論文 - 七島 篤志
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Perioperative non-tumorous factors associated with survival in HCC patients who underwent hepatectomy.
Nanashima A, Abo T, Hamasaki K, Wakata K, Tominaga T, Hidaka S, Takeshita H, Nagayasu T
Anticancer research 31 ( 12 ) 4545 - 51 2011年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Nanashima A., Abo T., Hamasaki K., Wakata K., Tominaga T., Hidaka S., Takeshita H., Nagayasu T.
Anticancer Research 31 ( 12 ) 4545 - 4551 2011年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Anticancer Research
Aim: To clarify perioperative factors associated with poor survival following hepatectomy. Patients and Methods: Clinical parameters and stress score, including surgical stress score (SSS) and comprehensive risk score (CRS) were examined from 183 hepatocellular carcinoma patients who underwent hepatectomy. Results: Factors associated with tumor relapse were increased blood loss/weight, uncontrolled ascites and grade B liver damage (p < 0.05). Ascites was identified as an independent risk factor by multivariate logistic regression analysis. Increased blood loss/weight, transfusion, high SSS, high CRS, ascites, and grade B liver damage were associated with poor disease-free survival (p < 0.05). Increased blood loss/weight, transfusion, ascites, and grade B liver damage were associated with poor overall survival (p < 0.05), and ascites, transfusion, male sex and grade B liver damage were identified as independent risk factors. Conclusion: Reducing blood loss and avoiding transfusion appear important for improving prognosis. Maintenance of liver function is necessary in cases showing poor liver function and uncontrolled ascites.
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Nanashima A., Abo T., Tobinaga S., Nonaka T., Nakao K., Hidaka S., Takeshita H., Fukuoka H., Sawai T., Yasutake T., Nagayasu T.
Acta Medica Nagasakiensia 56 ( 3 ) 93 - 97 2011年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Acta Medica Nagasakiensia
Laparoscopic surgery is a less invasive treatment option for tumors in the intraabdominal organs; however, the safety and indication of laparoscopic or laparoscopy assisted pancreaticoduodenectomy (LPD) is still controversial. We attempted LPD in four cases for intraductal papillary mucinous neoplasm (IPMN) located in the pancreatic head and we report the surgical records and short-term outcome. LPD was carried out in four patients including three patients with the combined type IPMN and one with the branch type, based on the International Consensus Guidelines. None of the patients had invasive carcinoma based on preoperative imaging diagnosis. Laparoscopic procedures were performed until isolation of the pancreas head and duodenum, and final resection of PD and intestinal reconstruction were performed using small incision laparotomy (7-8cm). The mean total operating time was 882 minutes (820-932 minutes), mean blood loss was 925ml (610-1550ml) and red cell transfusion was not required in any patients. One patient underwent reoperation for bleeding at the pancreaticojejunostomy site at day 1. Mean duration until patients were able to walk was 3.5 days (2-6 days) and duration of use of analgesia was limited to within 7 days. Grade B pancreatic fistula was observed in one patient and jejunal ileus was observed in one patient. There were no deaths. LPD was safely performed and blood loss was limited, although the operating time was long. Postoperative recovery in patients without complications might be better than the conventional PD under laparotomy. Future study is necessary.
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Predictive factor for photodynamic therapy effects on oral squamous cell carcinoma and oral epithelial dysplasia.
Uehara M, Ikeda H, Nonaka M, Sumita Y, Nanashima A, Nonaka T, Asahina I
Archives of oral biology 56 ( 11 ) 1366 - 72 2011年11月
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Tumor marker levels before and after curative treatment of hepatocellular carcinoma as predictors of patient survival.
Nanashima A, Taura N, Abo T, Ichikawa T, Sakamoto I, Nagayasu T, Nakao K
Digestive diseases and sciences 56 ( 10 ) 3086 - 100 2011年10月
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A case report of necrosis of the gastric remnant after distal gastrectomy
Nonaka T., Hidaka S., Fukuoka H., Abo T., Takeshita H., Nanashima A., Sawai T., Yasutake T., Nagayasu T.
Japanese Journal of Gastroenterological Surgery 44 ( 7 ) 829 - 835 2011年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Gastroenterological Surgery
The patient was a 65-year-old man who had received laparoscopy-assisted high anterior resection for advanced rectal cancer and distal gastrectomy without splenectomy for early gastric cancer at the same time. We could not point out any findings of ischemic change or anastomosis leakage in the early postoperative period. However, on POD 15, gastroscopic examination showed extensive mucosal necrosis mainly around the anastomotic region in the gastric remnant. Based on these findings, we performed total gastrectomy on POD 21. Ischemic necrosis of the gastric remnant is a rare and serious complication of distal gastrectomy. It is hoped that early diagnosis by a gastroscopy in the early postoperative period will help to save patients in which this complication is suspected. © 2011 The Japanese Society of Gastroenterological Surgery.
DOI： 10.5833/jjgs.44.829
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Esophagectomy in a patient with intestinal malrotation and interrupted inferior vena cava
Tominaga T., Hidaka S., Tanaka K., Taguchi T., Nanashima A., Sawai T., Yasutake T., Nagayasu T.
Japanese Journal of Gastroenterological Surgery 44 ( 8 ) 955 - 962 2011年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Gastroenterological Surgery
A 48-year-old man was referred to us because of a tumor in the esophagus. Abdominal CT and Chest CT revealed multiple abnormalities, intestinal malrotation, interrupted inferior vena cava, dilated azygous vein, and polysplenia. We performed esophagectomy with lymph nodes dissection, splenectomy and, retrosternal reconstruction with a gastric tube. He was discharged on postoperative day 32. It has been reported that patients with intestinal malformation occasionally have some other abnormality, Therefore esophagectomy in such cases could be more difficult. Preoperatively, we defined the abnormalities, and carefully planned the optimal operative procedure and approach. Esophagectomy was successfully performed in this patient with intestinal malrotation. © 2011 The Japanese Society of Gastroenterological Surgery.
DOI： 10.5833/jjgs.44.955
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Prognosis of patients with hepatocellular carcinoma after hepatic resection: are elderly patients suitable for surgery?
Nanashima A, Abo T, Nonaka T, Fukuoka H, Hidaka S, Takeshita H, Ichikawa T, Sawai T, Yasutake T, Nakao K, Nagayasu T
Journal of surgical oncology 104 ( 3 ) 284 - 91 2011年9月
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Prediction of indocyanine green retention rate at 15 minutes by correlated liver function parameters before hepatectomy.
Nanashima A, Abo T, Tobinaga S, Nonaka T, Fukuoka H, Hidaka S, Takeshita H, Sawai T, Yasutake T, Nagayasu T, Kudo T
The Journal of surgical research 169 ( 2 ) e119 - 25 2011年8月
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Advantages of laserphyrin compared with photofrin in photodynamic therapy for bile duct carcinoma.
Nonaka T, Nanashima A, Nonaka M, Uehara M, Isomoto H, Nonaka Y, Nagayasu T
Journal of hepato-biliary-pancreatic sciences 18 ( 4 ) 592 - 600 2011年7月
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Distal gastrectomy for advanced gastric cancer with vascular anomaly after coronary bypass grafting using the right gastroepiploic artery.
Kunizaki M, Hidaka S, Nonaka T, Takagi K, Tobinaga S, Takeshita H, Nanashima A, Sawai T, Yasutake T, Nagayasu T
American journal of surgery 201 ( 5 ) e35 - 7 2011年5月
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Left hepatectomy accompanied by a resection of the whole caudate lobe using the dorsally fixed liver-hanging maneuver.
Nanashima A, Tobinaga S, Abo T, Sawai T, Nagayasu T
Surgery today 41 ( 3 ) 453 - 8 2011年3月
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Intraductal papillary growth of liver metastasis originating from colon carcinoma in the bile duct: report of a case.
Nanashima A, Tobinaga S, Araki M, Kunizaki M, Abe K, Hayashi H, Harada K, Nakanuma Y, Nakagoe T, Takeshita H, Sawai T, Nagayasu T
Surgery today 41 ( 2 ) 276 - 80 2011年2月
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Usefulness of sonazoid-ultrasonography during hepatectomy in patients with liver tumors: A preliminary study.
Nanashima A, Tobinaga S, Abo T, Kunizaki M, Takeshita H, Hidaka S, Taura N, Ichikawa T, Sawai T, Nakao K, Nagayasu T
Journal of surgical oncology 103 ( 2 ) 152 - 7 2011年2月
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Preoperative diagnosis of lymph node metastasis in biliary and pancreatic carcinomas: evaluation of the combination of multi-detector CT and serum CA19-9 level.
Nanashima A, Sakamoto I, Hayashi T, Tobinaga S, Araki M, Kunizaki M, Nonaka T, Takeshita H, Hidaka S, Sawai T, Yasutake T, Nagayasu T
Digestive diseases and sciences 55 ( 12 ) 3617 - 26 2010年12月
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Relationship of hepatic functional parameters with changes of functional liver volume using technetium-99m galactosyl serum albumin scintigraphy in patients undergoing preoperative portal vein embolization: a follow-up report.
Nanashima A, Tobinaga S, Abo T, Sumida Y, Araki M, Hayashi H, Sakamoto I, Kudo T, Takeshita H, Hidaka S, Sawai T, Hatano K, Nagayasu T
The Journal of surgical research 164 ( 2 ) e235 - 42 2010年12月
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Evaluation of surgical resection for ampullar carcinoma at Japanese single cancer institute
Nanashima A., Tobinaga S., Abo T., Ohnita K., Norimura D., Yajima H., Takeshita H., Nonaka T., Hidaka S., Takeshima F., Yamaguchi N., Isomoto H., Sawai T., Nakao K., Nagayasu T.
Acta Medica Nagasakiensia 55 ( 1 ) 23 - 28 2010年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Acta Medica Nagasakiensia
Aims: Surgical resection is the only radical treatment option for duodenal ampullar carcinoma (AC) that results in an improved patient prognosis. Method: We examined the demographics, surgical records, and outcome in 23 patients with AC undergoing pancreaticoduodenectomy (PD). Results: Of 23 patients, 17 underwent pylorus preserving PD (PPPD) and 6 underwent PD, including subtotal stomach-preserving PD in 5. D2 lymphadenectomy was performed in 17 patients and D3 lymphadenectomy was performed in 6. The combined resection of the superior mesenteric vein was performed in 1 patient. Postoperative cancer recurrence was observed in 32%, and 6 patients died of cancer. The 3-year tumor-free survival rates were not different between the final stages (p=0.64) and the 5-year cancer-related overall survival rates were not different between stages either (p=0.28). Tumor size?3cm resulted in significantly poorer survival rate compared to smaller tumors (p=0.032). Node metastasis at Group 2, and moderately or poorly differentiated adenocarcinoma were significantly associated with poor survival (p < 0.05); however, cancer infiltration at cut-end margin, degree of node dissection and curability were not associated with overall prognosis. Conclusions: Radical surgical resection showed good patient prognosis; however, new adjuvant chemotherapy is a promising modality to improve patient survival in AC patients with poor prognostic factors. © 2006 Nagasaki University Library.
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Long-term results of chest wall reconstruction with DualMesh.
Nagayasu T, Yamasaki N, Tagawa T, Tsuchiya T, Miyazaki T, Nanashima A, Obatake M, Yano H
Interactive cardiovascular and thoracic surgery 11 ( 5 ) 581 - 4 2010年11月
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Reducing the incidence of post-hepatectomy hepatic complications by preoperatively applying parameters predictive of liver function.
Nanashima A, Tobinaga S, Abo T, Nonaka T, Takeshita H, Hidaka S, Sawai T, Nagayasu T
Journal of hepato-biliary-pancreatic sciences 17 ( 6 ) 871 - 8 2010年11月
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Effects of photodynamic therapy for superficial esophageal squamous cell carcinoma in vivo and in vitro.
Kawazoe K, Isomoto H, Yamaguchi N, Inoue N, Uehara R, Matsushima K, Ichikawa T, Takeshima F, Nonaka T, Nanashima A, Nagayasu T, Uehara M, Asahina I, Nakao K
Oncology letters 1 ( 5 ) 877 - 882 2010年9月