Papers - MORITAKE Hiroshi
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小児悪性肝Perivascular epithelioid cell tumorの1例 Reviewed
村上 雅一, 馬場 徳朗, 中目 和彦, 向井 基, 加治 建, 家入 里志, 児玉 祐一, 河野 嘉文, 齋藤 祐介, 盛武 浩
日本小児血液・がん学会雑誌 56 ( 2 ) 274 - 274 2019.9
Publishing type：Case report
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BTNL2 germline variants may be involved in the pathogenesis of renal granuloma Reviewed International journal
Nishimura T, Yamada A, Kinoshita M, Ohara O, Moritake H.
Pediatr Int 61 ( 8 ) 834 - 836 2019.8
Authorship：Lead author, Last author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1111/ped.13923
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Long-term Remission of Acute Myeloid Leukemia Developed From Systemic Mastocytosis by Conventional Chemotherapy. Reviewed
Yamada A, Kinoshita M, Sawa D, Saito Y, Kamimura S, Miyachi H, Moritake H
Journal of pediatric hematology/oncology 2019.8
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Ochiai K., Yamada A., Kimoto Y., Imamura H., Ikeda T., Matsukubo M., Ieiri S., Moritake H.
Pediatric Blood and Cancer 66 ( 8 ) e27804 2019.8
Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Pediatric Blood and Cancer
© 2019 Wiley Periodicals, Inc. We report a 38-month-old Japanese male with premature chromatid separation/mosaic variegated aneuploidy syndrome bearing biallelic BUB1B germline mutations who suffered from bilateral Wilms tumor. After right nephrectomy, dactinomycin monotherapy was administered for the left Wilms tumor; however, severe adverse reaction prevented the patient from receiving further chemotherapy. Left nephrectomy was then performed without postoperative chemotherapy. The patient survived for 15 months after bilateral nephrectomy without peritoneal relapse, metastasis of Wilms tumor, or the occurrence of rhabdomyosarcoma and maintained a good quality of life while receiving peritoneal dialysis at home.
DOI： 10.1002/pbc.27804
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嘔吐恐怖から回避・制限性食物摂取症を合併した自閉スペクトラム症 Reviewed
長尾 愛美, 松山 美靜代, 盛武 浩
日本認知・行動療法学会大会プログラム・抄録集 2019.8
Publishing type：Research paper (conference, symposium, etc.)
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Okumura T., Horie Y., Lai C., Lin H., Shoda H., Natsumoto B., Fujio K., Kumaki E., Okano T., Ono S., Tanita K., Morio T., Kanegane H., Hasegawa H., Mizoguchi F., Kawahata K., Kohsaka H., Moritake H., Nunoi H., Waki H., Tamaru S., Sasako T., Yamauchi T., Kadowaki T., Tanaka H., Kitanaka S., Nishimura K., Ohtaka M., Nakanishi M., Otsu M.
Stem Cell Research and Therapy 10 ( 1 ) 185 2019.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Stem Cell Research and Therapy
© 2019 The Author(s). Background: Disease modeling with patient-derived induced pluripotent stem cells (iPSCs) is a powerful tool for elucidating the mechanisms underlying disease pathogenesis and developing safe and effective treatments. Patient peripheral blood (PB) cells are used for iPSC generation in many cases since they can be collected with minimum invasiveness. To derive iPSCs that lack immunoreceptor gene rearrangements, hematopoietic stem and progenitor cells (HSPCs) are often targeted as the reprogramming source. However, the current protocols generally require HSPC mobilization and/or ex vivo expansion owing to their sparsity at the steady state and low reprogramming efficiencies, making the overall procedure costly, laborious, and time-consuming. Methods: We have established a highly efficient method for generating iPSCs from non-mobilized PB-derived CD34+ HSPCs. The source PB mononuclear cells were obtained from 1 healthy donor and 15 patients and were kept frozen until the scheduled iPSC generation. CD34+ HSPC enrichment was done using immunomagnetic beads, with no ex vivo expansion culture. To reprogram the CD34+-rich cells to pluripotency, the Sendai virus vector SeVdp-302L was used to transfer four transcription factors: KLF4, OCT4, SOX2, and c-MYC. In this iPSC generation series, the reprogramming efficiencies, success rates of iPSC line establishment, and progression time were recorded. After generating the iPSC frozen stocks, the cell recovery and their residual transgenes, karyotypes, T cell receptor gene rearrangement, pluripotency markers, and differentiation capability were examined. Results: We succeeded in establishing 223 iPSC lines with high reprogramming efficiencies from 15 patients with 8 different disease types. Our method allowed the rapid appearance of primary colonies (~ 8 days), all of which were expandable under feeder-free conditions, enabling robust establishment steps with less workload. After thawing, the established iPSC lines were verified to be pluripotency marker-positive and of non-T cell origin. A majority of the iPSC lines were confirmed to be transgene-free, with normal karyotypes. Their trilineage differentiation capability was also verified in a defined in vitro assay. Conclusion: This robust and highly efficient method enables the rapid and cost-effective establishment of transgene-free iPSC lines from a small volume of PB, thus facilitating the biobanking of patient-derived iPSCs and their use for the modeling of various diseases.
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当科で経験した難治頻回部分発作重積型急性脳炎(AERRPS)の3例 Reviewed
木許 恭宏, 谷口 英里奈, 唐澤 直希, 中原 彰彦, 池田 俊郎, 盛武 浩
脳と発達 51 S388 - S388 2019.5
Publishing type：Case report
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小児悪性肝Perivascular epithelioid cell tumorの1例 Reviewed
長野 綾香, 馬場 徳朗, 川野 孝文, 村上 雅一, 矢野 圭輔, 大西 峻, 春松 敏夫, 山田 和歌, 山田 耕嗣, 桝屋 隆太, 町頭 成郎, 中目 和彦, 向井 基, 加治 建, 家入 里志, 児玉 祐一, 河野 嘉文, 斎藤 祐介, 盛武 浩
日本小児外科学会雑誌 55 ( 3 ) 759 - 759 2019.5
Publishing type：Research paper (scientific journal)
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RAS関連自己免疫性リンパ増殖症候群様疾患(RALD)に対する造血細胞移植 Reviewed
江口 克秀, 石村 匡崇, 小野 宏彰, 長谷川 一太, 園田 素史, 白石 暁, 古賀 友紀, 盛武 浩, 高田 英俊, 大賀 正一
臨床血液 60 ( 5 ) 489 - 490 2019.5
Publishing type：Research paper (scientific journal)
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造血幹細胞移植後に急性白質脳症を示した1例 Reviewed
川上 沙織, 辻 百衣璃, 山田 愛, 小野 宏彰, 一宮 優子, 賀来 典之, 石崎 義人, 實藤 雅文, 大場 詩子, 古賀 友紀, 酒井 康成, 盛武 浩, 大賀 正一
脳と発達 51 S338 - S338 2019.5
Publishing type：Case report
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Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. Reviewed
Miyamura T, Moritake H, Nakayama H, Tanaka S, Tomizawa D, Shiba N, Saito AM, Tawa A, Shimada A, Iwamoto S, Hayashi Y, Koike T, Horibe K, Manabe A, Mizutani S, Taga T, Adachi S
British journal of haematology 2019.2
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Saito A., Nishikawa T., Oyoshi T., Nakagawa S., Kodama Y., Yamada A., Kinoshita M., Okamoto Y., Arita K., Moritake H., Kawano Y.
Bone Marrow Transplantation 54 ( 2 ) 312 - 315 2019.2
Language：English Publishing type：Research paper (scientific journal)
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KIT変異陽性全身性肥満細胞症から進展し異なる転帰を呈した急性骨髄性白血病の2例 Reviewed
山田 愛, 木下 真理子, 澤 大介, 齋藤 祐介, 上村 幸代, 宮地 勇人, 荻野 尚, 児玉 祐一, 河野 嘉文, 盛武 浩
日本小児科学会雑誌 123 ( 2 ) 319 - 319 2019.2
Publishing type：Case report
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新生児期に拡大を認めた巨大左心耳瘤の1例 Reviewed
山下 尚人), 近藤 恭平, 原田 雅子, 盛武 浩, 豊村 大亮, 鈴木 彩代, 鍋島 泰典, 寺師 英子, 倉岡 彩子, 兒玉 祥彦, 石川 友一, 中村 真, 佐川 浩一, 石川 司朗
日本小児科学会雑誌 123 ( 2 ) 365 - 365 2019.2
Publishing type：Case report
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3D mock-up to guide intrathecal drug administration to address SMA and scoliosis Reviewed
123 ( 2 ) 366 - 366 2019.2
Publishing type：Research paper (scientific journal)
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超大量フェノバルビタールとケトン食療法に加えペランパネルが奏功したAERRPS Reviewed
黒木 亜津子, 谷口 英里奈, 木許 恭宏, 池田 俊郎, 盛武 浩
日本小児科学会雑誌 123 ( 2 ) 416 - 416 2019.2
Publishing type：Research paper (scientific journal)
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赤芽球癆所見を示しミトコンドリアDNA欠失により診断したPearson症候群 Reviewed
西村 豊樹, 山田 愛, 木下 真理子, 澤 大介, 齋藤 祐介, 上村 幸代, 盛武 浩
日本小児科学会雑誌 123 ( 2 ) 491 - 491 2019.2
Publishing type：Research paper (scientific journal)
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パゾパニブが有効であった多発肺転移を有する難治性Ewing肉腫 Reviewed
横山 亮平, 山田 愛, 木下 真理子, 澤 大介, 齋藤 祐介, 上村 幸代, 盛武 浩
日本小児科学会雑誌 123 ( 2 ) 494 - 494 2019.2
Publishing type：Research paper (scientific journal)
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Dextromethorphan内服治療を行ったメトトレキサート脳症の1例 Reviewed
木許 恭宏, 谷口 英里奈, 池田 俊郎, 盛武 浩
脳と発達 51 ( 1 ) 42 - 42 2019.1
Publishing type：Case report
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KIT D816 変異陽性全身性肥満細胞症から進展し化学療法終了後2 ヶ月で再発した急性骨髄性白血病 Reviewed
原尾拓朗,山田愛,木下真理子, 澤大 介,齋藤祐介,上村幸代,宮地勇人,荻野尚，児玉祐一,岡本康裕，河野嘉文， 盛武浩
臨床血液 60 ( 5 ) 378 - 381 2019
Language：Japanese Publishing type：Research paper (scientific journal)