Papers - AYABE Takanori
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Tomita M., Ayabe T., Maeda R., Nakamura K.
In Vivo 32 ( 3 ) 663 - 667 2018.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：In Vivo
Background: The systemic immune-inflammation index (SII) is reported to be associated with clinical outcomes and has been proven to be a promising prognostic indicator in several solid tumor types. To the best of our knowledge, however, no studies regarding SII in patients with resectable non-small cell lung cancer (NSCLC) are available. Materials and Methods: Three hundred forty-one patients with NSCLC who underwent surgery at our Institution between 2008 and 2012 were included. The SII was calculated using the formula: platelet count × neutrophil/lymphocyte count. The optimal cutoff value was calculated using the Cutoff Finder (http://molpath.charite.de/cutoff). Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model. Results: The optimal cut-off value was 471.2×109/l for SII. A low SII was associated with female gender, never smoking status, adenocarcinoma histology, higher pathological TNM stage and low level of serum C-reactive protein, but not age, serum carcinoembryonic antigen or cytokeratin 19 fragment level. Patients of the low SII group had a significantly better 5-year overall survival than those with high SII (83.61% vs. 60.39%, p<0.001). Multivariate analysis revealed that the SII was a significant independent predictive indicator for cancer-specific survival (p=0.007). Conclusion: This is the first study to demonstrate that the SII could represent an independent prognostic factor for patients with resectable NSCLC.
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Tomita M., Ayabe T., Nakamura K.
Interactive CardioVascular and Thoracic Surgery 26 ( 2 ) 288 - 292 2018.2
Language：English Publishing type：Research paper (scientific journal)
© 2017 The Author. OBJECTIVES The usefulness of a recently developed advanced lung cancer inflammation index (ALI) has been reported in advanced non-small-cell lung cancer (NSCLC) and small-cell lung cancer. However, no previous studies have examined the prognostic significance of ALI in patients with operable NSCLC. Therefore, the aim of this study was to explore the relationship between ALI and the prognosis of resected NSCLC. METHODS Three hundred and forty-three patients with NSCLC who underwent surgery at our institution between 2008 and 2012 were included. The ALI score was calculated as body mass index × serum albumin/neutrophil to lymphocyte ratio. A Web-based software programme [Cutoff Finder (http://molpath.charite.de/cutoff/)] was used to determine the optimal cut-off value for ALI. The Kaplan-Meier methods and a multivariable Cox proportional hazards model were used to evaluate the potential prognostic factors. RESULTS The optimal cut-off value of ALI was defined as 37.66. The low-ALI group (ALI < 37.66) displayed more adverse clinical characteristics. Furthermore, compared with patients in the high-ALI group (ALI > 37.66), those in the low-ALI group had significantly poorer survival rates. On multivariable analysis, gender, histological diagnosis, pN status, serum carcinoembryonic antigen level, serum C-reactive protein level and ALI were associated independently with cancer-specific survival. CONCLUSIONS This study is the first to investigate whether ALI is useful for predicting postoperative survival in patients with NSCLC. Preoperative ALI might serve as a potentially clinically valuable marker of the prognosis for patients with operable NSCLC.
DOI： 10.1093/icvts/ivx329
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Tomita M., Ayabe T., Nakamura K.
Interactive Cardiovascular and Thoracic Surgery 26 ( 2 ) 288 - 292 2018.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Interactive Cardiovascular and Thoracic Surgery
© 2017 The Author. OBJECTIVES The usefulness of a recently developed advanced lung cancer inflammation index (ALI) has been reported in advanced non-small-cell lung cancer (NSCLC) and small-cell lung cancer. However, no previous studies have examined the prognostic significance of ALI in patients with operable NSCLC. Therefore, the aim of this study was to explore the relationship between ALI and the prognosis of resected NSCLC. METHODS Three hundred and forty-three patients with NSCLC who underwent surgery at our institution between 2008 and 2012 were included. The ALI score was calculated as body mass index × serum albumin/neutrophil to lymphocyte ratio. A Web-based software programme [Cutoff Finder (http://molpath.charite.de/cutoff/)] was used to determine the optimal cut-off value for ALI. The Kaplan-Meier methods and a multivariable Cox proportional hazards model were used to evaluate the potential prognostic factors. RESULTS The optimal cut-off value of ALI was defined as 37.66. The low-ALI group (ALI < 37.66) displayed more adverse clinical characteristics. Furthermore, compared with patients in the high-ALI group (ALI > 37.66), those in the low-ALI group had significantly poorer survival rates. On multivariable analysis, gender, histological diagnosis, pN status, serum carcinoembryonic antigen level, serum C-reactive protein level and ALI were associated independently with cancer-specific survival. CONCLUSIONS This study is the first to investigate whether ALI is useful for predicting postoperative survival in patients with NSCLC. Preoperative ALI might serve as a potentially clinically valuable marker of the prognosis for patients with operable NSCLC.
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Tomita M., Ayabe T., Nakamura K.
Asian Pacific Journal of Cancer Prevention 18 ( 12 ) 3353 - 3356 2017.12
Language：English Publishing type：Research paper (scientific journal)
Background: The effect of body mass index (BMI) on postoperative survival in non-small cell lung cancer (NSCLC) has been controversial. We retrospectively analysed the effect of preoperative BMI on postoperative outcomes of NSCLC surgery. Methods: Consecutive 384 NSCLC patients were enrolled. Patients were subdivided into 3 groups: low BMI group (BMI < 18.5 kg/m2), normal BMI group (BMI=18.5-24.0 kg/m2) and high BMI group (BMI > 24.0 kg/m2). The prognostic significance of BMI was examined retrospectively. Results: The 5-year survival of patients with low, normal and high BMI groups were 46.3%, 74.3% and 84.3%, respectively. The low BMI group had a poorer prognosis than the other groups (p < 0.001). The survival of high BMI group had a more favorable trend than that of normal BMI group, but this did not reach statistical significance (p=0.057). On multivariate analysis, significant risk factors for cancer-specific survival were male gender (p=0.0061), non-adenocarcinoma histology (p=0.0003), pN1-2 status (p=0.0007), high serum CEA level (p < 0.0001) and low BMI (low vs. others: p < 0.0001). Conclusions: Preoperative BMI is an independent prognostic factor for NSCLC patients after surgical resection, with low BMI patients having an unfavorable prognosis.
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Tomita M., Ayabe T., Nakamura K.
Asian Pacific Journal of Cancer Prevention 18 ( 12 ) 3353 - 3356 2017.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asian Pacific Journal of Cancer Prevention
Background: The effect of body mass index (BMI) on postoperative survival in non-small cell lung cancer (NSCLC) has been controversial. We retrospectively analysed the effect of preoperative BMI on postoperative outcomes of NSCLC surgery. Methods: Consecutive 384 NSCLC patients were enrolled. Patients were subdivided into 3 groups: low BMI group (BMI < 18.5 kg/m2), normal BMI group (BMI=18.5-24.0 kg/m2) and high BMI group (BMI > 24.0 kg/m2). The prognostic significance of BMI was examined retrospectively. Results: The 5-year survival of patients with low, normal and high BMI groups were 46.3%, 74.3% and 84.3%, respectively. The low BMI group had a poorer prognosis than the other groups (p < 0.001). The survival of high BMI group had a more favorable trend than that of normal BMI group, but this did not reach statistical significance (p=0.057). On multivariate analysis, significant risk factors for cancer-specific survival were male gender (p=0.0061), non-adenocarcinoma histology (p=0.0003), pN1-2 status (p=0.0007), high serum CEA level (p < 0.0001) and low BMI (low vs. others: p < 0.0001). Conclusions: Preoperative BMI is an independent prognostic factor for NSCLC patients after surgical resection, with low BMI patients having an unfavorable prognosis.
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Combination of Advanced Lung Cancer Inflammation Index and C-Reactive Protein Is a Prognostic Factor in Patients With Operable Non-Small Cell Lung Cancer.
Tomita M, Ayabe T, Maeda R, Nakamura K
World journal of oncology 8 ( 6 ) 175 - 179 2017.12
Language：Japanese Publishing type：Research paper (scientific journal)
DOI： 10.14740/wjon1076w
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Combination of Advanced Lung Cancer Inflammation Index and C-Reactive Protein Is a Prognostic Factor in Patients With Operable Non-Small Cell Lung Cancer.
Tomita M, Ayabe T, Maeda R, Nakamura K
World journal of oncology 8 ( 6 ) 175 - 179 2017.12
Language：Japanese Publishing type：Research paper (scientific journal)
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2016年の宮崎県における呼吸器外科手術の現状報告 Reviewed
富田雅樹、綾部貴典、別府樹一郎、市成秀樹、能勢直弘、枝川正雄、巻幡聡、森山裕一、中村都英
宮崎県医師会医学会誌 41 154 - 158 2017.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Unexpected Postoperative Paraplegia after Thoracotomy in Lung Cancer: Incidental Migration of Oxidized Regenerated Cellulose Used for Hemostasis of Intercostal Space Bleeding Reviewed
Takanori Ayabe, Masaki Tomita, Shigeko Shimizu, Etsuko Yokoyama, Manabu Okumura, Koichiro Itai, Kunihide Nakamura
Surgical Science 8 365 - 374 2017.8
Language：English Publishing type：Research paper (scientific journal)
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Influence of smoking status and mass body index on serum carcinoembryonic antigen concentration in patients with thoracic disease. Reviewed
Tomita, M., Ayabe, T., Tsuchiya, K. and Nakamura, K.
Surgical Science 8 279 - 286 2017.7
Language：English Publishing type：Research paper (scientific journal)
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Patient-Reported Outcomes of Chemotherapy Involving Non Small Cell Lung Cancer: Evaluation by Questionnaires of Quality of Life Regarding Anti-Aging and Anti-Cancer Drugs. Advances in Lung Cancer Reviewed
Ayabe, T., Tomita, M., Asada, T., Tsuchiya, K., Nemoto, M. and Nakamura, K.
Advances in Lung Cancer 6 13 - 35 2017.6
Language：English Publishing type：Research paper (scientific journal)
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Does Obesity-Related Hemodilution of Carcinoembryonic Antigen Exist in Non-Small Cell Lung Cancer Patients?
Tomita M, Ayabe T, Nakamura K
World journal of oncology 8 ( 2 ) 41 - 44 2017.5
Language：Japanese Publishing type：Research paper (scientific journal)
DOI： 10.14740/wjon1026w
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Patient-Reported Outcomes of Surgery of Non-Small Cell Lung Cancer: Evaluation Based on the Questionnaires of Anti-Aging Quality of Life and the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Reviewed
Ayabe, T., Tomita, M., Nose, N., Asada, T. and Nakamura, K.
Surgical Science 8 203 - 219 2017.4
Language：English Publishing type：Research paper (scientific journal)
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Tomita M., Ayabe T., Chosa E., Nose N., Nakamura K.
Asian Pacific Journal of Cancer Prevention 18 ( 1 ) 287 - 291 2017.4
Language：English Publishing type：Research paper (scientific journal)
Background: We retrospectively analysed the prognostic significance of a tumor marker index (TMI) based on preoperative serum carcinoembryonic antigen (CEA) and Krebs von den Lungen-6 (KL-6) levels in nonsmall cell lung cancer (NSCLC) patients. Materials and Methods: We enrolled 176 NSCLC patients who had preoperative serum CEA and KL-6 level measurements and had undergone curative surgery between 2009 and 2011. Results: The 5-year disease-specific survival of patients with high serum CEA levels was significantly poorer compared with that of patients with normal levels. The value for patients with high serum KL-6 levels was also poor. Patients with both normal serum CEA and KL-6 levels had a favourable prognosis, whereas those with both high serum CEA and KL-6 levels had a poor outcome. The5-year disease-specific survival rate was 82.9% for patients in the low TMI group compared to 47.5% in the high TMI group (p < 0.01). Both univariate and multivariate analyses revealed prognostic significance for TMI. Conclusions: TMI based on preoperative serum CEA and KL-6 levels might be useful for the prediction of the prognosis of NSCLC patients.
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Thymoma (World Health Organization type B3) with neuroendocrine differentiation in multiple endocrine neoplasia type 1 Reviewed
Tomita M, Ichiki N, Ayabe T, Tanaka H, Kataoka H, Nakamura K
Journal of Surgical Case Reports 4 1 - 3 2017.4
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1093/jscr/rjx071
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Preoperative Serum Krebs Von Den Lungen-6 and Surfactant Protein-D Levels in Non-Small Cell Lung Cancer Patients with Interstitial Pneumonia Reviewed
Tomita, M., Ayabe, T., Chosa, E., Asada, T., Tsuchiya, K. and Nakamura, K.
Open Journal of Thoracic Surgery 7 1 - 7 2017.4
Language：English Publishing type：Research paper (scientific journal)
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Does Obesity-Related Hemodilution of Carcinoembryonic Antigen Exist in Non-Small Cell Lung Cancer Patients?
Tomita M, Ayabe T, Nakamura K
World journal of oncology 8 ( 2 ) 41 - 44 2017.4
Language：Japanese Publishing type：Research paper (scientific journal)
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Thymoma (World Health Organization type B3) with neuroendocrine differentiation in multiple endocrine neoplasia type 1.
Tomita M, Ichiki N, Ayabe T, Tanaka H, Kataoka H, Nakamura K
Journal of surgical case reports 2017 ( 4 ) rjx071 2017.4
Language：Japanese Publishing type：Research paper (scientific journal)
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Changes in Safety Attitude and Improvement of Multidisciplinary Teamwork by Implementation of the WHO Surgical Safety Checklist in University Hospital Reviewed
Ayabe, T., Shinpuku, G., Tomita, M., Nakamura, S., Yokoyama, E., Shimizu, S., Okumura, M., Itai, K., Tsuneyoshi, I., Takeshima, H., and Nakamura, K.
Open Journal of Safety Science and Technology 7 22 - 41 2017.2
Language：English Publishing type：Research paper (scientific journal)
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Tomita M., Ayabe T., Chosa E., Nose N., Nakamura K.
Asian Pacific Journal of Cancer Prevention 18 ( 1 ) 287 - 291 2017
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Asian Pacific Journal of Cancer Prevention
Background: We retrospectively analysed the prognostic significance of a tumor marker index (TMI) based on preoperative serum carcinoembryonic antigen (CEA) and Krebs von den Lungen-6 (KL-6) levels in nonsmall cell lung cancer (NSCLC) patients. Materials and Methods: We enrolled 176 NSCLC patients who had preoperative serum CEA and KL-6 level measurements and had undergone curative surgery between 2009 and 2011. Results: The 5-year disease-specific survival of patients with high serum CEA levels was significantly poorer compared with that of patients with normal levels. The value for patients with high serum KL-6 levels was also poor. Patients with both normal serum CEA and KL-6 levels had a favourable prognosis, whereas those with both high serum CEA and KL-6 levels had a poor outcome. The5-year disease-specific survival rate was 82.9% for patients in the low TMI group compared to 47.5% in the high TMI group (p < 0.01). Both univariate and multivariate analyses revealed prognostic significance for TMI. Conclusions: TMI based on preoperative serum CEA and KL-6 levels might be useful for the prediction of the prognosis of NSCLC patients.