Papers - AYABE Takanori
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前領域肺尖部第1 肋骨浸潤肺癌に対する傍胸骨アプローチ Reviewed
清水哲哉,，富田雅樹，綾部貴典，米井彰洋，中尾大伸，中村都英，鬼塚敏男
胸部外科 65 ( 7 ) 555 - 558 2012.7
Language：Japanese Publishing type：Research paper (scientific journal)
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[Parasternal approach for anterior apical lung cancer with invasion of the first rib].
Shimizu T., Tomita M., Ayabe T., Yonei A., Nakao H., Nakamura K., Onitsuka T.
Kyobu geka. The Japanese journal of thoracic surgery 65 ( 7 ) 555 - 558 2012.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery
For complete resection of anterior apical invasive lung cancer, it is of clinical significance to select the appropriate surgical approaches based on the anatomic location of the tumor and extent of invasion of adjacent anatomic structures. However, patients with anterior apical lung cancer without vessel invasion are occasionally burdened with unnecessarily excessive surgical invasion. We present 2 cases of anterior apical lung cancer invading the 1st rib but not subclavian vein, who underwent complete resection through the parasternal approach. We also discuss the feasibility of this approach.
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肺癌に対するCBDCA＋weekly PTX化学療法 Reviewed
綾部貴典、富田雅樹、原政樹、清水哲哉、中村都英、鬼塚敏男
宮崎県医師会医学会会誌 36 108 - 115 2012.6
Language：Japanese Publishing type：Research paper (scientific journal)
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術前診断が困難であった対側肺転移を伴う肺類基底細胞癌の1切除例 Reviewed
綾部貴典、富田雅樹、盛口淸香、丸塚浩助、清水哲哉
日本呼吸器外科学会雑誌 26 ( 4 ) 77 - 81 2012.6
Language：Japanese Publishing type：Research paper (scientific journal)
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左胸膜外肺全摘術を施行した悪性胸膜中皮腫の１例 Reviewed
清水哲哉、富田雅樹、綾部貴典、米井彰洋、中尾大伸、中村都英、鬼塚敏男
宮崎県医師会医学会会誌 36 143 - 147 2012.6
Language：Japanese Publishing type：Research paper (scientific journal)
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精神疾患を有する乳癌手術症例の臨床的検討 Reviewed
綾部貴典、清水哲哉、富田雅樹、米井彰洋、中尾大伸、中村都英、鬼塚敏男
宮崎県医師会医学会会誌 36 131 - 137 2012.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Surgical resection of pulmonary basaloid carcinoma with contralateral metastasis
AYABE Takanori, TOMITA Masaki, MORIGUCHI Sayaka, MARUTSUKA Kousuke, SHIMIZU Tetsuya
The Journal of the Japanese Association for Chest Surgery 26 ( 4 ) 439 - 443 2012.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Association for Chest Surgery
A 76-year-old female who underwent surgery for breast cancer (T1N0M0, stage I) presented with bilateral lung tumors (lt., B<sup>9</sup>, B<sup>10</sup>, endobronchial growing tumor, 30×14 mm rt., S<sup>8</sup>, nodule, 10 mm). Preoperatively, transbronchial lung biopsy from the left lung tumor disclosed a pleomorphic adenoma. The right lung tumor was resected by wedge resection under video-assisted thoracic surgery, and the left tumor was resected with basal segmentectomy via open thoracotomy. Both tumors were eventually diagnosed as pulmonary basaloid carcinoma based on immunohistochemical results positive for AE1/AE3 and negative for Synaptophysin and Chromogranin A. Clinically, the right tumor was deemed a metastasis from the left one, and she was diagnosed with T1bNxM1, p-stage IV. Neither distant metastasis nor local recurrence was noted at the 17<sup>th</sup> postoperative month. Pulmonary basaloid carcinoma has been reported as an uncommon variant of large cell carcinoma, for which the preoperative diagnosis is difficult; however, aggressive surgical resection and close immunohistochemical examination should be performed.
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内分泌療法（アナストロゾール）が奏功した胸水貯留・胸膜転移を伴う転移性進行乳癌の１例 Reviewed
綾部貴典、清水哲哉、富田雅樹、米井彰洋、 鬼塚敏男
宮崎県医師会雑誌 36 35 - 43 2012.3
Language：Japanese Publishing type：Research paper (scientific journal)
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限局性気管支拡張症を呈した35年の経過をもつ気道異物の1例 Reviewed
久保和義、長友安弘、宮内俊一、楠元規生、上野史朗、松本紫朗、綾部貴典、富田雅樹、清水哲哉、岡山昭彦
日本呼吸器内視鏡学会誌 34 ( 3 ) 242 - 245 2012.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Takanori Ayabe, Testuya Shimizu, Masaki Tomita, and Toshio Onitsuka.
Ann. Cancer Res. Therap 20 ( 1 ) 1 - 6 2012.2
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.4993/acrt.20.01
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Preoperative Total Serum Cholesterol and Patients' Survival in Resected Nonsmall Cell Lung Cancer Reviewed
Tomita M., Ayabe T., Shimizu T., and Nakamura K
Lung Cancer International ( 2012 ) 463520 - 4 pages 2012.2
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1155/2012/463520.
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精神健康不全者に対し大学カウンセリング・ルームで奏功した心身医療に他のCAMを加えた統合医療的治療の試み Reviewed
秋坂真史、綾部貴典、山口昌俊、本部暢子、富田賢一、森 憲正、土屋利紀
日本統合医療学会誌 5 49 - 54 2012.2
Language：Japanese Publishing type：Research paper (scientific journal)
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A case of advanced lung cancer treated by surgery followed by adjuvant combination therapy of gefitinib and interleukin-2 lymphokine-activated killer cell immunotherapy. Reviewed
Ayabe T., Shimizu T., Tomita M., Kushima Y., Onitsuka T.
Ann. Cancer Res. Therap. 20 ( 1 ) 11 - 16 2012.2
Language：English Publishing type：Research paper (scientific journal)
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Taknori Ayabe, Tstsuya Shimizu, Masaki Tomita, Masaki Hara, and Toshio Onitsuka.
Ann. Cancer Res. Therap 19 ( 2 ) 62 - 65 2012.2
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.4993/acrt.19.62
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Ayabe T., Shimizu T., Tomita M., Kushima Y., Onitsuka T.
Ann. Cancer Res. Therap. 20 ( 1 ) 11 - 16 2012.2
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.4993/acrt.20.11
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Ayabe T., Shimizu T., Tomita M., Hara M., Yano M., Nakamura K.
Annals of Cancer Research and Therapy 20 ( 1 ) 24 - 31 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Cancer Research and Therapy
In 1999, a 60-year-old female diagnosed with tracheobronchial adenoid cystic carcinoma, was rejected due to the high risk reconstruction surgery of the carina. Our interventional radiological doctor implanted metallic stents for bilateral bronchial stenosis (right: Ultraflex, left: Spiral Z stent) to prevent endobronchial edematous asphyxia during radiation therapy. Radiotherapy showed that the tumor had decreased in size. The migrated right metallic stent was removed but the left one remained because it could not be removed. She had been unevenful for 3 years after the metallic stent implantation. In the 4th year, bronchoscopic balloon dilatation therapy had been performed for the produced dyspnea due to the exuberant granulation once every year for 4 years. The left lung had been destroyed by resuscitate pneumonia, thus we performed a pneumonectomy as salvage surgery using a cardiopulmonary bypass. The postpneumonectomy syndrome, dysphagia and dyspnea had confused her. Bronchoscopic balloon dilatation therapy had been continued for the right single airway stenosis every three months for 2 years. Eventually, she died of respiratory failure due to the recurrence of the disease after 12 years of treatment. We should require use of a silicone stent for the low grade malignancy of tracheobronchial airway stenosis. Eventual open thoracotomic removal should be done for management of the long-term complications of nonremovable metallic stents. © 2012, The Japanese Society of Strategies for Cancer Research and Therapy. All rights reserved.
DOI： 10.4993/acrt.20.24
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A Case of a Bronchial Foreign Body, Undiagnosed for 35 Years, Causing a Focal Bronchiectasia
Kubo Kazuyoshi, Okayama Akihiko, Nagatomo Yasuhiro, Miyauchi Shunichi, Kusumoto Norio, Ueno Shirou, Matsumoto Shiro, Ayabe Takanori, Tomita Masaki, Shimizu Tetsuya
The Journal of the Japan Society for Respiratory Endoscopy 34 ( 3 ) 242 - 245 2012
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society for Respiratory Endoscopy
Background. Bronchial foreign bodies can cause the bronchiectasis. However, a long interval (35 years) from the absorption of a foreign body at age of 5 years old was implicated in the present case. Case. A 40-year-old woman with wet cough and low grade fever was given a diagnosis of bronchiectasis. She was admitted to our hospital in May 2008 because of exacerbation of symptoms. She had right precordial crackles. Computed tomography (CT) showed bronchiectatic changes confined to the right upper lobe. Bronchoscopy revealed stenosis of the right main bronchus, orifice of the right upper lobe bronchus, and right truncus intermedius. The patient underwent right upper lobectomy and tracheobronchoplasty. When the right upper lobe was resected, a plastic body (12 mm in size) was found. Her bronchiectasis was considered caused by bronchial obstruction due to this foreign body. Her symptoms disappeared and her pulmonary function was improved after the surgical treatment. Detailed history taking revealed an episode of a foreign body (a plastic flower) aspiration at age 5. The plastic foreign body was difficult to detect by chest X-ray and CT. Conclusion. This case suggested that an intrabronchial foreign body can cause long-term obstruction of bronchus resulting in atypical bronchiectasis.
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Persistently High Neutrophil to Lymphocyte Ratio after Surgery Indicate Reviewed
Masaki Tomita, Tetsuya Shimizu, Takanori Ayabe, Toshio Onitsuka
Ann. Cancer Res. Therap 19 ( 2 ) 54 - 56 2011.12
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.4993/acrt.19.54
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Tomita M., Shimizu T., Ayabe T., Yonei A., Onitsuka T.
Anticancer Research 31 ( 9 ) 2995 - 2998 2011.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research
Background: The prognostic impact of neutrophil to lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) was examined using patients with a follow-up period more than 5 years. Patients and Methods: Two hundred and eighty four consecutive resected NSCLC patients were reviewed retrospectively. In this study, patients who were treated with a follow-up period less than 5 years were omitted, Results: The mean value of NLR was 2.44±2.22 (range: 0.56-29.44). The 5-year survival of the patients with a high NLR (≥2.5) was significantly worse than that of the patients with a low NLR (47.06% vs. 67.84%, p<0.0001). Univariate analysis of the clinicopathological factors affecting survival revealed that age, gender, histology, pT status, pN status, high serum CEA level, positive findings of pleural lavage cytology and high NLR were significant risk factors for reduced survival. On multivariate analysis, a high NLR was an independent risk factor for reduced survival. Conclusion: A high preoperative NLR may be a convenient biomarker to identify patients with a poor prognosis after resection for NSCLC.
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Preoperative neutrophil to lymphocyte ratio as a prognostic predictor after curative resection for non-small cell lung cancer.
Tomita M, Shimizu T, Ayabe T, Yonei A, Onitsuka T
Anticancer research 31 ( 9 ) 2995 - 8 2011.9
Language：Japanese Publishing type：Research paper (scientific journal)