Papers - KANEKO Masatoki
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Win K.D., Kawasue K., Kaneko M.
Sensors 25 ( 6 ) 2025.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Sensors
Highlights: What are the main findings? A non-contact method for measuring neonatal head circumference using a 3D imaging sensor was developed. What is the implication of the main finding? A top-view 3D imaging system can be used to estimate the head circumferences of neonates without direct contact, ensuring safety for their delicate skin. Because some portions of the head may be missing in the top-view images, these missing areas are estimated using mat information. The extracted features and head surface values contribute to the head circumference measurement. This approach enhances the feasibility of non-contact head circumference measurement, which could improve neonatal monitoring in clinical settings. In Japan, birth rates are declining, but there are a rising number of underweight newborns who require specialized care in neonatal intensive care units (NICUs). Head circumference is an important indicator of brain development for low-birth-weight infants. However, measuring head circumference requires extreme care because low-birth-weight infants have fragile skin. Therefore, a non-contact measurement system using a 3D imaging sensor was developed. Using this system, three-dimensional data for a newborn’s head can be obtained from outside the incubator. Briefly, the images are taken from above the incubator, so there is an area behind the head that cannot be captured by the camera, but the head circumference estimation takes into account the fact that the head is in contact with the mat. The proposed method allows head circumference estimation without touching the newborn. This approach minimizes stress for both the neonate and the nurse and improves efficiency and safety in the NICU.
DOI： 10.3390/s25061869
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The estimation of a cytomegalovirus immunoglobulin G avidity using the mathematical model Invited Reviewed
Masatoki Kaneko
Journal of Basic and Clinical Pharmacy 13 ( 127 ) 127 2022.3
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Kaneko M., Muraoka J., Kusumoto K., Minematsu T.
Viruses 13 ( 5 ) 2021.5
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Viruses
Human cytomegalovirus (CMV) is the leading cause of neurological sequelae in infants. Understanding the risk factors of primary CMV infection is crucial in establishing preventive strategies. Thus, we conducted a retrospective cohort study to identify risk factors of vertical transmission among pregnant women with immunoglobulin (Ig) M positivity. The study included 456 pregnant women with IgM positivity. Information on age, parity, occupation, clinical signs, IgM levels, and IgG avidity index (AI) was collected. The women were divided into infected and non-infected groups. The two groups showed significant differences in IgM level, IgG AI, number of women with low IgG AI, clinical signs, and number of pregnant women with single parity. In the multiple logistic regression analysis, pregnant women with single parity and low IgG AI were independent predictors. Among 40 women who tested negative for IgG antibody in their previous pregnancy, 20 showed low IgG AI in their current pregnancy. Among the 20 women, 4 had vertical transmission. These results provide better understanding of the risk factors of vertical transmission in pregnant women with IgM positivity.
DOI： 10.3390/v13050866
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Kaneko M., Ohhashi M., Fujii Y., Minematsu T., Kusumoto K.
International Journal of Infectious Diseases 100 1 - 6 2020.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Infectious Diseases
Objective: To establish a model to predict high cytomegalovirus (CMV) immunoglobulin (Ig)G avidity index (AI) using clinical information, to contribute to the mental health of CMV-IgM positive pregnant women. Methods: We studied 371 women with IgM positivity at ≤14 w of gestation. Information on the age, parity, occupation, clinical signs, IgM and G values, and IgG AI was collected. The IgG AI cut-off value for diagnosing congenital infection was calculated based on a receiver operating characteristic curve analysis. Between-group differences were assessed using the Mann–Whitney U-test or χ2 analysis. The factors predicting a high IgG AI were determined using multiple logistic regression. Results: The women were divided into high or low IgG AI groups based on an IgG AI cut-off value of 31.75. There were significant differences in the IgG and IgM levels, age, clinical signs, and the number of women with one parity between the two groups. In a multiple logistic regression analysis, IgM and the number of women with one parity were independent predictors. This result helped us establish a mathematical model that correctly classified the IgG AI level for 84.6% of women. Conclusion: We established a highly effective model for predicting a high IgG AI immediately after demonstrating IgM positivity.
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Intrapartum fetal heart rate monitoring in cases of cytomegalovirus infection Reviewed
金子 政時,鮫島 浩,池田 智明,池ノ上 克,峰松 俊夫
Am. J. Obstet. Gynecol. 191 1257 - 1262 2014.9
Language：English Publishing type：Research paper (scientific journal)
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特集 ローリスク妊婦ローリスク新生児のケア2025 妊娠時 妊婦健診における検体検査 Reviewed
金子 政時, 谷口 光代
周産期医学 55 ( 1 ) 32 - 34 2025.1
Publishing type：Research paper (scientific journal) Publisher：東京医学社
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Effect of domestic violence on the health-related quality of life of pregnant women during the COVID-19 pandemic Reviewed
Honoka Tsuda, Masatoki Kaneko, Kurumi Tsuruta, Keiko Yamazaki, Ayako Tanabe, Saori Yoshinaga, Mitsuyo Taniguchi, Yoshinori Fujii
Journal of Japan Health Medicine Association 33 ( 2 ) 200 - 207 2024.7
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Impact of COVID-19 on Cytomegalovirus Immunoglobulin M Antibody Index Reviewed
Kaneko M., Muraoka J., Yang L., Tokunaga S., Minematsu T.
Clinical and Experimental Obstetrics and Gynecology 50 ( 12 ) 2023.12
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Clinical and Experimental Obstetrics and Gynecology
Background: Coronavirus disease 2019 (COVID-19) influenced the prevalence of other infectious diseases, including congenital cytomegalovirus (CMV) infection. However, the effect of COVID-19 on antibody titers has not been reported. This study aimed to explore the influence of COVID-19 on levels of CMV immunoglobulin M (IgM) in pregnant women. Methods: This cross-sectional study included pregnant women who visited the University Hospital due to CMV IgM positivity during the 7th and 8th waves of COVID-19. Data, including maternal characteristics, history of COVID-19, CMV immunoglobulin G (IgG) and IgM index, and IgG avidity index (AI) were collected. Chemiluminescent immunoassay was performed to measure levels of IgG and IgM. Polymerase chain reaction using neonatal urine was performed to confirm congenital infection. Results: Of the 89 pregnant women, 36 (40%) (low IgG AI: n = 10; high IgG AI: n = 26) contracted COVID-19. Among 21 women with low IgG AI, 9 (false IgM positive: n = 8; primary infection: n = 1) had an IgG AI of 0. Among the eight women with false IgM positivity, six (75%) contracted COVID-19. The IgM index of pregnant women with false IgM positivity was 12.6 ± 10.9. Meanwhile, the CMV IgM index of pregnant women with false IgM positivity in the non-COVID-19-infected group was 1.7 ± 0.5. When the IgM indices of women who contracted (n = 36) and did not contract (n = 53) COVID-19 were compared, the IgM index of infected women (4.4 ± 5.7) was higher than those of non-infected women (2.7 ± 3.0) (p = 0.01). Regarding IgM and IgG AI, multiple logistic regression analysis revealed that there were no significantly different variables between the two groups. Conclusions: High prevalence of false IgM positivity was observed among women who contracted COVID-19. The IgM index of pregnant women with false IgM positivity was high. Caution should be exercised in interpreting CMV IgM indices in pregnant women with a history of COVID-19.
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特集 数値からみる周産期医療 産科編 先天性感染症 Reviewed
金子 政時
周産期医学 53 ( 8 ) 1214 - 1216 2023.8
Publishing type：Research paper (scientific journal) Publisher：東京医学社
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Yamada N., Kaneko M., Yang L., Matsuzawa S., Minematsu T., Kodama Y.
Journal of Infection and Chemotherapy 29 1071 - 1074 2023.7
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy
Human cytomegalovirus (HCMV) is the major cause of neurological sequelae in infants. Immune control of primary HCMV infection appears to depend on the interaction between humoral and cell-mediated immune responses. We report the case of an HCMV-transmitter mother observed with dissociation between humoral and cell-mediated immune responses. The patient had immunoglobulin (Ig) G and M positivity at 11 weeks of gestation and showed fetal hyperechoic bowel and minimal ascites at 21 weeks of gestation. At 25 weeks of gestation, the polymerase chain reaction result for HCMV using amniotic fluid was positive. The numbers of spots in the enzyme-linked immunosorbent spot (ELISPOT) assay at 25, 36, and 39 weeks of gestation were three, five, and six spots/2 × 105 peripheral blood mononuclear cells, respectively. Furthermore, IgG avidity indexes (AIs) at 21, 25, 36, and 39 weeks of gestation were 37.6, 49.7, 72.5, and 74.3, respectively. At 40+1 weeks of gestation, the patient delivered a symptomatic infected newborn with a weight of 2,384 g (−2.6 SD) and a head circumference of 30 cm (−2.6 SD). The neonate had a petechial rash and bilateral hearing loss although did not show liver dysfunction or thrombocytopenia. Cranial magnetic resonance imaging revealed mild ventriculomegaly, left lateral/parietal polymicrogyria, and a punctate white matter lesion. This case showed that IgG AI increased with increasing gestational age, whereas the numbers of spots in the ELISPOT assay had no change. The dissociation between humoral and cell-mediated immune responses may be characteristic of the immune response of a transmitter mother.
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Tanabe Ayako, Hisadome Aoi, Yamamoto Asuka, Suetsugu Norie, Kaneko Masatoki
The South Kyusyu journal of nursing 21 ( 1 ) 1 - 8 2023.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Work environment to achieve work-life balance in workers raising children: A questionnaire survey of young in Miyazaki Cityy Reviewed
21 ( 1 ) 1 - 8 2023.3
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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A qualitative study of maternal and child health coordinators on mothers' concerns Reviewed
kaho Yamshita, Keiko Yamazaki, Ayaka Matsuoka, Masatoki Kaneko
20 ( 1 ) 9 - 16 2023.3
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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Kaneko M., Yang L., Tanabe A., Fujii Y., Nakao H., Minematsu T.
Journal of Infection and Chemotherapy 29 485 - 489 2023
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy
Introduction: Variable rates of cytomegalovirus (CMV) seropositivity in mothers from different individual's background may translate to distinct epidemiological patterns of congenital CMV infection. Methods: The prospective cohort study was conducted in Japan to evaluate the prevalence of vertical transmission rate according to the type of maternal infection. Post hoc power as a follow-up analysis was evaluated to compare the statistical power with other studies from France, Finland and Brazil. One thousand one hundred sixty-three pregnant women were measured IgG, IgM and IgG avidity index. The urine samples of neonates of these women were evaluated using polymerase chain reaction to diagnose the vertical transmission. Results: The prevalence of congenital CMV infection in the study population was 0.4%. The proportions of patients with primary and nonprimary infections were 60% and 40%, respectively, with a maternal seroprevalence of 82.5%. The rate of vertical transmission among the seronegative pregnant women before pregnancy was statistically higher than that among the seropositive pregnant women before pregnancy (p < 0.05), with a study power of 52.7%. The same difference was observed in France and Finland for maternal seroprevalence of 61% and 72% and statistical power of 56.9% and 66.7%, respectively. Conclusion: The maternal seroprevalence of the present study conducted in Japan was much higher than that of studies in France and Finland. Nevertheless, seronegative pregnant women had a higher risk of vertical transmission before pregnancy.
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Sakakibara Kouhei, Yamada Naoshi, Kodama Yuki, Obata Shizuka, Tsuzuki Yasue, Muraoka Junsuke, Aoki Yoshinori, Yamashita Rie, Nakame Kazuhiko, Kaneko Masatoki, Katsuragi Shinji, Tsuzuki Ryo, Sato Yuichiro
Journal of Japan Society of Perinatal and Neonatal Medicine 59 ( 1 ) 116 - 121 2023
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Perinatal and Neonatal Medicine
Here we report a case of pulmonary lymphangiectasia that caused exacerbation of respiratory status after an infection. A preterm infant born at 23 weeks of gestation without obvious clinical intrauterine infection showed worsening respiratory status and increased c-reactive protein on day 15 of life. Chest X-ray showed consolidation in right upper lobe and whole left lung. Several broad-spectrum antibiotics were administered unsuccessfully. Finally, <i>Ureaplasma urealyticum</i> was detected in sputum culture, and azithromycin was administered. Although the inflammation improved, tension pneumothorax and pulmonary hypertension developed and he died on day 44 of life. At autopsy, there were few findings of lung inflammation, and congenital lymphangiectasia was diagnosed. It seems that exacerbation was triggered by the infection, although there was no remarkable evidence to support causality. There have been few case reports of pulmonary lymphangiectasia in extremely low birth weight infants. This case was considered to be classified as primary, although the respiratory condition at birth was relatively good. There are no clear diagnostic criteria for this disease and no effective treatments. Clinically, neonatologists should keep in mind pulmonary lymphangiectasia if respiratory failure in newborns does not respond to common treatment approach.
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先天性感染症
金子 政時
周産期医学 53 1214 - 1216 2023
Publishing type：Research paper (scientific journal)
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増刊号 191の疑問に答える周産期の栄養 産科編Q & A 妊娠中期 Q80 食後の胸焼けがひどくなりました。 食事はどうしたらよいですか? 薬はありますか? Reviewed
金子 政時, 前山 彩, 松岡 あやか
周産期医学 52 ( 13 ) 179 - 180 2022.11
Publishing type：Research paper (scientific journal) Publisher：東京医学社
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Muraoka J., Kaneko M., Doi K., Kodama Y., Sameshima H.
Microbiology Research 13 ( 3 ) 598 - 608 2022.9
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Microbiology Research
The use of prenatal antibiotics should be carefully considered, owing to their potential adverse effects on neonatal outcomes. This study aimed to identify the contributing factors to early-onset neonatal infection and to determine the influence of antepartum antibiotics on women and neonates. This study included 127 pregnant women without obvious intra-amniotic infection on admission, who delivered under 34 weeks of gestation. Information on maternal and neonatal characteristics was obtained from their medical charts. Vaginal swabs were taken from all women on admission. In total, 29 (22.8%) neonates developed early-onset infection. Multivariate analysis revealed that antepartum antibiotics were the most strongly associated factor for early-onset neonatal infection (odds ratio, 11.2; 95% confidence interval, 4.08–31.02). The frequency of early-onset neonatal infection was significantly higher in women who received antibiotic therapy than in those who did not; no significant difference in prolonging their gestation or neonatal morbidities was observed. The prevalence of women who hosted vaginal microorganisms on admission was similar to that in women whose infants subsequently developed early-onset neonatal infection compared with that of women whose infants did not. Among infants of the 40 women who received antepartum antibiotic therapy, 21 developed early-onset infection. Of the women who delivered these 21 infants, 62% (13/21) showed reduced lactobacilli and 43% (9/21) had resistant bacterial strains in their vaginal microbiota at the time of delivery. The use of antepartum antibiotics is the most strongly associated factor in early-onset neonatal infection; it does not prolong gestation and would change the vaginal environment.
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Antepartum antibiotic therapy under 34 weeks of gestation and its impact on early-onset neonatal infection and maternal vaginal microbiota Reviewed
Masatoki Kaneko
Microbiological Reserch 13 598 - 608 2022.8
Publishing type：Research paper (scientific journal)
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Association between chorioamnionitis severity and procalcitonin levels in umbilical venous blood Reviewed International journal
Masatoki Kaneko, Junsuke Muraoka, Naoshi Yamada, Yuki Kodama
Clinical and Experimental Obstetrics & Gynecology 49 ( 7 ) 160 2022.7
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：IMR Press
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Association between chorioamnionitis severity and procalcitonin levels in umbilical venous blood Reviewed
Masatoki Kaneko
Clinical and Experimental Obstetrics & Gynecology 49 ( 7 ) 16 2022.7
Publishing type：Research paper (scientific journal)
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先天性サイトメガロウイルス感染症の現状と課題 Invited
金子政時
日本周産期・新生児医学会雑誌 57 ( 4 ) 606 - 609 2022.4
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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A comparative study of changes in postural alignment, muscle stiffness around the shoulders over time and between good and bad posture in Cradle-hold position Reviewed
Ai Osaki, Ayaka Matsuoka, Masatoki Kaneko, Keiko Yamazaki
Japanese Journal of Maternal Health 63 ( 1 ) 112 - 120 2022.4
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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A survey regarding why the medical staff works while sick -Survey on the working conditions of medical personnel working at tertiary obstetric care facilities when they are sick- Reviewed
20 ( 1 ) 10 - 17 2022.4
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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Matsuoka Ayaka, Kaneko Masatoki, Imamura Tomomi
The South Kyusyu journal of nursing 20 ( 1 ) 10 - 17 2022.3
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Analysis of the factors affecting parents' hospital visit to their extremely low-birthweight infants in the Neonatal Care Unit Reviewed
Saki Yanagita, Masatoki Kaneko, Keiko Yamazaki, Ayaka Matsuoka
Japanese Journal of Maternal Health 62 ( 4 ) 771 - 778 2022.1
Authorship：Last author Publishing type：Research paper (scientific journal)
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Evaluation of blood collection training in collaboration with clinical nurses Reviewed
KATO Sayaka, SUETSUGU Norie, YOSHINAGA Saori, TSURUTA Kurumi, KANEKO Masatoki
Journal of Japan Association for Simulation-based Education in Healthcare Professionals 10 ( 0 ) 43 - 50 2022
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Association for Simulation-based Education in Healthcare Professionals
This study aimed to clarify the educational value of venous blood collection technique exercises in collaboration with clinical nurses. 52 nursing students were evaluated in their second and fourth years and were asked to complete a self-administered original questionnaire survey. The Wilcoxon signed-rank test was used to compare the results. Most of the self-evaluation scores were higher for the fourth-years compared with the second-years, particularly for factors that can be categorized as “medical security” and “venipuncture maneuver”. In particular, a significantly higher proportion of fourth-years compared to second-years were able to select the appropriate venipuncture site and puncture blood vessels(p < .05). The approach of clinical and university cooperation increased the motivation of nursing students to learn before graduation, suggesting the need for a smooth transition from basic nursing education to continuing practical nursing education.
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特集 周産期医学必修知識(第9版) 性感染症(STI/STD) Reviewed
金子 政時
周産期医学 51 ( 13 ) 9 - 12 2021.12
Publishing type：Research paper (scientific journal) Publisher：(株)東京医学社
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A case of facial cellulitis caused by group B streptococcus in an extremely low birthweight infant Reviewed
Muraoka J., Kodama Y., Higashi M., Yamada N., Yamashita R., Nakame K., Kaneko M., Sameshima H.
Journal of Infection and Chemotherapy 27 ( 9 ) 1369 - 1372 2021.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy
Group B streptococcus (GBS) is an important pathogen that causes neonatal sepsis and meningitis, which have high mortality and morbidity. Cellulitis is a rare presentation of late-onset neonatal GBS infection. We report the case of an extremely low birthweight infant with facial cellulitis caused by late-onset GBS infection. A 590-g male neonate was delivered by Cesarean section at 23 gestational weeks due to intrauterine GBS infection. Although he was effectively treated with 2 weeks of antimicrobial therapy for early-onset GBS sepsis, he subsequently developed facial and submandibular cellulitis caused by GBS at 44 days of age. He was treated with debridement and antibiotic therapy, and after 2 months his facial involvement had improved, but cosmetic issues remained. Neonatal GBS infection requires a prompt sepsis workup followed by the initiation of empiric antibiotic therapy. Additionally, lifesaving surgical debridement is sometimes necessary for cellulitis, even in premature infants.
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Congenital Cytomegalovirus Infection and Hearing Loss Invited
Masatoki Kaneko
261 27 - 30 2021.8
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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先天性サイトメガロウイルス感染症の胎児診断 Invited
金子 政時
ENTONI 261 27 - 30 2021.8
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
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Report on the maternity nursing practice under the COVID-19 pandemic Reviewed
Matsuoka Ayaka, Yamazaki Keiko, Kaneko Masatoki, Kuwahara Mayumi, Nagase Tuyako
The South Kyusyu journal of nursing 19 ( 1 ) 11 - 16 2021.3
Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal)
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Kaneko M., Ichida M., Fujii Y., Noda S., Ohi M.
Journal of Infection and Chemotherapy 27 ( 3 ) 434 - 438 2021.3
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy
Introduction: This study aimed to examine the immunity level against rubella in pregnant women of different birth cohorts. Methods: In total, 512 pregnant women who visited a primary clinic between May 2019 and March 2020 were enrolled. Information in terms of the patients’ hemagglutination inhibition (HI) titers, birthdate, obstetrical history, and vaccination history were collected. Participants were divided into three generational groups according to the vaccination policy in Japan. Publicly funded vaccination was administered twice as part of a routine program in group A (n = 11), once as part of a routine program and once in a catch-up program in group B (n = 181), and once in group C (n = 320). Results: All groups had some women with negative rubella HI antibody titers (7.6% of all the women, 18.2% of group A, 9.4% of group B, and 6.3% of group C) and those with rubella HI antibody titers of ≤1:16 (45.1% of all women, 90.9% of group A, 56.4% of group B, and 37.2% of group C). Rubella HI antibody titers differed between the groups; group C had higher titers than that in group B. In groups B and C, the proportions of women with rubella HI antibody titers of ≤1:16 were not statistically different between primipara and multipara. Conclusions: Our study showed that an increase in immunity to rubella, a vaccine-preventable disease, is nevertheless required among childbearing women to prevent rubella and congenital rubella syndrome.
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A very low birth weight infant with severe red blood cell polyagglutination: Case report Reviewed
Naoshi Yamada, Yuki Kodama, Tomoko Goto, RIe Yamashita, Kotaro Doi, Masatoki Kaneko, Yuichiro Sato, Hiroshi Sameshima
Journal of Neonatal Biology 9 ( 3 ) 1 - 3 2021.3
Publishing type：Research paper (scientific journal)
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サイトメガロウイルス感染症
金子 政時
臨床と微生物 48 53 - 57 2021
Publishing type：Research paper (scientific journal)
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特集 [必携]専攻医と指導医のための産科診療到達目標 病態･疾患編【その他】妊娠と感染症 サイトメガロウイルス Reviewed
金子 政時
周産期医学 50 ( 8 ) 1489 - 1491 2020.8
Publishing type：Research paper (scientific journal) Publisher：(株)東京医学社
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JICA 研修受入事業におけるシミュレーションワーク -JICA研修員と助産学生との協働によるチーム医療についての学び- Invited
松岡 あやか, 金子 政時, 山﨑 圭子
宮崎大学教育・学生支援センター紀要 4 19 - 25 2020.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：宮崎大学教育・学生支援センター
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Two cases of very low birth weight infants with congenital syphilis Reviewed
Tokuda Atsuko, Kodama Yuki, Kanno Chika, Goto Tomoko, Yamada Naoshi, Yamashita Rie, Doi Koutarou, Kaneko Masatoki, Sameshima Hiroshi
Journal of Japan Society of Perinatal and Neonatal Medicine 56 ( 3 ) 538 - 543 2020
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Perinatal and Neonatal Medicine
Syphilis is a sexually transmitted disease caused by <i>Treponema pallidum</i>. Congenital syphilis occurs as a result of vertical transmission from a mother to the fetus. The number of congenital syphilis cases has recently been rising in both the United States and Japan. Vertical transmission of syphilis can be prevented by early detection during pregnancy and adequate treatment of the mother. Here we report two cases of very low birth weight infants with congenital syphilis, who had different clinical courses. One survived and developed normally following successful antibiotic treatment, while the other died at 14 hours of age with <i>Treponema pallidum</i> infection in the placenta and multiple organs.
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妊娠と感染症：サイトメガロウイルス
金子 政時
周産期医学 50 1489 - 1491 2020
Publishing type：Research paper (scientific journal)
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Sho Takakura, Yuki Kodama, Rie Yamashita, Emi Kino, Noriko Kawano, Kayo Tominori, Yohei Maki, Koutaro Doi, Masatoki Kaneko, Hiroshi Sameshima
Journal of Obstetrics and Gynaecology Resarch 46 ( 3 ) 389 - 395 2019.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
Aim: To investigate the effects of Mycoplasma/Ureaplasma cultured in amniotic fluid on perinatal characteristics in preterm delivery between 22 and 33 weeks of gestation. Methods: The study was conducted in a tertiary perinatal center and involved 38 pregnant women who had undergone amniocentesis to evaluate intrauterine infection due to preterm labor or premature rupture of membranes. The subjects were divided into three groups based on the culture results: negative (Negative Group, n = 24), positive for Mycoplasma/Ureaplasma (M/U Group, n = 6), and positive for other pathogens (Other Pathogens Group, n = 8). One-way analysis of variance was used to compare the three groups. Results: The incidence of histological chorioamnionitis and neonatal sepsis was significantly different among the three groups (the Negative Group and the Other Pathogens Group, P < 0.01; the M/U Group and the Other Pathogens Group, P = 0.03). In the M/U Group, no infants had sepsis, severe intraventricular hemorrhage, cystic periventricular leukomalacia, or poor neurological outcomes, but one infant developed bronchopulmonary dysplasia and needed home oxygen treatment. Although one died of gastrorrhexis, the remaining five patients had normal brain magnetic resonance imaging findings and developed normally. Conclusion: The presence of Mycoplasma/Ureaplasma isolated from amniotic fluid did not cause neonatal sepsis or poor prognosis. In some infants, there was no histological chorioamnionitis in the placenta. These pathogens thus seem to be less invasive than any other microbes with respect to perinatal outcomes.
DOI： 10.1111/jog.14183
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妊婦サイトメガロウイルス抗体スクリーニングと妊産婦メンタルヘルスケア Reviewed
金子政時，松岡あやか，土谷倭子
宮崎県医師会医学会誌 2019.12
Language：Japanese Publishing type：Research paper (scientific journal)
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過去20年の総合周産期母子医療センターにおける産科症例の変遷 Reviewed
川越靖之、大西淳仁、古川誠志、児玉由紀、金子政時、鮫島浩、池ノ上克
宮崎県医師会医学会誌 2019.11
Language：Japanese Publishing type：Research paper (scientific journal)
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分娩時の低酸素ストレスが新生児プロカルシトニン値に与える影響 Reviewed
金子政時, 山口智子, 中山徹男, 谷口肇, 大橋昌尚, 児玉由紀
日本周産期・新生児医学会雑誌 2019.9
Language：Japanese Publishing type：Research paper (scientific journal)
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A cross-sectional study on maternal anxiety levels after cytomegalovirus screening Reviewed
Kanako Uehara, Masatoki Kaneko, Ayaka Matsuoka, Mana Kuroki & Toshio Minematsu
Journal of Psychosomatic Obstetrics and Gynecology 41 ( 3 ) 240 - 245 2019.8
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Psychosomatic Obstetrics and Gynecology
Purpose: we aimed to estimate the anxiety levels of pregnant women following maternal serum screening for CMV infection. Materials and methods: In this case-control study conducted from April 2016 to June 2017, we enrolled all pregnant women referred to our hospital who were CMV immunoglobulin (Ig) M antibody positive (IgM-positive group, n = 51); further, those who were CMV IgG positive but IgM negative (IgM-negative group, n = 51) during the same period were included as study controls. Data were collected on patient characteristics, CMV IgM levels, and whether patients were accompanied by their partners during the first hospital visit after CMV IgM testing. The State-Trait Anxiety Inventory was used to assess anxiety levels. Results: Both groups were age matched [mean age (years): IgM-positive, 30 ± 4.2 and IgM-negative, 29.9 ± 4.6]. The mean state-anxiety score was higher in the IgM-positive group (53 ± 9.6) than in the IgM-negative group (38.5 ± 7.0, p <.05) with no between-group differences in trait-anxiety scores. Similarly, a higher number of women were accompanied by their partners in the IgM-positive group. The state-anxiety scores and CMV IgM levels were not correlated in the IgM-positive group. Conclusion: Counseling support is essential for IgM-positive pregnant women following serum screening, and the screening should be avoided if support systems are unavailable.
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産科医療補償制度に学ぶ 助産師のための妊娠・分娩マネジメント講座 多胎
金子政時、池ノ上克
ペリネイタルケア 38巻 1号 70-75 2019.1
Language：Japanese Publishing type：Research paper (scientific journal)
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新生児けいれんを契機に診断された家族歴のない血友病の1例 Reviewed
河野猛嗣、児玉由紀、山下理絵、紀愛美、椎葉望、金子政時、鮫島浩、松澤聡史、大橋昌尚、堂福美佳、山田愛、木下真理子、上村幸代、盛武浩
宮崎県医師会医学会誌 2018.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Oral diatrizoate acid for meconium-related ileus in extremely preterm infants Reviewed
Kaori Michikata, Yuki Kodaa, Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Seiro Machigashira, Motoi Mukai, Motofumi Torikai, Kazuhiko Nakame
Pediatrics International 2018.8
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1111/ped.13606
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サイトメガロウイルスIgM抗体陽性妊婦の外来紹介受診状況と妊娠転帰に関する後方視的検討 Reviewed
黒木真菜，金子政時，水畑喜代子，永瀬つや子，松岡あやか
母性衛生 2018.7
Language：Japanese Publishing type：Research paper (scientific journal)
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胎内サイトメガロウイルス(CMV)感染症児におけるIgG抗体Avidity Indexの推移とその有用性 Reviewed
金子 政時,鮫島 浩,田中 博明,楠元 和美,池田 智明,池ノ上 克,峰松 俊夫
日本産婦人科・新生児血液学会雑誌 14 ( 1 ) 43 - 44 2018.4
Language：Japanese Publishing type：Research paper (scientific journal)
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Fetal left ventricular non-compaction cardiomyopathy with ascites: A case report. Reviewed
Junsuke Muraoka, Yuki Kodama, Hiroshi Sameshima, Kaori Michikata, Satoshi Matsuzawa, Masanao Oohashi, Masatoki Kaneko, Mayumi Akaki, Yuichiro Sato
Journal of Obstetrics and Gynaecology Resarch 2017.9
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Maternal immunoglobulin G avidity as a diagnostic tool to identify pregnant women at risk of congenital cytomegalovirus infection.
Kaneko M, Ohhashi M, Minematsu T, Muraoka J, Kusumoto K, Sameshima H
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 23 ( 3 ) 173 - 176 2017.3
Language：Japanese Publishing type：Research paper (scientific journal)
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胎内感染のメカニズムと児の長期予後に与える影響
金子政時
周産期医学 47巻、2号 167-170 2017.2
Language：Japanese Publishing type：Research paper (scientific journal)
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胎内感染のメカニズムと児の長期予後に与える影響
金子政時
周産期医学 47巻 2017.2
Language：Japanese Publishing type：Research paper (scientific journal)
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総論：胎児心拍数モニタリングの心得
金子政時
ペリネイタルケア 36巻、5号 18-21 2017
Language：Japanese Publishing type：Research paper (scientific journal)
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【周産期のチーム医療 サクセス8 case 今こそ助産師の専門性を発揮する】 (Case 6)多職種間連携による胎児および新生児の治療
水畑 喜代子, 荒木 彩香, 吉野 詩保美, 見越 香奈, 三輪 元子, 金子 政時
ペリネイタルケア 35巻 12号 54-57 2016.12
Language：Japanese Publishing type：Research paper (scientific journal)
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絨毛膜羊膜炎とプロカルシトニン
金子政時
周産期医学 46巻、11号 1317-1321 2016.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Trends in perinatal death and brain damage: A regional population-base study in southern Japan, 1998-2012. Reviewed
Yamashita R, Kodama Y, Sameshima H, Doi , Michikata K, Kaneko M, Ikenoue T
Austin Pediatrics, 2016, 3 (4), id 1043 2016.9
Language：English Publishing type：Research paper (scientific journal)
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新生児・小児における特発性血栓症の診断、予防および治療法の確立に関する研究．母体の血栓性素因スクリーニングによる新生児血栓症の早期診断
金子政時
厚生労働科学研究費補助金 難治性疾患克服研究事業 平成26－27年度 総合研究報告書 35 - 37 2016.3
Language：Japanese Publishing type：Research paper (other academic)
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新生児蘇生準備段階における保育器内汚染度に関する検討
田中美帆、金子政時
なし 2016
Language：Japanese Publishing type：Master’s thesis
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超低出生体重児の分娩時胎児心拍数陣痛図連続記録の質に影響を与える因子に関する研究
河野美津子、金子政時
なし 2016
Language：Japanese Publishing type：Master’s thesis
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Chronic histiocytic intervillositis同胞例における周産期予後の比較 Reviewed
村岡純輔、金子政時、松澤聡史、大橋昌尚、住吉佳恵子、道方香織、児玉由紀、鮫島浩
日本周産期・新生児医学会雑誌 2016、52巻、1号、125-129 2016
Language：Japanese Publishing type：Research paper (scientific journal)
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Hydrops fetalis associated with congenital cytoplasmic body myopathy. Reviewed
Kodama Y, Sameshima H, Kaneko M, Kawaguchi H, Ikeda T, Ikenoue T
Obstetrics and Gynecology Case-Reviews, 2016, 3 (7), 1-3 2016
Language：English Publishing type：Research paper (scientific journal)
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超低出生体重児の出生後経過に伴う閉鎖式保育器の汚染度に関する研究
山中瑠璃、金子政時
なし 2016
Language：Japanese Publishing type：Master’s thesis
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サイトメガロウイルスIgM抗体陽性妊婦の支援体制構築に向けた外来紹介受診状況と妊娠転帰に関する研究
黒木真菜、金子政時
なし 2016
Language：Japanese Publishing type：Master’s thesis
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Did antepartum hypoxic insult caused by fetal vessel thrombosis influence the procalcitonin level in umbilical blood? A case report Reviewed
M. Kaneko, A. Yamauchi, R. Yamashita, et al.
The Journal of Obstetrics and Gynecology Research 41 ( 11 ) 1839 - 1842 2015.11
Language：English Publishing type：Research paper (scientific journal)
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Kaneko M., Yamauchi A., Yamashita R., Sato Y., Kodama Y., Sameshima H.
Journal of Obstetrics and Gynaecology Research 41 ( 11 ) 1839 - 1842 2015.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
© 2015 Japan Society of Obstetrics and Gynecology. We report a case of marked elevation of the procalcitonin level in umbilical blood and neonatal blood at birth. The mother did not perceive fetal motion. Antepartum fetal heart rate monitoring showed a loss of variability and absence of acceleration. No fetal breathing movement, fetal movement, or fetal tone were observed by ultrasonography. The female neonate was delivered by cesarean section at 25-weeks of gestation, with birthweight 774-g. The umbilical arterial pH value at birth was 7.29. Mild elevation in interleukin-6 and tumor necrosis factor-α in umbilical blood were observed. Cytochrome c showed a high level in umbilical and neonatal blood at birth. Placental histopathology revealed multiple fetal vessel thrombosis in the large stem villi and chorionic vessels. The neonate showed no infectious signs throughout the neonatal period. Computed tomography at 3-months of age revealed atrophy in the cerebrum and cerebellum. At 1-year after birth, the infant showed spastic quadriplegia. In this case, antepartum asphyxia due to fetal vessel thrombosis may have influenced the elevation of procalcitonin level in umbilical blood and neonatal blood at birth.
DOI： 10.1111/jog.12828
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Perinatal morbidity and mortality for extremely low-birthweight infdants: A population-based study of regionalized maternal and neonatal transport. Reviewed
M. Kaneko, R. Yamashita, K. Kai, et al
The Journal of Obstetrics and Gynecology Research 41 ( 7 ) 1056 - 1066 2015.7
Language：English Publishing type：Research paper (scientific journal)
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Perinatal morbidity and mortality for extremely low-birthweight infants: A population-based study of regionalized maternal and neonatal transport.
Kaneko M, Yamashita R, Kai K, Yamada N, Sameshima H, Ikenoue T
The journal of obstetrics and gynaecology research 41 ( 7 ) 1056 - 66 2015.7
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Prospective study of the MD-twin score for antepartum evaluation of monochorionic diamniotic twins and its correlation with perinatal outcomes.
Oohashi M, Kaneko M, Sameshima H, Kodama Y, Ikenoue T
The journal of obstetrics and gynaecology research 40 ( 3 ) 711 - 7 2014.3
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Protein C deficiency as the major cause of thrombophilias in childhood Invited Reviewed
S Ohga, A Ishiguro, Y Takahashi, M Shima, M Taki, M Kaneko, et al.
Pediatrics International 55 267 - 271 2013.11
Language：English Publishing type：Research paper (scientific journal)
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Maternal IgG avidity, IgM and ultrasound abnormalities: combined method to detect congenital cytomegalovirus infection with sequelae Reviewed
M Kaneko, H Sameshima, T Minematsu, K Kusumoto, A Yamuchi, T Ikenoue
Journal of Perinatology 33 831 - 835 2013.7
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/jp.2013.87
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Protein C deficiency as the major cause of thrombophilias in childhood.
Ohga S, Ishiguro A, Takahashi Y, Shima M, Taki M, Kaneko M, Fukushima K, Kang D, Hara T, Japan Childhood Thrombophilia Study Group.
Pediatrics international : official journal of the Japan Pediatric Society 55 ( 3 ) 267 - 71 2013.6
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Mortality rates for extremely low-birthweight infants: a regional, population-based study in Japan during 2005-2009.
Kaneko M, Sameshima H, Kai K, Urabe H, Kodama Y, Ikenoue T
The journal of obstetrics and gynaecology research 38 ( 9 ) 1145 - 51 2012.9
Language：Japanese Publishing type：Research paper (scientific journal)
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Perinatal death and neurological damage as a sequential chain of poor outcome.
Doi K, Sameshima H, Kodama Y, Furukawa S, Kaneko M, Ikenoue T, Miyazaki Perinatal Data Groups.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 25 ( 6 ) 706 - 9 2012.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Case report and review of delayed -intereval delivery for dichorionic, diamniotic twins normal development Reviewed
Kaneko M, Kawagoe Y, Oonishi J. et al.
The Journal of Obstetrics and Gynaecology Research 38 ( 4 ) 741 - 744 2012.4
Language：English Publishing type：Research paper (scientific journal)
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Congenital infantile fibrosarcome in very low-birth-weight infant Reviewed
Mukai M, Sameshima H, Kodama Y, et al.
Journal of pediatric Surgery 47 1 - 4 2012.4
Language：English Publishing type：Research paper (scientific journal)
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Congenital infantile fibrosarcoma in a very low-birth-weight infant
Mukai M., Sameshima H., Kodama Y., Yamashita R., Kaneko M., Ikenoue T., Matsufuji H., Kondo K., Chijiiwa K.
Journal of Pediatric Surgery 47 ( 4 ) e1 - 4 2012.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Pediatric Surgery
We describe a prenatally diagnosed case with congenital infantile fibrosarcoma, which is a rare malignant tumor, of which there have been only 14 cases reported in the English literature. A giant mass on the left thigh was detected at 24 weeks' gestation by prenatal ultrasonography. Because of its rapid growth and nonreassuring fetal status in utero, the baby was delivered by cesarean delivery at 27 weeks' gestation. The case was complicated by hemorrhagic anemia, coagulopathy, and cardiac failure, and a tumor resection was performed on day 3. As of age 2.5 years, he was healthy without evidence of recurrence. Because some fetal cases with congenital infantile fibrosarcoma have a poor prognosis, termination of pregnancy at an appropriate time and postnatal early treatment are crucial for successful treatment. © 2012 Elsevier Inc.
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Kaneko M., Kawagoe Y., Oonishi J., Yamada N., Sameshima H., Ikenoue T.
Journal of Obstetrics and Gynaecology Research 38 ( 4 ) 741 - 744 2012.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
We report a case of delayed-interval delivery of a dichorionic, diamniotic twin pregnancy with the survival of both twins. The patient presented at 22 weeks and 1 day of gestation with vaginal bleeding and preterm labor. Five days later, the first twin was born. The second twin remained in utero. The management consisted of careful monitoring of both maternal and fetal status. Nine days later, the second twin was delivered vaginally. Both twins received full resuscitation and immediate life-support intervention; at 7 years of age both twins exhibited normal development. © 2012 2012 Japan Society of Obstetrics and Gynecology.
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超低出生体重の娩出法 ; 新生児及び母体の予後向上を目指して
古川 誠志, 鮫島 浩, 土井 宏太郎, 児玉 由紀, 金子 政時, 池ノ上 克, 西村 美保子, 高橋 典子
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 47 ( 4 ) 826 - 829 2011.12
Language：Japanese Publishing type：Research paper (scientific journal)
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KANEKO Masatoki, Masatoki KANEKO, Perinatal Center Department of Obstetrics and Gynecology University of Miyazaki
63 ( 12 ) N - 196-"N-200" 2011.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Perinatal death and neurological damage as a sequential chain of poor outcome Reviewed
Masatoki Kaneko
The Journal of Maternal-Fetal and Neonatal Medicine 1 - 4 2011.4
Language：English Publishing type：Research paper (scientific journal)
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Kaneko M., Tokunaga S., Mukai M., MacHigashira S., Maki Y., Kodama Y., Sameshima H., Ikenoue T.
Journal of Pediatric Surgery 46 ( 2 ) e37 - 40 2011.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Pediatric Surgery
Fetal monitoring is required to avoid hypoxic injury during ex utero intrapartum treatment (EXIT). We performed a tracheostomy under EXIT in a case of suspected airway obstruction caused by a cervical teratoma. The scalp electrode was applied for continuous fetal heart rate monitoring. This device enabled us to promptly deal with fetal bradycardia caused by cord compression. We describe here the usefulness of the fetal scalp electrode for fetal monitoring under EXIT. Crown Copyright © 2011 Published by Elsevier Inc. All rights reserved.
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町頭 成郎, 松藤 凡, 加治 建, 下野 隆一, 向井 基, 中目 和彦, 枡屋 隆太, 鮫島 浩, 金子 政時, 児玉 由紀, 池ノ上 克
日本小児外科学会雑誌 47 ( 6 ) 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本小児外科学会
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6)一絨毛膜双胎妊娠管理スコア指標とする立場に立って((3)一絨毛膜双胎娩出のタイミング,4)周産期,1.クリニカルディベート,生涯研修プログラム,第63回日本産科婦人科学会学術講演会)
金子 政時
日本産科婦人科學會雜誌 63 ( 2 ) 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本産科婦人科学会
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Rubella outbreak on Tokunoshima Island in 2004 : A population-based study of pregnant women
KUSUMOTO Kazumi, KANEKO Masatoki, SAMESHIMA Hiroshi, MINEMATSU Toshio, FURUTA Ken, IKENOUE Tsuyomu
The journal of obstetrics and gynaecology research 36 ( 5 ) 938 - 943 2010.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Clinical factors that enhance morbidity and mortality in intrauterine growth restricted foetuses delivered between 23 and 30 weeks of gestation. Reviewed
Sameshima H, Kodama Y, Kaneko M, Ikenoue T.
Journal of Maternal Fetal neonatal Medicine 23 ( 10 ) 1218 - 1224 2010.10
Language：English Publishing type：Research paper (scientific journal)
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Rubella outbreak on Tokunoshima Island in 2004: a population-based study of pregnat women. Reviewed
Kusumoto K, Kaneko M, Sameshima H, Minematsu T, Furuta K, Ikenoue T
Journal of Obstetrical Gynaecology Resarch 36 ( 5 ) 938 - 943 2010.10
Language：English Publishing type：Research paper (scientific journal)
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Rubella outbreak on Tokunoshima Island in 2004: a population-based study of pregnant women.
Kusumoto K, Kaneko M, Sameshima H, Minematsu T, Furuta K, Ikenoue T
The journal of obstetrics and gynaecology research 36 ( 5 ) 938 - 43 2010.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Sameshima H., Kodama Y., Kaneko M., Ikenoue T.
Journal of Maternal-Fetal and Neonatal Medicine 23 ( 10 ) 1218 - 1224 2010.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Maternal-Fetal and Neonatal Medicine
Objective.To find clinical factors that are associated with poor outcome (death and brain damage) in premature intrauterine growth restricted (IUGR) infants. Methods.A retrospective study was performed to compare the incidence of poor outcome between 45 IUGR and 203 appropriate-for-gestational-age (AGA) infants born before 30 weeks of gestation. Foetal tests included foetal heart rate monitoring, Doppler flow, amniotic fluid, and head circumference. Growth for gestational age was categorised as 10th through 3rd, third through first, and below first percentiles. Results.In infants below 25 weeks of gestation, the incidence of poor outcome was not different between IUGR and AGA. In infants between 25 and 30 weeks of gestation, the incidence of poor outcome was significantly increased in IUGR compared with AGA (12/40, 30 versus 11/136, 8.1, p < 0.01). Univariate analysis showed that abnormality in foetal heart rate monitoring [odds ratio (OR) 8.3, 95 confidence interval (CI) 1.5843.6], head circumference (OR 7.0, 95CI 1.4234.4), and Doppler flow (OR 10.9, 95CI 1.8364.6) was significantly associated with poor outcome in IUGR infants. However, no foetal tests were significantly associated with poor outcome after adjusting for the 3-grade birthweight percentiles. Conclusions.Immaturity outweighs clinical problem associated with IUGR in infants below 25 weeks of gestation. Between 25 and 30 weeks of gestation, there was a growth threshold below third percentile where foetal tests were not significant predictors of poor outcome, but that was primarily determined by birthweight. © 2010 Informa UK, Ltd.
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Developmental changes in catecholamine requirement, volume load and corticosteroid supplementation in premature infants born at 22 to 28 weeks of gestation Reviewed
Kaori Michikata, Hiroshi Sameshima, Kaeko Sumiyoshi, Yuki Kodama, Masatoki Kaneko, Tsuyomu Ikenoue
Early Human Development 86 401 - 405 2010.8
Language：English Publishing type：Research paper (scientific journal)
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Michikata K., Sameshima H., Sumiyoshi K., Kodama Y., Kaneko M., Ikenoue T.
Early Human Development 86 ( 7 ) 401 - 405 2010.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Early Human Development
Background: Due to circulatory instability, premature infants require volume loads, catecholamines and steroid supplementation to improve mortality and neurodevelopmental outcome. However, a complete quantitative analysis concerning the relationship between supplementation and gestational age, especially in infants born at 22 to 24 weeks of gestation, is lacking. Aim: To investigate whether less mature infants need higher doses of catecholamine, volume loads and steroid, and whether those who require higher doses have poorer outcome. Study design: A retrospective, observational study was performed at a tertiary center in a university setting. Among the consecutive 221 premature infants born at 22 to 28 weeks of gestation, we selected 108 infants who had no apparent pathological conditions other than prematurity. Catecholamines, volume loads and steroid, given to attain sufficient blood pressure and urinary output, were quantitatively analyzed during the first 24 hours. Outcome measures: Quantity of catecholamines, volume expanders and steroid supplementation as a function of gestational age and childhood outcome at 2 years. Results: Catecholamines and volume loads were increased in a step-wise manner with decreasing gestational age. Intact survival rate was significantly lower in infants born before 25 weeks of gestation compared with the more mature infants. Among infants born at 22 to 24 weeks' gestation, catecholamine and volume load increased significantly in poor outcome infants compared with good outcome infants. Conclusions: From a developmental viewpoint, progressively larger doses of catecholamine, volume expanders and corticosteroid are required to stabilize circulatory adaptation to neonatal life in infants between 22 to 28 weeks of gestation. © 2010 Elsevier Ltd.
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町頭 成郎, 松藤 凡, 加治 建, 向井 基, 堂地 勉, 桑波田 知樹, 川俣 和弥, 池ノ上 克, 鮫島 浩, 金子 政時
日本小児外科学会雑誌 46 ( 3 ) 2010
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本小児外科学会
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P001.胃穿孔を起こした超低出生体重児の1例(一般演題,第47回日本小児外科学会九州地方会)
町頭 成郎, 千々岩 一男, 近藤 千博, 池ノ上 克, 鮫島 浩, 金子 政時
日本小児外科学会雑誌 46 ( 6 ) 2010
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本小児外科学会
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金子 政時
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 45 ( 4 ) 994 - 997 2009.12
Language：Japanese Publishing type：Research paper (scientific journal)
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A substantive medical education program for students and doctors in collaboration with obstetricians and gynecologist, and pediatricians
45 ( 4 ) 994 - 997 2009.12
Language：Japanese Publishing type：Research paper (scientific journal)
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CMV胎内感染治療の展望 : 予後からみた今後の治療のありかた
丸山 有子, 茨 聡, 金子 政時, 児玉 由紀, 丸山 英樹, 徳久 琢也, 松井 貴子, 藤江 由夏, 中澤 祐介, 上塘 正人, 前田 隆嗣, 鮫島 浩, 池ノ上 克, 栄鶴 義人, 峰松 俊夫, 土井 宏太郎, 加藤 明彦, 寺原 賢人
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 45 ( 1 ) 5 - 9 2009.4
Language：Japanese Publishing type：Research paper (scientific journal)
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胎内サイトメガロウイルス感染症における抗原血症の臨床上の有用性
金子 政時, SAMESHIMA Hiroshi, IKENOUE Tsuyomu, KUSUMOTO Kazumi, MINEMATSU Toshio
Pediatrics international : official journal of the Japan Pediatric Society 51 ( 1 ) 1 - 4 2009.2
Language：Japanese Publishing type：Research paper (scientific journal)
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Clinical importance of cytomegalovirus antigenemia for intrauterine cytomegalovirus infection. （共著） Reviewed
Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Kazumi Kusumoto, Toshio Minematsu.
Pediatrics International 51 1 - 4 2009.2
Language：English Publishing type：Research paper (scientific journal)
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Clinical importance of cytomegalovirus antigenemia for intrauterine cytomegalovirus infection
Kaneko M., Sameshima H., Ikenoue T., Kusumoto K., Minematsu T.
Pediatrics International 51 ( 1 ) 1 - 4 2009.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Pediatrics International
Background: Little is known about the clinical importance of cytomegalovirus (CMV) antigenemia for intrauterine-CMV-infected newborns. The aims of the present study were to evaluate the diagnostic accuracy of CMV antigenemia during the neonatal period and its association with clinical manifestations. Methods: CMV antigenemia was analyzed using neonatal blood from 25 patients suspected of having intrauterine infection because of abnormal clinical manifestations in the mother, fetus, and newborn. Neonatal urine samples were collected for diagnosis of intrauterine infection. The diagnostic accuracy of the antigenemia analysis was evaluated by comparing it with the results of urinary CMV analyses. The clinical manifestations of antigenemia-positive and -negative infected newborns were compared in the infected newborns. Results: Fifteen newborns were congenitally infected and 10 were uninfected as diagnosed on virus isolation from neonatal urine. Six of 15 infected newborns were positive for CMV antigenemia. CMV antigenemia had a positive predictive value of 100%, a negative predictive value of 52.6%, a sensitivity of 40%, and a specificity of 100%. CMV retinitis and pneumonitis were more prevalent among antigenemia-positive newborns (4/6) than antigenemia-negative newborns (0/9; P < 0.05). Conclusions: Antigenemia was significantly associated with retinitis and pneumonia, but it was not sensitive enough to diagnose intrauterine CMV infection. © 2008 Japan Pediatric Society.
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金子 政時
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44 ( 4 ) 894 - 897 2008.12
Language：Japanese Publishing type：Research paper (scientific journal)
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KANEKO Masatoki, Masatoki KANEKO, Department of Obstetrics and Gynecology Center for Medical Education Faculty of Medicine University of Miyazaki
60 ( 12 ) 1945 - 1952 2008.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Sameshima H., Kodama Y., Kaneko M., Ikenoue T.
Japanese Journal of Infectious Diseases 61 ( 5 ) 400 - 401 2008.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Infectious Diseases
In a population-based study we investigated the early-onset, invasive sepsis caused by group B streptococcus (GBS) and non-GBS in the era of intrapartum antimicrobial prophylaxis. From 1998 to 2006, we had 387 perinatal deaths in 98,495 deliveries, and 9 full-term infants met the criteria of early-onset, invasive sepsis, in which microorganisms were proven from blood sampling. Of these cases, 4 involved GBS, 2 amipicillin-resistant Escherichia coli, 2 methicillin-resistant Staphylococcus aureus, and 1 was unidentified. All 4 cases of GBS related death underwent improper procedures contrary to the prophylaxis recommendation. Eighty percent of non-GBS related deaths had septicemia of antibiotic-resistant pathogens. We found in our population-based study that early-onset fatal sepsis in full-term infants is associated with insufficient adherence to the prophylaxis strategy for GBS and with the emergence of antimicrobial resistant non-GBS bacteria.
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New technique for enterostomy of extremely low-birth-weight infants - intestinal anchoring with gaze. "jointly worked" Reviewed
Kondo K, Chijiiwa K, Mukai M, Iwamura T, Matsuda H, Kaneko M, Kodama Y, Sameshima H, Ikenoue T.
Journal of Pediatric Surgery 43 ( 9 ) 1755 - 1760 2008.9
Language：English Publishing type：Research paper (scientific journal)
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Deaths of early-onset, invasive sepsis in full-term infants in Miyazaki: nine cases from a regional population-based analysis from 1998-2006.
Sameshima H, Kodama Y, Kaneko M, Ikenoue T, Miyazaki Perinatal Data Group.
Japanese journal of infectious diseases 61 ( 5 ) 400 - 1 2008.9
Language：Japanese Publishing type：Research paper (scientific journal)
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New technique for enterostomy of extremely low-birth-weight infants-intestinal anchoring with gauze
Kondo K., Chijiiwa K., Mukai M., Iwamura T., Matsuda H., Kaneko M., Kodama Y., Sameshima H., Ikenoue T.
Journal of Pediatric Surgery 43 ( 9 ) 1755 - 1760 2008.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Pediatric Surgery
Background: In enterostomy for extremely low-birth-weight infants ( < 1000 g), the technique of anchoring the intestine for a stoma to the abdominal wall is very difficult because of the small size and fragile nature of the intestine. Here we describe a novel technique for intestinal anchoring in such infants. Methods: In our approach to enterostomy, the intestine is anchored only by a strip of gauze packed into the subcutaneous space. No suturing is performed. The efficacy of this technique was evaluated in 21 infants with less than 1000 g of body weight who have intestinal perforation or obstruction. Results: Two patients (9.5%) had complications that were related to the enterostomy. The complications were parastomal and intrastomal intestinal prolapse, both of which were treated successfully by reoperation. Eighteen patients (86%) survived to closure of the enterostoma. Conclusions: Intestinal anchoring with gauze is an easy and effective technique for enterostomy in extremely low-birth-weight infants and can be applied in selected cases. © 2008 Elsevier Inc. All rights reserved.
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Deaths of early-onset, invasive sepsis in full-term infants in Miyazaki: nine cases from a regional population-based analysis from 1998-2006. "jointly worked" Reviewed
Samashima H, Kodama Y, Kaneko M, Ikenoue T
Jpn J Infect Dis 61 ( 5 ) 400 - 401 2008.7
Language：English Publishing type：Research paper (scientific journal)
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丸山 有子, 茨 聡, 丸山 英樹, 徳久 琢也, 松井 貴子, 藤江 由夏, 中澤 祐介, 金子 政時, 児玉 由紀, 上塘 正人, 前田 隆嗣, 栄鶴 義人, 峰松 俊夫, 鮫島 浩, 池ノ上 克
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44 ( 2 ) 271 - 272 2008.6
Language：Japanese Publishing type：Research paper (scientific journal)
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金子 政時
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44 ( 2 ) 2008.6
Language：Japanese Publishing type：Research paper (scientific journal)
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(2) 産婦人科医小児科医が連携した医師養成のための卒前・卒後教育(産婦人科医不足の解消を目指して,シンポジウム4,第60回日本産科婦人科学会学術講演会)
金子 政時, 宮崎大学
日本産科婦人科學會雜誌 = Acta obstetrica et gynaecologica Japonica 60 ( 2 ) 455 - 456 2008.2
Language：Japanese Publishing type：Research paper (scientific journal)
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MD-Twin Score による一絨毛膜二羊膜性双胎児の胎児評価
金子 政時, 鮫島 浩, 児玉 由紀, 山下 理恵, 池ノ上 克
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 43 ( 4 ) 987 - 990 2007.12
Language：Japanese Publishing type：Research paper (scientific journal)
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MD-Twin Socreによる一絨毛膜二羊膜性双胎児の胎児評価
金子政時、鮫島浩、児玉由紀、山下理絵、池ノ上克
日本周産期・新生児学会雑誌 43 ( 4 ) 987 - 999 2007.12
Language：Japanese Publishing type：Research paper (scientific journal)
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胎内サイトメガロウイルス感染症児IgG抗体Avidity Indexの推移と臨床経過
金子政時, 鮫島浩、田中博昭、池ノ上克、楠元和美、峰松俊夫
HERPES MANEGMENT 11 ( 1 ) 7 - 7 2007.11
Language：Japanese Publishing type：Research paper (scientific journal)
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MARUYAMA Yuko, SAMESHIMA Hiroshi, KAMITOMO Masato, IBARA Satoshi, KANEKO Masatoki, IKENOUE Tsuyomu, MINEMATSU Toshio, EIZURU Yoshihito
The Journal of obstetrics and gynaecology research 33 ( 5 ) 619 - 623 2007.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Fetal manifestations and poor outcomes of congenital cytomegalovirus infections: Possible candidates for intrauterine antiviral treatments Reviewed
Y Maruyama, H Sameshima, M Kamitomo, S Ibara, M Kaneko, T Ikenoue, T Minematsu, Y Eizuru
J. Obstet. Gynaecol. Res. 33 ( 5 ) 619 - 623 2007.10
Language：English Publishing type：Research paper (scientific journal)
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Maruyama Y., Sameshima H., Kamitomo M., Ibara S., Kaneko M., Ikenoue T., Minematsu T., Eizuru Y.
Journal of Obstetrics and Gynaecology Research 33 ( 5 ) 619 - 623 2007.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
Aim: This retrospective study was performed to reveal the natural history of cytomegalovirus (CMV) infected fetuses during the perinatal period and to find prenatal findings associated with poor outcomes. Methods: 33 neonates with CMV infection, born after 30 weeks of gestation, were registered from a total of 12 414 infants between 1995 and 2003. Maternal and neonatal medical records were reviewed regarding fetal growth; abdominal signs including ascites and hepatosplenomegaly; cerebral signs including ventriculomegaly, microcephaly, and calcification; and fetal heart rate monitoring, for signs which may have been detected by the standard obstetric ultrasonography. Univariate and multivariate analyses were performed to test for any associations between these manifestations and poor outcomes such as death and neurological damages. Results: Among the 33 infants, 6 died, 10 developed neurological damage including cerebral palsy (n = 8), epilepsy (n = 5), and hearing difficulties (n = 5), and the remaining 17 were normal. After adjusting for ganciclovir treatment and gender, death was 40-fold more likely associated with infants having abdominal signs (OR 40, 95%CI 4.6-930) than those without abdominal signs. Similarly, poor outcomes (death or neurological damage) were more likely associated with infants having either abdominal or cerebral signs (OR 39, 95%CI 3.8-1323). Fetal growth restriction and non-reassuring fetal heart rate patterns were not significantly associated with poor outcomes. Conclusion: The absence of abdominal signs guarantees the infant's survival. The presence of abdominal or cerebral signs is associated with poor outcomes, suggesting that these fetuses are possible candidates to receive in-utero therapy of congenital CMV infection. © 2007 The Authors.
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17 ( 1 ) "S - 59"-"S-60" 2007.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Prediction of placenta accreta in cases of placenta previa
DOI Koutarou, NAKANO Yuuki, TOKUNAGA Syuichi, KAWAGOE Yasuyuki, KANEKO Masatoki, SAMESHIMA Hiroshi, IKENOUE Tsuyomu
16 ( 2 ) 40 - 44 2007.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Serological and epidemiological analysis of pregnant women with rubella re-infection
KANEKO Masatoki, FURUTA Ken, SAMESHIMA Hiroshi, IKENOUE Tsuyomu, KUSUMOTO Kazumi, MINEMATSU Toshio
16 ( 2 ) 23 - 26 2007.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Prediction of placenta previa in cases of placenta previa Reviewed
16 ( 2 ) 40 - 44 2007.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Serological and epidemiological analysis of pregnant woman with rubella re-infection Invited Reviewed
Masatoki Kaneko, Ken Furuta, Hiroshi Sameshima, Tsuyomu Ikenoue, Kazumi Kuumoto, Toshio Minematsu
The Japanese Journal of Obstetrical, Gynecological & Neonatal Hematology 16 ( 2 ) 23 - 26 2007.3
Language：Japanese Publishing type：Research paper (scientific journal)
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P004.超低出生体重児に対する腸瘻造設法の工夫 : ガーゼ固定法(一般演題,第44回日本小児外科学会九州地方会)
近藤 千博, 千々岩 一男, 松田 博光, 金子 政時, 児玉 由紀, 鮫島 浩, 池ノ上 克, 岩村 威志
日本小児外科学会雑誌 43 ( 6 ) 809 - 810 2007
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本小児外科学会
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P008.腹腔内精巣を伴った腹壁破裂の1例(一般演題,第44回日本小児外科学会九州地方会)
松田 博光, 千々岩 一男, 近藤 千博, 児玉 由紀, 金子 政時, 鮫島 浩, 池ノ上 克, 上村 敏雄, 長野 正史
日本小児外科学会雑誌 43 ( 6 ) 810 - 811 2007
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本小児外科学会
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A Two-Step Strategy for Detecting Intrauterine Cytomegalovirus Infection with Clinical Manifestations in the Mother, Fetuts, and Newborn Reviewed
Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Toshio Minematsu
Jpn. J. Infect. Dis 59 363 - 366 2006.12
Language：English Publishing type：Research paper (scientific journal)
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Kaneko M., Sameshima H., Ikenoue T., Minematsu T.
Japanese Journal of Infectious Diseases 59 ( 6 ) 363 - 366 2006.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Infectious Diseases
We selected a high-risk group based on clinical manifestations and performed virological tests to detect intrauterine cytomegalovirus (CMV) infection. We tested the efficacy of this detection protocol in this study. We analyzed 2,309 newborns at 22 weeks or more of gestation from January 1992 to December 2000. Clinical manifestations of the mother, fetus, and newborn were used in the initial step to identify the high-risk group. For the high-risk group, if the causes of clinical manifestation remained unclear, we assayed for CMV DNA in the amniotic fluid, umbilical cord blood, or newborn urine using polymerase chain reaction (PCR) as a second step. Positive PCR results were confirmed by isolating CMV. The initial step detected 287 high-risk cases from 2,309 deliveries. In this group, 100 cases did not have reasonable explanations for the clinical manifestation. In the second-step PCR, intrauterine CMV infection was diagnosed in 10 of 100 cases (10%). The initial clinical classification reduced the proportion of cases needing laboratory investigation to 4%. Thus, our strategy detected intrauterine CMV infection in as many as 10% of high-risk patients after the first step, which is much higher than the general screening rate.
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A two-step strategy for detecting intrauterine cytomegalovirus infection with clinical manifestations in the mother, fetus, and newborn.
Kaneko M, Sameshima H, Ikenoue T, Minematsu T
Japanese journal of infectious diseases 59 ( 6 ) 363 - 6 2006.12
Language：Japanese Publishing type：Research paper (scientific journal)
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丸山 有子, 金子 政時, 栄鶴 義人, 峰松 俊夫, 茨 聡, 上塘 正人, 鮫島 浩, 向井 基, 徳久 琢也, 松井 貴子, 藤江 由夏, 前田 隆嗣, 中澤 祐介, 宇都宮 剛, 大城 達男, 角 健司, 小野 哲男, 児玉 由紀, 池ノ上 克
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 42 ( 4 ) 792 - 797 2006.11
Language：Japanese Publishing type：Research paper (scientific journal)
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山下 美和, 前田 真, 杉村 基, 金山 尚裕, 峰松 俊夫, 楠元 和美, 金子 政時, 池ノ上 克
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 42 ( 4 ) 785 - 788 2006.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Rubella outbreak on Tokunoshima island in 2004: Serological and epidemiological analysis of pregnant women with rubella Reviewed
Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Toshio Minematsu, Kazumi Kusumoto, Satoshi Ibara, Masato Kamitomo, Yuko Maruyama
J. Obstet. Gynaecol. Res. 32 ( 5 ) 461 - 467 2006.10
Language：English Publishing type：Research paper (scientific journal)
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KANEKO Masatoki, SAMESHIMA Hiroshi, IKENOUE Tsuyomu, MINEMATSU Toshio, KUSUMOTO Kazumi, IBARA Satoshi, KAMITOMO Masato, MARUYAMA Yuko
The Journal of obstetrics and gynaecology research 32 ( 5 ) 461 - 467 2006.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Rubella outbreak on Tokunoshima Island in 2004: serological and epidemiological analysis of pregnant women with rubella.
Kaneko M, Sameshima H, Ikenoue T, Minematsu T, Kusumoto K, Ibara S, Kamitomo M, Maruyama Y
The journal of obstetrics and gynaecology research 32 ( 5 ) 461 - 7 2006.10
Language：Japanese Publishing type：Research paper (scientific journal)
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丸山 有子, 茨 聡, 池ノ上 克, 金子 政時, 徳久 琢也, 松井 貴子, 向井 基, 藤江 由夏, 佐々木 恒, 中澤 祐介, 宇都宮 剛, 大橋 昌尚, 栄鶴 義人, 峰松 俊夫
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 42 ( 2 ) 2006.6
Language：Japanese Publishing type：Research paper (scientific journal)
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16 ( 1 ) "S - 23"-"S-24" 2006.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Intrauterine cytomegalovirus infection associated with maternal low IgG avidity index
KANEKO Masatoki, SAMESHIMA Hiroshi, IKENOUE Tsuyomu, KUSUMOTO Kazumi, MINEMATSU Toshio, SATO Yuichiro
15 ( 2 ) 41 - 46 2006.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Triplet babies after fertility treatment by a 46, XY, t(12;13)(q24.3;q32) father
( 7 ) 169 - 172 2006.3
Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
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Intrauterine cytomegalovirus infection associated with maternal low IgG avidity index Reviewed
The Japanese Journal of Obstetrical, Gynecological & Neonatal Hematology 15 ( 2 ) 41 - 46 2006.3
Language：Japanese Publishing type：Research paper (scientific journal)
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在胎22-27週で出生した新生児の特発性消化管穿孔に関する周産期因子の検討
甲斐 克秀, 池田 智明, 山下 理絵, 道方 香織, 金子 政時, 鮫島 浩, 茨 聡, 池ノ上 克
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 41 ( 4 ) 816 - 820 2005.12
Language：Japanese Publishing type：Research paper (scientific journal)
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古川 誠志, 鮫島 浩, 道方 香織, 稲森 美香, 児玉 由紀, 川越 靖之, 金子 政時, 池田 智昭, 池ノ上 克
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 41 2005.12
Language：Japanese Publishing type：Research paper (scientific journal)
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(1) 先天性風疹症候群の撲滅をめざして : 産科医療従事者の役割(ウイルスと周産期, 第46回 日本母性衛生学会総会 学術集会抄録集)
金子 政時
母性衛生 46 ( 3 ) 2005.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：日本母性衛生学会
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Rubella Virus Reinfection and Serological Response in Pregnant Women
15 ( 1 ) "S - 79"-"S-80" 2005.6
Language：Japanese Publishing type：Research paper (scientific journal)
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在胎22-27週で出生した新生児の特発性消化管穿孔と周産期因子の検討
甲斐 克秀, 山下 理絵, 道方 香織, 金子 政時, 池田 智明, 鮫島 浩, 池ノ上 克
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 41 ( 2 ) 2005.6
Language：Japanese Publishing type：Research paper (scientific journal)
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3. 超低出生体重児における動脈管結紮術についての検討(第18回 日本小児人工臓器研究会)
道方 香織, 金子 政時, 池田 智明, 鮫島 浩, 池ノ上 克
日本小児外科学会雑誌 41 ( 6 ) 2005
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本小児外科学会
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Intrapartum fetal heart rate monitoring in cases of cytomegalovirus infection.
Kaneko M, Sameshima H, Ikeda T, Ikenoue T, Minematsu T
American journal of obstetrics and gynecology 191 ( 4 ) 1257 - 62 2004.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Usefulness of Avidity Index for Intrauterine Cytomegalovirus Infected Newborn : A case report
14 ( 1 ) "S - 73"-"S-74" 2004.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Asphyxia 性脳障害の診断に関する臨床的および基礎的研究
池田 智明, 池ノ上 克, 鮫島 浩, 金子 政時, 川越 靖之, 古川 誠志, 米田 由香里, 大西 淳仁, ト部 浩俊, 大里 和広, 山下 理絵, 田中 博明, 福島 和子, 村田 雄二, QUILLIGAN Edward J., CHOI Ben H., PARK Soung-Day, 土井 茂治, PARER Julian T., 児玉 由紀, 寺尾 公成, 西口 俊裕, 河野 慶一郎, 嶋本 富博, 春山 康久, 今村 登志子, 桂木 真司, 高崎 泰, 三輪 勝洋, 徳永 修一, 山内 憲之, 園田 徹, 布井 博幸
日本新生児学会雑誌 39 ( 4 ) 724 - 732 2003.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus Reviewed
Masatoki Kaneko, Susan White, J Homan, Bryan Richardson
Am. J. Obstet. Gynecol. 188 ( 4 ) 961 - 972 2003.11
Language：English Publishing type：Research paper (scientific journal)
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Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus Reviewed International coauthorship
Kaneko M., White S., Homan J., Richardson B.
American Journal of Obstetrics and Gynecology 188 ( 4 ) 961 - 972 2003.4
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Obstetrics and Gynecology
OBJECTIVE: The purpose of this study was to determine the change in cerebral blood flow and substrate metabolism in relation to electrocortical activity in the near-term ovine fetus with repeated umbilical cord occlusion of a severe degree. STUDY DESIGN: Eight near-term fetal sheep were studied through a 2-hour control period, a 6-hour experimental period with repeated cord occlusion of 4 minutes' duration every 90 minutes, and a 16-hour recovery period. Regional cerebral blood flow was measured with the microsphere technique before, during, and after the first cord occlusion; blood flow in the superior sagittal sinus, the cerebral perfusion pressure, and the electrocortical activity were monitored continuously. Brachiocephalic arterial and sagittal venous blood were sampled at selected time points for blood gas and pH, oxygen content, and glucose and lactate levels. RESULTS: Severe umbilical cord occlusion as studied resulted in profound hypoxemia with modest hypercapnia and acidemia, to a similar degree with each insult, but with a return to preocclusion values after occluder release. Glucose values also fell acutely with each cord occlusion by approximately 30% but showed an overall increase through the experimental period, from 0.80 to 1.44 mmol/L; lactate values showed an increase, from 1.21 to 6.10 mmol/L (both P < .01). Fetal electrocortical activity was disrupted markedly, with an abrupt flattening of the electrocortical amplitude by 1.5 minutes of each cord occlusion on average and with an overall increase in indeterminate state activity during the experimental and through the recovery periods. Cerebral blood flow increased approximately 2.5- and 2.8-fold, as measured at 2 and 3.5 minutes during the first cord occlusion (both P < .01) and with the regional flow increase greater in the subcortex and brainstem. Cerebral extraction of oxygen fell toward zero, as measured at 2 minutes during the second and fourth occlusions (P < .05) with oxygen uptake no longer measurable; glucose extraction was now increased approximately 2-fold (P < .05), which indicates that anaerobic metabolism of glucose must be the predominant source of energy at this time. Superior sagittal sinus blood flow also increased in all animals, approximately 1.4- and 1.6-fold at 2 and 3.5 minutes of the first cord occlusion, but much less than the corresponding increase in arterial inflow; the increase was in response to subsequent occlusions was further reduced. CONCLUSION: Severe umbilical cord occlusion in the near-term ovine fetus results in a rapid decrease in the availability of oxygen to the brain. The low Po 2 gradient from blood to tissue rate limits for oxygen consumption by 2 minutes of insult (despite the marked increase in blood flow) and signals the shift to anaerobic metabolism, the suppression in electrocortical activity, and the probable shutdown of other energy-using processes.
DOI： 10.1067/mob.2003.219
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Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus. Reviewed
Kaneko M, White S, Homan J, Richardson B
American journal of obstetrics and gynecology 188 ( 4 ) 961 - 72 2003.4
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats.
Ikeda T, Xia YX, Kaneko M, Sameshima H, Ikenoue T
Neuroscience letters 329 ( 1 ) 33 - 6 2002.8
Language：Japanese Publishing type：Research paper (scientific journal)
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Antepartum Evaluation of Monochorionic Diamniotic Twins; MD-Twin Score: A New Scoring Method for Perinatal Outcome
Masatoki Kaneko, Sameshima Hiroshi, Tomoaki Ikeda, Yuki Kodama, Tsuyomu Ikenoue
Journal of Obstetrics Gynaecology Research 26 ( 2 ) 111 - 116 2000.10
Language：English Publishing type：Research paper (scientific journal)
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宮崎大学病院における未熟児網膜症の現状と発症因子について Reviewed
原田勇一郎,齋藤真美,森山 重人,直井 信久,大里和弘,金子 政時,池田 智明,鮫島 浩,池ノ上 克
眼科臨床医報 98 ( 6 ) 515 - 517 2000.4
Language：Japanese Publishing type：Research paper (scientific journal)
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Multicenter Study for Maternal Serum Triple Markers to Establish Japanese Standards
MIYAMURA Tsunetaka, SAITO Nakamiti, TOUNO Atsuhiko, NAGATA Shin, HIDAKI Tsutomu, ISHIMARU Tadayuki, MASUZAKI Hideaki, OHAMA Koso, MIHARU Norio, HISANAGA Sachio, SUENAGA Goro, SUENAGA Toshiro, HATAE Masayuki, KAMITOMO Masato, FUSE Masaki, HIRAI Masanao, NAGATA Hideki, KUROKI Satoshi, KUROKI Tohru, YAKUSHIJI Michiaki, HORI Daizo, NAKAYA Takayoshi, WASHIMI Hitoshi, WAKE Norio, MATSUDA Takao, KAWANO Katsuichi, KOZUMA Masutaka, TAKAYAMA Toshiya, IKENOUE Tsuyomu, KANEKO Masatoki, TATEYAMA Hiromichi, SHIMAMOTO Tomihiro, KANAZAWA Koji, SAKUMOTO Kaoru, ITO Takehisa, KAWANO Hideaki, NOMIYAMA Makoto, MATSUI Kazuo, YAMAZAKI Tomofumi, SHINAGAWA Hirotoshi, MIYAKAWA Isao, ANAI Takanobu, YOSHIMATSU Jun, KASHIMURA Masamichi, YOSHIMURA Kazuaki, ISHIKAWA Mutsuo, TAMATE Kenichi, KAYAMA Fumiyoshi, TOKUNAGA Akiteru, OCHI Hiroshi, YAMANAKA Kenji, ONOUE Toshikazu, YAMAZAKI Hiroshi, NIIKAWA Norio
51 ( 11 ) 1042 - 1048 1999
Language：Japanese Publishing type：Research paper (scientific journal)
Objective: We evaluated triple markers (α-fetoprotein, free β-human chorionic gonadotropin, and unconjugated estriol) in the second trimester to establish Japanese standards. Methods: Serum samples were collected from 2,201 pregnant women between 12 and 20 weeks of gestation as a part of a multicenter prenatal diagnostis study. Median values of each marker were calculated from 1,641 unaffected pregnancies. Multiples of the median for each of the three markers were also calcu1ated for trisomy 21. Results: The mean age, gestational weeks and maternal body weight were 30.5 years, 14.9 weeks and 52.6kg, respectively. The median α-fetoprotein value increased from 18.1 ng/ml at 12 weeks of gestation to 85.55 ng/ml at 20weeks of gestation. The median uncojugated estriol value also increased from 0.35 ng/ml at 12 weeks of gestation to 3.34 ng/ml at 20 weeks of gestation, but the median value of free β-human chorionic gonadotropin decreased from 53.85 ng/ml to 9.95 ng/ml. Seven cases of trisomy 21 were included in our study. In all of these seven cases, the multiples of the median of α-fetoprotein were less than l.0 and those of free β-human chorionic gonadotropin were more than 2.0. The multiples of the median of unconjugated estliol were less than l.0 in six of them. Conclusion: The medians or Japanese triple markers were calculated from l,641 unaffected pregnancies in a multi center study.