Papers - AYABE Takanori
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Squamous Cell Carcinoma of the Hilar Lymph Node with Unknown Primary Tumor: A Case Report Reviewed
Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Enomoto Y, and Onitsuka T
Ann Thorac Cardiovasc Surg 14 242 - 245 2008.7
Language：English Publishing type：Research paper (scientific journal)
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MATSUZAKI Yasunori, TOMITA Masaki, SHIMIZU Tetsuya, HARA Masaki, AYABE Takanori, ONITSUKA Toshio
Annals of thoracic and cardiovascular surgery 14 ( 3 ) 161 - 165 2008.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Prognostic impact of thrombocytosis in resectable non-small cell lung cancer
Tomita M, Shimizu T, Hara M, Ayabe T, and Onitsuka T
Interact Cardiovasc Thorac Surg 7 613 - 615 2008.6
Language：English Publishing type：Research paper (scientific journal)
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Matsuzaki Y., Tomita M., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Annals of Thoracic and Cardiovascular Surgery 14 ( 3 ) 161 - 165 2008.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic and Cardiovascular Surgery
Purpose: Despite extensive clinical research, no effective therapy for advanced malignant pleuralmesothelioma has been established. In this study, we induced apoptosis in patients with this disease, using intrapleural perfusion hyperthermo-chemotherapy, a new procedure developed in our surgical department. We then measured the tumorcidal effect. Material and Methods: Our study included 6 consecutive patients with malignant pleural mesothelioma (stage III: 5; stage IV: 1). Because of the advanced stage of the disease, none of the patients underwent tumor resection or pleurectomy. All patients, however, received perfusion treatment. Tumor cells collected from pleural effusions pre- and at 0, 24, and 48 h postperfusion were examined using an immunocytochemical stain to determine apoptosis. The percentage of positively stained cells was expressed as the apoptotic index. Results: Preperfusion, the apoptotic index was 3.8% ± 2.0%, indicating spontaneous apoptosis of untreated tumor cells. Postperfusion, the apoptotic index at 0, 24, and 48 h was 22.8% ± 5.15%, 63.8% ± 8.2%, and 47.8% ± 6.9%, respectively. The patients had a median survival time of 30 months. No patient morbidity was associated with the perfusion treatment. Conclusion: In patients with malignant pleural mesothelioma, intrapleural perfusion hyperthermo-chemotherapy induced potent apoptosis of tumor cells, increasing immediately postperfusion and peaking at 24 h. (Ann Thorac Cardiovasc Surg 2008; 14: 161-165).
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Induction of apoptosis by intrapleural perfusion hyperthermo-chemotherapy for malignant pleural mesothelioma.
Matsuzaki Y, Tomita M, Shimizu T, Hara M, Ayabe T, Onitsuka T
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 14 ( 3 ) 161 - 5 2008.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Impact of Preoperative Hemoglobin Level on Survival of Non-small Cell Lung Cancer Patients
Tomita M, Shimizu T, Hara M, Ayabe T, and Onitsuka T
Anticancer Research 28 1947 - 1950 2008.5
Language：English Publishing type：Research paper (scientific journal)
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Impact of preoperative hemoglobin level on survival of non-small cell lung cancer patients
Tomita M., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Anticancer Research 28 ( 3 B ) 1947 - 1950 2008.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research
Background: Only a few studies have reported any prognostic impact of the preoperative hemoglobin level itself in resectable non-small cell lung cancer (NSCLC). The survival impact of preoperative hemoglobin level and the relationship between hemoglobin and serum CEA level were investigated. Patients and Methods: Two hundred and forty consecutive NSCLC patients were reviewed retrospectively. Results: The 5-year survival of patients with low and those with a normal hemoglobin level was 42.99% and 73.47%, respectively. Both univariate and multivariate analyses indicated the independent prognostic impact of the hemoglobin level. The result for stage I patients was identical. Patients with normal hemoglobin could be subdivided into 2 groups based on their serum CEA level; the 5-year survival of patients with normal and those with elevated CEA was 81.72% and 57.24%, respectively. Conclusion: The preoperative hemoglobin level was a prognostic factor for NSCLC patients. The combined use of hemoglobin and CEA levels might be useful to predict the prognosis of patients.
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Impact of preoperative hemoglobin level on survival of non-small cell lung cancer patients.
Tomita M, Shimizu T, Hara M, Ayabe T, Onitsuka T
Anticancer research 28 ( 3B ) 1947 - 50 2008.5
Language：Japanese Publishing type：Research paper (scientific journal)
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DP-067-6 非小細胞肺癌切除例において血中CRP値は独立予後因子である(第108回日本外科学会定期学術集会)
原 政樹, 松崎 泰憲, 清水 哲哉, 富田 雅樹, 綾部 貴典, 仙波 速見, 鬼塚 敏男
日本外科学会雑誌 109 ( 2 ) 2008.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人日本外科学会
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Induction of apoptosis by intrapleural perfusion hyperthermo-chemotherapy for malignant pleural mesothelioma Reviewed
Matsuzaki Y, Tomita M, Shimizu T, Hara M, Ayabe T, and Onitsuka T
Ann Thorac Cardiovasc Surg 14 161 - 165 2008.4
Language：English Publishing type：Research paper (scientific journal)
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Preoperative Peripheral Naive / Memory Ratio and Prognosis of Nonsmall-Cell Lung Cancer Patients
HARA Masaki, MATSUZAKI Yasunori, SHIMIZU Tetsuya, TOMITA Masaki, AYABE Takanori, ENOMOTO Yusuke, ONITSUKA Toshio
Annals of thoracic and cardiovascular surgery 13 ( 6 ) 384 - 390 2007.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Preoperative peripheral naïve / memory ratio and prognosis of nonsmall-cell lung cancer patients.
Hara M, Matsuzaki Y, Shimizu T, Tomita M, Ayabe T, Enomoto Y, Onitsuka T
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 13 ( 6 ) 384 - 90 2007.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Preoperative peripheral naïve/memory ratio and prognosis of nonsmall-cell lung cancer patients
Hara M., Matsuzaki Y., Shimizu T., Tomita M., Ayabe T., Enomoto Y., Onitsuka T.
Annals of Thoracic and Cardiovascular Surgery 13 ( 6 ) 384 - 390 2007.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Annals of Thoracic and Cardiovascular Surgery
Purpose: This study focused on the relationship between preoperative peripheral blood CD4 + naïve/memory ratio and prognosis following surgery for patients with nonsmall-cell lung cancer. Methods: After measuring CD3, CD4, CD8, CD45RA, CD45RO, CD25, and intracellular CTLA4 levels, CD4 + naïve/memory ratios were determined for 13 controls and 38 patients. Results: Although we observed no significant difference in the ratios, the patients exhibited a wider range of values than the controls. Of the 38 patients, 24 subsequently underwent surgery and were divided into three groups based on their preoperative CD4 + naïve/memory ratio: Group I: <0.3; Group II: 0.3-0.8; and Group III: >0.8. Survival times were then evaluated. Group II survival was significantly better than Groups I and III. Conclusion: Our data suggest that the preoperative CD4 + naïve/memory ratio may serve as a prognostic factor for nonsmall-cell lung cancer patients.
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縦隔鏡下生検を施行した非小細胞肺癌46症例の検討. Reviewed
綾部貴典、松崎泰憲、清水哲哉、原 政樹、富田雅樹、鬼塚敏男
宮崎県医師会医学会会誌 31 21 - 28 2007.8
Language：Japanese Publishing type：Research paper (scientific journal)
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Preoperative serum C-reactive protein level in non-small cell lung cancer
Hara M., Matsuzaki Y., Shimuzu T., Tomita M., Ayabe T., Enomoto Y., Onitsuka T.
Anticancer Research 27 ( 4 C ) 3001 - 3004 2007.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research
We evaluated the significance of the preoperative serum C-reactive protein (CRP) level as a prognostic indicator in patients with non-small cell lung cancer (NSCLC). Patients and Methods: Two hundred and three patients who had undergone a curative resection of NSCLC were retrospectively reviewed. Results: The proportion of the tumor size over 3 cm per patient in the CRP-positive group (≥0.5 mg/dL: n=38) was significantly higher than that in the CRP-negative group (<0.5 mg/dL: n=165). The proportion of the adenocarcinoma in CRP-positive group was significantly lower than that in CRP-negative group. The overall and disease specific survival rates in the CRP-positive group were significantly lower than the rates in the CRP-negative group. Based on a multivariate analysis, the preoperative serum CRP level was selected as one of the unfavorable indicators regarding survival. Conclusion: The preoperative serum CRP level is an independent and significant indicator predictive of a poor prognosis in patients with NSCLC.
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Preoperative serum C-reactive protein level in non-small cell lung cancer.
Hara M, Matsuzaki Y, Shimuzu T, Tomita M, Ayabe T, Enomoto Y, Onitsuka T
Anticancer research 27 ( 4C ) 3001 - 4 2007.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Retrograde tube drainage for esophageal anastomotic leaks and perforation
Tomita M., Matsuzaki Y., Shimizu T., Hara M., Ayabe T., Onitsuka T.
Diseases of the Esophagus 20 ( 3 ) 247 - 250 2007.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Diseases of the Esophagus
The mortality and morbidity of esophageal anastomotic leaks or perforations remain high. We performed retrograde transanastomotic esophageal sump tube drainages for esophageal anastomotic leak or perforation in three patients. Our method is a modified procedure of the T-tube drainage. The Levin gastric tube was simply inserted into the esophagus via anastomotic leak or perforation to develop a defined fistula. All three patients were treated with a satisfactory outcome. An advantage of this method is that it is technically easy, and available for patients whose diseases are difficult to treat with standard T-tube drainage. In addition, one of our patients was successfully managed non-operatively by fluoroscopical guidance. This retrograde esophageal sump tube drainage was technically very easy, safe and useful for esophageal anastomotic leaks or perforations. © 2007 The Authors Journal compilation © 2007 The International Society for Diseases of the Esophagus.
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18FDG-PETで高度の集積を認めた炎症性筋線維芽細胞腫の1例. Reviewed
今井光一、芦谷淳一、小玉剛士、京楽由佳、佐野ありさ、松元信弘、中里雅光、綾部貴典、松崎泰憲、鬼塚敏男、山下 篤
日本胸部臨床 66 259 - 263 2007.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Inflammatory myofibroblastic tumor detected by positron emission tomography
Imai K., Ashitani J., Kodama T., Kyoraku Y., Sano A., Matsumoto N., Nakazato M., Ayabe T., Matsuzaki Y., Onitsuka T., Yamashita A.
Japanese Journal of Chest Diseases 66 ( 3 ) 259 - 263 2007.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Chest Diseases
A 33 year-old female was admitted to our hospital with a pulmonary nodule in the right upper lung field. Examinations including bronchofiberscopy revealed no clear diagnosis. Because of strongly positive detection by positron emission tomography, the nodule was removed surgically and diagnosed as inflammatory myofibroblastic tumor pathologically.
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Preoperative serum C-reactive protein level in non-small cell lung cancer. Reviewed
Hara M., Matsuzaki Y., Shimizu T., Tomita M., Ayabe T., Enomoto Y., Onitsuka T.
Anticancer Research 27 ( 4C ) 3001 - 3004 2007.4
Language：English Publishing type：Research paper (scientific journal)