Papers - MORITAKE Hiroshi
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Cytomegalovirus infection mimicking juvenile myelomonocytic leukemia showing hypersensitivity to granulocyte-macrophage colony stimulating factor Reviewed
Moritake H, Ikeda T, Manabe A, Kamimura S, Nunoi H
Pediatr Blood Cancer 53 ( 7 ) 1324 - 1326 2009.12
Authorship：Lead author Publishing type：Research paper (scientific journal)
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PP-196 Xp11.2転座/TFE3融合遺伝子関連腎癌の1例(腎腫瘍/症例2,一般演題ポスター,第97回日本泌尿器科学会総会) Reviewed
向井 尚一郎, 上村 敏雄, 田中 弘之, 盛武 浩, 長野 正史, 蓮井 良浩
日本泌尿器科学会雑誌 100 ( 2 ) 2009
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：一般社団法人 日本泌尿器科学会
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Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity Reviewed
Funakoshi-Tago M, Pelletier S, Moritake H, Parganas E, Ihle JN.
Mol Cell Biol 28 ( 5 ) 1792 - 1801 2008.3
Language：English Publishing type：Research paper (scientific journal)
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眼窩腫瘍を初発症状とした小児の急性巨核芽球性白血病の１例 Reviewed
白坂陽子,中馬秀樹,直井信久,満木ひとみ,盛武 浩
眼科 48 511 - 516 2006
Language：Japanese Publishing type：Case report
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Prognostic factors for relapsed childhood acute lymphoblastic leukemia: impact of allogeneic stem cell transplantation--a report from the Kyushu-Yamaguchi Children's Cancer Study Group Reviewed
Matsuzaki A, Nagatoshi Y, Inada H, Nakayama H, Yanai F, Ayukawa H, Kawakami K, Moritake H, Suminoe A, Okamura J
Pediatr Blood Cancer 45 ( 2 ) 111 - 120 2005.8
Language：English Publishing type：Research paper (scientific journal)
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Kuroda H., Moritake H., Sawada K., Kuwahara Y., Imoto I., Inazawa J., Sugimoto T.
Cancer Genetics and Cytogenetics 158 ( 2 ) 172 - 179 2005.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Cancer Genetics and Cytogenetics
Malignant rhabdoid tumors (MRT) of the liver are rare. A few liver MRT cell lines have been established but none has been characterized in detail. Here we describe a new MRT cell line from the liver, which is designated MP-MRT-AN, and describe it in detail. Immunohistochemical assays detected the expression of vimentin and cytokeratin but they were negative for neurofilament, desmin, α-smooth muscle actin, α-sarcomeric actin, and smooth muscle myosin heavy chains SM1 and SM2. RT-PCR assays revealed that this cell line did not express smooth muscle myosin heavy chain isoforms or MyoD1. No aberration was identified in 22q by G-banded analysis; however, the hSNF5/INI1 gene, a suppressor gene of MRT that maps to 22q11.2, was homozygously deleted from exons 1 to 5 in this cell line. Furthermore, the expression of another tumor suppressor gene, p16 (CDKN2A), was not detected by RT-PCR. This raises the possibility that the aggressive phe notype of malignant rhabdoid tumors is caused by the loss of two or more tumor suppressor genes. © 2005 Elsevier Inc. All rights reserved.
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Kosaka Y., Koh K., Kinukawa N., Wakazono Y., Isoyama K., Oda T., Hayashi Y., Ohta S., Moritake H., Oda M., Nagatoshi Y., Kigasawa H., Ishida Y., Ohara A., Hanada R., Sako M., Sato T., Mizutani S., Horibe K., Ishii E.
Blood 104 ( 12 ) 3527 - 3534 2004.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Blood
Forty-four infants with acute lymphoblastic leukemia (ALL) characterized by MLL gene rearrangements were treated on a protocol of intensive chemotherapy followed by hematopoietic stem cell transplantation (HSCT) between November 1998 and June 2002. The remission induction rate was 91.0%, and the 3-year overall survival and event-free survival (EFS) rates, with 95% confidence intervals, were 58.2% (43.5%-72.9%) and 43.6% (28.5%-58.7%), respectively. Univariate analysis of EFS by presenting features indicated a poorer outcome in patients younger than 6 months of age with high white blood cell counts (≥ 100 × 10 9 /L; EFS rate, 9.4% versus 55.1% for all others, P = .0036) and in those with central nervous system invasion (EFS rate, 10.0% versus 56.9% for all others, P = .0073). The 3-year posttransplantation EFS rate for the 29 patients who underwent HSCT in first remission was 64.4% (46.4%-82.4%). In this subgroup, only the timing of HSCT (first remission versus others) was a significant risk factor by multivariate analysis (P < .0001). These results suggest that early introduction of HSCT, possibly with a less toxic conditioning regimen, may improve the prognosis for infants with MLL + ALL. Identification of subgroups or patients who respond well to intensified chemotherapy alone should have a high priority in future investigations. © 2004 by The American Society of Hematology.
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Residential proximity to high-voltage power lines and risk of childhood hematological malignancies Reviewed
Mizoue T., Onoe Y., Moritake H., Okamura J., Sokejima S., Nitta H.
Journal of Epidemiology 14 ( 4 ) 118 - 123 2004.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Epidemiology
Background: Epidemiologic studies of electromagnetic fields and childhood cancers have focused on home exposure. The authors investigated whether residence in districts near high-voltage power lines is associated with childhood hematological malignancies, using small area analysis. Methods: Among 50,000 children in a city in Japan, 14 cases aged younger than 15 years were diagnosed with these malignancies in the period from 1992 through 2001. A total of 294 districts constituting this city were classified according to their proximity to high-voltage power lines (either 66 kV or 220 kV). Mantel-Haenszel rate ratio is used to calculate incidence rate ratio and its 95% confidence interval (CI). Results: Compared to districts of which no area fell within 300 m of high-voltage power lines, districts in which at least 50% of the area fell within 300 m of high-voltage power lines demonstrated an increased risk (incidence rate ratio: 2.2; 95% CI: 0.5-9.0). The association was strengthened for homes in which patients had resided for the longest interval of their lives (incidence rate ratio: 3.4; 95% CI: 0.9-13.2). Point-in-time measurements showed no increase in magnetic field levels for patient homes in districts near the lines. Conclusion: An increased, albeit nonsignificant, risk of childhood hematological malignancies associated with residential proximity to high-voltage power lines warrants further investigations. Copyright © 2005 by Japan Epidemiological Association.
DOI： 10.2188/jea.14.118
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Viral infections in juvenile myelomonocytic leukemia: prevalence and clinical implications. Reviewed
Manabe A,Yoshimasu T,Ebihara Y,Yagasaki H,Wada M,Ishikawa K,Hara J,Koike K,盛武 浩,Park YD,Tsuji K,Nakahata T
J Pediatr Hematol Oncol 26 636 - 641 2004.10
Language：English Publishing type：Research paper (scientific journal)
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MORITAKE Hiroshi, MITSUKI Hitomi, HIDAKA Fumio, TOYAMA Seiya, KAMIMURA Sachiyo, KONOMOTO Takao, SONODA Tohru, KANEKO Yasuhiko, NUNOI Hiroyuki
41 ( 1 ) 130 - 133 2004
Authorship：Lead author Language：Japanese Publishing type：Case report
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Moritake H., Sugimoto T., Kuroda H., Hidaka F., Takahashi Y., Tsuneyoshi M., Yoshida M., Cui Q., Akiyoshi K., Izumi T., Nunoi H.
Cancer Genetics and Cytogenetics 146 ( 2 ) 102 - 109 2003.10
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Cancer Genetics and Cytogenetics
Askin tumor is a malignant small round cell tumor that originates from the thoracopulmonary region and is a member of Ewing sarcoma family of tumors (ESFT). Only a few Askin tumor cell lines have been established. An Askin tumor cell line, designated MP-ASKIN-SA, was established from the left thoracic tumor of a 13-year-old Japanese boy. ESFT is known to have a high rate of distant metastases at diagnosis. The genes controlling the spread of ESFT cells, however, have not been elucidated. G-banding chromosome analysis revealed that the MP-ASKIN-SA cell line has complex chromosomal abnormalities including trisomy 8. The EWS/FLI1 chimeric transcript and c-myc overexpression were revealed by the reverse transcriptase-polymerase chain reaction and Northern blot analysis. Furthermore, we investigated the expression of the focal adhesion kinase (FAK) gene in the ESFT cell lines using Northern blot analysis. In addition to the MP-ASKIN-SA cell line, six Ewing sarcoma cell lines, one peripheral nerve sheath tumor cell line, and two Askin tumor cell lines were analyzed. All ESFT cell lines, including MP-ASKIN-SA, expressed five- to twenty-eight-fold-increased values of FAK, as compared with fibroblasts obtained from the bone marrow of a healthy volunteer. These results raise the possibility that the overexpression of c-myc and FAK are involved in the poor prognosis of ESFT. © 2003 Elsevier Inc. All rights reserved.
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Moritake H., Kamimura S., Akiyoshi K., Nagatoshi Y., Chuman H., Okamura J.
Medical and Pediatric Oncology 40 ( 3 ) 187 - 188 2003.3
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Medical and Pediatric Oncology
DOI： 10.1002/mpo.10115
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.Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene Reviewed
Moritake H, Sugimoto T, Asada Y, Yoshida MA, Maehara Y, Epstein AL, Kuroda H.Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene.Cancer Genet Cytogenet. 2002 May;135(1):48-56.[査読有]
Cancer Genetics and Cytogenetics 135 ( 1 ) 48 - 56 2002.6
Publishing type：Research paper (scientific journal)
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Analysis of PTEN/MMAC1 alteration in neuroblastoma Reviewed
H Moritake, Y Horii, H Kuroda, T Sugimoto
Cancer Genet Cytogenet 125 ( 2 ) 151 - 155 2001.3
Authorship：Lead author Publishing type：Research paper (scientific journal)
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Analysis of PTEN/MMAC1 alteration in neuroblastoma Reviewed
Moritake H, Horii Y, Kuroda H, Sugimoto T
Cancer Genet Cytogenet 2001.3
Language：English Publishing type：Research paper (scientific journal)
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Signal Transduction Pathways through TRK-A and TRK-B Receptors in Human Neuroblastoma Cells Reviewed
SUGIMOTO Tohru, KURODA Hiroshi, HORII Yoshihiro, MORITAKE Hiroshi, TANAKA Takeo, HATTORI Seisuke
Japanese journal of cancer research : gann 92 ( 2 ) 152 - 160 2001.2
Language：Japanese Publishing type：Research paper (scientific journal)
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A case report of aneurysmal bone cyst of the thoracic spine caused paraplegia Reviewed
HIDAKA Fumio, MORITAKE Hiroshi, KURODA Hiroshi, HORII Yoshihiro, SUGIMOTO Tohru, FUJIME Kenichi, GOYA Tomokazu, WAKISAKA Shinichirou, NABESHIMA Kazuki, KOONO Masashi
37 ( 4 ) 516 - 519 2000.12
Language：Japanese Publishing type：Case report
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Renin producing hepatoblastoma Reviewed
Moritake H, Taketomi A, Kamimura S, Ikuno Y, Seo Y, Fukuda T, Iguchi H, Okamura J.
J Pediatr Hematol Oncol 2000.2
Language：English Publishing type：Research paper (scientific journal)
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Renin producing hepatoblastoma Reviewed
Moritake H, Taketomi A, Kamimura S, Ikuno Y, Seo Y, Fukuda T, Iguchi H, Okamura J
J Pediatr Hematol Oncol 22 ( 1 ) 78 - 80 2000.1
Authorship：Lead author Publishing type：Research paper (scientific journal)
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Moritake H., Ikuno Y., Tasaka H., Koga H., Miyazaki S., Okamura J.
Bone Marrow Transplantation 21 ( 7 ) 725 - 726 1998.4
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Bone Marrow Transplantation
A 10-year-old boy with metastatic rhabdomyosarcoma had an HLA-identical sibling and received an allogeneic BMT. Recurrence was detected in the BM as the only site of treatment failure 12 months after BMT. Donor leukocyte infusion (DLI) was chosen as salvage therapy. Although sufficient cells (a total of 29.7 x 10 7 /kg) were infused, no signs of acute GVHD nor BM aplasia occurred and the patient died of disease progression 9 months after DLI.