論文 - 金子 政時
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Michikata K., Sameshima H., Sumiyoshi K., Kodama Y., Kaneko M., Ikenoue T.
Early Human Development 86 ( 7 ) 401 - 405 2010年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Early Human Development
Background: Due to circulatory instability, premature infants require volume loads, catecholamines and steroid supplementation to improve mortality and neurodevelopmental outcome. However, a complete quantitative analysis concerning the relationship between supplementation and gestational age, especially in infants born at 22 to 24 weeks of gestation, is lacking. Aim: To investigate whether less mature infants need higher doses of catecholamine, volume loads and steroid, and whether those who require higher doses have poorer outcome. Study design: A retrospective, observational study was performed at a tertiary center in a university setting. Among the consecutive 221 premature infants born at 22 to 28 weeks of gestation, we selected 108 infants who had no apparent pathological conditions other than prematurity. Catecholamines, volume loads and steroid, given to attain sufficient blood pressure and urinary output, were quantitatively analyzed during the first 24 hours. Outcome measures: Quantity of catecholamines, volume expanders and steroid supplementation as a function of gestational age and childhood outcome at 2 years. Results: Catecholamines and volume loads were increased in a step-wise manner with decreasing gestational age. Intact survival rate was significantly lower in infants born before 25 weeks of gestation compared with the more mature infants. Among infants born at 22 to 24 weeks' gestation, catecholamine and volume load increased significantly in poor outcome infants compared with good outcome infants. Conclusions: From a developmental viewpoint, progressively larger doses of catecholamine, volume expanders and corticosteroid are required to stabilize circulatory adaptation to neonatal life in infants between 22 to 28 weeks of gestation. © 2010 Elsevier Ltd.
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P001.胃穿孔を起こした超低出生体重児の1例(一般演題,第47回日本小児外科学会九州地方会)
町頭 成郎, 千々岩 一男, 近藤 千博, 池ノ上 克, 鮫島 浩, 金子 政時
日本小児外科学会雑誌 46 ( 6 ) 2010年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：特定非営利活動法人 日本小児外科学会
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町頭 成郎, 松藤 凡, 加治 建, 向井 基, 堂地 勉, 桑波田 知樹, 川俣 和弥, 池ノ上 克, 鮫島 浩, 金子 政時
日本小児外科学会雑誌 46 ( 3 ) 2010年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：特定非営利活動法人 日本小児外科学会
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金子 政時
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 45 ( 4 ) 994 - 997 2009年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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産婦人科医小児科医が連携した医師養成プログラム
金子政時
日本周産期・新生児医学会雑誌 45 ( 4 ) 994 - 997 2009年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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CMV胎内感染治療の展望 : 予後からみた今後の治療のありかた
丸山 有子, 茨 聡, 金子 政時, 児玉 由紀, 丸山 英樹, 徳久 琢也, 松井 貴子, 藤江 由夏, 中澤 祐介, 上塘 正人, 前田 隆嗣, 鮫島 浩, 池ノ上 克, 栄鶴 義人, 峰松 俊夫, 土井 宏太郎, 加藤 明彦, 寺原 賢人
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 45 ( 1 ) 5 - 9 2009年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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胎内サイトメガロウイルス感染症における抗原血症の臨床上の有用性
金子 政時, SAMESHIMA Hiroshi, IKENOUE Tsuyomu, KUSUMOTO Kazumi, MINEMATSU Toshio
Pediatrics international : official journal of the Japan Pediatric Society 51 ( 1 ) 1 - 4 2009年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Clinical importance of cytomegalovirus antigenemia for intrauterine cytomegalovirus infection. （共著） 査読あり
Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Kazumi Kusumoto, Toshio Minematsu.
Pediatrics International 51 1 - 4 2009年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Clinical importance of cytomegalovirus antigenemia for intrauterine cytomegalovirus infection
Kaneko M., Sameshima H., Ikenoue T., Kusumoto K., Minematsu T.
Pediatrics International 51 ( 1 ) 1 - 4 2009年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Pediatrics International
Background: Little is known about the clinical importance of cytomegalovirus (CMV) antigenemia for intrauterine-CMV-infected newborns. The aims of the present study were to evaluate the diagnostic accuracy of CMV antigenemia during the neonatal period and its association with clinical manifestations. Methods: CMV antigenemia was analyzed using neonatal blood from 25 patients suspected of having intrauterine infection because of abnormal clinical manifestations in the mother, fetus, and newborn. Neonatal urine samples were collected for diagnosis of intrauterine infection. The diagnostic accuracy of the antigenemia analysis was evaluated by comparing it with the results of urinary CMV analyses. The clinical manifestations of antigenemia-positive and -negative infected newborns were compared in the infected newborns. Results: Fifteen newborns were congenitally infected and 10 were uninfected as diagnosed on virus isolation from neonatal urine. Six of 15 infected newborns were positive for CMV antigenemia. CMV antigenemia had a positive predictive value of 100%, a negative predictive value of 52.6%, a sensitivity of 40%, and a specificity of 100%. CMV retinitis and pneumonitis were more prevalent among antigenemia-positive newborns (4/6) than antigenemia-negative newborns (0/9; P < 0.05). Conclusions: Antigenemia was significantly associated with retinitis and pneumonia, but it was not sensitive enough to diagnose intrauterine CMV infection. © 2008 Japan Pediatric Society.
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金子 政時
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44 ( 4 ) 894 - 897 2008年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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(2)産婦人科医・小児科医が連携した医師養成のための卒前・卒後教育(<特集>第60回学術講演会シンポジウム4「産婦人科医不足の解消を目指して」)
金子 政時, Masatoki KANEKO, 宮崎大学医学部医学教育改革推進センター 産婦人科, Department of Obstetrics and Gynecology Center for Medical Education Faculty of Medicine University of Miyazaki
日本産科婦人科學會雜誌 = Acta obstetrica et gynaecologica Japonica 60 ( 12 ) 1945 - 1952 2008年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
A substantive medical education system is very important for training young and talented doctors in order to avoid shortage of specialists in the field of obstetrics and gynecology. Before the establishment of a substantive medical education system in Miyazaki prefecture, the prefecture had the highest perinatal mortality rate in Japan. In order to overcome this situation, we began to educate the young and talented doctors who specialized in obstetrics and gynecology. As a result of this program, the number of doctors graduating with specialization in obstetrics and gynecology in Miyazaki prefecture increased exceptionally and exceeded the national average. Moreover, the improvement of the perinatal health care system was in parallel with the training of young and talented doctors, which resulted in more improved perinatal mortality index. Furthermore, the promotion of substantive medical education and advanced clinical research program led to improved and matured talented doctors. However at present, the number of specialist doctors graduating in the field of obstetrics and gynecology in Miyazaki prefecture has not seen any further increase in the past several years. In order to maintain the highest standard and an efficient level of the established perinatal health care system in Miyazaki prefecture, it is indispensable to educate young and talented doctors. Our aim is therefore to recruit young and talented doctors through the program entitled "A substantive medical education system for students and doctors in collaboration with obstetricians and gynecologist, and pediatricians".
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Sameshima H., Kodama Y., Kaneko M., Ikenoue T.
Japanese Journal of Infectious Diseases 61 ( 5 ) 400 - 401 2008年11月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Infectious Diseases
In a population-based study we investigated the early-onset, invasive sepsis caused by group B streptococcus (GBS) and non-GBS in the era of intrapartum antimicrobial prophylaxis. From 1998 to 2006, we had 387 perinatal deaths in 98,495 deliveries, and 9 full-term infants met the criteria of early-onset, invasive sepsis, in which microorganisms were proven from blood sampling. Of these cases, 4 involved GBS, 2 amipicillin-resistant Escherichia coli, 2 methicillin-resistant Staphylococcus aureus, and 1 was unidentified. All 4 cases of GBS related death underwent improper procedures contrary to the prophylaxis recommendation. Eighty percent of non-GBS related deaths had septicemia of antibiotic-resistant pathogens. We found in our population-based study that early-onset fatal sepsis in full-term infants is associated with insufficient adherence to the prophylaxis strategy for GBS and with the emergence of antimicrobial resistant non-GBS bacteria.
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New technique for enterostomy of extremely low-birth-weight infants - intestinal anchoring with gaze. "jointly worked" 査読あり
Kondo K, Chijiiwa K, Mukai M, Iwamura T, Matsuda H, Kaneko M, Kodama Y, Sameshima H, Ikenoue T.
Journal of Pediatric Surgery 43 ( 9 ) 1755 - 1760 2008年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Deaths of early-onset, invasive sepsis in full-term infants in Miyazaki: nine cases from a regional population-based analysis from 1998-2006.
Sameshima H, Kodama Y, Kaneko M, Ikenoue T, Miyazaki Perinatal Data Group.
Japanese journal of infectious diseases 61 ( 5 ) 400 - 1 2008年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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New technique for enterostomy of extremely low-birth-weight infants-intestinal anchoring with gauze
Kondo K., Chijiiwa K., Mukai M., Iwamura T., Matsuda H., Kaneko M., Kodama Y., Sameshima H., Ikenoue T.
Journal of Pediatric Surgery 43 ( 9 ) 1755 - 1760 2008年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Pediatric Surgery
Background: In enterostomy for extremely low-birth-weight infants ( < 1000 g), the technique of anchoring the intestine for a stoma to the abdominal wall is very difficult because of the small size and fragile nature of the intestine. Here we describe a novel technique for intestinal anchoring in such infants. Methods: In our approach to enterostomy, the intestine is anchored only by a strip of gauze packed into the subcutaneous space. No suturing is performed. The efficacy of this technique was evaluated in 21 infants with less than 1000 g of body weight who have intestinal perforation or obstruction. Results: Two patients (9.5%) had complications that were related to the enterostomy. The complications were parastomal and intrastomal intestinal prolapse, both of which were treated successfully by reoperation. Eighteen patients (86%) survived to closure of the enterostoma. Conclusions: Intestinal anchoring with gauze is an easy and effective technique for enterostomy in extremely low-birth-weight infants and can be applied in selected cases. © 2008 Elsevier Inc. All rights reserved.
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Deaths of early-onset, invasive sepsis in full-term infants in Miyazaki: nine cases from a regional population-based analysis from 1998-2006. "jointly worked" 査読あり
Samashima H, Kodama Y, Kaneko M, Ikenoue T
Jpn J Infect Dis 61 ( 5 ) 400 - 401 2008年7月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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丸山 有子, 茨 聡, 丸山 英樹, 徳久 琢也, 松井 貴子, 藤江 由夏, 中澤 祐介, 金子 政時, 児玉 由紀, 上塘 正人, 前田 隆嗣, 栄鶴 義人, 峰松 俊夫, 鮫島 浩, 池ノ上 克
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44 ( 2 ) 271 - 272 2008年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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金子 政時
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 44 ( 2 ) 2008年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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(2) 産婦人科医小児科医が連携した医師養成のための卒前・卒後教育(産婦人科医不足の解消を目指して,シンポジウム4,第60回日本産科婦人科学会学術講演会)
金子 政時, 宮崎大学
日本産科婦人科學會雜誌 = Acta obstetrica et gynaecologica Japonica 60 ( 2 ) 455 - 456 2008年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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MD-Twin Score による一絨毛膜二羊膜性双胎児の胎児評価
金子 政時, 鮫島 浩, 児玉 由紀, 山下 理恵, 池ノ上 克
日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 43 ( 4 ) 987 - 990 2007年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌）