論文 - 金子 政時
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Win K.D., Kawasue K., Kaneko M.
Sensors 25 ( 6 ) 2025年3月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Sensors
Highlights: What are the main findings? A non-contact method for measuring neonatal head circumference using a 3D imaging sensor was developed. What is the implication of the main finding? A top-view 3D imaging system can be used to estimate the head circumferences of neonates without direct contact, ensuring safety for their delicate skin. Because some portions of the head may be missing in the top-view images, these missing areas are estimated using mat information. The extracted features and head surface values contribute to the head circumference measurement. This approach enhances the feasibility of non-contact head circumference measurement, which could improve neonatal monitoring in clinical settings. In Japan, birth rates are declining, but there are a rising number of underweight newborns who require specialized care in neonatal intensive care units (NICUs). Head circumference is an important indicator of brain development for low-birth-weight infants. However, measuring head circumference requires extreme care because low-birth-weight infants have fragile skin. Therefore, a non-contact measurement system using a 3D imaging sensor was developed. Using this system, three-dimensional data for a newborn’s head can be obtained from outside the incubator. Briefly, the images are taken from above the incubator, so there is an area behind the head that cannot be captured by the camera, but the head circumference estimation takes into account the fact that the head is in contact with the mat. The proposed method allows head circumference estimation without touching the newborn. This approach minimizes stress for both the neonate and the nurse and improves efficiency and safety in the NICU.
DOI： 10.3390/s25061869
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The estimation of a cytomegalovirus immunoglobulin G avidity using the mathematical model 招待あり 査読あり
Masatoki Kaneko
Journal of Basic and Clinical Pharmacy 13 ( 127 ) 127 2022年3月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Kaneko M., Muraoka J., Kusumoto K., Minematsu T.
Viruses 13 ( 5 ) 2021年5月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Viruses
Human cytomegalovirus (CMV) is the leading cause of neurological sequelae in infants. Understanding the risk factors of primary CMV infection is crucial in establishing preventive strategies. Thus, we conducted a retrospective cohort study to identify risk factors of vertical transmission among pregnant women with immunoglobulin (Ig) M positivity. The study included 456 pregnant women with IgM positivity. Information on age, parity, occupation, clinical signs, IgM levels, and IgG avidity index (AI) was collected. The women were divided into infected and non-infected groups. The two groups showed significant differences in IgM level, IgG AI, number of women with low IgG AI, clinical signs, and number of pregnant women with single parity. In the multiple logistic regression analysis, pregnant women with single parity and low IgG AI were independent predictors. Among 40 women who tested negative for IgG antibody in their previous pregnancy, 20 showed low IgG AI in their current pregnancy. Among the 20 women, 4 had vertical transmission. These results provide better understanding of the risk factors of vertical transmission in pregnant women with IgM positivity.
DOI： 10.3390/v13050866
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Kaneko M., Ohhashi M., Fujii Y., Minematsu T., Kusumoto K.
International Journal of Infectious Diseases 100 1 - 6 2020年11月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：International Journal of Infectious Diseases
Objective: To establish a model to predict high cytomegalovirus (CMV) immunoglobulin (Ig)G avidity index (AI) using clinical information, to contribute to the mental health of CMV-IgM positive pregnant women. Methods: We studied 371 women with IgM positivity at ≤14 w of gestation. Information on the age, parity, occupation, clinical signs, IgM and G values, and IgG AI was collected. The IgG AI cut-off value for diagnosing congenital infection was calculated based on a receiver operating characteristic curve analysis. Between-group differences were assessed using the Mann–Whitney U-test or χ2 analysis. The factors predicting a high IgG AI were determined using multiple logistic regression. Results: The women were divided into high or low IgG AI groups based on an IgG AI cut-off value of 31.75. There were significant differences in the IgG and IgM levels, age, clinical signs, and the number of women with one parity between the two groups. In a multiple logistic regression analysis, IgM and the number of women with one parity were independent predictors. This result helped us establish a mathematical model that correctly classified the IgG AI level for 84.6% of women. Conclusion: We established a highly effective model for predicting a high IgG AI immediately after demonstrating IgM positivity.
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Intrapartum fetal heart rate monitoring in cases of cytomegalovirus infection 査読あり
金子 政時,鮫島 浩,池田 智明,池ノ上 克,峰松 俊夫
Am. J. Obstet. Gynecol. 191 1257 - 1262 2014年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Effectiveness of maternal respiratory syncytial virus vaccination in conferring infant immunity: review and future perspectives 査読あり
Masatoki Kaneko, Junsuke Muraoka
vaccines 14 2026年2月
担当区分：筆頭著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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A総合周産期母子医療センターにおける分娩誘発時の胎児心拍数の連続記録に影響を与える因子に関する後方視的検討 査読あり
山下彩花、谷口光代、金子政時
母性衛生 66 ( 4 ) 496 - 503 2026年1月
担当区分：責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌）
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子育て中の母親が子供を3人以上もつことに影響を与える要因の解明 査読あり
押川美月、谷口光代、ポッター美歩、金子政時
母性衛生 66 ( 4 ) 513 - 521 2026年1月
担当区分：責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌）
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新型コロナウイルス流行第７、8波における感染妊婦の特徴とワクチン接種の影響 ー宮崎市のコホート研究－ 査読あり
村岡純輔、金子政時、武本莉子、児玉由紀
日本産婦人科感染症学会誌 10 7 - 12 2026年1月
担当区分：責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Doi K., Kodama Y., Matsuzawa S., Goto T., Muraoka J., Fujisaki M., Yamada N., Taniguchi H., Furuta K., Kawagoe Y., Kaneko M., Katsuragi S., Ikenoue T., Sameshima H.
Early Human Development 216 106495 2026年1月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Early Human Development
Objective: The ultimate goal of perinatal care is to ensure that infants survive without neurological impairment. Despite advances in medical technology and healthcare systems that have markedly decreased perinatal mortality, cerebral palsy has shown only a gradual decline in recent population-based studies. The aim of this study was to use a pathway classification system to analyze brain injury cases detected at or beyond 35 weeks' gestation and to clarify temporal changes in the incidence and causal pathways of intrapartum brain injury and its contributing factors in Miyazaki Prefecture, Japan. Methods: Of 151,558 births recorded in Miyazaki Prefecture from 2001 to 2015, 303 cases of brain injury were registered in the regional perinatal case-review system. Of these, 134 were detected at ≥35 weeks. Brain injury was categorized as congenital anomalies, antepartum, intrapartum, or neonatal onset. Each case was further classified using a pathway system that considered distal and proximal risk factors. Temporal trend analysis was performed across three consecutive 5-year intervals (2001–2005, 2006–2010, and 2011–2015). Results: Of the 134 cases, 25% were classified as intrapartum-related, 23% as antepartum-related, and 5% as neonatal-related. Overall, the incidence of brain injury at ≥35 weeks decreased significantly over time. Significant downward trends were observed in total cases and intrapartum-related brain injury, with the reduction in intrapartum cases being especially pronounced. Antepartum-related brain injury declined more gradually. Further analysis revealed that the incidence of hypoxia-related intrapartum brain injuries decreased over time, whereas bacterial infection-related intrapartum cases were observed only in the earliest epoch. Conclusions: This population-based study identified temporal changes in perinatal brain injury detected at or beyond 35 weeks' gestation over 15 years. The incidence of perinatal brain injury declined significantly, particularly intrapartum-related cases with hypoxia-related injury. These improvements might reflect advances in regionalized perinatal care, the establishment of perinatal centers, or multidisciplinary education and training. Further efforts to optimize intrapartum assessment and management would contribute to continued reductions in severe perinatal brain injury.
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特集 周産期感染症2026 産科からみた周産期感染症 50.妊婦および挙児希望女性が海外渡航する場合の感染への留意点 招待あり
金子 政時, 谷口 光代, 髙間 有紀
周産期医学 55 ( 13 ) 220 - 223 2025年12月
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週末および夕方に実施された子宮頸がん集団検診が受診者の年齢層や新規受診者数に与えた効果 査読あり
富来 由華, 谷口 光代, 吉永 砂織, 金子 政時
日本健康医学会雑誌 34 ( 3 ) 402 - 407 2025年10月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本健康医学会
宮崎県の自治体で実施された子宮頸がん集団バス検診受診者の年齢層および自治体の取り組みの効果を明らかにすることを目的とした。2市6町8944名（2022年度4395名，2023年度4549名）の受診者を対象とした。実施回数は160回（2022年度84回，2023年度76回）であった。新規受診者は394名（2022年度89名，2023年度305名），年齢の中央値は，全受診者60歳，新規受診者23歳であった。キャンパス検診を取り入れた自治体において新規受診者の増加と年齢の有意な低下がみられた。5自治体が週末検診を実施（2022年度11回，2023年度13回）していた。5自治体全体では平日検診と週末検診間で新規受診者数に違いはなかった。しかし，週末検診（3回の夕方検診を含む）を14回（全体22回）実施した自治体の新規受診者数は平日検診と比較して有意に多く，有意差はないが年齢も若い傾向にあった。また，同自治体の1検診あたりの受診者数は，週末検診119.7人，平日検診68.6人であった。受診者の年齢層の分布は，子宮頸がん罹患年齢層の分布よりも高かった。宮崎県全体で若い年齢層の受診者を増やすための事業が必要である。週末検診の積極的な導入は，新規受診者の増加と受診者年齢の低下に繋がる可能性がある。
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Kataoka S., Kaneko M., Yang L., Ota H., Seki M., Kobamatsu A., Nakayama D., Furuta Y., Tanuma F., Fukushi Y., Wada S., Haseyama K., Yamada H.
Microorganisms 13 ( 9 ) 2025年9月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Microorganisms
Congenital cytomegalovirus infection (cCMV) is one of the most common congenital infections. This study aimed to evaluate the diagnostic performance of targeted screening with the use of clinical risk factors for cCMV. A total of 3063 pregnant women and their 3139 newborns were enrolled. Six clinical findings consisting of maternal fever or flu-like symptoms during pregnancy (fever/flu-like symptoms), hospitalization for threatened miscarriage or preterm labor before 34 weeks of gestation, preterm delivery before 34 weeks of gestation, fetal ultrasound abnormalities, small for gestational age (SGA), and refer results of automated auditory brainstem response screening (AABR refer) were defined as cCMV risk factors before participant registration. All newborns underwent urine cytomegalovirus polymerase chain reaction tests within one week of birth. The predictive accuracy of these six risk factors was analyzed. Nine (0.29%) of the three thousand one hundred and thirty-nine newborns were diagnosed with cCMV, having at least one of the six risk factors. Logistic regression analysis identified fever/flu-like symptoms (odds ratio (OR), 7.5; 95% CI, 1.9–30.3), fetal ultrasound abnormalities (OR, 17.9; 95% CI, 4.4–72.8), SGA (OR, 6.8; 95% CI, 1.8–25.6), and AABR refer (OR, 75.5; 95% CI, 19.7–289) as significant risk factors. The predictive accuracy of the targeted screening for cCMV, when at least one of the six risk factors was present, yielded 100% sensitivity (95% CI, 55.5–100) and 70.7% specificity (95% CI, 69.1–72.3), with a Youden index of 0.707. When at least one of the four significant risk factors was present, 100% sensitivity (95% CI, 55.5–100) and 81.2% specificity (95% CI, 79.8–82.6) with the maximum Youden index of 0.812 were achieved. In conclusion, targeted screening with the use of clinical risk factors in mothers and their newborns could effectively identify cCMV.
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先天性サイトメガロウイルス感染症に対する新生児マススクリーニングの重要性： 無症候性で、聴覚スクリーニング検査をパスした胎内感染症の１例 査読あり
金子政時、児玉由紀
日本産婦人科・新生児血液学会誌 34 ( 2 ) 131 - 136 2025年3月
担当区分：筆頭著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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COVID-19蔓延状況下でのDomestic violenceが妊婦の健康関連Quality of lifeに与える影響 査読あり
津歩香、金子政時、鶴田来美、山﨑圭子、田邉綾子、吉永砂織、谷口光代、藤井良宜
日本健康医学会雑誌 33 ( 2 ) 200 - 207 2024年7月
担当区分：責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Impact of COVID-19 on Cytomegalovirus Immunoglobulin M Antibody Index 査読あり
Kaneko M., Muraoka J., Yang L., Tokunaga S., Minematsu T.
Clinical and Experimental Obstetrics and Gynecology 50 ( 12 ) 2023年12月
担当区分：筆頭著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Clinical and Experimental Obstetrics and Gynecology
Background: Coronavirus disease 2019 (COVID-19) influenced the prevalence of other infectious diseases, including congenital cytomegalovirus (CMV) infection. However, the effect of COVID-19 on antibody titers has not been reported. This study aimed to explore the influence of COVID-19 on levels of CMV immunoglobulin M (IgM) in pregnant women. Methods: This cross-sectional study included pregnant women who visited the University Hospital due to CMV IgM positivity during the 7th and 8th waves of COVID-19. Data, including maternal characteristics, history of COVID-19, CMV immunoglobulin G (IgG) and IgM index, and IgG avidity index (AI) were collected. Chemiluminescent immunoassay was performed to measure levels of IgG and IgM. Polymerase chain reaction using neonatal urine was performed to confirm congenital infection. Results: Of the 89 pregnant women, 36 (40%) (low IgG AI: n = 10; high IgG AI: n = 26) contracted COVID-19. Among 21 women with low IgG AI, 9 (false IgM positive: n = 8; primary infection: n = 1) had an IgG AI of 0. Among the eight women with false IgM positivity, six (75%) contracted COVID-19. The IgM index of pregnant women with false IgM positivity was 12.6 ± 10.9. Meanwhile, the CMV IgM index of pregnant women with false IgM positivity in the non-COVID-19-infected group was 1.7 ± 0.5. When the IgM indices of women who contracted (n = 36) and did not contract (n = 53) COVID-19 were compared, the IgM index of infected women (4.4 ± 5.7) was higher than those of non-infected women (2.7 ± 3.0) (p = 0.01). Regarding IgM and IgG AI, multiple logistic regression analysis revealed that there were no significantly different variables between the two groups. Conclusions: High prevalence of false IgM positivity was observed among women who contracted COVID-19. The IgM index of pregnant women with false IgM positivity was high. Caution should be exercised in interpreting CMV IgM indices in pregnant women with a history of COVID-19.
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特集 数値からみる周産期医療 産科編 先天性感染症 査読あり
金子 政時
周産期医学 53 ( 8 ) 1214 - 1216 2023年8月
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Yamada N., Kaneko M., Yang L., Matsuzawa S., Minematsu T., Kodama Y.
Journal of Infection and Chemotherapy 29 1071 - 1074 2023年7月
担当区分：責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Infection and Chemotherapy
Human cytomegalovirus (HCMV) is the major cause of neurological sequelae in infants. Immune control of primary HCMV infection appears to depend on the interaction between humoral and cell-mediated immune responses. We report the case of an HCMV-transmitter mother observed with dissociation between humoral and cell-mediated immune responses. The patient had immunoglobulin (Ig) G and M positivity at 11 weeks of gestation and showed fetal hyperechoic bowel and minimal ascites at 21 weeks of gestation. At 25 weeks of gestation, the polymerase chain reaction result for HCMV using amniotic fluid was positive. The numbers of spots in the enzyme-linked immunosorbent spot (ELISPOT) assay at 25, 36, and 39 weeks of gestation were three, five, and six spots/2 × 105 peripheral blood mononuclear cells, respectively. Furthermore, IgG avidity indexes (AIs) at 21, 25, 36, and 39 weeks of gestation were 37.6, 49.7, 72.5, and 74.3, respectively. At 40+1 weeks of gestation, the patient delivered a symptomatic infected newborn with a weight of 2,384 g (−2.6 SD) and a head circumference of 30 cm (−2.6 SD). The neonate had a petechial rash and bilateral hearing loss although did not show liver dysfunction or thrombocytopenia. Cranial magnetic resonance imaging revealed mild ventriculomegaly, left lateral/parietal polymicrogyria, and a punctate white matter lesion. This case showed that IgG AI increased with increasing gestational age, whereas the numbers of spots in the ELISPOT assay had no change. The dissociation between humoral and cell-mediated immune responses may be characteristic of the immune response of a transmitter mother.
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子育て中の労働者がワーク・ライフ・バランスを実現するための職場環境に関する検討 -宮崎市の若年労働者への質問紙調査から- 査読あり
田邉 綾子, 久留 葵, 山本 明佳, 末次典恵, 金子 政時
南九州看護研究誌 21 ( 1 ) 1 - 8 2023年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：宮崎大学医学部看護学科
【目的】子育て中の労働者がワーク・ライフ・バランスを実現するために必要な職場環境を明らかにすることを目的とした。
【方法】宮崎市に居住もしくは勤務する20～40歳の労働者に、基本的属性、ワーク・ライフ・バランスの認識、職場環境、仕事と家庭の役割間の影響について無記名の調査を実施した。
【結果】365名より回答が得られた。子供がいる人は、いない人と比較し、家庭から仕事へのポジティブな影響があった。また、子供のいる140名に焦点をあて分析した結果、約7割がワーク・ライフ・バランスがとれていると認識していた。ワーク・ライフ・バランスがとれていると回答した人の職場環境とは、男性では円滑に業務遂行できる環境であり、女性ではキャリア形成を目指せる環境であった。
【考察】育児支援に取り組むことは企業にとって、労働者が仕事のやりがいや責任を果たす上で有益であることが示唆された。子育て中の労働者のワーク・ライフ・バランスがとれる職場環境は、性別により異なることを踏まえた上で、仕事と育児を両立しやすい職場環境づくりに取り組む必要がある: