Papers - NISHIYAMA Koichi
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[Role of the liaison officer in disaster countermeasures implemented by the Japanese Society of Neurology: Hope for the best and prepare for the worst].
Nakane S, Mizoguchi K, Abe K, Atsuta N, Iguchi Y, Ikeda Y, Kaji R, Kamei S, Kitagawa K, Kimura K, Suzuki M, Takashima H, Terayama Y, Nishiyama K, Furuya H, Matsubara E, Muramatsu SI, Yamamura O, Takeda A, Ito H, Committee for Measures Against Disaster, Japanese Society of Neurology
Rinsho shinkeigaku = Clinical neurology 60 ( 10 ) 643 - 652 2020.10
Language：Japanese Publishing type：Research paper (scientific journal)
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脈管のメカノバイオロジー 創傷治癒過程の血管新生における内腔圧の新たな役割の解明
福原 茂朋, 弓削 進弥, 有馬 勇一郎, 花田 保之, 花田 三四郎, 石井 智裕, 若山 勇紀, 横川 隆司, 三浦 岳, 望月 直樹, 西山 功一
脈管学 60 ( Suppl. ) S113 - S114 2020.10
Language：Japanese Publishing type：Research paper (other academic) Publisher：(一社)日本脈管学会
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血流依存的な転移がん血管内浸潤メカニズム解明に資する新規オンチップモデル
西山 功一, 花田 三四郎
日本癌学会総会記事 79回 OE10 - 7 2020.10
Language：Japanese Publishing type：Research paper (other academic) Publisher：(一社)日本癌学会
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An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling
Erickson S., Ihara H., Hanada S., Nishiyama K., Miura T., Yokokawa R.
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) 2020-January 444 - 447 2020.1
Language：Japanese Publishing type：Research paper (international conference proceedings) Publisher：Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pericytes are critical support cells for vasculature. They aid in sprout formation, promote the expression of junction proteins between endothelial cells, and help regulate blood flow. But to perform these roles, they must first be recruited by endothelial cells. Here, we use a microchannel device to create self-assembling vasculature and study the effect of inhibiting pericyte-endothelial cell communication. We explore the effect of pericytes on vascular morphology and track pericyte coverage with and without the inhibitory drug, Imatinib. We find that pericyte migration and vessel morphology are changed with inhibition of platelet-derived growth factor (PDGF) receptor. In this way, we show the value of this system for both drug development and basic biological studies.
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Oxygen metabolism analysis of a vascularized spheroid using a scanning electrochemical microscopy
Nashimoto Y., Mukomoto R., Terai T., Ino K., Nishiyama K., Yokokawa R., Miura T., Shiku H.
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 520 - 521 2020
Language：English Publishing type：Research paper (international conference proceedings) Publisher：MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
We investigated the effect of vascularization on oxygen metabolism in a fibroblast spheroid. By the scanning of a microelectrode, the oxygen reduction current was monitored, which allowed us to analyze the oxygen metabolism quantitatively. The oxygen metabolism of the spheroids were determined by the spheroid radius (volume) and did not depend on whether the spheroid was vascularized or not, implying the identical activity of oxygen metabolism of the fibroblast and endothelial cells. Our system is useful for the metabolic evaluation of a three-dimensional culture model.
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Angiogenesis derived from shear stress optimised by a microfruidic device
Teraoka Y., Nakayama M., Nashimoto Y., Nakamasu A., Hanada S., Arima Y., Torisawa Y.S., Kotera H., Nishiyama K., Miura T., Yokokawa R.
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 1072 - 1073 2020
Language：Japanese Publishing type：Research paper (conference, symposium, etc.) Publisher：21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Previously, we created a 3D vascular network in a microfluidic device and demonstrated that the luminal flow significantly enhanced the formation of angiogenic sprouts as compared to static conditions [1]. These results could not be explained based on either biochemical factors (oxygen and nutrient transport) or mechanical factors (pressure and shear stress) derived angiogenesis. In this study, we investigated the effect of flow rate and shear stress on angiogenesis induced by luminal flow. We calculated the shear stress exposed on the endothelium where new sprouting initiated. Our results showed that angiogenesis was induced in the specific range of shear stress.
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Perfusion culture through a vasculature constructed in a tumor spheroid
Nashimoto Y., Teraoka Y., Nakamasu A., Hanada S., Arima Y., Torisawa Y.S., Kotera H., Nishiyama K., Miura T., Yokokawa R.
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 1029 - 1030 2020
Language：English Publishing type：Research paper (other academic) Publisher：21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
We developed a microfluidic system for a perfusion culture of tumor spheroids utilizing engineered vasculatures. By the definition of the cellular interaction between fibroblast cells in a tumor spheroid and endothelial cells in microchannels, we successfully induced angiogenic sprouts from the microchannels, which anastomosed with the spheroid and formed perfusable vasculatures. We continuously supplied medium to the tumor spheroid through the vasculature and evaluated the effect of perfusion on the growth of the tumor spheroid. Our perfusion system greatly improved the cellular proliferation activity, mimicking the nutrition supply and evacuation of waste product through vasculatures surrounding tumors in vivo.
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Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells.
Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y, Nakagawa O
Angiogenesis 21 ( 2 ) 415 - 423 2018.5
Language：English Publishing type：Research paper (scientific journal)
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Perfusable Vascular Network with a Tissue Model in a Microfluidic Device.
Nashimoto Y, Teraoka Y, Banan Sadeghian R, Nakamasu A, Arima Y, Hanada S, Kotera H, Nishiyama K, Miura T, Yokokawa R
Journal of visualized experiments : JoVE ( 134 ) 2018.4
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Evaluation of Collateral Source Characteristics With 3-Dimensional Analysis Using Micro-X-Ray Computed Tomography.
Arima Y, Hokimoto S, Tabata N, Nakagawa O, Oshima A, Matsumoto Y, Sato T, Mukunoki T, Otani J, Ishii M, Uchikawa M, Yamamoto E, Izumiya Y, Kaikita K, Ogawa H, Nishiyama K, Tsujita K
Journal of the American Heart Association 7 ( 6 ) 2018.3
Language：English Publishing type：Research paper (scientific journal)
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Study on the tumor-induced angiogenesis using mathematical models.
Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ
Cancer science 109 ( 1 ) 15 - 23 2018.1
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Fetal Origins of Hypertension.
Arima Y, Nishiyama K, Izumiya Y, Kaikita K, Hokimoto S, Tsujita K
Advances in experimental medicine and biology 1012 41 - 48 2018
Language：English Publishing type：Research paper (scientific journal)
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Autonomy and Non-autonomy of Angiogenic Cell Movements Revealed by Experiment-Driven Mathematical Modeling.
Sugihara K, Nishiyama K, Fukuhara S, Uemura A, Arima S, Kobayashi R, Köhn-Luque A, Mochizuki N, Suda T, Ogawa H, Kurihara H
Cell reports 13 ( 9 ) 1814 - 27 2015.12
Language：English Publishing type：Research paper (scientific journal)
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Association of estimated central blood pressure measured non-invasively with pulse wave velocity in patients with coronary artery disease.
Sueta D, Yamamoto E, Tanaka T, Hirata Y, Sakamoto K, Tsujita K, Kojima S, Nishiyama K, Kaikita K, Hokimoto S, Jinnouchi H, Ogawa H
International journal of cardiology. Heart & vasculature 8 52 - 54 2015.9
Language：English Publishing type：Research paper (scientific journal)
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The accuracy of central blood pressure waveform by novel mathematical transformation of non-invasive measurement.
Sueta D, Yamamoto E, Tanaka T, Hirata Y, Sakamoto K, Tsujita K, Kojima S, Nishiyama K, Kaikita K, Hokimoto S, Jinnouchi H, Ogawa H
International journal of cardiology 189 244 - 6 2015
Language：English Publishing type：Research paper (scientific journal)
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Id1 gene transfer confers angiogenic property on fully differentiated endothelial cells and contributes to therapeutic angiogenesis.
Nishiyama K, Takaji K, Kataoka K, Kurihara Y, Yoshimura M, Kato A, Ogawa H, Kurihara H
Circulation 112 ( 18 ) 2840 - 50 2005.11
Language：English Publishing type：Research paper (scientific journal)
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Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men.
Nishiyama K, Yasue H, Moriyama Y, Tsunoda R, Ogawa H, Yoshimura M, Kugiyama K
American heart journal 141 ( 5 ) E9 2001.5
Language：English Publishing type：Research paper (scientific journal)
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The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity.
Moriyama Y, Yasue H, Yoshimura M, Mizuno Y, Nishiyama K, Tsunoda R, Kawano H, Kugiyama K, Ogawa H, Saito Y, Nakao K
The Journal of clinical endocrinology and metabolism 85 ( 5 ) 1834 - 40 2000.5
Language：English Publishing type：Research paper (scientific journal)
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Elevated levels of soluble intercellular adhesion molecule-1 in the coronary circulation of patients with coronary organic stenosis and spasm.
Ogawa H, Sakamoto T, Nishiyama K, Soejima H, Kaikita K, Takazoe K, Miyamoto S, Kugiyama K, Yoshimura M, Yasue H
Japanese circulation journal 64 ( 3 ) 170 - 6 2000.3
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Increased blood vascular endothelial growth factor levels in patients with acute myocardial infarction.
Ogawa H, Suefuji H, Soejima H, Nishiyama K, Misumi K, Takazoe K, Miyamoto S, Kajiwara I, Sumida H, Sakamoto T, Yoshimura M, Kugiyama K, Yasue H, Matsuo K
Cardiology 93 ( 1-2 ) 93 - 9 2000