研究者詳細 - 金子　政時

A multiple regression model for predicting a high cytomegalovirus immunoglobulin G avidity level in pregnant women with IgM positivity 査読あり

Kaneko M., Ohhashi M., Fujii Y., Minematsu T., Kusumoto K.

International Journal of Infectious Diseases 100 1 - 6 2020年11月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Infectious Diseases

Objective: To establish a model to predict high cytomegalovirus (CMV) immunoglobulin (Ig)G avidity index (AI) using clinical information, to contribute to the mental health of CMV-IgM positive pregnant women. Methods: We studied 371 women with IgM positivity at ≤14 w of gestation. Information on the age, parity, occupation, clinical signs, IgM and G values, and IgG AI was collected. The IgG AI cut-off value for diagnosing congenital infection was calculated based on a receiver operating characteristic curve analysis. Between-group differences were assessed using the Mann–Whitney U-test or χ2 analysis. The factors predicting a high IgG AI were determined using multiple logistic regression. Results: The women were divided into high or low IgG AI groups based on an IgG AI cut-off value of 31.75. There were significant differences in the IgG and IgM levels, age, clinical signs, and the number of women with one parity between the two groups. In a multiple logistic regression analysis, IgM and the number of women with one parity were independent predictors. This result helped us establish a mathematical model that correctly classified the IgG AI level for 84.6% of women. Conclusion: We established a highly effective model for predicting a high IgG AI immediately after demonstrating IgM positivity.

DOI： 10.1016/j.ijid.2020.08.034

Intrapartum fetal heart rate monitoring in cases of cytomegalovirus infection 査読あり

金子　政時,鮫島　浩,池田　智明,池ノ上　克,峰松　俊夫

Am. J. Obstet. Gynecol. 191 1257 - 1262 2014年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Impact of COVID-19 on Cytomegalovirus Immunoglobulin M Antibody Index 査読あり

Kaneko M., Muraoka J., Yang L., Tokunaga S., Minematsu T.

Clinical and Experimental Obstetrics and Gynecology 50 ( 12 ) 2023年12月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical and Experimental Obstetrics and Gynecology

Background: Coronavirus disease 2019 (COVID-19) influenced the prevalence of other infectious diseases, including congenital cytomegalovirus (CMV) infection. However, the effect of COVID-19 on antibody titers has not been reported. This study aimed to explore the influence of COVID-19 on levels of CMV immunoglobulin M (IgM) in pregnant women. Methods: This cross-sectional study included pregnant women who visited the University Hospital due to CMV IgM positivity during the 7th and 8th waves of COVID-19. Data, including maternal characteristics, history of COVID-19, CMV immunoglobulin G (IgG) and IgM index, and IgG avidity index (AI) were collected. Chemiluminescent immunoassay was performed to measure levels of IgG and IgM. Polymerase chain reaction using neonatal urine was performed to confirm congenital infection. Results: Of the 89 pregnant women, 36 (40%) (low IgG AI: n = 10; high IgG AI: n = 26) contracted COVID-19. Among 21 women with low IgG AI, 9 (false IgM positive: n = 8; primary infection: n = 1) had an IgG AI of 0. Among the eight women with false IgM positivity, six (75%) contracted COVID-19. The IgM index of pregnant women with false IgM positivity was 12.6 ± 10.9. Meanwhile, the CMV IgM index of pregnant women with false IgM positivity in the non-COVID-19-infected group was 1.7 ± 0.5. When the IgM indices of women who contracted (n = 36) and did not contract (n = 53) COVID-19 were compared, the IgM index of infected women (4.4 ± 5.7) was higher than those of non-infected women (2.7 ± 3.0) (p = 0.01). Regarding IgM and IgG AI, multiple logistic regression analysis revealed that there were no significantly different variables between the two groups. Conclusions: High prevalence of false IgM positivity was observed among women who contracted COVID-19. The IgM index of pregnant women with false IgM positivity was high. Caution should be exercised in interpreting CMV IgM indices in pregnant women with a history of COVID-19.

DOI： 10.31083/j.ceog5012279

特集数値からみる周産期医療産科編先天性感染症査読あり

金子政時

周産期医学 53 ( 8 ) 1214 - 1216 2023年8月

掲載種別：研究論文（学術雑誌）出版者・発行元：東京医学社

DOI： 10.24479/peri.0000001051

Cell-mediated and humoral immune responses to human cytomegalovirus in pregnant women with vertically transmitted infection following primary infection: A case report 査読あり

Yamada N., Kaneko M., Yang L., Matsuzawa S., Minematsu T., Kodama Y.

Journal of Infection and Chemotherapy 29 1071 - 1074 2023年7月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Infection and Chemotherapy

Human cytomegalovirus (HCMV) is the major cause of neurological sequelae in infants. Immune control of primary HCMV infection appears to depend on the interaction between humoral and cell-mediated immune responses. We report the case of an HCMV-transmitter mother observed with dissociation between humoral and cell-mediated immune responses. The patient had immunoglobulin (Ig) G and M positivity at 11 weeks of gestation and showed fetal hyperechoic bowel and minimal ascites at 21 weeks of gestation. At 25 weeks of gestation, the polymerase chain reaction result for HCMV using amniotic fluid was positive. The numbers of spots in the enzyme-linked immunosorbent spot (ELISPOT) assay at 25, 36, and 39 weeks of gestation were three, five, and six spots/2 × 105 peripheral blood mononuclear cells, respectively. Furthermore, IgG avidity indexes (AIs) at 21, 25, 36, and 39 weeks of gestation were 37.6, 49.7, 72.5, and 74.3, respectively. At 40+1 weeks of gestation, the patient delivered a symptomatic infected newborn with a weight of 2,384 g (−2.6 SD) and a head circumference of 30 cm (−2.6 SD). The neonate had a petechial rash and bilateral hearing loss although did not show liver dysfunction or thrombocytopenia. Cranial magnetic resonance imaging revealed mild ventriculomegaly, left lateral/parietal polymicrogyria, and a punctate white matter lesion. This case showed that IgG AI increased with increasing gestational age, whereas the numbers of spots in the ELISPOT assay had no change. The dissociation between humoral and cell-mediated immune responses may be characteristic of the immune response of a transmitter mother.

DOI： 10.1016/j.jiac.2023.07.004

子育て中の労働者がワーク・ライフ・バランスを実現するための職場環境に関する検討　‐宮崎市の若年労働者への質問紙調査から‐ 査読あり

田邊綾子、久留葵、山本明佳、末次典恵、金子政時

南九州看護研究誌 21 ( 1 ) 1 - 8 2023年3月

担当区分：責任著者記述言語：日本語掲載種別：研究論文（大学，研究機関等紀要）

母子保健コーディネーターが捉える母親達の悩みの実態査読あり

山下華歩、山﨑圭子、松岡あやか、金子政時

南九州看護研究誌 20 ( 1 ) 9 - 16 2023年3月

担当区分：責任著者記述言語：日本語掲載種別：研究論文（大学，研究機関等紀要）

Prevalence of congenital cytomegalovirus infection according to the type of maternal infection in Japan 査読あり

Kaneko M., Yang L., Tanabe A., Fujii Y., Nakao H., Minematsu T.

Journal of Infection and Chemotherapy 29 485 - 489 2023年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Infection and Chemotherapy

Introduction: Variable rates of cytomegalovirus (CMV) seropositivity in mothers from different individual's background may translate to distinct epidemiological patterns of congenital CMV infection. Methods: The prospective cohort study was conducted in Japan to evaluate the prevalence of vertical transmission rate according to the type of maternal infection. Post hoc power as a follow-up analysis was evaluated to compare the statistical power with other studies from France, Finland and Brazil. One thousand one hundred sixty-three pregnant women were measured IgG, IgM and IgG avidity index. The urine samples of neonates of these women were evaluated using polymerase chain reaction to diagnose the vertical transmission. Results: The prevalence of congenital CMV infection in the study population was 0.4%. The proportions of patients with primary and nonprimary infections were 60% and 40%, respectively, with a maternal seroprevalence of 82.5%. The rate of vertical transmission among the seronegative pregnant women before pregnancy was statistically higher than that among the seropositive pregnant women before pregnancy (p < 0.05), with a study power of 52.7%. The same difference was observed in France and Finland for maternal seroprevalence of 61% and 72% and statistical power of 56.9% and 66.7%, respectively. Conclusion: The maternal seroprevalence of the present study conducted in Japan was much higher than that of studies in France and Finland. Nevertheless, seronegative pregnant women had a higher risk of vertical transmission before pregnancy.

DOI： 10.1016/j.jiac.2023.01.020

ウレアプラズマ肺炎を契機に顕在化した超早産児肺リンパ管拡張症の一例査読あり

榊原康平, 山田直史, 児玉由紀, 小畑静, 都築康恵, 村岡純輔, 青木良則, 山下理絵, 中目和彦, 金子政時, 桂木真司, 都築諒, 佐藤勇一郎

日本周産期・新生児医学会雑誌 59 ( 1 ) 116 - 121 2023年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本周産期・新生児医学会

　肺リンパ管拡張症（Pulmonary lymphangiectasia；PL）は肺リンパ管拡張を特徴とし，肺胞拡張障害をきたして重篤な呼吸不全を起こす疾患である．今回，ウレアプラズマ肺炎を契機に呼吸状態が増悪し，剖検でPLと診断された症例を報告する．　症例は超低出生体重児（在胎23週2日，610g，男児）．母体は，妊娠23週1日に胎胞形成，23週2日に経腟分娩となった．児はサーファクタント投与後，安定化した状態で人工呼吸管理を行っていた．日齢15にCRP上昇と肺野の透過性低下が認められた．各種抗菌薬治療では改善なく，日齢30の気管内分泌物ウレアプラズマ培養陽性により，アジスロマイシン水和物を開始した．CRPは著減したが，呼吸不全は悪化して日齢44に死亡した．病理解剖では，肺リンパ管がびまん性に拡張したPLと診断した．臨床的にはウレアプラズマ肺炎を契機に顕在化したPLと考えられた．

DOI： 10.34456/jjspnm.59.1_116

増刊号 191の疑問に答える周産期の栄養産科編Q & A 妊娠中期 Q80 食後の胸焼けがひどくなりました。　食事はどうしたらよいですか?　薬はありますか? 査読あり

金子政時, 前山彩, 松岡あやか

周産期医学 52 ( 13 ) 179 - 180 2022年11月

掲載種別：研究論文（学術雑誌）出版者・発行元：東京医学社

DOI： 10.24479/peri.0000000490

Antepartum Antibiotic Therapy under 34 Weeks of Gestation and Its Impact on Early-Onset Neonatal Infection and Maternal Vaginal Microbiota 査読あり

Muraoka J., Kaneko M., Doi K., Kodama Y., Sameshima H.

Microbiology Research 13 ( 3 ) 598 - 608 2022年9月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Microbiology Research

The use of prenatal antibiotics should be carefully considered, owing to their potential adverse effects on neonatal outcomes. This study aimed to identify the contributing factors to early-onset neonatal infection and to determine the influence of antepartum antibiotics on women and neonates. This study included 127 pregnant women without obvious intra-amniotic infection on admission, who delivered under 34 weeks of gestation. Information on maternal and neonatal characteristics was obtained from their medical charts. Vaginal swabs were taken from all women on admission. In total, 29 (22.8%) neonates developed early-onset infection. Multivariate analysis revealed that antepartum antibiotics were the most strongly associated factor for early-onset neonatal infection (odds ratio, 11.2; 95% confidence interval, 4.08–31.02). The frequency of early-onset neonatal infection was significantly higher in women who received antibiotic therapy than in those who did not; no significant difference in prolonging their gestation or neonatal morbidities was observed. The prevalence of women who hosted vaginal microorganisms on admission was similar to that in women whose infants subsequently developed early-onset neonatal infection compared with that of women whose infants did not. Among infants of the 40 women who received antepartum antibiotic therapy, 21 developed early-onset infection. Of the women who delivered these 21 infants, 62% (13/21) showed reduced lactobacilli and 43% (9/21) had resistant bacterial strains in their vaginal microbiota at the time of delivery. The use of antepartum antibiotics is the most strongly associated factor in early-onset neonatal infection; it does not prolong gestation and would change the vaginal environment.

DOI： 10.3390/microbiolres13030042

Association between chorioamnionitis severity and procalcitonin levels in umbilical venous blood 査読あり国際誌

Masatoki Kaneko, Junsuke Muraoka, Naoshi Yamada, Yuki Kodama

Clinical and Experimental Obstetrics & Gynecology 49 ( 7 ) 160 2022年7月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：IMR Press

DOI： 10.31083/j.ceog4907160

先天性サイトメガロウイルス感染症の現状と課題招待あり

金子政時

日本周産期・新生児医学会雑誌 57 ( 4 ) 606 - 609 2022年4月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： https://doi.org/10.34456/jjspnm.57.4_606

横抱き授乳における姿勢アライメント、肩こりの自覚および筋硬度の経時的変化と姿勢の良否における検討査読あり

大崎愛、松岡あやか、金子政時、山﨑圭子

母性衛生 63 ( 1 ) 112 - 120 2022年4月

担当区分：責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）

医療従事者の体調不良時の勤務実態　‐産科3次施設で勤務する医療従事者の体調不良時の勤務実態に関する調査‐ 査読あり

今村友美、松岡あやか、金子政時

南九州看護研究誌 20 ( 1 ) 10 - 17 2022年4月

担当区分：責任著者記述言語：日本語掲載種別：研究論文（大学，研究機関等紀要）

NICU入院中の超低出生体重児に対する両親の面会の実態と関連要因査読あり

柳田紗希、金子政時、山﨑圭子、松岡あやか

母性衛生 62 ( 4 ) 771 - 778 2022年1月

担当区分：最終著者掲載種別：研究論文（学術雑誌）

教員と臨床看護師が連携する2年次と4年次の採血技術演習査読あり

加藤沙弥佳, 末次典恵, 吉永砂織, 鶴田来美, 金子政時

日本シミュレーション医療教育学会雑誌 10 ( 0 ) 43 - 50 2022年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本シミュレーション医療教育学会

本研究の目的は、2年次と4年次の採血技術演習における、看護教員と臨床看護師の連携による教育実践を報告するとともに、学生による採血技術の自己評価と演習に対する感想を分析することで、今後の教育支援への示唆を得ることである。採血技術演習の自己評価点については、ほとんどの項目で 4 年次で自己評価点が 2 年次よりも高くなっており、その中でも統計的に有意差が確認された項目は、医療安全と静脈穿刺の手技の 2 つに大別された。また、演習に対する感想を分析した結果、演習は少人数制で目の届く指導となっており、学生に好評価であったことが示唆された。これらのことから、4 年次の学生は演習を通して自分の手技を振り返り、技術の課題を明らかにできており、採血技術に関して経験や実習での経験をふまえた学びのサイクルが展開されたことが伺えた。教育と臨床との連携による演習の取り組みは、就職前に学生の学習意欲を高め、看護基礎教育から看護継続教育へスムーズに移行していくための動機づけとなることが示唆された。

DOI： 10.50950/jasehp.2022-10-12

特集周産期医学必修知識(第9版) 性感染症(STI/STD) 査読あり

金子政時

周産期医学 51 ( 13 ) 9 - 12 2021年12月

掲載種別：研究論文（学術雑誌）出版者・発行元：(株)東京医学社

DOI： 10.24479/j00621.2022108673

A case of facial cellulitis caused by group B streptococcus in an extremely low birthweight infant 査読あり

Muraoka J., Kodama Y., Higashi M., Yamada N., Yamashita R., Nakame K., Kaneko M., Sameshima H.

Journal of Infection and Chemotherapy 27 ( 9 ) 1369 - 1372 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Infection and Chemotherapy

Group B streptococcus (GBS) is an important pathogen that causes neonatal sepsis and meningitis, which have high mortality and morbidity. Cellulitis is a rare presentation of late-onset neonatal GBS infection. We report the case of an extremely low birthweight infant with facial cellulitis caused by late-onset GBS infection. A 590-g male neonate was delivered by Cesarean section at 23 gestational weeks due to intrauterine GBS infection. Although he was effectively treated with 2 weeks of antimicrobial therapy for early-onset GBS sepsis, he subsequently developed facial and submandibular cellulitis caused by GBS at 44 days of age. He was treated with debridement and antibiotic therapy, and after 2 months his facial involvement had improved, but cosmetic issues remained. Neonatal GBS infection requires a prompt sepsis workup followed by the initiation of empiric antibiotic therapy. Additionally, lifesaving surgical debridement is sometimes necessary for cellulitis, even in premature infants.

DOI： 10.1016/j.jiac.2021.04.021

先天性サイトメガロウイルス感染症と難聴招待あり

金子政時

ENTONI 261 27 - 30 2021年8月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：全日本病院出版会

先天性サイトメガロウイルス感染症の胎児診断招待あり

金子政時

ENTONI 261 27 - 30 2021年8月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）

Differences in levels of rubella hemagglutination inhibition antibody titers according to birth cohort 査読あり

Kaneko M., Ichida M., Fujii Y., Noda S., Ohi M.

Journal of Infection and Chemotherapy 27 ( 3 ) 434 - 438 2021年3月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Infection and Chemotherapy

Introduction: This study aimed to examine the immunity level against rubella in pregnant women of different birth cohorts. Methods: In total, 512 pregnant women who visited a primary clinic between May 2019 and March 2020 were enrolled. Information in terms of the patients’ hemagglutination inhibition (HI) titers, birthdate, obstetrical history, and vaccination history were collected. Participants were divided into three generational groups according to the vaccination policy in Japan. Publicly funded vaccination was administered twice as part of a routine program in group A (n = 11), once as part of a routine program and once in a catch-up program in group B (n = 181), and once in group C (n = 320). Results: All groups had some women with negative rubella HI antibody titers (7.6% of all the women, 18.2% of group A, 9.4% of group B, and 6.3% of group C) and those with rubella HI antibody titers of ≤1:16 (45.1% of all women, 90.9% of group A, 56.4% of group B, and 37.2% of group C). Rubella HI antibody titers differed between the groups; group C had higher titers than that in group B. In groups B and C, the proportions of women with rubella HI antibody titers of ≤1:16 were not statistically different between primipara and multipara. Conclusions: Our study showed that an increase in immunity to rubella, a vaccine-preventable disease, is nevertheless required among childbearing women to prevent rubella and congenital rubella syndrome.

DOI： 10.1016/j.jiac.2020.10.004

A very low birth weight infant with severe red blood cell polyagglutination: Case report 査読あり

Naoshi Yamada, Yuki Kodama, Tomoko Goto, RIe Yamashita, Kotaro Doi, Masatoki Kaneko, Yuichiro Sato, Hiroshi Sameshima

Journal of Neonatal Biology 9 ( 3 ) 1 - 3 2021年3月

掲載種別：研究論文（学術雑誌）

サイトメガロウイルス感染症

金子政時

臨床と微生物 48 53 - 57 2021年

掲載種別：研究論文（学術雑誌）

特集 [必携]専攻医と指導医のための産科診療到達目標病態･疾患編【その他】妊娠と感染症　サイトメガロウイルス査読あり

金子政時

周産期医学 50 ( 8 ) 1489 - 1491 2020年8月

掲載種別：研究論文（学術雑誌）出版者・発行元：(株)東京医学社

DOI： 10.24479/j00621.2020377253

先天梅毒を合併し異なる転帰をとった極低出生体重児の2例査読あり

徳田温子, 児玉由紀, 菅野知佳, 後藤智子, 山田直史, 山下理絵, 土井宏太郎, 金子政時, 鮫島浩

日本周産期・新生児医学会雑誌 56 ( 3 ) 538 - 543 2020年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本周産期・新生児医学会

　梅毒は未だに最もよくみられる先天感染であり，未治療母体では胎児感染が懸念される．近年米国だけでなく，本邦でも梅毒患者数が増加し，先天梅毒の報告数が増えている．先天梅毒は適切な治療により予防可能であることから，妊娠中の梅毒の早期発見と早期治療が重要である．今回，先天梅毒を合併し異なる経過をとった極低出生体重児2症例を報告する．いずれも妊娠20週以降で判明した母体梅毒であったが，抗菌薬治療10日間後に出生した1例は軽快退院した．抗菌薬1回治療後に，胎児機能不全のため出生し，新生児死亡した症例の胎盤と全身臓器には多数の<i>Treponema pallidum</i>が認められ，抗菌薬治療の限界と考えられた．

DOI： 10.34456/jjspnm.56.3_538

妊娠と感染症：サイトメガロウイルス

金子政時

周産期医学 50 1489 - 1491 2020年

掲載種別：研究論文（学術雑誌）

Characteristics and influence of Mycoplasma / Ureaplasma cultures in amniotic fluid on perinatal outcomes 査読あり

Sho Takakura, Yuki Kodama, Rie Yamashita, Emi Kino, Noriko Kawano, Kayo Tominori, Yohei Maki, Koutaro Doi, Masatoki Kaneko, Hiroshi Sameshima

Journal of Obstetrics and Gynaecology Resarch 46 ( 3 ) 389 - 395 2019年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Obstetrics and Gynaecology Research

Aim: To investigate the effects of Mycoplasma/Ureaplasma cultured in amniotic fluid on perinatal characteristics in preterm delivery between 22 and 33 weeks of gestation. Methods: The study was conducted in a tertiary perinatal center and involved 38 pregnant women who had undergone amniocentesis to evaluate intrauterine infection due to preterm labor or premature rupture of membranes. The subjects were divided into three groups based on the culture results: negative (Negative Group, n = 24), positive for Mycoplasma/Ureaplasma (M/U Group, n = 6), and positive for other pathogens (Other Pathogens Group, n = 8). One-way analysis of variance was used to compare the three groups. Results: The incidence of histological chorioamnionitis and neonatal sepsis was significantly different among the three groups (the Negative Group and the Other Pathogens Group, P < 0.01; the M/U Group and the Other Pathogens Group, P = 0.03). In the M/U Group, no infants had sepsis, severe intraventricular hemorrhage, cystic periventricular leukomalacia, or poor neurological outcomes, but one infant developed bronchopulmonary dysplasia and needed home oxygen treatment. Although one died of gastrorrhexis, the remaining five patients had normal brain magnetic resonance imaging findings and developed normally. Conclusion: The presence of Mycoplasma/Ureaplasma isolated from amniotic fluid did not cause neonatal sepsis or poor prognosis. In some infants, there was no histological chorioamnionitis in the placenta. These pathogens thus seem to be less invasive than any other microbes with respect to perinatal outcomes.

DOI： 10.1111/jog.14183

妊婦サイトメガロウイルス抗体スクリーニングと妊産婦メンタルヘルスケア査読あり

金子政時，松岡あやか，土谷倭子

宮崎県医師会医学会誌 2019年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

過去20年の総合周産期母子医療センターにおける産科症例の変遷査読あり

川越靖之、大西淳仁、古川誠志、児玉由紀、金子政時、鮫島浩、池ノ上克

宮崎県医師会医学会誌 2019年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）

分娩時の低酸素ストレスが新生児プロカルシトニン値に与える影響査読あり

金子政時, 山口智子, 中山徹男, 谷口肇, 大橋昌尚, 児玉由紀

日本周産期・新生児医学会雑誌 2019年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）

A cross-sectional study on maternal anxiety levels after cytomegalovirus screening 査読あり

Kanako Uehara, Masatoki Kaneko, Ayaka Matsuoka, Mana Kuroki & Toshio Minematsu

Journal of Psychosomatic Obstetrics and Gynecology 41 ( 3 ) 240 - 245 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Psychosomatic Obstetrics and Gynecology

Purpose: we aimed to estimate the anxiety levels of pregnant women following maternal serum screening for CMV infection. Materials and methods: In this case-control study conducted from April 2016 to June 2017, we enrolled all pregnant women referred to our hospital who were CMV immunoglobulin (Ig) M antibody positive (IgM-positive group, n = 51); further, those who were CMV IgG positive but IgM negative (IgM-negative group, n = 51) during the same period were included as study controls. Data were collected on patient characteristics, CMV IgM levels, and whether patients were accompanied by their partners during the first hospital visit after CMV IgM testing. The State-Trait Anxiety Inventory was used to assess anxiety levels. Results: Both groups were age matched [mean age (years): IgM-positive, 30 ± 4.2 and IgM-negative, 29.9 ± 4.6]. The mean state-anxiety score was higher in the IgM-positive group (53 ± 9.6) than in the IgM-negative group (38.5 ± 7.0, p <.05) with no between-group differences in trait-anxiety scores. Similarly, a higher number of women were accompanied by their partners in the IgM-positive group. The state-anxiety scores and CMV IgM levels were not correlated in the IgM-positive group. Conclusion: Counseling support is essential for IgM-positive pregnant women following serum screening, and the screening should be avoided if support systems are unavailable.

DOI： 10.1080/0167482X.2019.1658734

産科医療補償制度に学ぶ　助産師のための妊娠・分娩マネジメント講座　多胎

金子政時、池ノ上克

ペリネイタルケア　38巻　1号　70-75 2019年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）

新生児けいれんを契機に診断された家族歴のない血友病の1例査読あり

河野猛嗣、児玉由紀、山下理絵、紀愛美、椎葉望、金子政時、鮫島浩、松澤聡史、大橋昌尚、堂福美佳、山田愛、木下真理子、上村幸代、盛武浩

宮崎県医師会医学会誌 2018年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Oral diatrizoate acid for meconium-related ileus in extremely preterm infants 査読あり

Kaori Michikata, Yuki Kodaa, Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Seiro Machigashira, Motoi Mukai, Motofumi Torikai, Kazuhiko Nakame

Pediatrics International 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/ped.13606

サイトメガロウイルスIgM抗体陽性妊婦の外来紹介受診状況と妊娠転帰に関する後方視的検討査読あり

黒木真菜，金子政時，水畑喜代子，永瀬つや子，松岡あやか

母性衛生 2018年7月

記述言語：日本語掲載種別：研究論文（学術雑誌）

胎内サイトメガロウイルス(CMV)感染症児におけるIgG抗体Avidity Indexの推移とその有用性査読あり

金子　政時,鮫島　浩,田中　博明,楠元　和美,池田　智明,池ノ上　克,峰松　俊夫

日本産婦人科・新生児血液学会雑誌 14 ( 1 ) 43 - 44 2018年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Fetal left ventricular non-compaction cardiomyopathy with ascites: A case report. 査読あり

Junsuke Muraoka, Yuki Kodama, Hiroshi Sameshima, Kaori Michikata, Satoshi Matsuzawa, Masanao Oohashi, Masatoki Kaneko, Mayumi Akaki, Yuichiro Sato

Journal of Obstetrics and Gynaecology Resarch 2017年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/jog.13381

Maternal immunoglobulin G avidity as a diagnostic tool to identify pregnant women at risk of congenital cytomegalovirus infection.

Kaneko M, Ohhashi M, Minematsu T, Muraoka J, Kusumoto K, Sameshima H

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 23 ( 3 ) 173 - 176 2017年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.jiac.2016.12.001

Did antepartum hypoxic insult caused by fetal vessel thrombosis influence the procalcitonin level in umbilical blood? A case report

胎内感染のメカニズムと児の長期予後に与える影響

金子政時

周産期医学　47巻、2号　167-170 2017年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）

胎内感染のメカニズムと児の長期予後に与える影響

金子政時

周産期医学　47巻 2017年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）

総論：胎児心拍数モニタリングの心得

金子政時

ペリネイタルケア　36巻、5号　18-21 2017年

記述言語：日本語掲載種別：研究論文（学術雑誌）

【周産期のチーム医療　サクセス8 case　今こそ助産師の専門性を発揮する】 (Case 6)多職種間連携による胎児および新生児の治療

水畑喜代子, 荒木彩香, 吉野詩保美, 見越香奈, 三輪元子, 金子政時

ペリネイタルケア　35巻　12号　54-57 2016年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

絨毛膜羊膜炎とプロカルシトニン

金子政時

周産期医学　46巻、11号　1317-1321 2016年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Trends in perinatal death and brain damage: A regional population-base study in southern Japan, 1998-2012. 査読あり

Yamashita R, Kodama Y, Sameshima H, Doi , Michikata K, Kaneko M, Ikenoue T

Austin Pediatrics, 2016, 3 (4), id 1043 2016年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

新生児・小児における特発性血栓症の診断、予防および治療法の確立に関する研究．母体の血栓性素因スクリーニングによる新生児血栓症の早期診断

金子政時

厚生労働科学研究費補助金　難治性疾患克服研究事業　平成26－27年度　総合研究報告書 35 - 37 2016年3月

記述言語：日本語掲載種別：研究論文（その他学術会議資料等）

Hydrops fetalis associated with congenital cytoplasmic body myopathy. 査読あり

Kodama Y, Sameshima H, Kaneko M, Kawaguchi H, Ikeda T, Ikenoue T

Obstetrics and Gynecology Case-Reviews, 2016, 3 (7), 1-3 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）

超低出生体重児の分娩時胎児心拍数陣痛図連続記録の質に影響を与える因子に関する研究

河野美津子、金子政時

なし 2016年

記述言語：日本語掲載種別：学位論文（修士）

Chronic histiocytic intervillositis同胞例における周産期予後の比較査読あり

村岡純輔、金子政時、松澤聡史、大橋昌尚、住吉佳恵子、道方香織、児玉由紀、鮫島浩

日本周産期・新生児医学会雑誌　2016、52巻、1号、125-129 2016年

記述言語：日本語掲載種別：研究論文（学術雑誌）

新生児蘇生準備段階における保育器内汚染度に関する検討

田中美帆、金子政時

なし 2016年

記述言語：日本語掲載種別：学位論文（修士）

サイトメガロウイルスIgM抗体陽性妊婦の支援体制構築に向けた外来紹介受診状況と妊娠転帰に関する研究

黒木真菜、金子政時

なし 2016年

記述言語：日本語掲載種別：学位論文（修士）

超低出生体重児の出生後経過に伴う閉鎖式保育器の汚染度に関する研究

山中瑠璃、金子政時

なし 2016年

記述言語：日本語掲載種別：学位論文（修士）

Did antepartum hypoxic insult caused by fetal vessel thrombosis influence the procalcitonin level in umbilical blood? A case report 査読あり

M. Kaneko, A. Yamauchi, R. Yamashita, et al.

The Journal of Obstetrics and Gynecology Research 41 ( 11 ) 1839 - 1842 2015年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Kaneko M., Yamauchi A., Yamashita R., Sato Y., Kodama Y., Sameshima H.

Journal of Obstetrics and Gynaecology Research 41 ( 11 ) 1839 - 1842 2015年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Obstetrics and Gynaecology Research

© 2015 Japan Society of Obstetrics and Gynecology. We report a case of marked elevation of the procalcitonin level in umbilical blood and neonatal blood at birth. The mother did not perceive fetal motion. Antepartum fetal heart rate monitoring showed a loss of variability and absence of acceleration. No fetal breathing movement, fetal movement, or fetal tone were observed by ultrasonography. The female neonate was delivered by cesarean section at 25-weeks of gestation, with birthweight 774-g. The umbilical arterial pH value at birth was 7.29. Mild elevation in interleukin-6 and tumor necrosis factor-α in umbilical blood were observed. Cytochrome c showed a high level in umbilical and neonatal blood at birth. Placental histopathology revealed multiple fetal vessel thrombosis in the large stem villi and chorionic vessels. The neonate showed no infectious signs throughout the neonatal period. Computed tomography at 3-months of age revealed atrophy in the cerebrum and cerebellum. At 1-year after birth, the infant showed spastic quadriplegia. In this case, antepartum asphyxia due to fetal vessel thrombosis may have influenced the elevation of procalcitonin level in umbilical blood and neonatal blood at birth.

DOI： 10.1111/jog.12828

Perinatal morbidity and mortality for extremely low-birthweight infdants: A population-based study of regionalized maternal and neonatal transport. 査読あり

M. Kaneko, R. Yamashita, K. Kai, et al

The Journal of Obstetrics and Gynecology Research 41 ( 7 ) 1056 - 1066 2015年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Perinatal morbidity and mortality for extremely low-birthweight infants: A population-based study of regionalized maternal and neonatal transport.

Kaneko M, Yamashita R, Kai K, Yamada N, Sameshima H, Ikenoue T

The journal of obstetrics and gynaecology research 41 ( 7 ) 1056 - 66 2015年7月

記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/jog.12686

Prospective study of the MD-twin score for antepartum evaluation of monochorionic diamniotic twins and its correlation with perinatal outcomes.

Oohashi M, Kaneko M, Sameshima H, Kodama Y, Ikenoue T

The journal of obstetrics and gynaecology research 40 ( 3 ) 711 - 7 2014年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/jog.12258

Protein C deficiency as the major cause of thrombophilias in childhood 招待あり査読あり

S Ohga, A Ishiguro, Y Takahashi, M Shima, M Taki, M Kaneko, et al.

Pediatrics International 55 267 - 271 2013年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Maternal IgG avidity, IgM and ultrasound abnormalities: combined method to detect congenital cytomegalovirus infection with sequelae 査読あり

M Kaneko, H Sameshima, T Minematsu, K Kusumoto, A Yamuchi, T Ikenoue

Journal of Perinatology 33 831 - 835 2013年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/jp.2013.87

Protein C deficiency as the major cause of thrombophilias in childhood.

Ohga S, Ishiguro A, Takahashi Y, Shima M, Taki M, Kaneko M, Fukushima K, Kang D, Hara T, Japan Childhood Thrombophilia Study Group.

Pediatrics international : official journal of the Japan Pediatric Society 55 ( 3 ) 267 - 71 2013年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/ped.12102

Mortality rates for extremely low-birthweight infants: a regional, population-based study in Japan during 2005-2009.

Kaneko M, Sameshima H, Kai K, Urabe H, Kodama Y, Ikenoue T

The journal of obstetrics and gynaecology research 38 ( 9 ) 1145 - 51 2012年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/j.1447-0756.2012.01851.x

Perinatal death and neurological damage as a sequential chain of poor outcome.

Doi K, Sameshima H, Kodama Y, Furukawa S, Kaneko M, Ikenoue T, Miyazaki Perinatal Data Groups.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 25 ( 6 ) 706 - 9 2012年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： 10.3109/14767058.2011.587061

Case report and review of delayed-interval delivery for dichorionic, diamniotic twins with normal development

Case report and review of delayed -intereval delivery for dichorionic, diamniotic twins normal development 査読あり

Kaneko M, Kawagoe Y, Oonishi J. et al.

The Journal of Obstetrics and Gynaecology Research 38 ( 4 ) 741 - 744 2012年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Congenital infantile fibrosarcome in very low-birth-weight infant 査読あり

Mukai M, Sameshima H, Kodama Y, et al.

Journal of pediatric Surgery 47 1 - 4 2012年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Kaneko M., Kawagoe Y., Oonishi J., Yamada N., Sameshima H., Ikenoue T.

Journal of Obstetrics and Gynaecology Research 38 ( 4 ) 741 - 744 2012年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Obstetrics and Gynaecology Research

We report a case of delayed-interval delivery of a dichorionic, diamniotic twin pregnancy with the survival of both twins. The patient presented at 22 weeks and 1 day of gestation with vaginal bleeding and preterm labor. Five days later, the first twin was born. The second twin remained in utero. The management consisted of careful monitoring of both maternal and fetal status. Nine days later, the second twin was delivered vaginally. Both twins received full resuscitation and immediate life-support intervention; at 7 years of age both twins exhibited normal development. © 2012 2012 Japan Society of Obstetrics and Gynecology.

DOI： 10.1111/j.1447-0756.2011.01761.x

Congenital infantile fibrosarcoma in a very low-birth-weight infant

Mukai M., Sameshima H., Kodama Y., Yamashita R., Kaneko M., Ikenoue T., Matsufuji H., Kondo K., Chijiiwa K.

Journal of Pediatric Surgery 47 ( 4 ) e1 - 4 2012年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Pediatric Surgery

We describe a prenatally diagnosed case with congenital infantile fibrosarcoma, which is a rare malignant tumor, of which there have been only 14 cases reported in the English literature. A giant mass on the left thigh was detected at 24 weeks' gestation by prenatal ultrasonography. Because of its rapid growth and nonreassuring fetal status in utero, the baby was delivered by cesarean delivery at 27 weeks' gestation. The case was complicated by hemorrhagic anemia, coagulopathy, and cardiac failure, and a tumor resection was performed on day 3. As of age 2.5 years, he was healthy without evidence of recurrence. Because some fetal cases with congenital infantile fibrosarcoma have a poor prognosis, termination of pregnancy at an appropriate time and postnatal early treatment are crucial for successful treatment. © 2012 Elsevier Inc.

DOI： 10.1016/j.jpedsurg.2011.11.052

超低出生体重の娩出法 ; 新生児及び母体の予後向上を目指して

古川誠志, 鮫島浩, 土井宏太郎, 児玉由紀, 金子政時, 池ノ上克, 西村美保子, 高橋典子

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 47 ( 4 ) 826 - 829 2011年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

6)一絨毛膜双胎妊娠管理スコアを指標とする立場に立って((3)一絨毛膜双胎娩出のタイミング,4)周産期,クリニカルディベート,第63回日本産科婦人科学会第63回学術講演会生涯研修プログラム,研修コーナー)

金子政時, Masatoki KANEKO, 宮崎大学, Perinatal Center Department of Obstetrics and Gynecology University of Miyazaki

日本産科婦人科學會雜誌 = Acta obstetrica et gynaecologica Japonica 63 ( 12 ) N - 196-"N-200" 2011年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Perinatal death and neurological damage as a sequential chain of poor outcome 査読あり

Masatoki Kaneko

The Journal of Maternal-Fetal and Neonatal Medicine 1 - 4 2011年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Application of a fetal scalp electrode for continuous fetal heart rate monitoring during an ex utero intrapartum treatment

Kaneko M., Tokunaga S., Mukai M., MacHigashira S., Maki Y., Kodama Y., Sameshima H., Ikenoue T.

Journal of Pediatric Surgery 46 ( 2 ) e37 - 40 2011年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Pediatric Surgery

Fetal monitoring is required to avoid hypoxic injury during ex utero intrapartum treatment (EXIT). We performed a tracheostomy under EXIT in a case of suspected airway obstruction caused by a cervical teratoma. The scalp electrode was applied for continuous fetal heart rate monitoring. This device enabled us to promptly deal with fetal bradycardia caused by cord compression. We describe here the usefulness of the fetal scalp electrode for fetal monitoring under EXIT. Crown Copyright © 2011 Published by Elsevier Inc. All rights reserved.

DOI： 10.1016/j.jpedsurg.2010.10.026

6)一絨毛膜双胎妊娠管理スコア指標とする立場に立って((3)一絨毛膜双胎娩出のタイミング,4)周産期,1.クリニカルディベート,生涯研修プログラム,第63回日本産科婦人科学会学術講演会)

町頭成郎, 松藤凡, 加治建, 下野隆一, 向井基, 中目和彦, 枡屋隆太, 鮫島浩, 金子政時, 児玉由紀, 池ノ上克

日本小児外科学会雑誌 47 ( 6 ) 2011年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：特定非営利活動法人日本小児外科学会

DOI： 10.11164/jjsps.47.6_922_2

金子政時

日本産科婦人科學會雜誌 63 ( 2 ) 2011年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本産科婦人科学会

Rubella outbreak on Tokunoshima Island in 2004 : A population-based study of pregnant women

KUSUMOTO Kazumi, KANEKO Masatoki, SAMESHIMA Hiroshi, MINEMATSU Toshio, FURUTA Ken, IKENOUE Tsuyomu

The journal of obstetrics and gynaecology research 36 ( 5 ) 938 - 943 2010年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Rubella outbreak on Tokunoshima Island in 2004: a population-based study of pregnat women. 査読あり

Kusumoto K, Kaneko M, Sameshima H, Minematsu T, Furuta K, Ikenoue T

Journal of Obstetrical Gynaecology Resarch 36 ( 5 ) 938 - 943 2010年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Clinical factors that enhance morbidity and mortality in intrauterine growth restricted foetuses delivered between 23 and 30 weeks of gestation. 査読あり

Sameshima H, Kodama Y, Kaneko M, Ikenoue T.

Journal of Maternal Fetal neonatal Medicine 23 ( 10 ) 1218 - 1224 2010年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Rubella outbreak on Tokunoshima Island in 2004: a population-based study of pregnant women.

Kusumoto K, Kaneko M, Sameshima H, Minematsu T, Furuta K, Ikenoue T

The journal of obstetrics and gynaecology research 36 ( 5 ) 938 - 43 2010年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/j.1447-0756.2010.01277.x

Clinical factors that enhance morbidity and mortality in intrauterine growth restricted foetuses delivered between 23 and 30 weeks of gestation

Sameshima H., Kodama Y., Kaneko M., Ikenoue T.

Journal of Maternal-Fetal and Neonatal Medicine 23 ( 10 ) 1218 - 1224 2010年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Maternal-Fetal and Neonatal Medicine

Objective.To find clinical factors that are associated with poor outcome (death and brain damage) in premature intrauterine growth restricted (IUGR) infants. Methods.A retrospective study was performed to compare the incidence of poor outcome between 45 IUGR and 203 appropriate-for-gestational-age (AGA) infants born before 30 weeks of gestation. Foetal tests included foetal heart rate monitoring, Doppler flow, amniotic fluid, and head circumference. Growth for gestational age was categorised as 10th through 3rd, third through first, and below first percentiles. Results.In infants below 25 weeks of gestation, the incidence of poor outcome was not different between IUGR and AGA. In infants between 25 and 30 weeks of gestation, the incidence of poor outcome was significantly increased in IUGR compared with AGA (12/40, 30 versus 11/136, 8.1, p < 0.01). Univariate analysis showed that abnormality in foetal heart rate monitoring [odds ratio (OR) 8.3, 95 confidence interval (CI) 1.5843.6], head circumference (OR 7.0, 95CI 1.4234.4), and Doppler flow (OR 10.9, 95CI 1.8364.6) was significantly associated with poor outcome in IUGR infants. However, no foetal tests were significantly associated with poor outcome after adjusting for the 3-grade birthweight percentiles. Conclusions.Immaturity outweighs clinical problem associated with IUGR in infants below 25 weeks of gestation. Between 25 and 30 weeks of gestation, there was a growth threshold below third percentile where foetal tests were not significant predictors of poor outcome, but that was primarily determined by birthweight. © 2010 Informa UK, Ltd.

DOI： 10.3109/14767050903580367

Developmental changes in catecholamine requirement, volume load and corticosteroid supplementation in premature infants born at 22 to 28weeks of gestation

Developmental changes in catecholamine requirement, volume load and corticosteroid supplementation in premature infants born at 22 to 28 weeks of gestation 査読あり

Kaori Michikata, Hiroshi Sameshima, Kaeko Sumiyoshi, Yuki Kodama, Masatoki Kaneko, Tsuyomu Ikenoue

Early Human Development 86 401 - 405 2010年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Michikata K., Sameshima H., Sumiyoshi K., Kodama Y., Kaneko M., Ikenoue T.

Early Human Development 86 ( 7 ) 401 - 405 2010年7月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Early Human Development

Background: Due to circulatory instability, premature infants require volume loads, catecholamines and steroid supplementation to improve mortality and neurodevelopmental outcome. However, a complete quantitative analysis concerning the relationship between supplementation and gestational age, especially in infants born at 22 to 24 weeks of gestation, is lacking. Aim: To investigate whether less mature infants need higher doses of catecholamine, volume loads and steroid, and whether those who require higher doses have poorer outcome. Study design: A retrospective, observational study was performed at a tertiary center in a university setting. Among the consecutive 221 premature infants born at 22 to 28 weeks of gestation, we selected 108 infants who had no apparent pathological conditions other than prematurity. Catecholamines, volume loads and steroid, given to attain sufficient blood pressure and urinary output, were quantitatively analyzed during the first 24 hours. Outcome measures: Quantity of catecholamines, volume expanders and steroid supplementation as a function of gestational age and childhood outcome at 2 years. Results: Catecholamines and volume loads were increased in a step-wise manner with decreasing gestational age. Intact survival rate was significantly lower in infants born before 25 weeks of gestation compared with the more mature infants. Among infants born at 22 to 24 weeks' gestation, catecholamine and volume load increased significantly in poor outcome infants compared with good outcome infants. Conclusions: From a developmental viewpoint, progressively larger doses of catecholamine, volume expanders and corticosteroid are required to stabilize circulatory adaptation to neonatal life in infants between 22 to 28 weeks of gestation. © 2010 Elsevier Ltd.

DOI： 10.1016/j.earlhumdev.2010.05.016

P001.胃穿孔を起こした超低出生体重児の1例(一般演題,第47回日本小児外科学会九州地方会)

町頭成郎, 千々岩一男, 近藤千博, 池ノ上克, 鮫島浩, 金子政時

日本小児外科学会雑誌 46 ( 6 ) 2010年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：特定非営利活動法人日本小児外科学会

DOI： 10.11164/jjsps.46.6_983_1

PO-194 EX Utero Intrapartum Treatment (EXIT)の適応と手技に関して : EXIT検討3症例の経験を通して(新生児・胎児治療,ポスターセッション,病気の子供達に笑顔小児外科に夢そして革新を,第47回日本小児外科学会学術集会)

町頭成郎, 松藤凡, 加治建, 向井基, 堂地勉, 桑波田知樹, 川俣和弥, 池ノ上克, 鮫島浩, 金子政時

日本小児外科学会雑誌 46 ( 3 ) 2010年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：特定非営利活動法人日本小児外科学会

DOI： 10.11164/jjsps.46.3_695_2

産婦人科医小児科医が連携した医師養成プログラム

金子政時

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 45 ( 4 ) 994 - 997 2009年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

産婦人科医小児科医が連携した医師養成プログラム

金子政時

日本周産期・新生児医学会雑誌 45 ( 4 ) 994 - 997 2009年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

CMV胎内感染治療の展望 : 予後からみた今後の治療のありかた

丸山有子, 茨聡, 金子政時, 児玉由紀, 丸山英樹, 徳久琢也, 松井貴子, 藤江由夏, 中澤祐介, 上塘正人, 前田隆嗣, 鮫島浩, 池ノ上克, 栄鶴義人, 峰松俊夫, 土井宏太郎, 加藤明彦, 寺原賢人

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 45 ( 1 ) 5 - 9 2009年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）

胎内サイトメガロウイルス感染症における抗原血症の臨床上の有用性

金子政時, SAMESHIMA Hiroshi, IKENOUE Tsuyomu, KUSUMOTO Kazumi, MINEMATSU Toshio

Pediatrics international : official journal of the Japan Pediatric Society 51 ( 1 ) 1 - 4 2009年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Clinical importance of cytomegalovirus antigenemia for intrauterine cytomegalovirus infection. （共著）査読あり

Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Kazumi Kusumoto, Toshio Minematsu.

Pediatrics International 51 1 - 4 2009年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

Clinical importance of cytomegalovirus antigenemia for intrauterine cytomegalovirus infection

Kaneko M., Sameshima H., Ikenoue T., Kusumoto K., Minematsu T.

Pediatrics International 51 ( 1 ) 1 - 4 2009年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Pediatrics International

Background: Little is known about the clinical importance of cytomegalovirus (CMV) antigenemia for intrauterine-CMV-infected newborns. The aims of the present study were to evaluate the diagnostic accuracy of CMV antigenemia during the neonatal period and its association with clinical manifestations. Methods: CMV antigenemia was analyzed using neonatal blood from 25 patients suspected of having intrauterine infection because of abnormal clinical manifestations in the mother, fetus, and newborn. Neonatal urine samples were collected for diagnosis of intrauterine infection. The diagnostic accuracy of the antigenemia analysis was evaluated by comparing it with the results of urinary CMV analyses. The clinical manifestations of antigenemia-positive and -negative infected newborns were compared in the infected newborns. Results: Fifteen newborns were congenitally infected and 10 were uninfected as diagnosed on virus isolation from neonatal urine. Six of 15 infected newborns were positive for CMV antigenemia. CMV antigenemia had a positive predictive value of 100%, a negative predictive value of 52.6%, a sensitivity of 40%, and a specificity of 100%. CMV retinitis and pneumonitis were more prevalent among antigenemia-positive newborns (4/6) than antigenemia-negative newborns (0/9; P < 0.05). Conclusions: Antigenemia was significantly associated with retinitis and pneumonia, but it was not sensitive enough to diagnose intrauterine CMV infection. © 2008 Japan Pediatric Society.

DOI： 10.1111/j.1442-200X.2008.02651.x

(2)産婦人科医・小児科医が連携した医師養成のための卒前・卒後教育(<特集>第60回学術講演会シンポジウム4「産婦人科医不足の解消を目指して」)

サイトメガロウイルスの母子感染

金子政時

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44 ( 4 ) 894 - 897 2008年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

金子政時, Masatoki KANEKO, 宮崎大学医学部医学教育改革推進センター産婦人科, Department of Obstetrics and Gynecology Center for Medical Education Faculty of Medicine University of Miyazaki

日本産科婦人科學會雜誌 = Acta obstetrica et gynaecologica Japonica 60 ( 12 ) 1945 - 1952 2008年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

A substantive medical education system is very important for training young and talented doctors in order to avoid shortage of specialists in the field of obstetrics and gynecology. Before the establishment of a substantive medical education system in Miyazaki prefecture, the prefecture had the highest perinatal mortality rate in Japan. In order to overcome this situation, we began to educate the young and talented doctors who specialized in obstetrics and gynecology. As a result of this program, the number of doctors graduating with specialization in obstetrics and gynecology in Miyazaki prefecture increased exceptionally and exceeded the national average. Moreover, the improvement of the perinatal health care system was in parallel with the training of young and talented doctors, which resulted in more improved perinatal mortality index. Furthermore, the promotion of substantive medical education and advanced clinical research program led to improved and matured talented doctors. However at present, the number of specialist doctors graduating in the field of obstetrics and gynecology in Miyazaki prefecture has not seen any further increase in the past several years. In order to maintain the highest standard and an efficient level of the established perinatal health care system in Miyazaki prefecture, it is indispensable to educate young and talented doctors. Our aim is therefore to recruit young and talented doctors through the program entitled "A substantive medical education system for students and doctors in collaboration with obstetricians and gynecologist, and pediatricians".

Deaths of early-onset, invasive sepsis in full-term infants in Miyazaki: Nine cases from a regional population-based analysis from 1998-2006

Sameshima H., Kodama Y., Kaneko M., Ikenoue T.

Japanese Journal of Infectious Diseases 61 ( 5 ) 400 - 401 2008年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Infectious Diseases

In a population-based study we investigated the early-onset, invasive sepsis caused by group B streptococcus (GBS) and non-GBS in the era of intrapartum antimicrobial prophylaxis. From 1998 to 2006, we had 387 perinatal deaths in 98,495 deliveries, and 9 full-term infants met the criteria of early-onset, invasive sepsis, in which microorganisms were proven from blood sampling. Of these cases, 4 involved GBS, 2 amipicillin-resistant Escherichia coli, 2 methicillin-resistant Staphylococcus aureus, and 1 was unidentified. All 4 cases of GBS related death underwent improper procedures contrary to the prophylaxis recommendation. Eighty percent of non-GBS related deaths had septicemia of antibiotic-resistant pathogens. We found in our population-based study that early-onset fatal sepsis in full-term infants is associated with insufficient adherence to the prophylaxis strategy for GBS and with the emergence of antimicrobial resistant non-GBS bacteria.

New technique for enterostomy of extremely low-birth-weight infants - intestinal anchoring with gaze. "jointly worked" 査読あり

Kondo K, Chijiiwa K, Mukai M, Iwamura T, Matsuda H, Kaneko M, Kodama Y, Sameshima H, Ikenoue T.

Journal of Pediatric Surgery 43 ( 9 ) 1755 - 1760 2008年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Deaths of early-onset, invasive sepsis in full-term infants in Miyazaki: nine cases from a regional population-based analysis from 1998-2006.

Sameshima H, Kodama Y, Kaneko M, Ikenoue T, Miyazaki Perinatal Data Group.

Japanese journal of infectious diseases 61 ( 5 ) 400 - 1 2008年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）

New technique for enterostomy of extremely low-birth-weight infants-intestinal anchoring with gauze

Kondo K., Chijiiwa K., Mukai M., Iwamura T., Matsuda H., Kaneko M., Kodama Y., Sameshima H., Ikenoue T.

Journal of Pediatric Surgery 43 ( 9 ) 1755 - 1760 2008年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Pediatric Surgery

Background: In enterostomy for extremely low-birth-weight infants ( < 1000 g), the technique of anchoring the intestine for a stoma to the abdominal wall is very difficult because of the small size and fragile nature of the intestine. Here we describe a novel technique for intestinal anchoring in such infants. Methods: In our approach to enterostomy, the intestine is anchored only by a strip of gauze packed into the subcutaneous space. No suturing is performed. The efficacy of this technique was evaluated in 21 infants with less than 1000 g of body weight who have intestinal perforation or obstruction. Results: Two patients (9.5%) had complications that were related to the enterostomy. The complications were parastomal and intrastomal intestinal prolapse, both of which were treated successfully by reoperation. Eighteen patients (86%) survived to closure of the enterostoma. Conclusions: Intestinal anchoring with gauze is an easy and effective technique for enterostomy in extremely low-birth-weight infants and can be applied in selected cases. © 2008 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.jpedsurg.2008.04.032

(2) 産婦人科医小児科医が連携した医師養成のための卒前・卒後教育(産婦人科医不足の解消を目指して,シンポジウム4,第60回日本産科婦人科学会学術講演会)

Deaths of early-onset, invasive sepsis in full-term infants in Miyazaki: nine cases from a regional population-based analysis from 1998-2006. "jointly worked" 査読あり

Samashima H, Kodama Y, Kaneko M, Ikenoue T

Jpn J Infect Dis 61 ( 5 ) 400 - 401 2008年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

CMV胎内感染治療の展望

丸山有子, 茨聡, 丸山英樹, 徳久琢也, 松井貴子, 藤江由夏, 中澤祐介, 金子政時, 児玉由紀, 上塘正人, 前田隆嗣, 栄鶴義人, 峰松俊夫, 鮫島浩, 池ノ上克

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44 ( 2 ) 271 - 272 2008年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

サイトメガロウイルスの母子感染

金子政時

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44 ( 2 ) 2008年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

金子政時, 宮崎大学

日本産科婦人科學會雜誌 = Acta obstetrica et gynaecologica Japonica 60 ( 2 ) 455 - 456 2008年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）

MD-Twin Score による一絨毛膜二羊膜性双胎児の胎児評価

金子政時, 鮫島浩, 児玉由紀, 山下理恵, 池ノ上克

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 43 ( 4 ) 987 - 990 2007年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

MD-Twin Socreによる一絨毛膜二羊膜性双胎児の胎児評価

金子政時、鮫島浩、児玉由紀、山下理絵、池ノ上克

日本周産期・新生児学会雑誌 43 ( 4 ) 987 - 999 2007年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

胎内サイトメガロウイルス感染症児IgG抗体Avidity Indexの推移と臨床経過

金子政時, 鮫島浩、田中博昭、池ノ上克、楠元和美、峰松俊夫

HERPES MANEGMENT 11 ( 1 ) 7 - 7 2007年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Fetal manifestations and poor outcomes of congenital cytomegalovirus infections : Possible candidates for intrauterine antiviral treatments

MARUYAMA Yuko, SAMESHIMA Hiroshi, KAMITOMO Masato, IBARA Satoshi, KANEKO Masatoki, IKENOUE Tsuyomu, MINEMATSU Toshio, EIZURU Yoshihito

The Journal of obstetrics and gynaecology research 33 ( 5 ) 619 - 623 2007年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Fetal manifestations and poor outcomes of congenital cytomegalovirus infections: Possible candidates for intrauterine antiviral treatments 査読あり

Y Maruyama, H Sameshima, M Kamitomo, S Ibara, M Kaneko, T Ikenoue, T Minematsu, Y Eizuru

J. Obstet. Gynaecol. Res. 33 ( 5 ) 619 - 623 2007年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Fetal manifestations and poor outcomes of congenital cytomegalovirus infections: Possible candidates for intrauterine antiviral treatments

Maruyama Y., Sameshima H., Kamitomo M., Ibara S., Kaneko M., Ikenoue T., Minematsu T., Eizuru Y.

Journal of Obstetrics and Gynaecology Research 33 ( 5 ) 619 - 623 2007年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Obstetrics and Gynaecology Research

Aim: This retrospective study was performed to reveal the natural history of cytomegalovirus (CMV) infected fetuses during the perinatal period and to find prenatal findings associated with poor outcomes. Methods: 33 neonates with CMV infection, born after 30 weeks of gestation, were registered from a total of 12 414 infants between 1995 and 2003. Maternal and neonatal medical records were reviewed regarding fetal growth; abdominal signs including ascites and hepatosplenomegaly; cerebral signs including ventriculomegaly, microcephaly, and calcification; and fetal heart rate monitoring, for signs which may have been detected by the standard obstetric ultrasonography. Univariate and multivariate analyses were performed to test for any associations between these manifestations and poor outcomes such as death and neurological damages. Results: Among the 33 infants, 6 died, 10 developed neurological damage including cerebral palsy (n = 8), epilepsy (n = 5), and hearing difficulties (n = 5), and the remaining 17 were normal. After adjusting for ganciclovir treatment and gender, death was 40-fold more likely associated with infants having abdominal signs (OR 40, 95%CI 4.6-930) than those without abdominal signs. Similarly, poor outcomes (death or neurological damage) were more likely associated with infants having either abdominal or cerebral signs (OR 39, 95%CI 3.8-1323). Fetal growth restriction and non-reassuring fetal heart rate patterns were not significantly associated with poor outcomes. Conclusion: The absence of abdominal signs guarantees the infant's survival. The presence of abdominal or cerebral signs is associated with poor outcomes, suggesting that these fetuses are possible candidates to receive in-utero therapy of congenital CMV infection. © 2007 The Authors.

DOI： 10.1111/j.1447-0756.2007.00621.x

胎内サイトメガロウイルス感染症児に対する ganciclovir 治療と血中薬物動態

金子政時, 鮫島浩, 池ノ上克, 日高宗明, 楠元和美, 峰松俊夫

日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology 17 ( 1 ) "S - 59"-"S-60" 2007年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

前置胎盤症例における癒着胎盤の画像評価

土井宏太郎, 中野ゆうき, 徳永修一, 川越靖之, 金子政時, 鮫島浩, 池ノ上克

日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology 16 ( 2 ) 40 - 44 2007年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）

風疹抗体保有妊婦における妊娠中風疹再感染と抗体反応

金子政時, 古田賢, 鮫島浩, 池ノ上克, 楠元和美, 峰松俊夫

日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology 16 ( 2 ) 23 - 26 2007年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）

前置胎盤症例における癒着胎盤の画像評価査読あり

土井宏太郎、中野ゆうき、徳永修一、川越靖之、金子政時、鮫島浩、池ノ上克

日本産婦人科新生児血液学会雑誌 16 ( 2 ) 40 - 44 2007年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）

風疹抗体保有妊婦における妊娠中風疹再感染と抗体反応招待あり査読あり

金子政時、古田賢、鮫島浩、池ノ上克、楠元和美、峰松俊夫

日本産婦人科新生児血液学会雑誌 16 ( 2 ) 23 - 26 2007年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）

P004.超低出生体重児に対する腸瘻造設法の工夫 : ガーゼ固定法(一般演題,第44回日本小児外科学会九州地方会)

近藤千博, 千々岩一男, 松田博光, 金子政時, 児玉由紀, 鮫島浩, 池ノ上克, 岩村威志

日本小児外科学会雑誌 43 ( 6 ) 809 - 810 2007年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：特定非営利活動法人日本小児外科学会

DOI： 10.11164/jjsps.43.6_809_4

P008.腹腔内精巣を伴った腹壁破裂の1例(一般演題,第44回日本小児外科学会九州地方会)

松田博光, 千々岩一男, 近藤千博, 児玉由紀, 金子政時, 鮫島浩, 池ノ上克, 上村敏雄, 長野正史

日本小児外科学会雑誌 43 ( 6 ) 810 - 811 2007年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：特定非営利活動法人日本小児外科学会

DOI： 10.11164/jjsps.43.6_810_4

A Two-Step Strategy for Detecting Intrauterine Cytomegalovirus Infection with Clinical Manifestations in the Mother, Fetuts, and Newborn 査読あり

Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Toshio Minematsu

Jpn. J. Infect. Dis 59 363 - 366 2006年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

A two-step strategy for detecting intrauterine cytomegalovirus infection with clinical manifestations in the mother, fetus, and newborn

Kaneko M., Sameshima H., Ikenoue T., Minematsu T.

Japanese Journal of Infectious Diseases 59 ( 6 ) 363 - 366 2006年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Journal of Infectious Diseases

We selected a high-risk group based on clinical manifestations and performed virological tests to detect intrauterine cytomegalovirus (CMV) infection. We tested the efficacy of this detection protocol in this study. We analyzed 2,309 newborns at 22 weeks or more of gestation from January 1992 to December 2000. Clinical manifestations of the mother, fetus, and newborn were used in the initial step to identify the high-risk group. For the high-risk group, if the causes of clinical manifestation remained unclear, we assayed for CMV DNA in the amniotic fluid, umbilical cord blood, or newborn urine using polymerase chain reaction (PCR) as a second step. Positive PCR results were confirmed by isolating CMV. The initial step detected 287 high-risk cases from 2,309 deliveries. In this group, 100 cases did not have reasonable explanations for the clinical manifestation. In the second-step PCR, intrauterine CMV infection was diagnosed in 10 of 100 cases (10%). The initial clinical classification reduced the proportion of cases needing laboratory investigation to 4%. Thus, our strategy detected intrauterine CMV infection in as many as 10% of high-risk patients after the first step, which is much higher than the general screening rate.

A two-step strategy for detecting intrauterine cytomegalovirus infection with clinical manifestations in the mother, fetus, and newborn.

Kaneko M, Sameshima H, Ikenoue T, Minematsu T

Japanese journal of infectious diseases 59 ( 6 ) 363 - 6 2006年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

サイトメガロウイルス胎内感染の予後予測と周産期管理

丸山有子, 金子政時, 栄鶴義人, 峰松俊夫, 茨聡, 上塘正人, 鮫島浩, 向井基, 徳久琢也, 松井貴子, 藤江由夏, 前田隆嗣, 中澤祐介, 宇都宮剛, 大城達男, 角健司, 小野哲男, 児玉由紀, 池ノ上克

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 42 ( 4 ) 792 - 797 2006年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）

先天性サイトメガロウイルス感染症と IgG Avidity

山下美和, 前田真, 杉村基, 金山尚裕, 峰松俊夫, 楠元和美, 金子政時, 池ノ上克

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 42 ( 4 ) 785 - 788 2006年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Rubella outbreak on Tokunoshima island in 2004: Serological and epidemiological analysis of pregnant women with rubella 査読あり

Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Toshio Minematsu, Kazumi Kusumoto, Satoshi Ibara, Masato Kamitomo, Yuko Maruyama

J. Obstet. Gynaecol. Res. 32 ( 5 ) 461 - 467 2006年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Rubella outbreak on Tokunoshima Island in 2004 : Serological and epidemiological analysis of pregnant women with rubella

KANEKO Masatoki, SAMESHIMA Hiroshi, IKENOUE Tsuyomu, MINEMATSU Toshio, KUSUMOTO Kazumi, IBARA Satoshi, KAMITOMO Masato, MARUYAMA Yuko

The Journal of obstetrics and gynaecology research 32 ( 5 ) 461 - 467 2006年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Rubella outbreak on Tokunoshima Island in 2004: serological and epidemiological analysis of pregnant women with rubella.

Kaneko M, Sameshima H, Ikenoue T, Minematsu T, Kusumoto K, Ibara S, Kamitomo M, Maruyama Y

The journal of obstetrics and gynaecology research 32 ( 5 ) 461 - 7 2006年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/j.1447-0756.2006.00445.x

サイトメガロウイルス胎内感染の予後予測と周産期管理

丸山有子, 茨聡, 池ノ上克, 金子政時, 徳久琢也, 松井貴子, 向井基, 藤江由夏, 佐々木恒, 中澤祐介, 宇都宮剛, 大橋昌尚, 栄鶴義人, 峰松俊夫

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 42 ( 2 ) 2006年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

母児の臨床像および抗体検査からみた cytomegalovirus IgG avidity index の有用性に関する検討

金子政時, 鮫島浩, 池ノ上克, 楠元和美, 峰松俊夫

日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology 16 ( 1 ) "S - 23"-"S-24" 2006年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

母体の cytomegalovirus (CMV) IgG Avidity Index が低値を示した胎内CMV感染症の胎児・新生児経過

金子政時, 鮫島浩, 池ノ上克, 楠元和美, 峰松俊夫, 佐藤勇一郎

日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology 15 ( 2 ) 41 - 46 2006年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）

母体のcytomegalovirus (CMV) IgG avidity indexが低値を示した胎内CMV感染症の胎児・新生児経過査読あり

金子政時、鮫島浩、池ノ上克、楠元和美、峰松俊夫、佐藤勇一郎

日本産婦人科新生児血液学会誌 15 ( 2 ) 41 - 46 2006年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）

不妊治療による46,XY,t(12;13)(q24.3;q32)の父親からの3胎

園田徹、金子政時、鮫島浩、池ノ上克、河野慶一郎

九州保健福祉大学　研究紀要 ( 7 ) 169 - 172 2006年3月

記述言語：日本語掲載種別：研究論文（大学，研究機関等紀要）

在胎22-27週で出生した新生児の特発性消化管穿孔に関する周産期因子の検討

甲斐克秀, 池田智明, 山下理絵, 道方香織, 金子政時, 鮫島浩, 茨聡, 池ノ上克

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 41 ( 4 ) 816 - 820 2005年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

超早産症例の周産期管理

古川誠志, 鮫島浩, 道方香織, 稲森美香, 児玉由紀, 川越靖之, 金子政時, 池田智昭, 池ノ上克

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 41 2005年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

(1) 先天性風疹症候群の撲滅をめざして : 産科医療従事者の役割(ウイルスと周産期, 第46回日本母性衛生学会総会学術集会抄録集)

金子政時

母性衛生 46 ( 3 ) 2005年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本母性衛生学会

風疹抗体保有妊婦における妊娠中風疹再感染と抗体反応

金子政時, 古田賢, 鮫島浩, 池田智明, 池ノ上克, 楠元和美, 峰松俊夫

日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology 15 ( 1 ) "S - 79"-"S-80" 2005年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

在胎22-27週で出生した新生児の特発性消化管穿孔と周産期因子の検討

甲斐克秀, 山下理絵, 道方香織, 金子政時, 池田智明, 鮫島浩, 池ノ上克

日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 41 ( 2 ) 2005年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

3. 超低出生体重児における動脈管結紮術についての検討(第18回日本小児人工臓器研究会)

道方香織, 金子政時, 池田智明, 鮫島浩, 池ノ上克

日本小児外科学会雑誌 41 ( 6 ) 2005年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：特定非営利活動法人日本小児外科学会

DOI： 10.11164/jjsps.41.6_843_2

Intrapartum fetal heart rate monitoring in cases of cytomegalovirus infection.

Kaneko M, Sameshima H, Ikeda T, Ikenoue T, Minematsu T

American journal of obstetrics and gynecology 191 ( 4 ) 1257 - 62 2004年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.ajog.2004.03.015

胎内サイトメガロウイルス(CMV)感染症児におけるIgG抗体 Avidity Index の推移とその有用性

金子政時, 鮫島浩, 田中博明, 楠元和美, 池田智明, 池ノ上克, 峰松俊夫

日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology 14 ( 1 ) "S - 73"-"S-74" 2004年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Asphyxia 性脳障害の診断に関する臨床的および基礎的研究

池田智明, 池ノ上克, 鮫島浩, 金子政時, 川越靖之, 古川誠志, 米田由香里, 大西淳仁, ト部浩俊, 大里和広, 山下理絵, 田中博明, 福島和子, 村田雄二, QUILLIGAN Edward J., CHOI Ben H., PARK Soung-Day, 土井茂治, PARER Julian T., 児玉由紀, 寺尾公成, 西口俊裕, 河野慶一郎, 嶋本富博, 春山康久, 今村登志子, 桂木真司, 高崎泰, 三輪勝洋, 徳永修一, 山内憲之, 園田徹, 布井博幸

日本新生児学会雑誌 39 ( 4 ) 724 - 732 2003年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus 査読あり

Masatoki Kaneko, Susan White, J Homan, Bryan Richardson

Am. J. Obstet. Gynecol. 188 ( 4 ) 961 - 972 2003年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus 査読あり国際共著

Kaneko M., White S., Homan J., Richardson B.

American Journal of Obstetrics and Gynecology 188 ( 4 ) 961 - 972 2003年4月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Journal of Obstetrics and Gynecology

OBJECTIVE: The purpose of this study was to determine the change in cerebral blood flow and substrate metabolism in relation to electrocortical activity in the near-term ovine fetus with repeated umbilical cord occlusion of a severe degree. STUDY DESIGN: Eight near-term fetal sheep were studied through a 2-hour control period, a 6-hour experimental period with repeated cord occlusion of 4 minutes' duration every 90 minutes, and a 16-hour recovery period. Regional cerebral blood flow was measured with the microsphere technique before, during, and after the first cord occlusion; blood flow in the superior sagittal sinus, the cerebral perfusion pressure, and the electrocortical activity were monitored continuously. Brachiocephalic arterial and sagittal venous blood were sampled at selected time points for blood gas and pH, oxygen content, and glucose and lactate levels. RESULTS: Severe umbilical cord occlusion as studied resulted in profound hypoxemia with modest hypercapnia and acidemia, to a similar degree with each insult, but with a return to preocclusion values after occluder release. Glucose values also fell acutely with each cord occlusion by approximately 30% but showed an overall increase through the experimental period, from 0.80 to 1.44 mmol/L; lactate values showed an increase, from 1.21 to 6.10 mmol/L (both P < .01). Fetal electrocortical activity was disrupted markedly, with an abrupt flattening of the electrocortical amplitude by 1.5 minutes of each cord occlusion on average and with an overall increase in indeterminate state activity during the experimental and through the recovery periods. Cerebral blood flow increased approximately 2.5- and 2.8-fold, as measured at 2 and 3.5 minutes during the first cord occlusion (both P < .01) and with the regional flow increase greater in the subcortex and brainstem. Cerebral extraction of oxygen fell toward zero, as measured at 2 minutes during the second and fourth occlusions (P < .05) with oxygen uptake no longer measurable; glucose extraction was now increased approximately 2-fold (P < .05), which indicates that anaerobic metabolism of glucose must be the predominant source of energy at this time. Superior sagittal sinus blood flow also increased in all animals, approximately 1.4- and 1.6-fold at 2 and 3.5 minutes of the first cord occlusion, but much less than the corresponding increase in arterial inflow; the increase was in response to subsequent occlusions was further reduced. CONCLUSION: Severe umbilical cord occlusion in the near-term ovine fetus results in a rapid decrease in the availability of oxygen to the brain. The low Po 2 gradient from blood to tissue rate limits for oxygen consumption by 2 minutes of insult (despite the marked increase in blood flow) and signals the shift to anaerobic metabolism, the suppression in electrocortical activity, and the probable shutdown of other energy-using processes.

DOI： 10.1067/mob.2003.219

Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus. 査読あり

Kaneko M, White S, Homan J, Richardson B

American journal of obstetrics and gynecology 188 ( 4 ) 961 - 72 2003年4月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Effect of the free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), on hypoxia-ischemia-induced brain injury in neonatal rats.

Ikeda T, Xia YX, Kaneko M, Sameshima H, Ikenoue T

Neuroscience letters 329 ( 1 ) 33 - 6 2002年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）