Papers - KANEKO Masatoki
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3. 超低出生体重児における動脈管結紮術についての検討(第18回 日本小児人工臓器研究会)
道方 香織, 金子 政時, 池田 智明, 鮫島 浩, 池ノ上 克
日本小児外科学会雑誌 41 ( 6 ) 2005
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本小児外科学会
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Intrapartum fetal heart rate monitoring in cases of cytomegalovirus infection.
Kaneko M, Sameshima H, Ikeda T, Ikenoue T, Minematsu T
American journal of obstetrics and gynecology 191 ( 4 ) 1257 - 62 2004.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Usefulness of Avidity Index for Intrauterine Cytomegalovirus Infected Newborn : A case report
14 ( 1 ) "S - 73"-"S-74" 2004.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Asphyxia 性脳障害の診断に関する臨床的および基礎的研究
池田 智明, 池ノ上 克, 鮫島 浩, 金子 政時, 川越 靖之, 古川 誠志, 米田 由香里, 大西 淳仁, ト部 浩俊, 大里 和広, 山下 理絵, 田中 博明, 福島 和子, 村田 雄二, QUILLIGAN Edward J., CHOI Ben H., PARK Soung-Day, 土井 茂治, PARER Julian T., 児玉 由紀, 寺尾 公成, 西口 俊裕, 河野 慶一郎, 嶋本 富博, 春山 康久, 今村 登志子, 桂木 真司, 高崎 泰, 三輪 勝洋, 徳永 修一, 山内 憲之, 園田 徹, 布井 博幸
日本新生児学会雑誌 39 ( 4 ) 724 - 732 2003.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus Reviewed
Masatoki Kaneko, Susan White, J Homan, Bryan Richardson
Am. J. Obstet. Gynecol. 188 ( 4 ) 961 - 972 2003.11
Language：English Publishing type：Research paper (scientific journal)
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Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus Reviewed International coauthorship
Kaneko M., White S., Homan J., Richardson B.
American Journal of Obstetrics and Gynecology 188 ( 4 ) 961 - 972 2003.4
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：American Journal of Obstetrics and Gynecology
OBJECTIVE: The purpose of this study was to determine the change in cerebral blood flow and substrate metabolism in relation to electrocortical activity in the near-term ovine fetus with repeated umbilical cord occlusion of a severe degree. STUDY DESIGN: Eight near-term fetal sheep were studied through a 2-hour control period, a 6-hour experimental period with repeated cord occlusion of 4 minutes' duration every 90 minutes, and a 16-hour recovery period. Regional cerebral blood flow was measured with the microsphere technique before, during, and after the first cord occlusion; blood flow in the superior sagittal sinus, the cerebral perfusion pressure, and the electrocortical activity were monitored continuously. Brachiocephalic arterial and sagittal venous blood were sampled at selected time points for blood gas and pH, oxygen content, and glucose and lactate levels. RESULTS: Severe umbilical cord occlusion as studied resulted in profound hypoxemia with modest hypercapnia and acidemia, to a similar degree with each insult, but with a return to preocclusion values after occluder release. Glucose values also fell acutely with each cord occlusion by approximately 30% but showed an overall increase through the experimental period, from 0.80 to 1.44 mmol/L; lactate values showed an increase, from 1.21 to 6.10 mmol/L (both P < .01). Fetal electrocortical activity was disrupted markedly, with an abrupt flattening of the electrocortical amplitude by 1.5 minutes of each cord occlusion on average and with an overall increase in indeterminate state activity during the experimental and through the recovery periods. Cerebral blood flow increased approximately 2.5- and 2.8-fold, as measured at 2 and 3.5 minutes during the first cord occlusion (both P < .01) and with the regional flow increase greater in the subcortex and brainstem. Cerebral extraction of oxygen fell toward zero, as measured at 2 minutes during the second and fourth occlusions (P < .05) with oxygen uptake no longer measurable; glucose extraction was now increased approximately 2-fold (P < .05), which indicates that anaerobic metabolism of glucose must be the predominant source of energy at this time. Superior sagittal sinus blood flow also increased in all animals, approximately 1.4- and 1.6-fold at 2 and 3.5 minutes of the first cord occlusion, but much less than the corresponding increase in arterial inflow; the increase was in response to subsequent occlusions was further reduced. CONCLUSION: Severe umbilical cord occlusion in the near-term ovine fetus results in a rapid decrease in the availability of oxygen to the brain. The low Po 2 gradient from blood to tissue rate limits for oxygen consumption by 2 minutes of insult (despite the marked increase in blood flow) and signals the shift to anaerobic metabolism, the suppression in electrocortical activity, and the probable shutdown of other energy-using processes.
DOI： 10.1067/mob.2003.219
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Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus. Reviewed
Kaneko M, White S, Homan J, Richardson B
American journal of obstetrics and gynecology 188 ( 4 ) 961 - 72 2003.4
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats.
Ikeda T, Xia YX, Kaneko M, Sameshima H, Ikenoue T
Neuroscience letters 329 ( 1 ) 33 - 6 2002.8
Language：Japanese Publishing type：Research paper (scientific journal)
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Antepartum Evaluation of Monochorionic Diamniotic Twins; MD-Twin Score: A New Scoring Method for Perinatal Outcome
Masatoki Kaneko, Sameshima Hiroshi, Tomoaki Ikeda, Yuki Kodama, Tsuyomu Ikenoue
Journal of Obstetrics Gynaecology Research 26 ( 2 ) 111 - 116 2000.10
Language：English Publishing type：Research paper (scientific journal)
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宮崎大学病院における未熟児網膜症の現状と発症因子について Reviewed
原田勇一郎,齋藤真美,森山 重人,直井 信久,大里和弘,金子 政時,池田 智明,鮫島 浩,池ノ上 克
眼科臨床医報 98 ( 6 ) 515 - 517 2000.4
Language：Japanese Publishing type：Research paper (scientific journal)
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Multicenter Study for Maternal Serum Triple Markers to Establish Japanese Standards
MIYAMURA Tsunetaka, SAITO Nakamiti, TOUNO Atsuhiko, NAGATA Shin, HIDAKI Tsutomu, ISHIMARU Tadayuki, MASUZAKI Hideaki, OHAMA Koso, MIHARU Norio, HISANAGA Sachio, SUENAGA Goro, SUENAGA Toshiro, HATAE Masayuki, KAMITOMO Masato, FUSE Masaki, HIRAI Masanao, NAGATA Hideki, KUROKI Satoshi, KUROKI Tohru, YAKUSHIJI Michiaki, HORI Daizo, NAKAYA Takayoshi, WASHIMI Hitoshi, WAKE Norio, MATSUDA Takao, KAWANO Katsuichi, KOZUMA Masutaka, TAKAYAMA Toshiya, IKENOUE Tsuyomu, KANEKO Masatoki, TATEYAMA Hiromichi, SHIMAMOTO Tomihiro, KANAZAWA Koji, SAKUMOTO Kaoru, ITO Takehisa, KAWANO Hideaki, NOMIYAMA Makoto, MATSUI Kazuo, YAMAZAKI Tomofumi, SHINAGAWA Hirotoshi, MIYAKAWA Isao, ANAI Takanobu, YOSHIMATSU Jun, KASHIMURA Masamichi, YOSHIMURA Kazuaki, ISHIKAWA Mutsuo, TAMATE Kenichi, KAYAMA Fumiyoshi, TOKUNAGA Akiteru, OCHI Hiroshi, YAMANAKA Kenji, ONOUE Toshikazu, YAMAZAKI Hiroshi, NIIKAWA Norio
51 ( 11 ) 1042 - 1048 1999
Language：Japanese Publishing type：Research paper (scientific journal)
Objective: We evaluated triple markers (α-fetoprotein, free β-human chorionic gonadotropin, and unconjugated estriol) in the second trimester to establish Japanese standards. Methods: Serum samples were collected from 2,201 pregnant women between 12 and 20 weeks of gestation as a part of a multicenter prenatal diagnostis study. Median values of each marker were calculated from 1,641 unaffected pregnancies. Multiples of the median for each of the three markers were also calcu1ated for trisomy 21. Results: The mean age, gestational weeks and maternal body weight were 30.5 years, 14.9 weeks and 52.6kg, respectively. The median α-fetoprotein value increased from 18.1 ng/ml at 12 weeks of gestation to 85.55 ng/ml at 20weeks of gestation. The median uncojugated estriol value also increased from 0.35 ng/ml at 12 weeks of gestation to 3.34 ng/ml at 20 weeks of gestation, but the median value of free β-human chorionic gonadotropin decreased from 53.85 ng/ml to 9.95 ng/ml. Seven cases of trisomy 21 were included in our study. In all of these seven cases, the multiples of the median of α-fetoprotein were less than l.0 and those of free β-human chorionic gonadotropin were more than 2.0. The multiples of the median of unconjugated estliol were less than l.0 in six of them. Conclusion: The medians or Japanese triple markers were calculated from l,641 unaffected pregnancies in a multi center study.