Papers - AYABE Takanori
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Relationship between serum carcinoembryonic antigen level and T status in non-small cell lung cancer. Reviewed
Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Anticancer Res., 26(5B)：3845-3848, (2006) 26 ( 5B ) 3845 - 3848 2006.2
Language：English Publishing type：Research paper (scientific journal)
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Preoperative prognostic factors for pN2 non-small cell lung cancer.
Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 12 ( 1 ) 15 - 20 2006.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
PURPOSE: The prognosis of non-small cell lung cancer (NSCLC) with pathologic mediastinal lymph node involvement (pN2) is poor in general. The majority of previously reported prognostic factors of pN2 disease are not available preoperatively. When we perform preoperative induction chemotherapy, we should undertake therapeutic planning according to preoperative factors. METHODS: We focused on preoperative clinicopathologic factors, and investigated the prognosis in 78 patients with pN2 NSCLC who received complete resection. RESULTS: Age, gender, histologic subtype, tumor location, smoking status and cT status were not related to patients' survival. On the other hand patients with cN0 disease and normal serum carcinoembryonic antigen (CEA) level had a significant favorable survival (p = 0.038 and p = 0.019, respectively). In addition, comorbidity had a significant survival impact (p = 0.031). Despite there being no independent prognostic factors by multivariate analysis, the patients without all of cN1-2 disease, elevated serum CEA level and comorbidity had a significant favorable prognosis (p = 0.008). CONCLUSION: Among the preoperative factors examined, pN2 patients with all cN0 disease, normal serum CEA level and no comorbidities might have a favorable prognosis. Combined use of these might be a useful prognostic determinant, and even in the presence of pN2 disease, patients without these unfavorable 3 factors might have a favorable prognosis when treated with surgery alone.
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Preoperative prognostic factors for pN2 non-small cell lung cancer.
Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Onitsuka T
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 12 ( 1 ) 15 - 20 2006.2
Language：Japanese Publishing type：Research paper (scientific journal)
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Preoperative prognostic factors for pN2 non-small cell lung cancer. Reviewed
Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Ann. Thorac. Cardiovasc. Surg. 12 ( 1 ) 15 - 20 2006.1
Language：English Publishing type：Research paper (scientific journal)
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Right lung cancer with right aortic arch and posterior aortic left innominate vein
Hara Masaki, Matsuzaki Yasunori, Shimizu Tetsuya, Tomita Masaki, Ayabe Takanori, Onitsuka Toshio
The Journal of the Japanese Association for Chest Surgery 20 ( 2 ) 166 - 170 2006
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Chest Surgery
A 61-year-old woman was admitted to our hospital for surgical treatment of a right upper lobe adenocarcinoma. The patient had a right aortic arch with an aberrant left subclavian artery and a posterior left aortic innominate vein. Right upper lobectomy with mediastinal lymphadenectomy was performed via right thoracotomy. Although paratracheal and tracheobronchial lymph nodes were easily resected, there was difficulty resecting the superior mediastinal and pretracheal lymph nodes because of the aortic arch, aortic diverticulum and posterior left aortic innominate vein compression. Preoperative MDCT and FDG-PET are useful in planning the operative approach and likelihood of success.
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von Recklinghausen 病に合併した胸部外科疾患. Reviewed
綾部貴典, 松崎泰憲, 枝川正雄, 清水哲哉, 原 政樹, 二宮浩範, 緒方克己, 鬼塚敏男
胸部外科 58 ( 3 ) 219 - 225 2005.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Vascular endothelial growth factor expression in pN2 non-small cell lung cancer: Lack of prognostic value. Reviewed
Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Respirology, 10(1): 31-35, (2005) 10 ( 1 ) 31 - 35 2005.12
Language：English Publishing type：Research paper (scientific journal)
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HARA Masaki, MATSUZAKI Yasunori, SHIMIZU Tetsuya, TOMITA Masaki, AYABE Takanori, ONITSUKA Toshio
Haigan 45 ( 7 ) 829 - 832 2005.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Lung Cancer Society
<b><i>Background.</i></b> Distant metastatic lesions of lung cancer are generally regarded as inoperable. This case report describes long-term survival achieved with surgical resection of primary and metastatic lesions in combination with perioperative chemotherapy. <b><i>Case.</i></b> A 62-year old man was referred to our institution with an irregularly shaped right upper lobe nodule in October 1999. Intraoperative frozen section of the nodule at the time of right upper lobectomy and mediastinal lymph node dissection confirmed adenocarcinoma of the lung. A left humeral head lesion identified by bone scintigraphy in January 2000 was confirmed to be metastatic adenocarcinoma by biopsy. Following 2 courses of chemotherapy (CDDP & TXT) the patient underwent left humeral head resection and reconstruction in April 2000. The final pathologic examination failed to demonstrate any malignant cells in the specimen, which was interpreted to indicate a complete histologic response to chemotherapy. Five years later, the patient is well without evidence of recurrence. <b><i>Conclusion.</i></b> Long term survival in a patient with primary lung cancer and a solitary bone metastasis was achieved through lobectomy, perioperative chemotherapy, and resection of the metastatic lesion.
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Surgery for the thymoma combined with pure red cell aplasia and myasthenia gravis
Ayabe T., Matsuzaki Y., Edagawa M., Shimizu T., Hara M., Tomita M., Akiyama Y., Onitsuka T.
Kyobu geka. The Japanese journal of thoracic surgery 58 ( 12 ) 2005.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery
Pure red cell aplasia (PRCA) and myasthenia gravis (MG) are respectively combined with thymoma, however, these 3 complications are extremely rare coexisted as a clinical triad. A 73-year-old female with mediastinal tumor found in 2000 was pointed out anemia in June 2002. As PRCA was diagnosed by the bone marrow examination, blood transfusion had been performed. By a chest computed tomography (CT), a thymoma in size of 7 x 5 cm in diameter was recognized in the anterior mediastinum. The serum level of anti-acetylcholine receptor antibody was elevated to be 35 nmol/l. MG was simultaneously diagnosed with a decreased power of neck muscle. The extended thymectomy was performed in August 2002, and pathological diagnosis disclosed a 'type AB' by World Health Organization (WHO) classification. After the operation, the decreased power of neck muscle had been improved, however, PRCA had not been remitted in the early-postoperative term. Blood transfusion had been required (2-4 units/1-2 weeks) for the postoperative 7 months' term. A cyclosporin (250 mg/day) as an adjuvant therapy was administered in April 2003. One month later, the patient's serum level of Hb had been over 10 g/dl without blood transfusion. The patient has been followed up with reducing the dose of cyclosporin. Conclusions: Surgery for a thymoma combined with PRCA and MG was effective for MG but not for PRCA in an early-postoperative term, however, a multimodality therapy with immunosuppressant as a postoperative adjuvant should bring a favorable outcome to patient's clinical data, and the postoperative long-observation must be critical in this case.
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Prognostic significance of carcinoembryonidc antigen level in pleural lavage fluid for patients with lung adenocarcinoma. Reviewed
Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Ann. Thorac. Surg. 80 ( 1 ) 276 - 281 2005.10
Language：English Publishing type：Research paper (scientific journal)
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原発性肺癌外科切除例の臨床的検討. Reviewed
綾部貴典, 松崎泰憲, 枝川正雄, 清水哲哉, 原 政樹, 富田雅樹, 鬼塚敏男
宮崎県医師会医学会会誌 29 ( 2 ) 85 - 93 2005.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Thoracic and Cardiovascular Surgeon 53 ( 5 ) 300 - 304 2005.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Thoracic and Cardiovascular Surgeon
Background: Several reports have indicated that preoperative high serum carcinoembryonic antigen (CEA) levels are associated with poor survival after surgical resection in lung cancer. Methods: 82 consecutive lung cancer patients with preoperative high serum CEA levels (> 5 ng/mL) were included in this study. Postoperative serum CEA level was also measured. Prognostic indicators were evaluated. Results: Among patients with a preoperative high serum CEA level, a serum CEA level higher than 10 ng/mL, pT status, pN status, and positive pleural lavage cytology findings were unfavorable prognostic indicators, whereas age, gender, smoking status, histologic subtype were not. Postoperative serum CEA levels of all but 2 patients decreased, however those of 28 patients did not return to normal range. Our result showed that patients with postoperative high serum CEA level had poor prognosis. Multivariate analysis demonstrated that pT status, pN status, and postoperative high serum CEA level was an independent prognostic determinant. Conclusions: In lung cancer patients with preoperative high serum CEA levels, pT status, pN status, and normalization of serum CEA level after surgery are significant prognostic determinants. © Georg Thieme Verlag KG · Stuttgart.
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Serum carcinoembryonic antigen level in pN1 non-small cell lung cancer patients
Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Anticancer Research 25 ( 5 ) 3601 - 3605 2005.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research
Background: Although the prognostic significance of the serum carcinoembryonic antigen (CEA) level in non-small cell lung cancer has been reported in several studies, it is unknown whether the serum CEA level is a prognostic determinant for pN1 disease or not. Materials and Methods: Seventy patients with pN1 non-small cell lung cancer who received complete resection were reviewed. The preoperative serum CEA level was measured in all patients. Results: The pN1 patients with pT2-4 disease, hilar node involvement, multiple N1 station and elevated serum CEA level (>5 ng/mL) had a significantly unfavorable prognosis. Although a serum CEA level higher than 5 ng/mL was not an independent prognostic determinant, more than 10 ng/mL was an independent factor by multivariate analysis. In patients with pT1-2N1 disease, a serum CEA level more than 10 ng/mL was also a prognostic determinant. Conclusion: An elevated serum CEA level, especially higher than 10 ng/mL, is a significant prognostic determinant for pN1 lung cancer patients.
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Serum carcinoembryonic antigen level in pN1 non-small cell lung cancer patients.
Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Onitsuka T
Anticancer research 25 ( 5 ) 3601 - 5 2005.9
Language：Japanese Publishing type：Research paper (scientific journal)
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Tomita M., Shimizu T., Matsuzaki Y., Hara M., Ayabe T., Onitsuka T.
Annals of Thoracic Surgery 80 ( 1 ) 276 - 281 2005.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic Surgery
Background. Prognostic indicators for non-small cell lung cancer patients traditionally include TNM staging, pleural lavage cytology, and serum carcinoembryonic antigen levels. This prospective study evaluates carcinoembryonic antigen levels in pleural lavage fluid as a potential determinant for patients with lung adenocarcinoma. Methods. One hundred and fifty patients underwent thoracotomy. Pleural lavage fluid was collected, and pleural lavage cytology and lavage carcinoembryonic antigen levels were determined. The control group included 40 patients with nonmalignant disease. Results. Sixteen patients (10.7%) had positive pleural lavage cytologies. These patients and those with elevated serum carcinoembryonic antigen levels generally had a poor prognosis. Thirty-seven patients (24.7%), however, showed elevated lavage carcinoembryonic antigen levels, and a significant correlation with patient survival was demonstrated. Multivariate analysis confirmed these results. We also found a correlation between positive pleural lavage cytologies and serum carcinoembryonic antigen levels and patient survival in patients with pN0 disease but not in those with pN1-2 disease. Elevated lavage carcinoembryonic antigen levels, however, correlated significantly with survival rates in patients with pN1-2 disease. Conclusions. An elevated lavage carcinoembryonic antigen level is an independent prognostic determinant for patients with lung adenocarcinoma, even with advanced disease, and may be a more useful marker of subclinical microdissemination than pleural lavage cytology. © 2005 by The Society of Thoracic Surgeons.
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Prognostic determinants for lung cancer patients with preoperative high serum carcinoembryonic antigen levels. Reviewed
Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Thorac. cardiovasc. Surg. 53 300 - 304 2005.6
Language：English Publishing type：Research paper (scientific journal)
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Serum carcinoembryonic antigen level in pN1 Non-small cell lung cancer patients. Reviewed
Tomita M., Matsuzaki Y., Shimizu T, Hara M, Ayabe T., Onitsuka T
Anticancer Research 25 ( 5 ) 3601 - 3606 2005.6
Language：English Publishing type：Research paper (scientific journal)
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Primary lung cancer; assessment of the disclosed 5-year survival rate by the Internet website
Ayabe T., Matsuzaki Y., Edagawa M., Shimizu T., Hara M., Tomita M., Ninomiya H., Onitsuka T.
Kyobu geka. The Japanese journal of thoracic surgery 58 ( 6 ) 451 - 459 2005.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery
The disclosed 5-year survival rate for lung cancer in the Internet website represents a various difference by each institution. The better inferiority of the survival has been listed in a table to compare with other institutions and has been reported in magazines and media with a lack of an enough inspection, i.e., with a sufficient considering of a risk adjustment such as patient's background, operative policy, postoperative adjuvant therapy, and statistical background. We report our outcome of the surgical treatment for primary lung cancer. Of 875 patients treated for lung cancer in our department for 23 years between January 1980 and December 2002, 115 patients containing of 42 cases in 1997 and of 48 ones in 1992 and of 25 ones in 1987 were selected and the accumulated survival analysis was treated by Kaplan-Meier method. Eighty males and 35 females were between 15 and 80-year-old (average 63.2 +/- 11.4). The pathological classification was adenocarcinoma (n=69), squamous cell carcinoma (n=32), and others (n=14). The operative procedures were pneumonectomy (n=14), bilobectomy (n=12), lobectomy (n=85), and wedge resection (n=4). The survival time was from 29 days to 182 months (median survival time was 1471+/- 1180 days, the averaged time was 49 months). The 5-year survival rate was 41.4 +/- 9.1% (n=25) in 1987, 35.6 +/- 6.2% (n=48) in 1992, and 56.0 +/- 7.0% (n=42) in 1987, respectively (log-rank test, p = 0.2555). The 10-year survival rate was 24.1 +/- 7.9% in 1987 and 8.5 +/- 3.6% in 1992, respectively. The 5-year survival rate was as follows: IA 81.0 +/- 8.6% (n=20), IB 73.7 +/- 10.1% (n=19), IIA 57.1 +/- 18.7% (n=7), IIB 55.6 +/- 16.6% (n=9), IIIA 28.6 +/- 7.6% (n=35), IIIB 15.4 +/- 10.0% (n=13), IV 16.7 +/- 10.8% (n=12), respectively. The 5-year survival rate was as follows: male 42.8 +/- 5.3% (n=80), female 63.2 +/- 7.3% (n=35), respectively (p = 0.0147). In regard to the histological classification, the 5-year survival rate was as follows: adenocarcinoma 47.2 +/- 5.9% (n=69), squamous cell carcinoma 50.8 +/- 8.9% (n=32), respectively (p = 0.9012). As a rule of the disclosure on the internet website, we report our survival data by accompanying with minimum parameters such as, patient's background, pathological types, gender, pathological stages, and mean survival rate with standard error. When we compare the 5-year survival rate with other institutes, in considering of a risk adjustment, we would carefully have to estimate the determined survival rate with a standard error.
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Intrapleural Hyperthermic Perfusion with Chemotherapy Increases Apoptosis in Malignant Pleuritis. Reviewed
54. Matsuzaki Y, Edagawa M, Shimizu T, Hara M, Tomita M, Ayabe T., Onitsuka T.
Ann. Thorac. Surg. 78 ( 5 ) 1769 - 1773 2005.5
Language：English Publishing type：Research paper (scientific journal)
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インターネット上で公開された原発性肺癌の術後５年生存率の問題点. Reviewed
綾部貴典, 松崎泰憲, 枝川正雄, 清水哲哉, 原 政樹, 二宮浩範, 緒方克己, 鬼塚敏男
胸部外科 58 ( 6 ) 451 - 459 2005.5
Language：Japanese Publishing type：Research paper (scientific journal)