論文 - 上野 浩晶
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Ueno H., Nakazato M.
Nippon rinsho. Japanese journal of clinical medicine 64 Suppl 9 292 - 296 2006年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Nippon rinsho. Japanese journal of clinical medicine
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Osawa H., Kita H., Ohnishi H., Nakazato M., Date Y., Bowlus C., Ishino Y., Watanabe E., Shiiya T., Ueno H., Hoshino H., Satoh K., Sugano K.
Journal of Gastroenterology 41 ( 10 ) 954 - 961 2006年10月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Gastroenterology
Background: Ghrelin is a body weight-regulating peptide produced and secreted primarily by the gastric mucosa. Helicobacter pylori infection impairs gastric ghrelin production, leading to a lower plasma ghrelin concentration. However, the effect of H. pylori eradication on plasma ghrelin levels and its relation to body weight change after H. pylori cure are still uncertain. We examined the association of plasma ghrelin levels with gastric ghrelin production and body weight change before and after H. pylori eradication. Methods: Plasma ghrelin concentrations, gastric ghrelin expression, and body weight were determined in a total of 134 consecutive individuals before and 12 weeks after successful H. pylori eradication. Gastric ghrelin expression was evaluated by determining mRNA expression levels and the number of ghrelin-producing cells in gastric mucosa biopsy specimens by real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry, respectively. Results: Plasma ghrelin concentration increased in 50 patients and decreased in 84 patients after H. pylori eradication. After H. pylori cure, however, gastric preproghrelin mRNA expression was increased nearly fourfold (P < 0.0001), and the number of ghrelin-positive cells was increased or unchanged. In contrast, plasma ghrelin changes after H. pylori cure were inversely correlated with both body weight change (P < 0.0001) and initial plasma ghrelin levels (P < 0.0001). Conclusions: Changes in plasma ghrelin concentrations before and after H. pylori cure were inversely correlated with body weight change and initial plasma ghrelin levels but not with gastric ghrelin production in Japanese patients. © Springer-Verlag Tokyo 2006.
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視床下部に形態異常を有さない視床下部性性腺機能低下症男性7例の臨床像
米川 忠人, 山口 秀樹, 上野 浩晶, 中里 雅光, 年森 啓隆, 長田 幸夫, 松倉 茂, 片上 秀喜
ホルモンと臨牀 54 6 - 9 2006年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Tanaka M., Tanaka M., Nakahara T., Muranaga T., Kojima S., Yasuhara D., Ueno H., Nakazato M., Inui A., Inui A.
Hormones and Behavior 50 ( 2 ) 261 - 265 2006年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Hormones and Behavior
Patients with bulimia nervosa (BN) have bulimic and depressive symptoms, which have been associated with abnormalities in the neuroendocrine and vagal systems. Subjects included twenty-four female drug-free outpatients with BN that were selected from patients seeking treatment for eating behavior in our hospital along with twenty-five age-matched healthy females who served as controls. We investigated ghrelin and leptin levels, cardiac vagal tone and sympathovagal balance, frequency of sets of binge-eating and vomiting episodes per week and the Profile of Mood States (POMS) depression scale in BN before and after a 16-week administration of the serotonin selective reuptake inhibitor (SSRI) paroxetine combined with cognitive-behavioral therapy. Compared to controls, the BN group had higher ghrelin levels and resting cardiac vagal tone, and lower leptin levels and resting cardiac sympathovagal balance before treatment, although there was a significant difference between the two groups for the body mass index (BMI). The elevated ghrelin levels (301.7 ± 18.9 pmol/l, mean ± SEM vs. 202.8 ± 15.6 pmol/l, P < 0.01), cardiac vagal tone (2246.4 ± 335.5 ms2 vs. 1128.5 ± 193.3 ms2, P < 0.01), frequency of sets of binge-eating and purging episodes and T scores for the POMS depression scale were all significantly decreased after treatment despite similar BMI, percent body fat and leptin levels. In close association with cardiac vagal function and ghrelin recoveries, abnormal eating behavior and depressive symptoms improved, indicating the usefulness of these indexes in the assessment of clinical condition and therapeutic efficacy in BN. © 2006 Elsevier Inc. All rights reserved.
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脳炎症状の改善とともに急激な内因性インスリン分泌改善が認められ, 1型か, 2型かの判断が困難であった糖尿病の1例
宮内 俊一, 京楽 格, 野間 健之, 上野 浩晶, 塩見 一剛, 水田 雅也, 中里 雅光
糖尿病 = Journal of the Japan Diabetes Society 49 ( 6 ) 435 - 439 2006年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：THE JAPAN DIABETES SOCIETY
症例は63歳男性．これまで糖尿病を指摘されたことはなかったが，2004年5月中旬より異常行動がみられるようになり近医に入院．随時血糖317 mg/d<i>l</i>, HbA<sub>1C</sub> 13.5%. 入院後にけいれん発作が出現するようになり脳炎を疑われて，5月21日当科を紹介され入院した．入院直後の随時血糖は300 mg/d<i>l</i>以上，尿中C-ペプチドは5.1～21.9 μg/日，抗GAD抗体1.7 U/m<i>l</i>を示し，インスリン治療を開始した．ウイルス性脳炎と診断し，抗ウイルス薬，γ-グロブリン投与およびステロイドパルス療法を行った．その後中枢神経症状の改善とともにインスリン必要量が減少し，6月24日には完全にインスリンを離脱し，尿中C-ペプチドは233～262 μg/日と著明な改善がみられた．退院時には抗GAD抗体は0.3 U/m<i>l</i>未満まで低下した．短期間に著明な内因性インスリン分泌の改善が得られた興味深い症例であり，文献的考察を加えた．
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上野 浩晶, 中里 雅光
日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 127 ( 2 ) 73 - 76 2006年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本薬理学会
近年，肥満者の増加と，肥満を基礎にして発症する糖尿病，脂質代謝異常，高血圧症などの肥満症やメタボリックシンドロームを呈する患者数が増加している．しかし，その根底にある肥満の治療法は不十分なままである．最近，NPYやそのファミリー（PP，PYY）を含めてさまざまな摂食調節物質の同定や機能解析が進んでいる．NPYは中枢神経系に存在しており，強力な摂食亢進作用を有している．NPYニューロンを活性化する入力系としてグレリンやオレキシン，抑制する入力系としてレプチンやインスリンがある．入力系の中でも胃から分泌される摂食亢進ペプチドであるグレリンは迷走神経や神経線維を介してNPYニューロンにシグナルを伝達してその作用を発揮している．PPは主に膵臓に発現しており，摂食抑制作用を有する．PYYは十二指腸から結腸までの腸管で産生され，摂食抑制作用を有する．PYYは迷走神経を介して中枢の摂食抑制系ペプチドであるPOMCニューロンを活性化してその作用を発揮している．これら摂食調節ペプチドの機能解析が進んで，ペプチドそのものや受容体のアゴニスト，アンタゴニストといった新規の抗肥満薬の開発や実用化が期待される．<br>
DOI： 10.1254/fpj.127.73
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[Appetite regulation by NPY and its related neuropeptides].
Ueno H, Nakazato M
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 127 ( 2 ) 73 - 6 2006年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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長池 涼子, 水田 雅也, 上野 浩晶, 斎藤 幸枝, 澤田 浩武, 長嶺 元久, 中里 雅光
糖尿病 = Journal of the Japan Diabetes Society 48 ( 12 ) 859 - 861 2005年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本糖尿病学会
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Plasma leptin and ghrelin concentrations in patients with Crohn's disease
Nishi Y., Isomoto H., Isomoto H., Isomoto H., Ueno H., Ohnita K., Wen C., Takeshima F., Mishima R., Nakazato M., Kohno S., Kohno S.
World Journal of Gastroenterology 11 ( 46 ) 7314 - 7317 2005年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：World Journal of Gastroenterology
Aim: To determine the concentrations of leptin and ghrelin, which have opposite effects on appetite, energy expenditure, and weight control, in the plasma of patients with Crohn's disease (CD), which is often associated with weight loss and malnutrition. Methods: Plasma leptin and ghrelin concentrations were determined in 28 outpatients with CD by radioimmunoassay. Age- and sex-matched controls with and without Helicobacter pylori (H pylori) infection (28 for each) were enrolled in the study. Circulating levels of these hormones were assessed with respect to CD activity, disease localization and medical treatment. Results: There were no significant differences in ghrelin levels between CD patients and H pylori-negative controls. However, circulating ghrelin levels were significantly lower in H pylori-infected subjects than in CD patients and uninfected controls. Plasma leptin levels were comparable among the groups. Localization and medication profile had no significant impact on circulating ghrelin and leptin levels. Conclusion: Apart from H pylori infection, CD itself has no significant influence on circulating ghrelin and leptin levels in the outpatients who were mostly in inactive state. © 2005 The WJG Press and Elsevier Inc. All rights reserved.
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Impact of Helicobacter pylori infection on gastric and plasma ghrelin dynamics in humans 査読あり
Isomoto H, Ueno H, Saenko VA, Mondal MS, Nishi Y, Kawano N, Ohnita K, Mizuta Y, Ohtsuru A, Yamashita S, Nakazato M, Kohno S
Am J Gastroenterol 100 1711 - 1720 2005年11月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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The relationship between plasma and gastric ghrelin levels and strain diversity in helicobacter pylori virulence 査読あり
Isomoto H, Nishi Y, Ohnita K, Mizuta Y, Kohno S, Ueno H, Nakazato M
Am J Gastroenterol 100 1425 - 1427 2005年11月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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ターナー症候群に合併した緩徐進行型１型糖尿病の２症例 査読あり
長池涼子, 水田雅也, 上野浩晶, 齋藤幸枝, 澤田浩武, 長嶺元久, 中里雅光
糖尿病 48 859 - 861 2005年11月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Plasma leptin and ghrelin concentrations in patients with Crohn's disease. 査読あり
Nishi Y, Isomoto H, Ueno H, Ohnita K, Wen CY, Takeshima F, Mishima R, Nakazato M, Kohno S.
World J Gastroenterol. 11 7314 - 7317 2005年11月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Circulating ghrelin levels in patients with various upper gastrointestinal diseases 査読あり
Isomoto H, Ueno H, Nishi Y, Yasutake T, Tanaka K, Kawano N, Ohnita K, Mizuta Y, Inoue K, Nakazato M, Kohno S
Dig Dis Sci 50 833 - 838 2005年10月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Altered ghrelin and peptide YY responses to meals in bulimia nervosa 査読あり
Kojima S, Nakahara T, Nagai N, Muranaga T, Tanaka M, Yasuhara D, Masuda A, Date Y, Ueno H, Nakazato M, Naruo T
Clin Endocrinol 62 74 - 78 2005年8月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Circulating ghrelin levels in patients with various upper gastrointestinal diseases
Isomoto H., Isomoto H., Ueno H., Nishi Y., Yasutake T., Tanaka K., Kawano N., Ohnita K., Mizuta Y., Inoue K., Nakazato M., Kohno S.
Digestive Diseases and Sciences 50 ( 5 ) 833 - 838 2005年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Digestive Diseases and Sciences
The stomach is the main source of circulating ghrelin. Plasma concentrations of this hormone in patients with various upper gastrointestinal diseases remain undetermined. Thus we measured plasma ghrelin levels by radioimmunoassay in 225 subjects, including 134 Helicobacter pylori-infected and 91 uninfected subjects. They included 67 patients with chronic gastritis (CG), 26 with benign gastric polyp (BGP), 24 with gastric ulcer (GU), 24 with reflux esophagitis (RE), 18 with duodenal ulcer (DU), 28 with acute gastritis (AG), 23 with gastric cancer (GC), and 39 who had normal mucosa on upper endoscopy (N). Plasma pepsinogen I and II levels were also measured. The extent of gastritis was assessed endoscopically. Ghrelin levels differed significantly among the different disease groups. Plasma ghrelin concentrations were lowest in the CG group, followed by the GU group, and highest in the AG patients. There was a significant difference in the levels between differentiated and undifferentiated GC. Ghrelin concentrations in BGP, RE, and DU patients were comparable to those in the N group. Ghrelin circulating levels were lower in H. pylori-positive than -negative individuals, but the significant differences among disease groups were still observed in H. pylori-infected and uninfected populations. Ghrelin concentrations correlated positively with plasma pepsinogen I levels and I/II ratios and inversely with the extent of H. pylori-related gastritis. Plasma ghrelin levels varied widely in diverse conditions of the upper digestive tract, reflecting the inflammatory and atrophic events of the background gastric mucosa. Further investigation is warranted to unravel the mechanisms of the high circulating ghrelin levels in certain upper gastrointestinal diseases. © 2005 Springer Science+Business Media, Inc.
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Impaired production of gastric ghrelin combined with decreased plasma ghrelin in chronic gastritis associated with helicobacter pylori 招待あり 査読あり
Osawa H, Nakazato M, Date Y, Kita H, Ohnishi H, Ueno H, Shiiya T, Satoh K, Ishino Y, Sugano K
J Clin Endocrinol Metab 90 10 - 16 2005年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma
Isomoto H., Ueno H., Nishi Y., Wen C., Nakazato M., Kohno S.
World Journal of Gastroenterology 11 ( 11 ) 1644 - 1648 2005年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：World Journal of Gastroenterology
Aim: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, influences appetite, energy balance, gastric motility and acid secretion. The stomach is the main source of circulating ghrelin. There are inconsistent reports on the influence of Helicobacter pylori (H pylori) infection on circulating ghrelin levels. We sought to elucidate the relationship between ghrelin and various peptides in plasma, with special reference to H pylori. Methods: Plasma ghrelin levels were measured by radioimmunoassay in 89 subjects who were referred for upper gastrointestinal endoscopy, consisting of 42 H pylori infected and 47 uninfected ones. Plasma gastrin, somatostatin, leptin, insulin-like growth hormone 1 (IGF-1) and chromogranin A concentrations were also measured. Twelve patients were treated with anti- H pylori regimen. Results: Ghrelin circulating levels were greatly decreased in H pylori-positive than negative individuals (194.2±90.2 fmol/mL and 250.4±84.1 respectively, P<0.05), but did not significantly alter following the cure of infection (176.5±79.5 vs 191.3±120.4). There was a significant negative correlation between circulating ghrelin and leptin levels, as well as body mass index, for the whole and uninfected population, but not in H pylori-infected patients. Plasma ghrelin concentrations correlated positively with IGF-1 in H pylori-negative group and negatively with chromogranin A in the infected group. There were no significant correlations among circulating levels of ghrelin, gastrin and somatostatin irrespective of H pylori status. Conclusion: H pylori infection influences plasma ghrelin dynamics and its interaction with diverse bioactive peptides involved energy balance, growth and neuroendocrine function. © 2005 The WJG Press and Elsevier Inc. All rights reserved.
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Ghrelin: a gastric peptide that regulates food intake and energy homeostasis.
Ueno H, Yamaguchi H, Kangawa K, Nakazato M
Regulatory peptides 126 ( 1-2 ) 11 - 9 2005年3月