MISC - NISHITOH Hideki
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The Role of Zinc and ER Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis
TSUBURAYA Naomi, HOMMA Kengo, NISHITOH Hideki, ICHIJO Hidenori
Biomedical research on trace elements 23 ( 1 ) 14 - 23 2012.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：日本微量元素学会
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西頭 英起
助成研究報告集 44 2012
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：病態代謝研究会
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西頭 英起
助成研究報告集 44 ( 0 ) 2012
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：病態代謝研究会
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The Role of Zinc and ER Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis
Tsuburaya Naomi, Homma Kengo, Nishitoh Hideki, Ichijo Hidenori
Biomedical Research on Trace Elements 23 ( 1 ) 14 - 23 2012
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：Japan Society for Biomedical Research on Trace Elements
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the selective loss of upper and lower motoneurons. Approximately 10% of all ALS cases are genetically inherited, and a mutation in the Cu, Zn superoxide dismutase (SOD1) gene is thought to be a cause of motoneuron dysfunction. Importantly, the motoneuron toxicity appears to result from a toxic gain-of-function mutation in SOD1 and not from the loss of superoxide dismutase activity. Transgenic mice overexpressing several types of SOD1 mutant show the ALS-like phenotype and are widely accepted as animal models of ALS. However, no common toxic mechanism has been identified among these SOD1 mutants. Studies using autopsies of ALS patients or model mouse have suggested multiple causes of ALS including oxidative stress, mitochondrial dysfunction, excitotoxicity, neurofilaments abnormality and protein aggregation. Endoplasmic reticulum (ER) stress mediated motoneuron death is also suggested to be included in the pathogenesis of ALS. ALS-related mutant SOD1 evokes ER stress through the specific interaction with Derlin-1, a component of ER associated degradation (ERAD) machinery, leading to the subsequent motoneuron death. Zinc plays an important role in the function of nervous system and its dyshomeostasis is also thought to be one of the causes of ALS. In fact, zinc accumulation is observed in the brains and the spinal cords of mutant SOD1 transgenic mice. Moreover, zinc chelation extends the life span of these mise. There seems to be relationships between zinc dysregulation and several pathogenic processes of ALS. In this review, we will focus on the pathological role of ER stress and zinc in ALS.
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Apoptosis signaling kinases: from stress response to health outcomes（共著）
Kohsuke Takeda, Isao Naguro, Hideki Nishitoh, Atsushi Matsuzawa, Hidenori Ichijo
Antioxidants & Redox Signaling 15 ( 3 ) 719 - 761 2011.8
Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：Antioxidants & Redox Signaling
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西頭 英起
医科学応用研究財団研究報告 29 302 - 305 2010
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：鈴木謙三記念医科学応用研究財団
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[Molecular mechanisms of ALS-linked mutant SOD1-induced motor neuron death].
Nishitoh H, Ichijo H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54 ( 3 ) 237 - 244 2009.3
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：3
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[Molecular mechanisms of ER stress-induced apoptosis]
Nishitoh H, Ichijo H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 49 ( 7 Suppl ) 1006 - 1009 2004.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：7 Suppl
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小胞体ストレス誘導性アポトーシスの分子機構 (細胞における 蛋白質の一生--生成・成熟・輸送・管理・分解・病態) -- (蛋白質の品質管理)
西頭英起, 一條秀憲
蛋白質核酸酵素 49 ( 7 ) 1006 - 1009 2004.5
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：共立出版
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基礎 アポトーシスとシグナル伝達 (特集 シグナル伝達の基礎と臨床応用)
門脇寿枝, 一條秀憲, 西頭英起
現代医療 35 ( 12 ) 2835 - 2843 2003.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：現代医療社
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ASK1を介した小胞体ストレスによるJNK活性化ならびにアポトーシスの分子機構
西頭英起
歯科基礎医学会雑誌 45 ( 5 ) 2003.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会
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公田有子, 西頭英起, 一條秀憲
歯科基礎医学会雑誌 44 ( 5 ) 2002.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会
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マウスApoptosis Signal-regulating Kinase(ASK)2の遺伝子構造解析
邊見麻希, 飛梅圭, 畑井多喜子, 西頭英起, 武田弘資, 大山紀美栄, 一條秀憲
歯科基礎医学会雑誌 44 ( 5 ) 2002.9
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会
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MAPキナーゼを介した小胞体ストレス誘導性アポトーシスのメカニズム (特集 小胞体ストレスとアポトーシス:オルガネラから発信される新たな死のシグナル)
西頭英起
細胞工学 21 ( 4 ) 377 - 381 2002.4
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：秀潤社
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Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
西頭 英起
Antioxid Redox Signal. 4(3):415-25. 2002
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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西頭英起, 一條秀憲
口腔病学会雑誌 68 ( 4 ) 2001.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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482 インフルエンザウイルス(IV)感染によるASK1/MAP kinase活性化機構の解析
丸岡秀一郎, 橋本修, 水村賢司, 権寧博, 浅井保清, 清水一史, 西頭英起, 一條秀憲, 堀江孝至
アレルギー 50 ( 9 ) 2001.10
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：日本アレルギー学会
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Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.
西頭 英起
Cancer Res. 61(14):5432-40. 2001
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution)
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ストレスシグナルにおけるApoptosis Signal-Regulating Kinase(ASK)1の活性化機構の解明
西頭英起, 一條秀憲
歯科基礎医学会雑誌 42 ( 5 ) 2000.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会
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ASK1-MAPキナーゼ系によるアポトーシスシグナルの制御機構
一條秀憲, 西頭英起, 武田弘資
歯科基礎医学会雑誌 42 ( 5 ) 2000.8
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (bulletin of university, research institution) Publisher：歯科基礎医学会