論文 - 七島 篤志
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Nakagoe T., Ishikawa H., Sawai T., Tsuji T., Tanaka K., Hidaka S., Shibasaki S., Nanashima A., Yamaguchi H., Yasutake T.
Acta Medica Nagasakiensia 47 ( 3-4 ) 139 - 144 2002年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Acta Medica Nagasakiensia
Purpose. The purpose of this study was to determine whether the type of operation [sphincter-saving resection (SSR) or abdominoperineal resection (APR)] for primary adenocarcinoma of the rectum at or below the peritoneal reflection affects survival after non-curative surgery. Methods. This retrospective study included 42 patients who underwent non-curative surgery by the following two types of operation between 1989 and 1998: (1) SSR (n=19 patients) included low anterior resection with either double-stapling technique (n=16) or transanal coloanal anastomosis (n=3); (2) APR (n=23). 'Non-curative' resection implied 'Curability B' and 'Curability C' defined by the Japanese Classification of Colorectal Carcinoma. Outcome measure was disease-specific survival. Univariate and multivariate Cox's regression analyses were used to evaluate data. Median follow-up was 17.2 months at study conclusion. Results. Disease-specific survival after non-curative surgery did not differ between the two types of operations. Multivariate analyses showed that the type of operation was not a significant independent variable in predicting disease-specific survival after surgery. One variable - 'Curability' - was significant predictor of outcome after surgery. Conclusions. The type of operation (SSR or APR) did not affect survival after non-curative resection for adenocarcinoma of the rectum at or below the peritoneal reflection.
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Nakagoe T., Fukushima K., Sawai T., Tsuji T., Jibiki M., Nanashima A., Tanaka K., Yamaguchi H., Yasutake T., Ayabe H., Ishikawa H.
Journal of Experimental and Clinical Cancer Research 21 ( 3 ) 363 - 369 2002年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Experimental and Clinical Cancer Research
Early gastric cancer can be divided morphologically into two categories, penetrating growth type-A (Pen-A type) and other growth types (non-Pen-A types). Sialyl Lewis x antigen has been demonstrated to play an important role in tumor metastasis by serving as a functional ligand in the cell adhesion system. The aim of this study is to ascertain whether or not sialyl Le x antigen expression correlates with tumor growth patterns of early gastric carcinoma. An immunohistochemical assay was performed using monoclonal antibody CSLEX1 in 12 Pen-A type and 79 non-Pen-A type cancers. Scoring was based on the percentage of immunoreactive cells: negative, low expression (≤25%), and high expression ( > 25%). Lymph node metastasis was found more frequently in Pen-A type than non-Pen-A type cancers (P=0.0004). Furthermore, sialyl Le x antigen high expression was detected more often in Pen-A type cancers (7 out of 12; 58.3%) than non-Pen-A type cancers (13 out of 79; 16.5 %) (P=0.0036). Multivariate logistic regression analysis showed that these variables are related independently to the Pen-A type and the non-Pen-A type tumor growth patterns. These data suggest that the difference in sialyl Le x antigen expression between the Pen-A type and non-Pen-A type tumor growth patterns of early gastric cancer may, at least partially, reflect different biological behavior during tumor progression.
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[CPT-11 hepatic arterial injection plus oral UFT administration for liver metastasis of rectal cancer--report of two cases].
Sawai T, Tsuji T, Yamashita H, Hidaka S, Fukuoka H, Shibasaki S, Tanaka K, Nanashima A, Yamaguchi H, Yasutake T, Nakagoe T, Ayabe H
Gan to kagaku ryoho. Cancer & chemotherapy 29 ( 8 ) 1469 - 73 2002年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Sawai T., Tsuji T., Yamashita H., Hidaka S., Fukuoka H., Shibasaki S., Tanaka K., Nanashima A., Yamaguchi H., Yasutake T., Nakagoe T., Ayabe H.
Japanese Journal of Cancer and Chemotherapy 29 ( 8 ) 1469 - 1473 2002年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Cancer and Chemotherapy
The first patient was a 51-year-old male who had 5-fluorouracil-resistant recurrent rectal cancer with multiple liver metastases. He was given our new combination chemotherapy consisting of hepatic arterial injection of CPT-11 (20 mg/body) on day 1 and day 2 and oral administration of UFT (300 mg/day) on days 3 to 6 of a 7 day cycle starting in January 2001. Six weeks after the beginning of chemotherapy, the liver metastatic lesions were reduced. He is now living with outpatient treatment. The second patient was a 76-year-old male who had initial recurrent rectal cancer with multiple liver metastases. Thirty-two weeks after the same chemotherapy, the metastatic lesions had completely disappeared. Twelve months have passed since this chemotherapy, and we have not found any recurrent tumor. While significant antitumor effects were observed, there were few adverse events in either patient. These results suggest that combined chemotherapy of CPT-11 by hepatic arterial injection and oral administration of UFT is an effective treatment for liver metastases of rectal cancer.
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Nanashima A., Pillay P., Verran D., Painter D., Nakasuji M., Crawford M., Shi L., Ross A.
Transplantation Proceedings 34 ( 4 ) 1231 - 1235 2002年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Transplantation Proceedings
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Minilaparotomy approach to terminal ileal Crohn's disease.
Nakagoe T, Sawai T, Tsuji T, Jibiki MA, Nanashima A, Yamaguchi H, Yasutake T, Ayabe H
World journal of surgery 26 ( 6 ) 721 - 5 2002年6月
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Nakagoe T., Sawai T., Tsuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H., Arisawa K., Ishikawa H.
Anticancer Research 22 ( 1 A ) 451 - 458 2002年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Anticancer Research
Preoperative serum levels of sialyl Lewisa(CA19-9), sialyl Lewisx(SLX) and sialyl Tn (STN) antigens in 180 patients with gastric cancer were examined to establish predictive factors for serum levels of these antigens compared with carcino-embryonic antigen (CEA). The patients were divided into low and high antigen groups. Multivariate logistic regression analysis revealed the following independent predictive factors for high antigen levels [odds ratio]: liver metastasis for CA19-9 [4.40], SLX [9.90], STN [39.65] and CEA [5.14]; peritoneal dissemination for SLX [4.78] or STN [13.01]; venous invasion for CEA [3.56]; lymph node metastasis for CA19-9 [4.51]. In addition, high CA19-9 levels were independently related to lymph node metastasis in patients with stage I or II tumors. In conclusion, high serum levels of CA19-9, SLX and STN are associated with liver metastasis, while high serum levels of SLX and STN are associated with peritoneal dissemination. In addition, high serum CA19-9 levels may represent an independent predictor for lymph node metastasis.
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Nakagoe T., Fukushima K., Tanaka K., Sawai T., Tsuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H., Arisawa K.
Journal of Experimental and Clinical Cancer Research 21 ( 1 ) 107 - 113 2002年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Experimental and Clinical Cancer Research
This study aimed to determine whether sialyl Lewis a (Le a ), sialyl Lewisx (Le x ), or sialyl Tn antigen expression could identify a subset of node-negative colorectal cancer patients that are at high risk for recurrence after curative surgery. Tumor tissue samples from 90 patients with node-negative colorectal cancer, who had undergone surgical resection, were analyzed immunohistochemically for the expression of each antigen. Patients were classified as having low or high antigen expression depending on whether more or less than 40% of the field showed positive staining. The main outcome measure for each variable was disease-free interval. Sialyl Le a , sialyl Le x , and siaiyl Tn antigens were expressed in 53 (58.9%), 41 (45.6%), and 34 (37.8%) carcinomas, respectively. The median follow-up was 83.5 months. Patients with high sialyl Lex x expression had shorter disease-free intervals than those with low sialyl Le x expression (P=0.0041); the expression of sialyl Le x or sialyl Tn antigens did not show a significant relationship with disease-free survival. Cox's regression analysis revealed that sialyl Le x expression was an independent predictor for disease-free survival, separate from T factor or tumor location. High sialyl Le x expression may be useful in identifying a subset of node-negative colorectal cancer patients who are at high risk for recurrence.
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Nakagoe T., Sawai T., Tsuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H., Arisawa K., Ishikawa H.
Journal of Clinical Gastroenterology 34 ( 4 ) 408 - 415 2002年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Clinical Gastroenterology
Sialyl Lewis a (CA19-9) and sialyl Lewis x antigens (SLX) may play a role in tumor metastasis by serving as functional ligands in the cell adhesion system. The authors examined preoperative serum levels of CA19-9 and SLX in 218 patients who underwent resection for gastric cancer to determine their prognostic value. The patients were divided into two groups, termed the low and high antigen groups, based on a value selected as a diagnostic cutoff. Correlation between the antigen serum levels, various established clinicopathologic factors, and prognosis were studied by univariate and multivariate analysis. The disease-specific interval for high CA19-9 and SLX groups was significantly shorter than that of their respective low groups (p = 0.0024 and p < 0.0001, respectively). Patients with stage III/IV tumors who had high serum SLX levels had shorter disease-specific intervals than those with low serum levels (p = 0.0017). A Cox's regression analysis revealed a high serum SLX level as an independent factor for worse outcome. In addition, logistic regression analysis revealed that a high serum SLX level was an independent predictor for liver metastasis. In conclusion, an elevated preoperative serum SLX level was a predictor for poor outcome after resection for gastric cancer, whereas CA19-9 was not.
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Difference in prognostic value between sialyl Lewis(a) and sialyl Lewis(x) antigen levels in the preoperative serum of gastric cancer patients.
Nakagoe T, Sawai T, Tsuji T, Jibiki MA, Nanashima A, Yamaguchi H, Yasutake T, Ayabe H, Arisawa K, Ishikawa H
Journal of clinical gastroenterology 34 ( 4 ) 408 - 15 2002年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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[Liver transplantation for hepatocellular carcinoma: experience at an Australian transplantation unit].
Nanashima A
Nihon Geka Gakkai zasshi 103 ( 4 ) 381 - 5 2002年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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症例報告 豪州における肝細胞癌に対する肝移植の臨床経験 査読あり
七島篤志
日本外科学会雑誌 103 ( 4 ) 381 - 385 2002年4月
担当区分：筆頭著者 記述言語：日本語 掲載種別：症例報告 出版者・発行元：Nippon Geka Gakkai zasshi
The author experienced 11 cases of orthotopic liver transplantation (LTx) for hepatocellular carcinoma (HCC) in Sydney, Australia, series. LTx was selected in 5 cases for the treatment of HCC and in 6 for terminal liver failure. Three patients had new lesions, which were not detected on preoperative imaging, and 5 had vascular or extrahepatic infiltrations. Two patients with hepatitis C had recurrence of hepatitis at an early stage. Two had tumor recurrence, one of which had 7 lesions with invasion to the vessels and bare area. Thus some problems remain in LTx for HCC, including the recurrence of hepatitis in hepatitis C and tumor recurrence in cases with high-risk factors based on the pathologic findings.
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A case report of intestinal perforation causing by dialysis-related amyloidosis
Takashi T., Terumitsu S., Shinichi S., Atsushi N., Masaaki J., Hiroyuki Y., Tohru Y., Tohru N., Hiroyoshi A., Kuniko A.
Japanese Journal of Gastroenterological Surgery 35 ( 2 ) 176 - 179 2002年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Gastroenterological Surgery
We experienced a case with an intestinal perforation resulting from dialysis-related amyloidosis. A fifty-six-year old women who had been receiving hemodialysis for twenty-three years underwent an operation for bilateral carpal tunnel syndrome and destructive spondyloarthropathy. She had experienced the onset of diarrhea four months earlier, and was operated on for perforative peritonitis. The middle part of the small intestine contained a 16 × 8 mm hole. Partial resection of the small bowel and end-to-end anastomosis was performed. A pathological examination revealed an amyloid deposit in a perivascular area of the submucosal layer, and immunohistochemistry for β2-microglobulin was positive. She was diagnosed as having dialysis-related amyloidosis. Anastomotic leakage occurred early during the post-operative day. She was died five months later because of a sepsis.
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Nakagoe T., Sawai T., Tuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H., Matuo T., Tagawa Y.
Digestive Diseases and Sciences 47 ( 2 ) 322 - 330 2002年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Digestive Diseases and Sciences
We examined the immunohistochemical expression of sialosyl-Tn antigen in the colorectal cancer tissues of 116 patients who underwent curative resection to determine the association between patient prognosis and the expression of sialosyl-Tn in two different tissues: carcinoma and transitional mucosa. Negative or positive expression of sialosyl-Tn in the carcinoma and transitional mucosal tissues were denoted as CA-or CA+and TM-or TM+, respectively. Patients were classified into one of four groups: CA-/TM-, CA-/TM+, CA+/TM-, and CA+/TM+. CA-/TM-was observed in 13 patients and CA-/TM+, CA+/TM-, or CA+/TM+was observed in 103 patients. The difference in five-year survival between the CA-/TM-group and all the other groups was statistically significant (P = 0.0457), and multivariate analysis showed that sialosyl-Tn expression in at least one of the two tissues was an independent prognostic factor. We conclude that the evaluation of sialosyl-Tn expression in carcinoma as well as transitional mucosa is useful for predicting survival in colorectal cancer patients.
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Increased expression of sialyl Lewis(x) antigen as a prognostic factor in patients with stage 0, I, and II gastric cancer.
Nakagoe T, Fukushima K, Sawai T, Tsuji T, Jibiki Ma, Nanashima A, Tanaka K, Yamaguchi H, Yasutake T, Ayabe H, Arisawa K, Ishikawa H
Cancer letters 175 ( 2 ) 213 - 21 2002年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Nakagoe T., Fukushima K., Sawai T., Tsuji T., Jibiki M., Nanashima A., Tanaka K., Yamaguchi H., Yasutake T., Ayabe H., Arisawa K., Ishikawa H.
Cancer Letters 175 ( 2 ) 213 - 221 2002年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Cancer Letters
Immunohistochemically detected expression of sialyl Lewis x (Le x ) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le x antigen within their tumors had shorter disease-specific intervals than those with negative- or low-expressing tumors (P < 0.0001). This difference was noted particularly in stage I-B or II disease. Multivariate Cox's regression analysis revealed sialyl Le x antigen expression to be an independent predictor of disease-specific survival (Hazard ratio=9.10). In conclusion, the increased expression of sialyl Le x antigen may serve as a prognostic factor after curative surgery for stages 0-II gastric cancer. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
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Predictive factors for preoperative serum levels of sialy Lewis(x), sialyl Lewis(a) and sialyl Tn antigens in gastric cancer patients.
Nakagoe T, Sawai T, Tsuji T, Jibiki MA, Nanashima A, Yamaguchi H, Yasutake T, Ayabe H, Arisawa K, Ishikawa H
Anticancer research 22 ( 1A ) 451 - 8 2002年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Analysis of tumor morphology in metastatic colorectal cancer: does this classification have any clinical significance?
Nanashima A, Yamaguchi H, Sawai T, Shibasaki S, Yasutake T, Tsuji T, Hidaka S, Jibiki M, Nakagoe T, Ayabe H
Journal of gastroenterology 37 ( 10 ) 791 - 7 2002年
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Application of argyrophilic nucleolar organizer region (AgNOR) staining for cytology of biliary tract carcinomas.
Nanashima A, Yamaguchi H, Nishizawa-Takano JE, Hatano K, Shibasaki S, Sawai T, Yasutake T, Obatake M, Nakagoe T, Ayabe H
Journal of hepato-biliary-pancreatic surgery 9 ( 4 ) 485 - 9 2002年
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Nanashima A., Pillay P., Crawford M., Nakasuji M., Verran D., Painter D.
Journal of Hepato-Biliary-Pancreatic Surgery 8 ( 6 ) 557 - 563 2001年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Hepato-Biliary-Pancreatic Surgery
Background/Purpose. We investigated the causes and examined patient outcomes following the postrevascularization syndrome (PRS) during orthotopic liver transplantation (OLTx). Methods. PRS was defined as a fall in the mean arterial pressure at 5 min after revascularization to less than 70% of the baseline and lasting for 5 min. Data from 100 adult patients who underwent OLTx between January 1998 and September 2000 were analyzed. Analyzed data included donor and recipient demographic data, recipient operative and postoperative courses, and recipient outcome. Results. Twenty-nine patients (29%) exhibited PRS during OLTx (PRS group). There was a higher incidence of older donors ( > 50 years) in the PRS group (48% vs 23%; P < 0.05). Postrevascularization hyperkalemia and metabolic acidosis were observed in both the PRS and non-PRS groups. Transaminase and lactate levels after revascularization were significantly higher in the PRS group (P < 0.05). Alkaline phosphatase and gamma-glutamyl transpeptidase levels on day 7 tended to be higher in the PRS group; although the difference was not significant (p ≥ 0.05). Serum creatinine was significantly elevated on day 7 in the PRS group (P < 0.01). Conclusions. Our results indicate that PRS following OLTx tended to be more common in liver allografts from older donors and was associated with posttransplantation liver and renal dysfunction.