論文 - 山口 奈美
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Clinical backgrounds and outcomes of patients with Barrett's esophageal adenocarcinoma treated via endoscopic submucosal dissection in Kyushu, Japan: A retrospective multicenter cohort study. 査読あり
Sasaki F, Mizukami K, Akashi T, Yamaguchi N, Gushima R, Miyamoto H, Uehara S, Ono Y, Hisabe T, Kinjo Y, Nasu Y, Fukuda K, Inada T, Sumida Y, Akutagawa T, Miike T, Suzuki S, Fukuya H, Mukasa M, Esaki M, Kumei S, Minoda Y, Kinjo T, Yamaguchi D, Fukuda Y, Hashiguchi K, Yano H, Fujita H, Shimoda R, GI‐Kysuhu study group
DEN open 6 ( 1 ) e70102 2026年4月
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悪性腫瘍と鑑別を要した原発性結核膿瘍の1例 査読あり
鮫島 勇汰, 大田 智美, 田島 卓也, 山口 奈美, 長澤 誠, 森田 雄大, 横江 琢示, 土屋 慧祐, 帖佐 悦男, 亀井 直輔
整形外科と災害外科 74 ( 4 ) 827 - 830 2025年9月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：西日本整形・災害外科学会
【はじめに】転移性結核膿瘍の報告は散見されるが，原発病変のない結核膿瘍は稀である．悪性腫瘍と鑑別を要した原発性結核膿瘍の1例を経験したので報告する．【症例】73歳男性．誘因なく背部腫瘤を自覚し，MRIで背部皮下に8×7 cm大で中心部T2 high，T1 low，辺縁部T2 high，lowが混在し，一部胸腔内に浸潤した腫瘤を認めた．PETCTでも腫瘤に高度集積あり，悪性軟部腫瘍を疑った．切開生検術の際，多量の排膿あり，培養で<i>M. tuberculosis</i>が同定され，結核膿瘍の診断となった．INH，RFP，EB，PZAの内服を12か月継続し，現在再発は認めていない．【考察】原発巣のない結核膿瘍は非常に稀であり，炎症で見られる疼痛・発赤・熱感に乏しいことが多く，画像上も悪性腫瘍を疑ったため，排膿を確認するまで結核膿瘍を疑えなかった症例である．結核膿瘍の診断について，文献的考察を加え報告する．
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ハムストリング近位部損傷における当科での2例の手術経験 査読あり
土屋 慧祐, 森田 雄大, 田島 卓也, 山口 奈美, 大田 智美, 長澤 誠, 横江 琢示, 帖佐 悦男, 亀井 直輔
整形外科と災害外科 74 ( 3 ) 634 - 636 2025年9月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：西日本整形・災害外科学会
【はじめに】ハムストリングの肉ばなれはスポーツ外傷において比較的頻繁に経験するが，手術に至るケースは稀である．今回，ハムストリング腱近位部損傷において手術加療を要した2例を経験したので報告する．【症例1】22歳男性，実業団柔道選手．練習中に強制開脚位となり受傷．MRIにて大腿二頭筋腱，半腱様筋腱の坐骨結節からの断裂（JISS分類：3型3度）と診断し手術を施行した．術後6か月で競技復帰し経過良好であった．【症例2】17歳男性，走高跳選手．跳躍時に踏み込んだ際に左臀部痛自覚．MRIにて大腿二頭筋腱損傷（JISS分類：2型3度）と診断し手術施行した．術後3か月で競技復帰し経過良好であった．【考察】スポーツ選手においてハムストリング腱の3型3度損傷は絶対的手術適応であるが，2型損傷においても手術加療を選択する場合がある．今回，2型，3型損傷に対して手術加療を行い，再損傷なく元のレベルに競技復帰可能であり良好な成績を得た．
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Impact of lymph-node dissection during radical cystectomy for non-muscle-invasive bladder cancer: Japanese multicenter retrospective study. 査読あり
Sazuka T, Taoka R, Miki J, Saito R, Fukuokaya W, Matsui Y, Hatakeyama S, Kawahara T, Matsuda A, Kawai T, Kato M, Sano T, Urabe F, Kashima S, Naito H, Murakami Y, Miyake M, Daizumoto K, Matsushita Y, Hayashi T, Inokuchi J, Sugino Y, Shiga K, Yamaguchi N, Yamamoto S, Yasue K, Abe T, Nakanishi S, Hashine K, Sawada A, Nishihara K, Matsumoto H, Tatarano S, Wada K, Sekito S, Maruyama R, Nishiyama N, Nishiyama H, Kitamura H, Ichikawa T, Japan Urological Oncology Group
International journal of clinical oncology 2025年5月
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Effects of the Number of Neoadjuvant Cycles and Addition of Adjuvant Chemotherapy on the Prognosis of Muscle-Invasive Bladder Cancer Treated With Radical Cystectomy. 査読あり
Hatakeyama S, Taoka R, Miki J, Saito R, Fukuokaya W, Matsui Y, Kawahara T, Matsuda A, Kawai T, Kato M, Sazuka T, Sano T, Urabe F, Kashima S, Naito H, Murakami Y, Miyake M, Daizumoto K, Matsushita Y, Hayashi T, Inokuchi J, Sugino Y, Shiga KI, Yamaguchi N, Taguchi M, Yasue K, Abe T, Nakanishi S, Hashine K, Fujii M, Nishihara K, Matsumoto H, Tatarano S, Wada K, Sekito S, Maruyama R, Nishiyama N, Nishiyama H, Kitamura H, Ohyama C, Japanese Urological Oncology Group
Cancer medicine 14 ( 9 ) e70782 2025年5月
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Stage III substaging and outcomes in patients with bladder cancer undergoing radical cystectomy. 査読あり
Hara S, Fukuokaya W, Miki J, Taoka R, Saito R, Matsui Y, Hatakeyama S, Kawahara T, Matsuda A, Kawai T, Kato M, Sazuka T, Sano T, Urabe F, Kashima S, Naito H, Murakami Y, Miyake M, Daizumoto K, Matsushita Y, Hayashi T, Inokuchi J, Sugino Y, Shiga K, Yamaguchi N, Yamamoto S, Yasue K, Abe T, Nakanishi S, Hashine K, Fujii M, Nishihara K, Matsumoto H, Tatarano S, Wada K, Sekito S, Maruyama R, Nishiyama N, Nishiyama H, Kitamura H, Kimura T, Japan Urological Oncology Group
International journal of urology : official journal of the Japanese Urological Association 32 ( 5 ) 544 - 552 2025年5月
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Patient Preferences for Post-Radical Cystectomy Treatment in Muscle-Invasive Bladder Cancer: A Discrete Choice Experiment in Japan. 査読あり
Yajima S, Hata S, Masumori N, Matsuoka Y, Sawada A, Miki J, Tambo M, Kobayashi Y, Matsuda A, Nakane K, Kobayashi T, Tanaka H, Yamaguchi N, Kaneko G, Miller R, Seto T, Ito H, Kikuchi E
International journal of urology : official journal of the Japanese Urological Association 2025年3月
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Yokoe T., Yang F., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Foot and Ankle Surgery 31 ( 1 ) 20 - 24 2025年1月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Foot and Ankle Surgery
Background: This study aimed to investigate ankle syndesmosis in healthy subjects under non-weight bearing (NWB) and weight bearing (WB) conditions using two US methods. Methods: The anterior tibiofibular clear space (ATFCS) was measured in healthy subjects in NWB and WB conditions using two US procedures. Method 1 measured 10 mm above the ankle joint and Method 2 measured 30° from the line of 10 mm above the ankle joint. Results: A total of 60 ankles from 30 subjects (male/female, 15/15) were included. There was a significant difference in the ATFCS between the two US methods (p < 0.001), and Method 2 was better at detecting the change in diastasis from NWB to WB conditions. The ATFCS was significantly greater on WB than on NWB, irrespective of the US method. Conclusions: Method 2 was better at detecting diastasis of the syndesmosis from NWB to WB conditions. The influence of WB needs to be considered when evaluating syndesmosis using US. Level of evidence: Cross-sectional cohort study; Level of evidence, Ⅳ
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Direct repair of the chronic ochronotic Achilles tendon rupture: a case report 査読あり
Yokoe T., Nagasawa M., Tajima T., Yamaguchi N., Ota T., Morita Y., Chosa E.
BMC Musculoskeletal Disorders 25 ( 1 ) 843 2024年12月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：BMC Musculoskeletal Disorders
Background: Alkaptonuria (AKU) is a rare hereditary disease. Ochronotic arthropathy, tendinopathy, and osteopenia/osteoporosis are generally musculoskeletal manifestations in patients with AKU. Because of the ochronotic tendinopathy and osteopenia, the surgical strategy for chronic ochronotic Achilles tendon rupture may be challenging. No studies have reported the surgical treatment of chronic Achilles tendon rupture in patients with AKU. Case presentation: We report a case of AKU that required surgical treatment for chronic Achilles tendon rupture. A 60-year-old woman was referred to our department for the assessment of left hindfoot pain that persisted for more than nine months after an ankle sprain. Three years prior to the first presentation to our hospital, she was diagnosed with AKU due to pigmented hip cartilage at the time of total hip arthroplasty. The patient was diagnosed as chronic Achilles tendon rupture based on the results of physical examination and magnetic resonance imaging (MRI). The MRI showed enlarged scar tissue of the Achilles tendon with an intrasubstance high signal intensity. We performed resection of the central part of the scar tissue (total length, 24 mm) followed by direct repair using the proximal and distal stumps of the scar tissue. The MRI at 12months after surgery showed continuity of the repaired Achilles tendon. At 18 months after surgery, the Achilles Tendon Total Rupture Score improved from 22 points preoperatively to 84 points postoperatively. The foot and ankle outcome score also improved. Conclusions: We reported a case of AKU with chronic Achilles tendon rupture in which direct repair using scar tissue between the tendon stumps was effective. Careful selection of the surgical procedure for the treatment of chronic ochronotic Achilles tendon rupture is recommended because of concomitant ochronotic tendinopathy and osteopenia/osteoporosis.
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Morita Y., Tajima T., Yamaguchi N., Yokoe T., Nagasawa M., Ota T., Ouchi K., Chosa E.
Scientific Reports 14 ( 1 ) 6192 2024年12月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Scientific Reports
Posterior tibial translation (PTT) after double-bundle posterior cruciate ligament (PCL) reconstruction has sometimes occurred. Purpose of this study is to identify the risk factors for postoperative PTT after double-bundle PCL reconstruction with a hamstring autograft. Comparing the results of bilateral gravity sag view (GSV) at 12 months after surgery, over 5-mm PTT was defined as ‘failure’ in this study. Of 26 isolated PCL reconstruction cases, over 5-mm PTT was seen in 7 cases (group F: 9.57 ± 1.28 mm), and 19 cases had less than 5 mm (group G: 2.84 ± 1.29 mm). Age, sex, body mass index (BMI), preoperative GSV, posterior slope angle of the tibia, anterolateral bundle (ALB) and posteromedial bundle (PMB) graft diameters, and tibial tunnel diameter were evaluated. The two groups were compared with the 2 × 2 chi-squared test, the Mann Whitney U-test, and Spearman’s rank correlation coefficient. Multivariate logistic regression analysis was also performed to determine the risk factor. Statistical significance was indicated as p < 0.01 for correlation with postoperative PTT, and as p < 0.05 for all other comparisons. Mean age (group G 31.8 ± 12.5 vs group F 34.9 ± 15.9 years), sex (male/female: 15/4 vs 3/4), BMI (25.6 ± 4.6 vs 24.9 ± 3.9 kg/m<sup>2</sup>), preoperative GSV (11.3 ± 2.2 vs 11.6 ± 2.9 mm), PMB diameter (5.37 ± 0.33 vs 5.36 ± 0.48 mm), and tibial tunnel diameter (9.32 ± 0.58 vs 9.29 ± 0.49 mm) showed no significant differences. ALB diameter was significantly greater in group G (7.0 ± 0.5 mm) than in group F (6.5 ± 0.29 mm; p = 0.022). There was also a significant difference in posterior tibial slope angle (group G 9.19 ± 1.94 vs group F 6.54 ± 1.45, p = 0.004). On Spearman rank correlation coefficient analysis, ALB diameter GSV (correlation coefficient: − 0.561, p = 0.003) and posterior tibial slope angle (correlation coefficient: − 0.533, p = 0.005) showed a significant correlation with postoperative PTT. Multivariate logistic regression analysis showed that ALB diameter (OR 19.028; 95% CI 1.082–334.6; p = 0.044) and posterior slope angle of tibia (OR 3.081; 95% CI 1.109–8.556; p = 0.031) were independently associated with postoperative PTT, respectively. In double-bundle PCL reconstruction with hamstring, smaller ALB graft diameter and lower (flatted) tibial slope angle were considered risk factors for postoperative PTT.
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Reproductive organ involvement in women undergoing radical cystectomy for urothelial bladder cancer: a nationwide multicenter study. 査読あり
Kato M, Taoka R, Miki J, Saito R, Fukuokaya W, Matsui Y, Yamamoto S, Matsue T, Hatakeyama S, Kawahara T, Matsuda A, Kawai T, Sazuka T, Sano T, Urabe F, Kashima S, Naito H, Murakami Y, Miyake M, Daizumoto K, Matsushita Y, Hayashi T, Inokuchi J, Sugino Y, Shiga K, Yamaguchi N, Yamamoto S, Yasue K, Abe T, Nakanishi S, Hashine K, Fujii M, Nishihara K, Matsumoto H, Tatarano S, Wada K, Sekito S, Maruyama R, Nishiyama N, Nishiyama H, Kitamura H, Uchida J, Japan Urological Oncology Group
International journal of clinical oncology 29 ( 12 ) 1937 - 1945 2024年12月
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Yokoe T., Yang F., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Foot and Ankle Surgery 30 ( 7 ) 608 - 611 2024年10月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Foot and Ankle Surgery
Background: This study aimed to evaluate the shape of the retromalleolar groove of the tibialis posterior tendon (TPT) using computed tomography (CT). Methods: CT images of patients with foot or ankle pathologies were retrospectively reviewed. The morphology of the retromalleolar groove of the TPT was assessed at two different levels: the ankle joint and 10 mm above the ankle joint. The groove shape was classified into three types; concave, flat, or irregular. In cases with concave grooves, the width and depth of the grooves were measured. Results: Of the 116 ankles from 116 subjects included in this study, 80.2 % showed a shallow concave shape (mean depth, 1.6 mm) at the two scan levels. The shape and width of the groove differed significantly by gender, although there was no significant difference in the groove depth. Conclusion: Approximately 80% showed a shallow concave groove of the TPT. The groove characteristics differed by gender, although there was no significant difference in the groove depth. Level of evidence: Cross-sectional cohort study; Level of evidence, Ⅳ
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リファンピシン使用によりステロイド作用が減弱し治療に難渋した手関節非結核性抗酸菌症の1例 査読あり
松永 美穂, 大田 智美, 田島 卓也, 山口 奈美, 長澤 誠, 森田 雄大, 横江 琢示, 帖佐 悦男
整形外科と災害外科 73 ( 3 ) 602 - 605 2024年9月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：西日本整形・災害外科学会
【はじめに】ステロイド薬は他薬との薬物相互作用が比較的少なく汎用されるが，抗結核薬のリファンピシン（以下RFP）との相互作用はあまり知られていない．ネフローゼ症候群加療中に非結核性抗酸菌症（以下NTM）を合併し，ステロイドとRFPの併用で原疾患およびNTMの治療に難渋した1例を経験した．【症例】41歳男性，21歳時にネフローゼ症候群と診断され，ステロイドを内服中に手関節掌背側の腫脹を認め，滑膜切除術後に非結核性抗酸菌性滑膜炎の診断となった．RFPを含む抗結核薬3剤を開始したところ，ネフローゼ症候群が悪化しステロイドを増量，尿蛋白は改善するも手関節腫脹が再発し，2回目の滑膜切除術施行後，高気圧酸素療法で感染は鎮静化した．【考察】NTMにはRFPが汎用されるが，ステロイドとの相互作用により治療に難渋することがある．薬物の相互作用を十分に熟知し，NTMの治療にあたる必要がある．
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Prognostic impact of histological discordance between transurethral resection and radical cystectomy. 査読あり
Matsuda A, Taoka R, Miki J, Saito R, Fukuokaya W, Hatakeyama S, Kawahara T, Fujii Y, Kato M, Sazuka T, Sano T, Urabe F, Kashima S, Naito H, Murakami Y, Miyake M, Daizumoto K, Matsushita Y, Hayashi T, Inokuchi J, Sugino Y, Shiga K, Yamaguchi N, Iio H, Yasue K, Abe T, Nakanishi S, Matsumura M, Fujii M, Nishihara K, Matsumoto H, Tatarano S, Wada K, Sekito S, Maruyama R, Nishiyama N, Nishiyama H, Kitamura H, Matsui Y, Japanese Urological Oncology Group
BJU international 134 ( 2 ) 207 - 218 2024年8月
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Differences in Retromalleolar Fibular Groove Morphology According to Level of Axial Computed Tomography Scans 査読あり
Takuji Yokoe, Takuya Tajima, Koki Ouchi, Nami Yamaguchi, Yudai Morita, and Etsuo Chosa
The Orthopaedic Journal of Sports Medicine 12 ( 3 ) 2024年3月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Screening of Undiagnosed Increased Lateral Ankle Laxity Using Stress Ultrasonography 査読あり
Yokoe T., Tajima T., Chosa E., Yamaguchi N., Morita Y.
Orthopaedic Journal of Sports Medicine 12 ( 4 ) 23259671241235162 2024年3月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Orthopaedic Journal of Sports Medicine
Background: Some patients with lateral ankle sprain (LAS) will experience chronic lateral ankle instability (CLAI). However, not all of those with residual increased lateral ankle laxity (ILAL) become symptomatic. There is a lack of evidence regarding the prevalence of undiagnosed ILAL in the general population. Purpose: To evaluate the prevalence of undiagnosed ILAL with the use of stress ultrasonography (US) and to investigate the percentage of ankle sprain copers (ASCs) with ILAL. Study Design: Cross-sectional study; Level of evidence, 3. Methods: The anterior talofibular ligament (ATFL) lengths in college students without diagnosis of CLAI were measured consecutively in stress and nonstress positions. The ATFL ratio was calculated as an indicator of lateral ankle laxity according to a previously reported method. The manual anterior drawer test was also performed. The Cumberland Ankle Instability Tool (CAIT) and Ankle Instability Instrument (AII) were used to assess subjective impairments related to CLAI. The correlation between the ATFL ratio and CAIT score was evaluated. Results: A total of 207 ankles from 106 participants (mean age, 23.9 ± 2.2 years; male/female, 64/42) were included. Overall, 38 participants (35.8%; 50 ankles [24.2%]) were classified as having undiagnosed ILAL. Of the ankles with no history of LAS, 8% showed ILAL. Overall, 53 participants (50%) had a history of LAS and were all classified as ASCs. Of the 82 ankles from these ASCs, 40 (48.8%) were regarded as having undiagnosed ILAL. There was no correlation between the ATFL ratio and CAIT scores (r = -0.09, P =.414). Conclusion: The prevalence of undiagnosed ILAL by stress US screening was approximately one-third in young adults. In this study, 48.8% of the ankles from ASCs showed ILAL.
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An Analysis of Delayed Bleeding in Cases of Colorectal Endoscopic Submucosal Dissection Due to Types of Direct Oral Anticoagulants in Japan. 査読あり
Yoshida N, Hayashi Y, Togo D, Oka S, Takada K, Fukunaga S, Morita Y, Hayashi T, Kozuka K, Tsuji Y, Murakami T, Yamamura T, Komeda Y, Takeuchi Y, Shinmura K, Fukuda H, Yoshii S, Ono S, Katsuki S, Kawashima K, Nemoto D, Yamamoto H, Saito Y, Tamai N, Iwao A, Itoi Y, Tsuji S, Inagaki Y, Inada Y, Soga K, Hasegawa D, Murakami T, Yoriki H, Fukumoto K, Motoyoshi T, Nakatani Y, Sano Y, Iguchi M, Fujii S, Ban H, Harada K, Okamoto K, Nishiyama H, Sasaki F, Mizukami K, Shono T, Shimoda R, Miike T, Yamaguchi N
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 22 ( 2 ) 271 - 282.e3 2024年2月
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Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study. 査読あり
Fukuda K, Mizukami K, Yamaguch D, Tanaka Y, Hashiguchi K, Akutagawa T, Shimoda R, Suzuki S, Miike T, Sumida Y, Maeda H, Sasaki F, Gushima R, Miyamoto H, Hashiguchi K, Yamaguchi N, Ohira T, Kinjo T, Ohnita K, Moriyama T, Ohtsu K, Aso A, Ogawa R, Ueo T, Fukuda M
PloS one 19 ( 11 ) e0312385 2024年
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Journal of Orthopaedic Science 28 ( 6 ) 1543 - 1547 2023年11月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Orthopaedic Science
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Remnant-Preserved Single-Bundle Anterior Cruciate Ligament Augmentation in Multi-ligamentous Knee Reconstruction. 査読あり
Tajima T, Yamaguchi N, Morita Y, Yokoe T, Nagasawa M, Ota T, Kawagoe S, Nakamura Y, Chosa E.
J Knee Surg 36 ( 10 ) 1095 - 1101 2023年10月
記述言語：英語 掲載種別：研究論文（学術雑誌）