Papers - KANEKO Masatoki
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Win K.D., Kawasue K., Kaneko M.
Sensors 25 ( 6 ) 2025.3
Language：English Publishing type：Research paper (scientific journal) Publisher：Sensors
Highlights: What are the main findings? A non-contact method for measuring neonatal head circumference using a 3D imaging sensor was developed. What is the implication of the main finding? A top-view 3D imaging system can be used to estimate the head circumferences of neonates without direct contact, ensuring safety for their delicate skin. Because some portions of the head may be missing in the top-view images, these missing areas are estimated using mat information. The extracted features and head surface values contribute to the head circumference measurement. This approach enhances the feasibility of non-contact head circumference measurement, which could improve neonatal monitoring in clinical settings. In Japan, birth rates are declining, but there are a rising number of underweight newborns who require specialized care in neonatal intensive care units (NICUs). Head circumference is an important indicator of brain development for low-birth-weight infants. However, measuring head circumference requires extreme care because low-birth-weight infants have fragile skin. Therefore, a non-contact measurement system using a 3D imaging sensor was developed. Using this system, three-dimensional data for a newborn’s head can be obtained from outside the incubator. Briefly, the images are taken from above the incubator, so there is an area behind the head that cannot be captured by the camera, but the head circumference estimation takes into account the fact that the head is in contact with the mat. The proposed method allows head circumference estimation without touching the newborn. This approach minimizes stress for both the neonate and the nurse and improves efficiency and safety in the NICU.
DOI： 10.3390/s25061869
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The estimation of a cytomegalovirus immunoglobulin G avidity using the mathematical model Invited Reviewed
Masatoki Kaneko
Journal of Basic and Clinical Pharmacy 13 ( 127 ) 127 2022.3
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Kaneko M., Muraoka J., Kusumoto K., Minematsu T.
Viruses 13 ( 5 ) 2021.5
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Viruses
Human cytomegalovirus (CMV) is the leading cause of neurological sequelae in infants. Understanding the risk factors of primary CMV infection is crucial in establishing preventive strategies. Thus, we conducted a retrospective cohort study to identify risk factors of vertical transmission among pregnant women with immunoglobulin (Ig) M positivity. The study included 456 pregnant women with IgM positivity. Information on age, parity, occupation, clinical signs, IgM levels, and IgG avidity index (AI) was collected. The women were divided into infected and non-infected groups. The two groups showed significant differences in IgM level, IgG AI, number of women with low IgG AI, clinical signs, and number of pregnant women with single parity. In the multiple logistic regression analysis, pregnant women with single parity and low IgG AI were independent predictors. Among 40 women who tested negative for IgG antibody in their previous pregnancy, 20 showed low IgG AI in their current pregnancy. Among the 20 women, 4 had vertical transmission. These results provide better understanding of the risk factors of vertical transmission in pregnant women with IgM positivity.
DOI： 10.3390/v13050866
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Kaneko M., Ohhashi M., Fujii Y., Minematsu T., Kusumoto K.
International Journal of Infectious Diseases 100 1 - 6 2020.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：International Journal of Infectious Diseases
Objective: To establish a model to predict high cytomegalovirus (CMV) immunoglobulin (Ig)G avidity index (AI) using clinical information, to contribute to the mental health of CMV-IgM positive pregnant women. Methods: We studied 371 women with IgM positivity at ≤14 w of gestation. Information on the age, parity, occupation, clinical signs, IgM and G values, and IgG AI was collected. The IgG AI cut-off value for diagnosing congenital infection was calculated based on a receiver operating characteristic curve analysis. Between-group differences were assessed using the Mann–Whitney U-test or χ2 analysis. The factors predicting a high IgG AI were determined using multiple logistic regression. Results: The women were divided into high or low IgG AI groups based on an IgG AI cut-off value of 31.75. There were significant differences in the IgG and IgM levels, age, clinical signs, and the number of women with one parity between the two groups. In a multiple logistic regression analysis, IgM and the number of women with one parity were independent predictors. This result helped us establish a mathematical model that correctly classified the IgG AI level for 84.6% of women. Conclusion: We established a highly effective model for predicting a high IgG AI immediately after demonstrating IgM positivity.
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Intrapartum fetal heart rate monitoring in cases of cytomegalovirus infection Reviewed
金子 政時,鮫島 浩,池田 智明,池ノ上 克,峰松 俊夫
Am. J. Obstet. Gynecol. 191 1257 - 1262 2014.9
Language：English Publishing type：Research paper (scientific journal)
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Effectiveness of maternal respiratory syncytial virus vaccination in conferring infant immunity: review and future perspectives Reviewed
Masatoki Kaneko, Junsuke Muraoka
vaccines 14 2026.2
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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A retrospective study of factors influencing continuous fetal heart rate recording during induction of labor at a single perinatal center Reviewed
66 ( 4 ) 496 - 503 2026.1
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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factors infuencing a mother's decision to have three or more children while raising a family: A questionnaire survey Reviewed
66 ( 4 ) 513 - 521 2026.1
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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The characteristics of pregnant women with COVID-19 and effects of vaccines during from the 7th to 8th wave of the pandemic: A regional cohort study Reviewed
10 7 - 12 2026.1
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Doi K., Kodama Y., Matsuzawa S., Goto T., Muraoka J., Fujisaki M., Yamada N., Taniguchi H., Furuta K., Kawagoe Y., Kaneko M., Katsuragi S., Ikenoue T., Sameshima H.
Early Human Development 216 106495 2026.1
Language：English Publishing type：Research paper (scientific journal) Publisher：Early Human Development
Objective: The ultimate goal of perinatal care is to ensure that infants survive without neurological impairment. Despite advances in medical technology and healthcare systems that have markedly decreased perinatal mortality, cerebral palsy has shown only a gradual decline in recent population-based studies. The aim of this study was to use a pathway classification system to analyze brain injury cases detected at or beyond 35 weeks' gestation and to clarify temporal changes in the incidence and causal pathways of intrapartum brain injury and its contributing factors in Miyazaki Prefecture, Japan. Methods: Of 151,558 births recorded in Miyazaki Prefecture from 2001 to 2015, 303 cases of brain injury were registered in the regional perinatal case-review system. Of these, 134 were detected at ≥35 weeks. Brain injury was categorized as congenital anomalies, antepartum, intrapartum, or neonatal onset. Each case was further classified using a pathway system that considered distal and proximal risk factors. Temporal trend analysis was performed across three consecutive 5-year intervals (2001–2005, 2006–2010, and 2011–2015). Results: Of the 134 cases, 25% were classified as intrapartum-related, 23% as antepartum-related, and 5% as neonatal-related. Overall, the incidence of brain injury at ≥35 weeks decreased significantly over time. Significant downward trends were observed in total cases and intrapartum-related brain injury, with the reduction in intrapartum cases being especially pronounced. Antepartum-related brain injury declined more gradually. Further analysis revealed that the incidence of hypoxia-related intrapartum brain injuries decreased over time, whereas bacterial infection-related intrapartum cases were observed only in the earliest epoch. Conclusions: This population-based study identified temporal changes in perinatal brain injury detected at or beyond 35 weeks' gestation over 15 years. The incidence of perinatal brain injury declined significantly, particularly intrapartum-related cases with hypoxia-related injury. These improvements might reflect advances in regionalized perinatal care, the establishment of perinatal centers, or multidisciplinary education and training. Further efforts to optimize intrapartum assessment and management would contribute to continued reductions in severe perinatal brain injury.
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特集 周産期感染症2026 産科からみた周産期感染症 50.妊婦および挙児希望女性が海外渡航する場合の感染への留意点 Invited
金子 政時, 谷口 光代, 髙間 有紀
周産期医学 55 ( 13 ) 220 - 223 2025.12
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：東京医学社
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Tomiki Yuka, Taniguchi Mitsuyo, Yoshinaga Saori, Kaneko Masatoki
JOURNAL OF JAPAN HEALTH MEDICINE ASSOCIATION 34 ( 3 ) 402 - 407 2025.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：JAPAN HEALTH MEDICINE ASSOCIATION
This study aimed to elucidate the age groups of cervical cancer screening examinees conducted by local governments in Miyazaki Prefecture and the effects of municipal initiatives. This study included 8944 examinees [4395 in Fiscal year (FY) 2022 and 4549 in FY2023] from two cities and six towns. The number of examinations was 160 (84 in FY2022 and 76 in FY2023). The number of new examinees was 394 (89 in FY2022 and 305 in FY2023), and the median age was 60 and 23 years for all and new examinees, respectively. The municipality that implemented campus screening of cervical cancer demonstrated an increase in the number of new examinees and a significant decrease in the age of new examinees. Five municipalities conducted weekend examination (11 times in FY2022 and 13 times in FY2023), and no difference in the number of new examinees was noted between weekday and weekend examinations in all five municipalities. However, the number of new examinees was significantly higher than the number of new examinees for weekday examinations in the municipality that conducted 14 weekend examinations, including three evening examinations (total examinations : 22), and the age of the examinees tended to be younger ; although, the difference was not significant. In this municipality, the number of examinees per examination was 119.7 and 68.6 for weekend and weekday examinations, respectively. The examinees exhibited a higher age distribution than the age groups affected by cervical cancer. Initiatives are required to increase the number of examinees in younger age groups across Miyazaki Prefecture. Actively introducing weekend examinations may result in an increased number of new examinees and a decreased age of examinees.
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Kataoka S., Kaneko M., Yang L., Ota H., Seki M., Kobamatsu A., Nakayama D., Furuta Y., Tanuma F., Fukushi Y., Wada S., Haseyama K., Yamada H.
Microorganisms 13 ( 9 ) 2025.9
Language：English Publishing type：Research paper (scientific journal) Publisher：Microorganisms
Congenital cytomegalovirus infection (cCMV) is one of the most common congenital infections. This study aimed to evaluate the diagnostic performance of targeted screening with the use of clinical risk factors for cCMV. A total of 3063 pregnant women and their 3139 newborns were enrolled. Six clinical findings consisting of maternal fever or flu-like symptoms during pregnancy (fever/flu-like symptoms), hospitalization for threatened miscarriage or preterm labor before 34 weeks of gestation, preterm delivery before 34 weeks of gestation, fetal ultrasound abnormalities, small for gestational age (SGA), and refer results of automated auditory brainstem response screening (AABR refer) were defined as cCMV risk factors before participant registration. All newborns underwent urine cytomegalovirus polymerase chain reaction tests within one week of birth. The predictive accuracy of these six risk factors was analyzed. Nine (0.29%) of the three thousand one hundred and thirty-nine newborns were diagnosed with cCMV, having at least one of the six risk factors. Logistic regression analysis identified fever/flu-like symptoms (odds ratio (OR), 7.5; 95% CI, 1.9–30.3), fetal ultrasound abnormalities (OR, 17.9; 95% CI, 4.4–72.8), SGA (OR, 6.8; 95% CI, 1.8–25.6), and AABR refer (OR, 75.5; 95% CI, 19.7–289) as significant risk factors. The predictive accuracy of the targeted screening for cCMV, when at least one of the six risk factors was present, yielded 100% sensitivity (95% CI, 55.5–100) and 70.7% specificity (95% CI, 69.1–72.3), with a Youden index of 0.707. When at least one of the four significant risk factors was present, 100% sensitivity (95% CI, 55.5–100) and 81.2% specificity (95% CI, 79.8–82.6) with the maximum Youden index of 0.812 were achieved. In conclusion, targeted screening with the use of clinical risk factors in mothers and their newborns could effectively identify cCMV.
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Importance of universal newborn screening for congenital cytomegalovirus infection: A case involving a patient who did not present with clinical manifestations and passed the automated auditory brainstem response test Reviewed
The Japanese Journal of Obstetrical, Gynecological & Neonatal Hematology 34 ( 2 ) 131 - 136 2025.3
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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特集 ローリスク妊婦ローリスク新生児のケア2025 妊娠時 妊婦健診における検体検査 Invited
金子 政時, 谷口 光代
周産期医学 55 ( 1 ) 32 - 34 2025.1
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：東京医学社
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Effect of domestic violence on the health-related quality of life of pregnant women during the COVID-19 pandemic Reviewed
Honoka Tsuda, Masatoki Kaneko, Kurumi Tsuruta, Keiko Yamazaki, Ayako Tanabe, Saori Yoshinaga, Mitsuyo Taniguchi, Yoshinori Fujii
Journal of Japan Health Medicine Association 33 ( 2 ) 200 - 207 2024.7
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Impact of COVID-19 on Cytomegalovirus Immunoglobulin M Antibody Index Reviewed
Kaneko M., Muraoka J., Yang L., Tokunaga S., Minematsu T.
Clinical and Experimental Obstetrics and Gynecology 50 ( 12 ) 2023.12
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Clinical and Experimental Obstetrics and Gynecology
Background: Coronavirus disease 2019 (COVID-19) influenced the prevalence of other infectious diseases, including congenital cytomegalovirus (CMV) infection. However, the effect of COVID-19 on antibody titers has not been reported. This study aimed to explore the influence of COVID-19 on levels of CMV immunoglobulin M (IgM) in pregnant women. Methods: This cross-sectional study included pregnant women who visited the University Hospital due to CMV IgM positivity during the 7th and 8th waves of COVID-19. Data, including maternal characteristics, history of COVID-19, CMV immunoglobulin G (IgG) and IgM index, and IgG avidity index (AI) were collected. Chemiluminescent immunoassay was performed to measure levels of IgG and IgM. Polymerase chain reaction using neonatal urine was performed to confirm congenital infection. Results: Of the 89 pregnant women, 36 (40%) (low IgG AI: n = 10; high IgG AI: n = 26) contracted COVID-19. Among 21 women with low IgG AI, 9 (false IgM positive: n = 8; primary infection: n = 1) had an IgG AI of 0. Among the eight women with false IgM positivity, six (75%) contracted COVID-19. The IgM index of pregnant women with false IgM positivity was 12.6 ± 10.9. Meanwhile, the CMV IgM index of pregnant women with false IgM positivity in the non-COVID-19-infected group was 1.7 ± 0.5. When the IgM indices of women who contracted (n = 36) and did not contract (n = 53) COVID-19 were compared, the IgM index of infected women (4.4 ± 5.7) was higher than those of non-infected women (2.7 ± 3.0) (p = 0.01). Regarding IgM and IgG AI, multiple logistic regression analysis revealed that there were no significantly different variables between the two groups. Conclusions: High prevalence of false IgM positivity was observed among women who contracted COVID-19. The IgM index of pregnant women with false IgM positivity was high. Caution should be exercised in interpreting CMV IgM indices in pregnant women with a history of COVID-19.
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特集 数値からみる周産期医療 産科編 先天性感染症 Reviewed
金子 政時
周産期医学 53 ( 8 ) 1214 - 1216 2023.8
Publishing type：Research paper (scientific journal) Publisher：東京医学社
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Yamada N., Kaneko M., Yang L., Matsuzawa S., Minematsu T., Kodama Y.
Journal of Infection and Chemotherapy 29 1071 - 1074 2023.7
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Infection and Chemotherapy
Human cytomegalovirus (HCMV) is the major cause of neurological sequelae in infants. Immune control of primary HCMV infection appears to depend on the interaction between humoral and cell-mediated immune responses. We report the case of an HCMV-transmitter mother observed with dissociation between humoral and cell-mediated immune responses. The patient had immunoglobulin (Ig) G and M positivity at 11 weeks of gestation and showed fetal hyperechoic bowel and minimal ascites at 21 weeks of gestation. At 25 weeks of gestation, the polymerase chain reaction result for HCMV using amniotic fluid was positive. The numbers of spots in the enzyme-linked immunosorbent spot (ELISPOT) assay at 25, 36, and 39 weeks of gestation were three, five, and six spots/2 × 105 peripheral blood mononuclear cells, respectively. Furthermore, IgG avidity indexes (AIs) at 21, 25, 36, and 39 weeks of gestation were 37.6, 49.7, 72.5, and 74.3, respectively. At 40+1 weeks of gestation, the patient delivered a symptomatic infected newborn with a weight of 2,384 g (−2.6 SD) and a head circumference of 30 cm (−2.6 SD). The neonate had a petechial rash and bilateral hearing loss although did not show liver dysfunction or thrombocytopenia. Cranial magnetic resonance imaging revealed mild ventriculomegaly, left lateral/parietal polymicrogyria, and a punctate white matter lesion. This case showed that IgG AI increased with increasing gestational age, whereas the numbers of spots in the ELISPOT assay had no change. The dissociation between humoral and cell-mediated immune responses may be characteristic of the immune response of a transmitter mother.
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Tanabe Ayako, Hisadome Aoi, Yamamoto Asuka, Suetsugu Norie, Kaneko Masatoki
The South Kyusyu journal of nursing 21 ( 1 ) 1 - 8 2023.3
Language：Japanese Publishing type：Research paper (scientific journal)