy (n=14), bilobectomy (n=12), lobectomy (n=85), and wedge resection (n=4). The survival time was from 29 days to 182 months (median survival time was 1471+/- 1180 days, the averaged time was 49 months). The 5-year survival rate was 41.4 +/- 9.1% (n=25) in 1987, 35.6 +/- 6.2% (n=48) in 1992, and 56.0 +/- 7.0% (n=42) in 1987, respectively (log-rank test, p = 0.2555). The 10-year survival rate was 24.1 +/- 7.9% in 1987 and 8.5 +/- 3.6% in 1992, respectively. The 5-year survival rate was as follows: IA 81.0 +/- 8.6% (n=20), IB 73.7 +/- 10.1% (n=19), IIA 57.1 +/- 18.7% (n=7), IIB 55.6 +/- 16.6% (n=9), IIIA 28.6 +/- 7.6% (n=35), IIIB 15.4 +/- 10.0% (n=13), IV 16.7 +/- 10.8% (n=12), respectively. The 5-year survival rate was as follows: male 42.8 +/- 5.3% (n=80), female 63.2 +/- 7.3% (n=35), respectively (p = 0.0147). In regard to the histological classification, the 5-year survival rate was as follows: adenocarcinoma 47.2 +/- 5.9% (n=69), squamous cell carcinoma 50.8 +/- 8.9% (n=32), respectively (p = 0.9012). As a rule of the disclosure on the internet website, we report our survival data by accompanying with minimum parameters such as, patient's background, pathological types, gender, pathological stages, and mean survival rate with standard error. When we compare the 5-year survival rate with other institutes, in considering of a risk adjustment, we would carefully have to estimate the determined survival rate with a standard error.

Clinical assessment of the thoracic surgical diseases associated with von Recklinghausen's disease

Intrapleural Hyperthermic Perfusion with Chemotherapy Increases Apoptosis in Malignant Pleuritis. Reviewed

54. Matsuzaki Y, Edagawa M, Shimizu T, Hara M, Tomita M, Ayabe T., Onitsuka T.

Ann. Thorac. Surg. 78 ( 5 ) 1769 - 1773 2005.5

Language：English Publishing type：Research paper (scientific journal)

インターネット上で公開された原発性肺癌の術後５年生存率の問題点. Reviewed

綾部貴典, 松崎泰憲, 枝川正雄, 清水哲哉, 原　政樹, 二宮浩範, 緒方克己, 鬼塚敏男

胸部外科 58 ( 6 ) 451 - 459 2005.5

Language：Japanese Publishing type：Research paper (scientific journal)

肺癌の上腕骨移転に対し、化学療法後に切除を行い長期生存中の１例. Reviewed

原　政樹, 松崎泰憲, 清水哲哉, 富田雅樹, 綾部貴典, 鬼塚敏男

Japanese Journal of Lung Cancer 45 ( 7 ) 829 - 832 2005.5

Language：Japanese Publishing type：Research paper (scientific journal)

Ayabe T., Matsuzaki Y., Edagawa M., Shimizu T., Hara M., Ninomiya H., Ogata K., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 58 ( 3 ) 219 - 225 2005.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

Type I neurofibromatosis (NF-I), also referred to as von Recklinghausen's disease, is an autosomal dominant disease characterized by neurofibromas and abnormal cutaneous pigmentation (café-au-lait spot). We studied retrospectively the 8 cases operated in our hospital between January 1979 to December 2002, which were complicated with von Recklinghausen's disease and a thoracic surgical disease. The patients were 6 males and 2 females and the age from 16 to 70 (the averaged age was 36 +/- 22). The thoracic diseases were consist of mediastinal tumors (n = 7) and esophageal cancer (n = 1). The operative procedures were tumorectomy (n = 6), subtotal esophagectomy (n = 1), and pericardial cystectomy (n = 1). The mediastinal tumors were neurofibroma (n = 3), malignant schawannoma (n = 1), ganglioneurinoma (n = 2), and pericardial cyst (n = 1). Malignant neoplasms were recognized in 2 cases (25%). The postoperative survival was 10 months for malignant schwannoma, and 8 months for esophageal cancer, and the others were alive. For 1 case of neurofibromas, there was observed to be the reoperated one after the postoperative recurrence. von Recklinghausen's disease are apt to be complicated with thoracic surgical neoplasms, it should be required a careful and systemic exploration especially for malignant neoplasms.

Vascular endothelial growth factor expression in pN2 non-small cell lung cancer: Lack of prognostic value

純赤芽球癆と重症筋無力症を合併した胸腺腫. Reviewed

綾部貴典, 松崎泰憲, 枝川正雄, 清水哲哉, 原　政樹, 富田雅樹, 秋山　裕, 鬼塚敏男

胸部外科 58 ( 6 ) 1023 - 1031 2005.2

Language：Japanese Publishing type：Research paper (scientific journal)

Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.

Respirology 10 ( 1 ) 31 - 35 2005.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Respirology

Objective: Although several previous studies have investigated the prognostic significance of vascular endothelial growth factor (VEGF) expression in non-small cell lung (NSCL) cancer, no previous study has concentrated on NSCL cancer with pathologically abnormal mediastinal nodes (pN2). Methodology: A total of 60 patients with pN2 NSCL cancer who had undergone a complete resection with a systematic mediastinal lymph node dissection were reviewed retrospectively. Immunohistochemical examination, using antibodies against VEGF, was conducted. The prognostic significance of VEGF expression and clinicopathological factors were analysed. Results: The overall 5-year survival rate was 21.7%. With respect to clinicopathological factors, single N2 involvement and skip metastasis were significantly associated with patients' survival. Expression of VEGF was found in 35/60 (58.3%) patients. VEGF expression was not related to the clinicopathological parameters examined. There was no relationship between survival rates and patients positive and negative for VEGF. Multivariate analysis showed that single N2 disease was an independent prognostic factor, while VEGF expression was not. Conclusions: Although VEGF expression might be important for tumour development and maintenance, no prognostic significance of VEGF expression in pN2 NSCL cancer was found.

DOI： 10.1111/j.1440-1843.2005.00655.x

Bilateral lower lobectomies for pulmonary mucormycosis

Ayabe T., Matsuzaki Y., Edagawa M., Shimizu T., Hara M., Ninomiya H., Yamashita A., Marutsuka K., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 57 ( 13 ) 1185 - 1190 2004.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

Mucormycosis is an extremely rare case of pulmonary mycosis, its prognosis is very poor, and known as an opportunistic infection among immunocompromised hosts accompanied with other primary chronic disease. We report here a case of bilateral lower lobectomies carried out by two-stage operation for pulmonary mucormycosis combined with diabetes mellitus (type I) and severe resistance to an antimycobiotics under biblicographical considerations. A 36-year-old female was diagnosed as a diabetes mellitus (type I), and has been administrated with an insulin injection in 1989 at the age of 22-year-old. The patient was suffered a dry cough in June and the bilateral abnormal shadows were pointed out by the chest X-ray film in November, 2002. By transbronchial lung biopsy, Mucor fungus was confirmed in grannulomatous lung specimen. Intravenous injection of amphotericin B could not be continued due to the unavoidable side-effects from this agent. As the lung mass shadow was enlarged increasing and strongly suggested an abscess, formation in its focus, and then the left lower lobectomy was performed as the first step of surgical treatment and the right lower lobectomy was done on the postoperative forty-fourth day as the second step. The postoperative prognosis was considerably uneventful. After bilateral lower lobectomies, the patient could try a walk and go upstairs with a moderate dyspnea. A possible surgical resection should be conducted for the pulmonary mucormycosis, when the medicinal therapy showed an uneffectiveness and/or an infectious lesion was shown as restricted lesion.

[Bilateral lower lobectomies for pulmonary mucormycosis].

Ayabe T, Matsuzaki Y, Edagawa M, Shimizu T, Hara M, Ninomiya H, Yamashita A, Marutsuka K, Onitsuka T

Kyobu geka. The Japanese journal of thoracic surgery 57 ( 13 ) 1185 - 90 2004.12

Language：Japanese Publishing type：Research paper (scientific journal)

Intrapleural hyperthermic perfusion with chemotherapy increases apoptosis in malignant pleuritis

Matsuzaki Y., Edagawa M., Shimizu T., Hara M., Tomita M., Ayabe T., Onitsuka T.

Annals of Thoracic Surgery 78 ( 5 ) 1769 - 1772 2004.11

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic Surgery

Background Previously, we reported on the effectiveness of intrapleural hyperthermic perfusion with chemotherapy, a new treatment we developed for patients with malignant pleuritis. The present study analyzes the mechanism of the effectiveness of this therapy by examining the induction ratio of apoptosis among tumor cells following the perfusion treatment. Methods This study included 11 consecutive patients with primary pulmonary adenocarcinoma and accompanying pleural seedlings and pleural effusions containing tumor cells but without distant metastasis. All patients underwent surgical resection of the primary lesion and then received sequential perfusion treatment. Tumor cells collected from the effusion both before and again at 24 hours following the perfusion treatment were subsequently examined using an immunocytochemical stain to determine apoptosis among tumor cells. The percentage of positively stained cells was expressed as the apoptotic index. We compared the survival rate of these 11 patients with the survival rate of a second group of 11 patients with malignant pleuritis who underwent surgical resection of the primary lesion but who did not receive the perfusion treatment (control group). Results The ratio of spontaneous apoptosis of untreated tumor cells was 2.8% ± 2.0%. Following the perfusion, apoptosis among tumor cells was 25.2% ± 4.6%, clearly a significant increase. While the median survival time for patients receiving the perfusion treatment was 20 months, the median survival time for the control group was 6 months. Conclusions In patients with malignant pleuritis, intrapleural hyperthermic perfusion with chemotherapy induced potent apoptosis of tumor cells in the pleural cavity and also improved the survival rate of these patients as compared with patients who did not receive the perfusion treatment. © 2004 by The Society of Thoracic Surgeons.

DOI： 10.1016/j.athoracsur.2004.05.025

Thymothymectomy for the thymoma with pure red cell aplasia; report of a case

Ayabe T., Matsuzaki Y., Edagawa M., Shimizu T., Hara M., Ninomiya H., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 57 ( 9 ) 905 - 909 2004.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

We report a case of thymothymectomy for the thymoma with pure red cell aplasia (PRCA). A 31-year-old male with a general fatigue had a severe anemia (hemoglobin 3.1 g/dl) since November 1997. By the bone marrow examination, PRCA was diagnosed and treated with blood transfusion and immunosuppressive drug (cyclosporin: CYA) administration but anemia had not been improved. The chest computed tomography displayed a 3 cm in a diameter of thymoma located in the anterior mediastinum. The extended thymothymectomy had been performed in February 1998, pathological detection disclosed Masaoka classification stage I, type AB was diagnosed due to the World Health Organization (WHO) classification. PRCA had not obtained an immediate remission during the postoperative-early term, while, adjuvant therapy (CYA 300 mg/day) has been continued and it brought a complete remission of PRCA in August 2001 (after the postoperative 3 years and 6 months later). Conclusions: Even though only thymothymectomy for thymoma with PRCA showed no effectiveness for the postoperative-early remission of PRCA, however, the combination of thymectomy and the postoperative adjuvant therapy (CYA) should bring a better outcome, and the continuous follow-up would be required for a long postoperative term.

Micrometastasis and expression of nm23 messenger RNA of lymph nodes from lung cancer and the postoperative clinical outcome.

Ayabe T., Tomita M., Matsuzaki Y., Ninomiya H., Hara M., Shimizu T., Edagawa M., Onitsuka T., Hamada M.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 10 ( 3 ) 152 - 159 2004.6

BACKGROUND: Based on the metastatic route in lymph nodes from lung cancer, we investigated micrometastasis in the dissected lymph nodes by genetic analysis of keratin 19 and nm23-H1 (the expression of a tumor-metastatic suppressor gene) and evaluated the postoperative outcomes. METHODS: Ten patients operated with lung cancer were 4 males and 6 females, who were stage IA; 2, stage IB; 3, stage IIA; 2, stage IIB; 1, and stage IIIA; 2, respectively. After total RNA extraction from the dissected lymph nodes, the expression of nm23-H1 and keratin 19 messenger ribonucleic acid (mRNA) were analyzed with reverse-transcripted polymerase chain reaction (RT-PCR). RESULTS: The confirmation of micrometastasis in lymph nodes was realized in seven of 10 cases (70%), in their 5-year follow-up term. In three patients there was recurrence (43%, 3/7), and the one of them had died from the mediastinal recurrence. On the expression of nm23-H1 mRNA in lymph nodes, there was no significant difference between the pathologically lymph-node metastasis positive group and the negative one, and between the group with a tumor size over 30 mm and the group with a tumor size under 30 mm, respectively. The expression ratio of nm23-H1 gene was significantly expressed in the group with micrometastasis in lymph nodes (47%, 9/19) as compared to those without micrometastasis (10%, 1/10) (p<0.05). On the all-positive expression of nm23-H1 in the examined lymph nodes (n=4), no patient had recurrence (0%, 0/4). However, in the rest of the six patients without the all-positive expression of nm23-H1 in those lymph nodes (n=6), four patients had recurrence (67%, 4/6). There was no significance between the recurrent ratio in the all-positive expression of nm23-H1 suggesting lower incidence as compared to that in patients without all-positive expression of nm23-H1. CONCLUSION: A detection of micrometastasis in lymph nodes could be a useful tool to identify the subpopulation of patients who might have a higher risk of recurrence and distant metastases. The nm23-H1 gene might be involved in a suppression role for micrometastasis in lymph nodes through the lymphatic route in lung cancer.

"The Law of 3": prognostic parameters for resected metastatic pulmonary tumors.

破裂性腹部大動脈瘤術後に合併した急性腎不全治療の経験. Reviewed

綾部貴典, 福島靖典, 矢野義和, 吉岡　誠, 鬼塚敏男

宮崎県医師会医学会会誌 28 ( 1 ) 63 - 67 2004.5

Language：Japanese Publishing type：Research paper (scientific journal)

純赤芽球癆を合併した胸腺腫の１例. Reviewed

綾部貴典, 松崎泰憲, 枝川正雄, 清水哲哉, 原　政樹, 二宮浩範, 鬼塚敏男

胸部外科 57 ( 9 ) 905 - 910 2004.5

Language：Japanese Publishing type：Research paper (scientific journal)

Micrometastasis and expression of nm23 messenger RNA of lymph nodes from lung cancer and the postoperative clinical outcome Reviewed

Takanori Ayabe, Masaki Tomita, Yasunori Matsuzaki, Hironori Ninomiya, Testuya Shimizu, Masao Edagawa, Masaki Hara, Toshio Onitsuka, and Minoru Hamada

Ann Thoracic Cardiovasc Surg 10 152 - 159 2004.4

Language：English Publishing type：Research paper (scientific journal)

肺ムコール症に対する両側下葉切除. Reviewed

58. 綾部貴典, 松崎泰憲, 枝川正雄, 清水哲哉, 原　政樹, 二宮浩範, 山下　篤, 丸塚浩助, 鬼塚敏男

胸部外科 57 ( 13 ) 1185 - 1190 2004.2

Language：Japanese Publishing type：Research paper (scientific journal)

"The law of 3": prognostic parameters for resectsd metastatic pulmonary tumors. Reviewed

63. Matsuzaki Y., Shimizu T., Edagawa M., Hara M., Tomita M., Ayabe T., Onitsuka T.

Ann. Thorac. Cardiovasc. Surg., 9(5): 290-294, (2003) 9 ( 5 ) 290 - 294 2003.12

Language：English Publishing type：Research paper (scientific journal)

慢性膿胸に対する外科的治療法の臨床的検討 - 大網充填法を中心に - . Reviewed

綾部貴典, 吉岡　誠, 福島靖典, 松崎泰憲, 鬼塚敏男

胸部外科 56 ( 12 ) 989 - 996 2003.12

Language：Japanese Publishing type：Research paper (scientific journal)

Matsuzaki Y., Shimizu T., Edagawa M., Hara M., Tomita M., Ayabe T., Onitsuka T.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 9 ( 5 ) 290 - 294 2003.10

Metastatic tumors from various organs are found in pulmonary tissue because of the unique anatomical function of the lungs as a filter for systemic venous return. A retrospective study of the clinical factors used to assess the prognosis of 80 patients who underwent resections of metastatic pulmonary tumors in our surgical department between September 1978 and December 2002 is presented. The overall 5-year survival rate in our study was 31.7%. We demonstrated four significant factors used in predicting the prognosis of patients with resected metastatic pulmonary tumors: diameter of the tumor (</=3.0 cm or >3.0 cm), number of tumors (</=3 or >3), disease-free interval (>/=3 years or <3 years), and ratio of the diameter of the largest tumor to the diameter of the smallest tumor in patients with multiple metastases (</=3 or >3). Based on our results, we have applied the term "the law of 3" to these valuable prognostic factors. Among these parameters, the ratio of the diameter of the largest to the diameter of the smallest tumor may be applicable as a new prognostic parameter for surgery in patients with multiple foci. (Ann Thorac Cardiovasc Surg 2003; 9: 290-4)

Clinical study on the surgical cases of the ruptured thoracic aortic aneurysm

Ayabe T., Nakamura K., Yano M., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 56 ( 7 ) 555 - 559 2003.7

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

The prognosis of the ruptured thoracic aortic aneurysm is poor. Even if the surgical treatment was performed, the clinical outcome does not sufficiently satisfy us. Between January 1978 to July 1999, 171 cases of thoracic aortic surgery were operated in our department, in which 12 patients were with the ruptured thoracic aortic aneurysm without acute dissection. The aneurysm was located in ascending aorta (2), aortic arch (6), descending aorta (3), and thoracoabdominal aorta (1). The aneurysm was ruptured into thorax (4), pericardium (2), mediastinum (3), lung (2), and esophagus (1). The operative procedure was artificial vascular graft replacement (9), patch closure (2), and aneurysmal interposition (1) [bypass with ascending aorta to abdominal aorta)]. The operations were performed during hypothermic circulatory arrest with antegrade selective cerebral perfusion (6), under total (1) or partial complete extracorporeal circulation (5). The hospital death was 33% (4/12). The causes of death were cerebral complication (2), sepsis (1), and multiple organ failure (1). The 12 patients were divided into 2 groups: group A; 8 cases with alive; group D; 4 cases with hospital death. We compared and analyzed the perioperative factors of these 2 groups. On intraoperative factors, operation time (minute) demonstrated a significant difference (498 +/- 129 in group A v.s. 851 +/- 227 in group D, p < 0.05). No significant difference was observed between the groups on extracorporeal circulation time, aortic clumping time, selective cerebral perfusion time, systemic circulatory arrest time, intraoperative blood loss, and blood transfusion. The postoperative major complication was revealed in 6 cases (50%, 6/12), cerebral infarction (3), sepsis (2), and hoarsness (1). In conclusions, to make an effort to shorten an operative time as possible, and to prevent the postoperative neurological dysfunction under selective cerebral perfusion, those efforts should contribute to a good postoperative outcome for the ruptured thoracic aortic aneurysm.

Veno-venous ECMO for the respiratory failure after coronary artery bypass grafting

心筋梗塞に合併した後心室中隔穿孔に対する急性期Daggett手術の経験. Reviewed

綾部貴典, 福島靖典, 帖佐英一, 吉岡　誠, 鬼塚敏男

宮崎県医師会医学会会誌 27 ( 1 ) 54 - 57 2003.5

Language：Japanese Publishing type：Research paper (scientific journal)

下腹壁動脈をcomposite graftとして使用したCABG (特集). Reviewed

綾部貴典, 福島靖典, 吉岡　誠, 鬼塚敏男

胸部外科 56 ( 9 ) 731 - 741 2003.5

Language：Japanese Publishing type：Research paper (scientific journal)

破裂性胸部大動脈瘤手術症例の臨床検討. Reviewed

綾部貴典, 中村都英, 矢野光洋, 鬼塚敏男

胸部外科 56 ( 7 ) 555 - 559 2003.5

Language：Japanese Publishing type：Research paper (scientific journal)

急性虫垂炎発症を契機に発見された盲腸癌の１例. Reviewed

綾部貴典, 土田裕一, 井上正邦, 中島清美, 小坂裕之, 鬼塚敏男

宮崎県医師会医学会会誌 27 120 - 123 2003.5

Language：Japanese Publishing type：Research paper (scientific journal)

私の医療情報伝達法. Reviewed

綾部貴典

胸部外科 56 ( 10 ) 861 - 866 2003.4

Language：Japanese Publishing type：Research paper (scientific journal)

重度多発外傷を合併した外傷性横隔膜破裂の1救命治験例. Reviewed

綾部貴典, 吉岡　誠, 福島靖典, 櫻井俊孝, 鬼塚敏男

宮崎県医師会医学会会誌, 27： 39-43, (2003) 27 39 - 43 2003.3

Language：Japanese Publishing type：Research paper (scientific journal)

大動脈弁と肺動脈弁に感染性心内膜炎を伴ったValsalva洞動脈瘤破裂の外科的治療例. Reviewed

綾部貴典, 福島靖典, 帖佐英一, 吉岡　誠, 鬼塚敏男

日本心臓血管外科学会雑誌 31 ( 1 ) 61 - 64 2002.12

Language：Japanese Publishing type：Research paper (scientific journal)

Adenylate Kinase, Wiley Encyclopedia of Molecular Medicine, 5 Vol. Set, Edited by Thomas Creighton, John Wiley & Sons, Inc., New York, NY, 76-77, (2002) Reviewed

Ayabe T. and Hamada M.

Wiley Encyclopedia of Molecular Medicine 76 - 77 2002.5

Language：English Publishing type：Research paper (other academic)

緊急冠状動脈バイパス術後生じた呼吸不全に対しveno- venous ECMOを用い救命した１例. Reviewed

福島靖典, 綾部貴典, 中村栄作, 吉岡　誠, 松尾由美子, 鬼塚敏男

胸部外科, 55(3): 203-206, (2002) 55 ( 3 ) 203 - 206 2002.4

Language：Japanese Publishing type：Research paper (scientific journal)

機能的内胸動脈グラフト症例の右側開胸到達法による僧帽弁再手術. Reviewed

綾部貴典, 福島靖典, 帖佐英一, 吉岡　誠, 鬼塚敏男

宮崎県医師会医学会会誌, 26(2) : 147-150, (2002) 26 ( 2 ) 147 - 150 2002.4

Language：Japanese Publishing type：Research paper (scientific journal)

Fukushima Y., Ayabe T., Nakamura E., Yoshioka M., Matsuo Y., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 55 ( 3 ) 203 - 206 2002.3

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

We encountered a 60-year-old man with severe respiratory failure after CABG. The patient received veno-venous extracorporeal membrane oxygenation (ECMO) in which blood was drained from the right atrium through a cannula and was returned via a cannula in the left femoral vein. During ECMO, the flow rate was 2.8-3.0 l/min (about 40 ml/kg/min) and the assist was needed for 5 years. Veno-venous ECMO is a simple and effective therapy for acute respiratory failure unresponsive to conventional treatment.

Anti-bleeding effect of nafamostat mesilate for the surgery of thoracic ascending aorta

Ayabe T., Nakamura K., Nakajima S., Yano Y., Matsuzaki Y., Onitsuka T.

Kyobu geka. The Japanese journal of thoracic surgery 54 ( 9 ) 773 - 776 2001.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

During extracorporeal cardiopulmonary bypass (ECB), the activated coagulation and fibrinogenolysis system causes bleeding and postoperative multiple organ failures. We studied the effect of an anti-bleeding agent, nafamostat mesilate (NM) during the surgery of thoracic ascending aorta to decrease a side effect of bleeding. From March 1980 to January 1998, for thoracic ascending aorta operations in our department (true aneurysm, 16-, psudoaneurysm, 2-, and dissection, 11 cases, in 29 cases, respectively), age from 16 to 79 (mean 62.9 +/- 9.5 year of age), we classified the objects in two groups, NM group (intraoperative infusion with NM of 60 mg/hr and with heparin 300 IU/kg) and C group (only with heparin treated, 500 IU/kg). We investigated the preoperative factors (age and aneurysmal diameter), the intraoperative factors (ACT, hematcrit, platelet, aorta clamping time, operative time, ECB time, bleeding volume, and blood transfusion), and the postoperative factors (bleeding and blood transfusion) after the administration of NM. RESULTS: There was no significance for the protection effect of NM infusion on the preoperative and the postoperative factors. However, intraoperative bleeding and blood transfusion volume in NM group were significantly lesser than those in group C. CONCLUSIONS: It might be useful for NM infusion during the surgery of thoracic ascending aorta due to the decrease of volume of intraoperative bleeding and blood transfusion amount with the remarkable anti-bleeding effect.

Expression of nm23-H1 gene product in mediastinal lymph nodes from lung cancer patients

Tomita M., Ayabe T., Matsuzaki Y., Onitsuka T.

European Journal of Cardio-thoracic Surgery 19 ( 6 ) 904 - 907 2001.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：European Journal of Cardio-thoracic Surgery

Objective: Although numerous studies have shown that nm23-H1 gene product expression is inversely related to metastatic potential in some cancers, the expression in lymph nodes has not been studied in detail. An analysis of nm23-H1 gene product expression in mediastinal lymph nodes from lung cancer patients is reported. Methods: One hundred and thirty-four, randomly selected lymph nodes (63 with positive pathological lymph node status) from 39 surgically treated lung cancer patients were examined. Expression of nm23-H1 gene product was determined using specific monoclonal antibodies. Metastatic cancer cells were highlighted using anti-cytokeratin antibody. Results: Expression of nm23-H1 gene product in patients with less and more than 50% nodes-positive was 12/23 (52.2%) and 15/16 (93.8%) cases, respectively. Immunohistochemical studies with cytokeratin revealed micrometastasis in 6/39 (15.4%) patients and 9/71 (12.7%) nodes previously reported as cancer negative. Expression of nm23-H1 gene product in micrometastasis and metastasis-positive nodes was 5/9 (55.6%) and 55/63 (87.3%), respectively. We also found nm23-H1 gene product expression in germinal center cells. However, we found no relationship between expression of nm23-H1 gene product in germinal center cells and extent of metastasis. Conclusions: Our study demonstrates a positive relationship between expression of nm23-H1 gene product and extent of metastasis in mediastinal lymph nodes from lung cancer patients. Our data for normal germinal center cells suggests that nm23-H1 gene product expression does not play a specific biological role in suppressing tumor metastasis in lung cancer. Copyright © 2001 Elsevier Science B.V.

DOI： 10.1016/S1010-7940(01)00710-2

Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival

破裂性腹部大動脈瘤耐術症例の遠隔期予後の検討. Reviewed

綾部貴典, 福島靖典,帖佐英一, 吉岡　誠, 鬼塚敏男

外科 63 ( 10 ) 1231 - 1236 2001.5

Language：Japanese Publishing type：Research paper (scientific journal)

Tomita M., Ayabe T., Matsuzaki Y., Edagawa M., Maeda M., Shimizu T., Hara M., Onitsuka T.

BMC Cancer 1 2001.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：BMC Cancer

Background: We assessed the nm23-H1 gene product expression and its relationship with lymphatic and blood vessel invasion in patients with esophageal squamous cell carcinoma. Methods: Formalin-fixed and paraffin-embedded tissue sections from 45 patients who were treated surgically were used in this study. Pathologists graded lymphatic and blood vessel invasion in each of the tissue samples. Expression of nm23-Hl gene product was determined using a specific monoclonal antibody. Results: Expression of nm23-H1 gene product was present in 17 (37.8%) cases. We found an inverse correlation between nm23-H1 gene product expression and lymphatic vessel invasion, whereas no correlation between nm23-H1 gene product expression and blood vessel invasion. Overall survival rate was not different between nm23-H1 gene product positive and negative patients (p = 0.21). However, reduced expression of nm23-H1 gene product was associated with shorter overall survival in patients with involved lymph nodes (p < 0.05), but not in patients without involved lymph nodes (p = 0.87). Conclusions: In patients with esophageal squamous cell carcinoma, there appears to be an inverse relationship between nm23-H1 gene product expression and lymphatic vessel invasion. Furthermore, nm23-H1 gene product expression might be a prognostic marker in patients with involved lymph nodes. Our data does not demonstrate any correlation between nm23-H1 gene product expression and blood vessel invasion. © 2001 Tomita et al; licensee BioMed Central Ltd.

DOI： 10.1186/1471-2407-1-3

The Steady-State Kinetics of the Enzyme Reaction Tested by Site-Directed Mutagenesis of Hydrophobic Residues (Val,Leu,and Cys) in the C-Terminal α-Helix of Human Adenylate Kinase

Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival. Reviewed

72. Tomita M., Ayabe T., Matsuzaki Y., Edagawa M., Maeda M., Shimizu T., Hara M., Onitsuka T.

BMC Cancer, 1 : 3, (2001) 1 3 2001.4

Language：English Publishing type：Research paper (scientific journal)

Expression of nm23-H1 gene product in mediastinal lymph nodes from lung cancer patients. Reviewed

Tomita M., Ayabe T., Matsuzaki Y., Onitsuka T.

Eur.J. Cardiothorac. Surg., 19(6): 904-907, (2001) 19 ( 6 ) 904 - 907 2001.3

Language：English Publishing type：Research paper (scientific journal)

橈骨動脈グラフトに対するニトログリセリン経皮剤の血管拡張作用に関する検討. Reviewed

綾部貴典, 福島靖典,帖佐英一, 吉岡　誠, 鬼塚敏男

宮崎県医師会医学会誌, 25(2): 114-117, (2001) 25 ( 2 ) 114 - 117 2001.3

Language：Japanese Publishing type：Research paper (scientific journal)

開腹手術の既往を有する腹部大動脈瘤手術症例の検討. Reviewed

綾部貴典, 中村都英, 矢野光洋, 鬼塚敏男

日本血管外科学会雑誌 10 ( 6 ) 601 - 605 2001.2

Language：Japanese Publishing type：Research paper (scientific journal)

胸部下行大動脈手術におけるnafamostat mesilateの出血防止効果 Reviewed

綾部貴典、中村都英、中嶋誠司、矢野義和、松崎泰憲、鬼塚敏男

胸部外科 54 773 - 776 2001.1

Language：Japanese Publishing type：Research paper (scientific journal)

Ayabe Takanori, Park Seung Kyu, Takenaka Hitoshi, TAKENAKA Osamu, MARUYAMA Hideharu, SUMIDA Michihiro, ONITSUKA Tochio, HAMADA Minoru

The journal of biochemistry 128 ( 2 ) 181 - 187 2000.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Biochemical Society

Surgical management of ductus arteriosus aneurysm in adults.

Ayabe T., Nakamura K., Nakajima S., Yano Y., Matsuzaki Y., Onitsuka T.

The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi 48 ( 5 ) 304 - 306 2000.5

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi

Aneurysm of the ductus arteriosus is rare, especially in adults, and preoperative diagnosis is very difficult, requiring intraoperative diagnosis. A 71-year-old man was preoperatively diagnosed with ductus arteriosus aneurysm by computed tomographic scanning, magnetic resonance imaging, and aortography, which demonstrated a saccular aneurysm of the distal aortic arch. Under partial extracorporeal circulation, the aneurysm was replaced by an artificial vascular graft. The location and morphology of the aneurysm confirmed the preoperative diagnosis. The postoperative course was uneventful. Surgery for this condition is safe and is recommended the same as for common thoracic aortic aneurysm.

DOI： 10.1007/BF03218144

The steady-state kinetics of the enzyme reaction tested by site-directed mutagenesis of hydrophobic residues (Val, Leu, and Cys) in the C-terminal alpha-helix of human adenylate kinase. Reviewed

Takanori Ayabe, Seung Kyu Park, Osamu Takenaka, Hideharu Maruyama, Michihiro Sumida, Toshio Onitsuka, and Minoru Hamada

Journal of Biochemistry 128 181 - 187 2000.2

Language：English Publishing type：Research paper (scientific journal)

Surgical Management of Ductus Arteriosus Aneurysm in Adults Reviewed

Takanori Ayabe, Kunihide Nakamura, Seiji Nakajima, Yoshikazu Yano, Yasunori Matsuzaki, and Toshio Onitsuka

Jpn. J. of Thoracic and CardioVasc. Surg 48 304 - 306 2000.1

Language：English Publishing type：Research paper (scientific journal)

The reaction mechanism of human adenylate kinase. The steady-state kinetics of the mutants constructed by protein engineering of site-directed mutagenesis. Recent Res. Devel. Biochem., Research Signpost (India), 2: 1-39, (2000) Reviewed

Ayabe T. and Hamada M.

Recent Res. Devel. Biochem 2 1 - 39 2000.1

Language：English Publishing type：Research paper (other academic)

The steady-state kinetics of the enzyme reaction tested by site-directed mutagenesis of hydrophobic residues (Val, Leu, and Cys) in the C-terminal α-helix of human adenylate kinase

Ayabe T., Park S.K., Takenaka H., Takenaka O., Maruyama H., Sumida M., Onitsuka T., Hamada M.

Journal of Biochemistry 128 ( 2 ) 181 - 187 2000

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Biochemistry

To elucidate whether the C-terminal region in human adenylate kinase participates in the interaction with the substrate (MgATP2- and/or AMP2-), hydrophobic residues (Val-182, Vall86, Cys187, Leu190, and Leu193) were substituted by site-directed mutagenesis and the steady-state kinetics of fifteen mutants were analyzed. A change in the hydrophobic residues in the C-terminal domain affects the affinity for substrates (K(m)), that is, not only for MgATP2- but also for AMP2-, and the catalytic efficiency (k(cat)). The results obtained have led to the following conclusions: (i) Val182 may interact with both MgATP2- and AMP2- substrates, but to a greater extent with MgAT2-, and play a role in catalysis. (ii) Val186 appears to play a functional role in catalysis by interacting with both MgATP2- and AMP2- to nearly the same extent. (iii) Cys187 appears to play a functional role in catalysis. (iv) Leu190 appears to interact with both MgATP2- and AMP2- substrates but to a greater extent with AMP2-. (v) Leu193 appears to interact with both MgATP2- and AMP2- but to a greater extent with AM2-. The activity of all mutants decreased due to the change in substrate-affinity. The closer the residue is located to the C-terminal end, the more its mutation affects not only MgATP2- but also AMP2- substrate binding. The hydrophobic alterations disrupt hydrophobic interactions with substrates and that might destabilize the conformation of the active site. The more C-terminal part of the α-helix appears to interact with AMP, as if it has swung out and rotated to cover the adenine moieties. The C-terminal α-helix of human adenylate kinase appears to be essential for the interaction with adenine substrates by swinging out during catalysis.

DOI： 10.1093/oxfordjournals.jbchem.a022739

A novel interventional therapy using the combination of bilateral bronchial stent dilatation and percutaneous cardiopulmonary support for critical airway obstruction due to metastatic carcinomatous carina.

Ayabe T., Matsuzaki Y., Edagawa M., Asado M., Onitsuka T.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 5 ( 5 ) 331 - 335 1999.10

For an inoperative critical airway obstruction (bilateral bronchial stenoses) from a carcinomatous carina due to the mediastinal lymphnodal metastasis from uterine cancer, we succeeded in improving the patient's severe dyspnea by the combination of bilateral bronchial stent dilatation and a percutaneous cardiopulmonary support (PCPS) system. The imminent airway stenosis with severe dyspnea may have a high risk of asphyxia and contact-flooding during implanting of the stent. By the novel use of PCPS in advance for blood-oxygenation as a respiratory support, we could safely perform the interventional therapy of bronchial expandable metallic stents, and the patient obtained a good quality of life without dyspnea until she died of systemic metastatic cachexia. This technique may possibly be approved as an option for temporary remission therapy of a critical airway obstruction.

Immunohistochemical analysis of nm23-H1 gene product in node-positive lung cancer and lymph nodes

Immunohistochemical　analysis of nm23-H1 gene product in node-positive lung cancer and lymph nodes Reviewed

Masaki Tomita, Takanori Ayabe, Yasunori Matsuzaki, Toshio Onitsuka

Lung Cancer 24 11 - 16 1999.5

Language：English Publishing type：Research paper (scientific journal)

Tomita M., Ayabe T., Matsuzaki Y., Onitsuka T.

Lung Cancer 24 ( 1 ) 11 - 16 1999.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Lung Cancer

The nm23-H1 gene product has been considered as an anti-metastatic protein and the level of its expression has been reported to correlate inversely with metastatic potential in some cancers. However, the expression of nm23-H1 gene product in the metastatic sites have not been studied in detail. We examined the expression of nm23-H1 gene product in surgically resected 46 pairs of primary lung cancers and metastatic lymph nodes by immunohistochemistry. The positive staining of nm23-H1 gene product in primary cancers and metastatic lymph nodes were observed in 56.5 and 67.4%, respectively. The heterogeneity of nm23-H1 gene product expression between primary cancers and metastatic lymph nodes was observed in 41.3%. No correlations were found between the nm23-H1 gene product expression in lung cancers and the patients survival. No significant association was also observed between nm23-H1 gene product expression in lymph nodes and the patients survival. There was, furthermore, no correlation between the heterogeneity of nm23-H1 gene product expression and the patients survival. In conclusion, the level of nm23-H1 gene product expression does not significantly reveal prognostic value in node-positive lung cancers. Expression of nm23-H1 gene product in metastatic lymph nodes was also unrelated to patients survival. Copyright (C) 1999 Elsevier Science Ireland Ltd.

DOI： 10.1016/S0169-5002(99)00018-5

Site-directed mutagenesis and steady-state kinetic analysis of mutant enzymes of human adenylate kinase

A Novel Interventional Therapy Using the Combination of Bilateral Bronchial Stent Dilatation and Percutaneous Cardiopulmonary Support for Critical Airway Obstruction due to Metastatic Carcinomatous Carina Reviewed

Takanori Ayabe, Yasunori Matsuzaki, Masao Edagawa, Mikio Asado, and Toshio Onitsuka

Anｎ Thorac Cardiovasc Surg 5 331 - 335 1999.2

Language：English Publishing type：Research paper (scientific journal)

Site-directed mutagenesis　and steady-state kinetic analysis of mutant enzymes of human adenylate kinase Reviewed

Takanori Ayabe, Seung Kyu Park, Hiroyuki Nagahama, Hideharu Maruyama, Michihiro Sumida, Hitoshi Takenaka, Osamu Takenaka, Toshio Onitsuka, and Minoru Hamada

Biochemistry and Molecular Biology International 46 673 - 680 1998.2

Language：English Publishing type：Research paper (scientific journal)

Ayabe T., Park S.K., Nagahama H., Marayama H., Sumida M., Takenaka H., Takenaka O., Onitsuka T., Hamada M.

Biochemistry and Molecular Biology International 46 ( 4 ) 673 - 680 1998

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biochemistry and Molecular Biology International

Site-directed mutagenesis of human adenylate kinase (AK) was carried out on residues His36, Lys55, and the C-terminal segment (Val182, V186, and Leu 193). Five mutants ((H36T, K55G, V182G, V186S, and L193Stop (deletion of residues 193-194)) were generated and analyzed by steady-state kinetics. H36T, K55G, and L193Stop mutants showed an increase of K(m) values (19.8-, 19.7-, and 11.3-fold) for AMP2- compared to that for the wild-type enzyme, and these residues appeared to interact with AMP2-. V182G showed an increased K(m) value (7.4-fold) for MgATP2-. Therefore, V182 may be essential for interaction with MgATP2-. V186S increased the K(m) value (7.0- and 7.5-fold) for MgATP2- and AMP2-. V186 may thus interact with both substrates. The C-terminal domain of AK appears to be essential for MgATP2- and AMP2- binding.

DOI： 10.1080/15216549800204202

Essential Lysine Residues in the N-terminal and the C-terminal Domain of Human Adenylate Kinase Interact with Adenine Nucleotides as found by Site-Directed Random Mutagenesis Reviewed

Takanori Ayabe, H. Takenaka, O. Takenaka, M. Sumida, M. Hideharu, T. Onitsuka, K. Shibata, S. Uesugi, and M. Hamada

Biochemistry 36 4027 - 4033 1997.10

Language：English Publishing type：Research paper (scientific journal)

Essential lysine residues in the N-terminal and the C-terminal domain of human adenylate kinase interact with adenine nucleotides as found by site- directed random mutagenesis

Ayabe T., Takenaka H., Takenaka O., Sumida M., Maruyama H., Onitsuka T., Shibata K., Uesugi S., Hamada M.

Biochemistry 36 ( 13 ) 4027 - 4033 1997.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biochemistry

To elucidate the minimum requirement of amino acid residues for the active center in human adenylate kinase (hAK1), we carried out random site- directed mutagenesis of key lysine residues (K9, K21, K27, K31, K63, K131, and K194), which were conserved in mammalian AK1 species, with the pMEX8- hAK1 plasmid [Ayabe, T., et al. (1996) Biochem. Mol. Biol. Int. 38, 373- 381]. Twenty different mutants were obtained and analyzed by steady-state kinetics, and all mutants showed activity loss by K(m) and/or k(cat) effects on MgATP2-, AMP2-, or both. The results have led to the following conclusions. (1) Lys9 would appear to interact with both MgATP2- and AMP2- but to a larger extent than with AMP2-. (2) Lys21 is likely to play a role in substrate binding of both MgATP2- and AMP2- but more strongly affects MgATP2- . (3) Lys27 and Lys131 would appear to play a functional role in catalysis by interacting strongly with MgATP2-. (4) Lys31 would appear to interact with MgATP2- and AMP2- at the MgATP2- site. (5) Lys63 would be more likely to interact with MgATP2- than with AMP2-. (6) Lys194 in the flanking C-terminal domain would appear to interact not only with MgATP2- but also with AMP2- at the MgATP2- site by stabilizing substrate binding. The loss of the positively charged ε-amino group of lysine affects both the affinity for the substrate and the catalytic efficiency. Hence, hydrophilic lysine residues in hAK1 would appear to be essential for substrate-enzyme interaction with the coordination of some arginine residues, reported previously [Kim, H. J., et al. (1990) Biochemistry 29, 1107-1111].

DOI： 10.1021/bi961796a

Substrate-binding and catalytic roles of Lys194 in the C-terminus in human adenylate kinase by site-directed random mutagenesis

Substrate-Binding and Catalytic Roles of Lys194 In the C-terminus in Human Adenylate Kinase by Site-directed Random Mutagenesis Reviewed

Takanori Ayabe, H. Takenaka, O. Takenaka, T. Onotsuka, K. Shibata, S. Uesugi, and M. Hamada

Biochemistry and Molecular Biology International 41 367 - 375 1997.2

Language：English Publishing type：Research paper (scientific journal)

Ayabe T., Takenaka H., Takenaka O., Onitsuka T., Shibata K., Uesugi S., Hamada M.

Biochemistry and Molecular Biology International 41 ( 2 ) 367 - 375 1997.2

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biochemistry and Molecular Biology International

Site-directed random mutagenesis of Lys194 residue in the C-terminus of human adenylate kinase (AK) was performed, and six mutants were analyzed by steady-state kinetics. K194-mutants variously affected the apparent Michaelis constants (K(m) values) for ATP and AMP, although the k(cat) values strikingly decreased. The Lys194 residue appears to interact not only with MgATP2- but also with the AMP2- substrates by salt bridge formation with a nucleotide and to play a functional role in stabilizing the phosphate-transfer during catalysis. Lys194 could be essential for substrate-holdings and in catalysis and not replaceable to the other amino acids.

DOI： 10.1080/15216549700201381

Site-directed random mutagenesis of the c-terminal residue (K194) of human adenylate kinase

Catalytic roles of Lysines (K9, K27, K31) in the N-terminal domain in human adenylate kinase by random site-directed mutagenesis. Reviewed

Takanori Ayabe, S. K. Park, H. Takenaka, M. Sumida, S. Uesugi, O. Takenaka, and M.Hamada

Biochemistry and Molecular Biology International 40 897 - 906 1996.12

Language：English Publishing type：Research paper (scientific journal)

Construction of the plasmid pMEX8-hAK1 and random site-directed mutagenesis of human cytosolic adenylate kinase. Reviewed

Takanori Ayabe, Hitoshi Takenaka, Osamu Takenaka, Akiko Takenaka, Hiroyuki Nagahama,Hideharu Maruyama, Atsushi Yamamoto, Masahiko Nagata, Yasunori Koga, Michihiro Sumida, and Minoru Hamada

Biochemistry and Molecular Biology International 38 373 - 381 1996.12

Language：English Publishing type：Research paper (scientific journal)

Ayabe T., Takenaka H., Maruyama H., Koga Y., Hamada M.

FASEB Journal 10 ( 6 ) 1996.12

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：FASEB Journal

Human adenylate kinase (AK) consisting of 194 amino acid residues is a ubiquitous enzyme which catalyzes the reaction: MgATP2- + AMP2MgADP- + ADP-. The Lys 194 was substituted by site-directed random mutagenesis of the pMEX8-hAKl vector. Six mutants, K194S, K194I, K194L, K194P, K194N, and K194V, were obtained and steady-slate kinetics showed interesting results. The Km value of K194S was increased (14.7fold) for MgATP2- and that of K194V was increased (20.6-fold) for AMP2compared to those of wild type AK. On K1941 and K194N, the Km values were not changed (0.6 -1.6 fold) for AMP2-, this is not a significant change, however, the Vmax values were decreased (less 5%). On K194L, the Km value was increased (9.7-fold) for MgATP2- and the kcat/Km value was decreased (0.01%), even though the Km value for AMP2- was dramatically decreased (0.05-fold) and the kcal/Km value was increased (5.2-fold). Lys 194 residue might specifically affect either of the MgATP2 or AMP2substrates while the C-terminal domain was deduced to locate closely to MgATP2- binding site in the X-ray model. The flexible C-terminal domain might play an important role in catalysis by moving and holding the substrates therby facilitating the reaction. Lys 194 may be essential for the C-terminus to play this role in the enzyme molecule.

Construction of the plasmid pMEX8-hAK1 and random site-directed mutagenesis of human cytosolic adenylate kinase

Ayabe T., Takenaka H., Takenaka O., Takenaka A., Nagahama H., Maruyama H., Yamamoto A., Nagata M., Koga Y., Sumida M., Hamada M.

Biochemistry and Molecular Biology International 38 ( 2 ) 373 - 381 1996.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biochemistry and Molecular Biology International

The pMEX8-hAK1 vector was devised from the pAK plasmid, which could directly express human adenylate kinase proteins without recombination and its single strand DNA could be withdrawn with helper phage for random site-directed mutagenesis. The conserved key residues at Lys21, Lys27, and Thr39 were engineered to obtain mutants for kinetic analysis. Three mutants were obtained as K21P, K27R, and T39S, their specific activities were strikingly reduced compared to those of wild type adenylate kinase. This pMEX8-hAK1 will be a powerful tool for site-directed mutagenesis to detect the substrate-enzyme interaction for human adenylate kinase including various other enzymes.

Catalytic roles of lysines (K9, K27, K31) in the N-terminal domain in human adenylate kinase by random site-directed mutagenesis

Steady-state Kinetics of Thr35- and Thr39-mutants in Human Adenylate Kinase by Site-directed Mutagenesis Reviewed

Takanori Ayabe, H. Takenaka, T. Onitsuka, K. Shibata, O. Takenaka, S. Uesugi, and M. Hamada

Enzyme & Protein 49 305 - 312 1996.5

Language：English Publishing type：Research paper (scientific journal)

Site-directed random mutagenesis of the c-terminal residue (K194) of human adenylate kinase Reviewed

Ayabe, T., Takenaka, H., Maruyama, H., Koga, Y., Hamada, M.

FASEB Journal 10 ( 6 ) A1103 1996.2

Language：English Publishing type：Research paper (scientific journal)

Ayabe T., Park S.K., Takenaka H., Sumida M., Uesugi S., Takenaka O., Hamada M.

Biochemistry and Molecular Biology International 40 ( 5 ) 897 - 906 1996

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biochemistry and Molecular Biology International

To elucidate lysine residues in the N-terminal domain of human cytosolic adenylate kinase (hAK1, EC 2.7.4.3), random site-directed mutagenesis of K9, K27, and K31 residues was performed, and six mutants were analyzed by steady-state kinetics. K9 residue may play an important role in catalysis by interacting with AMP2-. K27 and K31 residues appear to play a functional role in catalysis by interacting with MgATP2-. In human AK, the ε-amino group in the side chain of these lysine residues would be essential for phosphoryl transfer between MgATP2- and AMP2- during transition state.

DOI： 10.1080/15216549600201513

Steady-state kinetics of Thr35 and Thr39 mutants in human adenylate kinase by site-directed mutagenesis

Ayabe T., Takencika H., Onitsnka T., Shibata K., Takenaka O., Uesitgi S., Hamada M.

Enzyme and Protein 49 ( 5-6 ) 305 - 312 1996

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Enzyme and Protein

Adenylate kinase (AK; EC 2.7.4.3, hAK1) catalyzes the reaction: MgATP2- + AMP2- ⇆ MgADP + ADP3-. To elucidate the catalytic and structural roles of threonine residues in human AK, Thr35 and Thr39 mutants were analyzed by steady-state kinetics. The K(m) values of T35P and T35Y were not changed for MgATP2- and AMP2-, and the k(cat) values were decreased by 1/39 compared to those of wild-type AK. Thr35 was suggested to be essential for catalysis. The K(m), values of T39S, T39V, and T39P were increased 5.6- to 59.0-fold for AMP2-; however, the k(cat) values were not reduced. Although the K(m) values of T39F and T39L were unchanged, the k(cat) values were reduced by more than 1/57. Thr39 appears to play an important role in the binding of AMP2- and to be essential for catalysis. As noted above, a hydroxyl group of the Thr residue in human AK appears to be important.

DOI： 10.1159/000468640