Papers - AYABE Takanori
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Chapter 24 : 気管支鏡と医療倫理 Reviewed
綾部貴典
気管支鏡ベストテクニック改訂３版 398 - 405 2024.7
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：中外医学社
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I. 基礎： 気管支鏡検査と安全対策（医療安全管理と臨床倫理の視点）
綾部貴典
第47回日本呼吸器内視鏡学会学術集会 第36回気管支鏡セミナー 1 - 11 2024.6
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：中外医学社
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Radiological features and surgical management of lung abscess directly extending into the chest wall: A case report Reviewed
Shoei Kuroki, Mayu Inomata, Ayako Matsuno, Fumiya Kawano, Takanori Ayabe, Ryo Maeda,
International Journal of Surgery Case Reports 111 108887 2023.10
Language：English Publishing type：Research paper (scientific journal)
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Kuroki S., Inomata M., Matsuo A., Kawano F., Ayabe T., Maeda R.
International Journal of Surgery Case Reports 111 108887 2023.10
Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Surgery Case Reports
Introduction and importance: We presented an extremely rare case of lung abscess following bronchoscopy associated with lung cancer that extended directly into the chest wall. Case presentation: A 49-year-old man with adenocarcinoma underwent bronchoscopy. Eight days after the biopsy, the patient presented with chills and anterior chest wall pain. Chest computed tomography (CT) scan revealed a gas-containing lung abscess, measuring 10 cm in the left upper lobe and subcutaneous emphysema. The coronal view of the CT indicated a continuous passage of air from the lung abscess to the subcutaneous emphysema beneath the pectoralis muscle. Surgical debridement of the subcutaneous abscess was performed, resulting in drainage of a large volume of purulent material. We confirmed that the lung abscess had directly extended to the chest wall, leading to a decision to perform segmentectomy of the upper division of the left lung. Clinical discussion: Lung abscess associated with lung cancer is a rare, life-threatening complication, which may lead to significant delays in the commencement of oncological treatment and potentially worsen long-term outcomes. In the present case, surgical findings confirmed a lung abscess extending directly to the chest wall. Surgical therapy is the treatment of choice for this rare condition, providing rapid focus control. Therefore, prompt initiation of surgical therapy is essential when conservative measures prove ineffective. Conclusion: Lung abscesses may extend into the chest wall during differential diagnosis of infectious diseases of the chest wall. Successful treatment of this rare condition depends on prompt surgical intervention.
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臨床倫理コンサルテーションにおいて倫理支援を行うメンバーに求められるコンピテンシー Reviewed
三浦由香里、板井孝壱郎、綾部貴典、深谷基裕
臨床倫理 ( 11 ) 66 - 78 2023.9
Language：Japanese Publishing type：Research paper (scientific journal)
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Video-assisted thoracoscopic left upper lobectomy in a patient with situs inversus totalis
Kuroki Shoei, Inomata Mayu, Ayabe Takanori, Maeda Ryo
The Journal of the Japanese Association for Chest Surgery 37 ( 2 ) 146 - 151 2023.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Chest Surgery
Complete situs inversus is a rare abnormality of autosomal recessive inheritance. The surgical management of this entity is complex because the viscus anatomy mirrors the normal anatomy. Here, we report a patient with complete situs inversus, who underwent lobectomy using video-assisted thoracic surgery for lung cancer of the left upper lobe. The procedure was successfully performed despite the patient's atypical anatomy, which mirrored the normal anatomy. Before the surgical intervention, we created a virtual image of left upper lobectomy in a patient with complete situs inversus by horizontally reversing a typical video of right upper lobectomy.
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Pulmonary torsion after resuscitative thoracotomy: a case report
Hara Daisuke, Hamahiro Tomoka, Maeda Ryo, Ayabe Takanori, Tomita Masaki
Japanese Journal of Acute Care Surgery 13 ( 0 ) 62 - 66 2023
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Society for the Acute Care Surgery
The patient was a 30-year-old woman with a history of schizophrenia. She was transferred to our department due to abdominal trauma caused by suicide. She was undergone aortic clamping and cardiac massage by resuscitative thoracotomy for hemorrhagic shock and cardiac arrest. Subsequently, damage control surgery was performed for intraabdominal hemorrhage. On the second postoperative day, reoperation was scheduled for gauze depacking and gastrointestinal reconstruction, but a preoperative chest x-ray and chest CT showed decreased permeability of the left upper lobe. Postoperative pneumonia was diagnosed and reoperation was performed as scheduled. After that, a CT scan showed the same abnormality in the left lung, and left upper lobe pulmonary torsion was diagnosed by thoracic surgeon. Emergency operation was performed and the twisted upper lobe was removed. We report a rare case of pulmonary torsion that may be caused by resuscitative thoracotomy. The pulmonary torsion is required careful treatment.
DOI： 10.50840/jjacs.13-06
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Competencies required for members who provide ethical support in clinical ethics consultations Reviewed
Miura Yukari, Itai Koichiro, Ayabe Takanori, Fukaya Motohiro
Journal of Clinical Ethics 11 ( 0 ) 66 - 78 2023
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Association for Clinial Ethics
In clinical ethics consultations in Japan, activities are carried out to provide appropriate advice in order to assist concerned parties in resolving anxieties and conflicts, such as withholding or discontinuing treatment, supporting patient decision-making, and so on. The purpose of this study is to conduct semi-structured interviews with senior clinical ethicists to clarify their competencies. The participants were 38 people from 20 medical institutions. Using theme analysis, 49 subcategories, 11 categories, and 4 themes were extracted from the verbatim transcripts. Clinical ethicists listens to the client’s anxieties regardless of their own perspective, sees through to the essence of the problem, and builds ethical reasoning. They support the discussion process itself in order to activate the exchange of opinions among participants through conferences and derive concrete measures for resolution. Above all, it is important to divide roles and promote cooperation within the ethics consulting team in order to demonstrate individual abilities. It was deduced from the narrative that they used a wide variety of competencies to support medical staff facing ethical issues.
DOI： 10.34329/jce.11.0_66
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Promotion of Patient Safety Through an Enhanced Awareness of Clinical Ethics. Attempts to Collaborate between Safety Management and Clinical Ethics. Reviewed
Koichiro Itai, Yukari Miura , Takanori Ayabe
Journal of Philosophy and Ethics in Health Care and Medicine 16 64 - 70 2022.12
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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「医療安全・質の向上」を改善し、レジリエント・ヘルスケアで医療を変革する Invited Reviewed
綾部貴典
宮崎県医師会雑誌 46 107 - 127 2022.9
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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A spontaneous reduction in tumor size of a thymic carcinoma: a case report.
Kuroki S, Ayabe T, Tanaka H, Nakada H, Maeda R
Surgical case reports 8 ( 1 ) 154 2022.8
Language：English Publishing type：Research paper (scientific journal)
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Intrapulmonary solitary fibrous tumor coexisting with lung adenocarcinomas.
Kuroki S, Ayabe T, Gi T, Sato Y, Nakada H, Maeda R
Surgical case reports 8 ( 1 ) 150 2022.8
Language：English Publishing type：Research paper (scientific journal)
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Approach to seamless pre- and post-graduation medical safety education (1): Questionnaire survey regaring near-miss experiences of Japanse medical students Reviewed
Yukiko Kai, Takanori Ayabe, Taro Funamoto, Yamamoto Emiko, Yumiko Takeyama, Amy Hombu
Journal of Medical Safety 2022 17 - 24 2022.6
Language：English Publishing type：Research paper (scientific journal)
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Approach to seamless pre- and post-graduation medical safety education (2): Comparative survey regarding near-miss experience of Japanese medical students and residents Reviewed
Yukiko Kai, Takanori Ayabe, Taro Funamoto, Emiko Yamamoto, Yumiko Takeyama, Amy Hombu
Journal of Medical Safety 2022 25 - 36 2022.6
Language：English Publishing type：Research paper (scientific journal)
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Okumura, M., Iwakiri, T., Yoshikawa, N., Nagatomo, T., Ayabe, T. Tsuneyoshi, I., Ikeda, R.,
Int. J. Mol. Sci. 23 ( 16 ) 9108 2022.6
Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Molecular Sciences
Aberrant activation of hepatocyte growth factor (HGF) and its receptor c-Met axis promotes tumor growth. Therefore, many clinical trials have been conducted. A phase 3 trial investigating a monoclonal antibody targeting HGF in combination with fluoropyrimidine-based chemotherapy had to be terminated prematurely; however, the reason behind the failure remains poorly defined. In this study, we investigated the influence of HGF on the antineoplastic effects of 5-fluorouracil (5-FU), a fluoropyrimidine, in HepG2 cells. HGF suppressed the proliferative activity of cells concomitantly treated with 5-FU more robustly as compared to that of cells treated with 5-FU alone, and markedly increased the expression of uridine phosphorylase 1 (UPP1). Intracellular concentration of 5-fluorouridine, an initial anabolite of 5-FU catalyzed by UPP1, was increased by HGF. Interestingly, erlotinib enhanced HGF-induced increase in UPP1 mRNA; in contrast, gefitinib suppressed it. Furthermore, erlotinib suppressed HGF-increased phosphorylation of the epidermal growth factor receptor at the Tyr1173 site involved in downregulation of extracellular signal-regulated kinase (Erk) activation, and enhanced the HGF-increased phosphorylation of Erk. Collectively, these findings suggest that inhibition of the HGF/c-Met axis diminishes the effects of fluoropyrimidine through downregulation of UPP1 expression. Therefore, extreme caution must be exercised in terms of patient safety while offering chemotherapy comprising fluoropyrimidine concomitantly with inhibitors of the HGF/c-Met axis.
DOI： 10.3390/ijms23169108
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A spontaneous reduction in tumor size of a thymic carcinoma: A case report. Reviewed
Shoei Kuroki; Takanori Ayabe; Hioyuki Tanaka; Hiroshi Nakada; Ryo Maeda.
Surgical Case Reports 12 154 2022.6
Language：English Publishing type：Case report
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Intrapulmonary solitary fibrous tumor coexisting with lung adenocarcinomas. Reviewed
Shoei Kuroki, Takanori Ayabe, Toshihiro Gi, Yuchiro Sato, Hioshi Nakada, Ryo Maeda.
Surgical Case Reports 8 ( 1 ) 150 2022.6
Language：English Publishing type：Case report
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第122回日本外科学会定期学術集会、特別企画(6)「医療安全を支えるNon-Technical Skills」 6. 「大学病院における多職種ノンテクニカルスキルの実践」 安全管理確保のための質改善向上の取り組み Reviewed
綾部貴典、奥村 学、神田久美子、中村小夜子、小田浩美、山本亜矢、甲斐由紀子、恒吉勇男
日本外科学会雑誌 123 ( 6 ) 633 - 635 2022.6
Authorship：Lead author Language：Japanese Publishing type：Research paper (other academic)
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MIURA Yukari, ITAI Koichiro, AYABE Takanori, FUKAYA Motohiro
Journal of Humanities in Medicine 12 ( 0 ) 19 - 32 2022
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Philosophical and Ethical Researches in Medicine (Kyushu)
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Approach to seamless pre-and post-graduation medical safety education (2)：：Comparative survey regarding near-miss experiences of Japanese medical students and residents Reviewed
甲斐 由紀子, 綾部 貴典, 舩元 太郎, 竹山 ゆみ子, 山本 恵美子
International Association of Risk Management in Medicine 1 2022
Publishing type：Research paper (scientific journal)