Papers - IKEDA Masahiro
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Arterial blood gas anomaly in canine hepatobiliary disease Reviewed
Kaneko, Y., Torisu, S., Kobayashi, T., Mizutani, S., Tsuzuki, N., Sonoda, H., Ikeda, M., Naganobu, K.
J. Vet. Med. Sci. 77 ( 12 ) 1633 - 1638 2016.1
Language：English Publishing type：Research paper (scientific journal)
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Regulation of aquaporins by vasopressin in the kidney Invited
Ikeda, M., Matsuzaki, T.
Vitam. Horm. 98 307 - 337 2015.2
Language：English Publishing type：Research paper (scientific journal)
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Urinary excretion pattern of exosomal aquaporin-2 in rats receiving gentamicin Reviewed
Abdeen, A., Sonoda, H., El-Shawarby, R., Takahashi, S., Ikeda, M.
Am. J. Physiol. Renal Physiol. 307 ( 11 ) F1227 - F1237 2014.12
Language：English Publishing type：Research paper (scientific journal)
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The role of cysteine 227 in subcellular localization, water permeability, and multimerization of aquaporin-11 Reviewed
Takahashi, S., Muta, K., Sonoda, H., Kato, A., Abdeen, A., Ikeda, M.
FEBS Open Bio 4 315 - 320 2014.3
Language：English Publishing type：Research paper (scientific journal)
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Alpha Lipoic Acid supressed migration and invasion via downregulation of cell surface β1-integrin expression in badder cancer cells Reviewed
Yamasaki, M., Iwase, M., Kawano, K., Sakakibara, Y., Suiko, M., Ikeda, M., Nishiyama, K.
J. Clin. Biochem. Nutr. 54 ( 1 ) 18 - 25 2014.1
Language：English Publishing type：Research paper (scientific journal)
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Excretion of urinary exosomal AQP2 in rats is regulated by vasopressin and urinary pH Reviewed
Higashijima, Y., Sonoda, H., Takahashi, S., Kondo, H., Shigemura, K., Ikeda, M.
Am. J. Physiol. Renal Physiol. 304 ( 10 ) F1295 - F1307 2013.11
Language：English Publishing type：Research paper (scientific journal)
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A new method for rapid detection of the mutant allele for Chediak-Higashi syndrome in Japanese Black cattle Reviewed
Abdeen, A., Sonoda, H., Kobayashi, I., Kitahara, G., Ikeda, M.
J. Vet. Med. Sci. 2013.9
Language：English Publishing type：Research paper (scientific journal)
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Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress Reviewed
Atochina-Vasserman, E.N., Biktasova, A., Abramova, E., Cheng, D.S., Polosukhin, V.V., Tanjore, H., Takahashi, S., Sonoda, H., Foye, L., Venkov, C., Ryzhov, S.V., Novitskiy, S., Shlonimskaya, N., Ikeda, M., Blackwell, T.S., Lawson, W.E., Gow, A.J., Harris, R.C., Dikov, M.M., Tchekneva, E.E.
Am J. Physiol. Renal Physiol 304 ( 10 ) F1295 - F1307 2013.5
Language：English Publishing type：Research paper (scientific journal)
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Spironolactone, but not eplerenone, impairs glucose tolerance in a rat model of metabolic syndrome Reviewed
Homma, T., Fujisawa, M., Arai, K., Ishii, M., Sada, T., Ikeda, M.
J. Vet. Med. Sci. 74 ( 8 ) 1015 - 1022 2012.8
Language：English Publishing type：Research paper (scientific journal)
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Homma T., Homma T., Sonoda H., Manabe K., Arai K., Mizuno M., Sada T., Ikeda M.
American Journal of Physiology - Renal Physiology 302 ( 6 ) F750 - 61 2012.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：American Journal of Physiology - Renal Physiology
Although chronic cardiac dysfunction is known to progressively exacerbate renal injury, a condition known as type 2 cardiorenal syndrome (CRS), the mechanism responsible is largely unknown. The present study was undertaken to clarify the mechanism of renal injury in rats with both unilateral nephrectomy (NX) and surgically induced myocardial infarction (MI), corresponding to a model of type 2 CRS. Compared with a control group, rats with both MI and NX (MI+NX) exhibited progressive proteinuria during the experimental period (34 wk after MI surgery), whereas proteinuria was not observed in rats with MI alone and was moderate in rats with NX alone. The proteinuria in rats with MI+NX was associated with renal lesions such as glomerulosclerosis and infiltration of mononuclear cells and upregulation of the renal proinflammatory and -fibrotic cytokine and angiotensin II type 1a receptor (AT1aR) genes. In contrast, plasma renin activity was lowered in rats with MI+NX. Immunohistochemistry revealed that the increased AT1R protein was present mainly in renal interstitial mononuclear cells. Olmesartan medoxomil, an AT1R blocker, markedly reduced the proteinuria and infiltration of mononuclear cells, whereas spironolactone, a mineralocorticoid receptor blocker, did not. The present findings demonstrate the pathogenetic role of renal interstitial AT1R signaling in a model of type 2 CRS, providing evidence that AT1R blockade can be a useful therapeutic option for this syndrome. © 2012 the American Physiological Society.
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The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function Reviewed
Ikeda, M., Andoo, A., Shimono, M., Takamatsu, N., Taki, A., Muta, K., Matsushita, W., Uechi, T., Matsuzaki, T., Kenmochi, N., Takata, K., Sasaki, S., Ito, K., Ishibashi, K.
J. Biol. Chem. 286 ( 5 ) 3342 - 3350 2011.2
Language：English Publishing type：Research paper (scientific journal)
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The protective effect of radicicol against renal ischemia-reperfusion injury in mice Reviewed
Sonoda, H., Prachasilchai, W., Kondo, H., Yokota-Ikeda, N., Oshikawa, S., Ito, K., Ikeda, M.
J. Pharmacol. Sci. 112 ( 2 ) 242 - 246 2010.2
Language：English Publishing type：Research paper (scientific journal)
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Decreased abundance of urinary exosomal aquaporin-1 in renal ischemia reperfusion injury Reviewed
Sonoda, H., Yokota-Ikeda, N., Oshikawa, S., Kanno, Y., Yoshinaga, K., Uchida, K., Ueda, Y., Kimiya, K., Uezono, S., Ueda, A., Ito, K., Ikeda, M.
Am. J. Physiol. Renal Physiol. 297 ( 4 ) F1006 - F1016 2009.10
Language：English Publishing type：Research paper (scientific journal)
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Amelioration of renal ischemia-reperfusion injury by inhibition of IL-6 production in the poloxamer 407-induced mouse model of hyperlipidemia Reviewed
Sharyo, S., Kumagai, K, Yokota-Ikeda, N., Ito, K., Ikeda, M.
J. Pharmacol. Sci. 110 ( 1 ) 47 - 54 2009.5
Language：English Publishing type：Research paper (scientific journal)
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A protective role of unfolded protein response in mouse ischemic acute kidney injury
Prachasilchai W., Sonoda H., Yokota-Ikeda N., Oshikawa S., Aikawa C., Uchida K., Ito K., Kudo T., Imaizumi K., Ikeda M.
European Journal of Pharmacology 592 ( 1-3 ) 138 - 145 2008.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：European Journal of Pharmacology
Although renal ischemia-reperfusion is known to activate the unfolded protein response, the renal site and role of activation of this response following the insult in vivo remains largely unknown. Here we studied the renal spatio-temporal expression pattern of glucose-regulated protein (GRP) 78, a central regulator of the unfolded protein response network, following renal ischemia-reperfusion and the effects of the specific chemical unfolded protein response inducers, tunicamycin and thapsigargin, on renal ischemia-reperfusion injury in mice. Renal ischemia-reperfusion resulted in expression of the spliced form of the X-box binding protein-1 (XBP-1s) transcript, an unfolded protein response target, at 1 and 2 h after the insult. This response was followed by an increase in the GRP78 transcript and protein. The increased amount of GRP78 protein after ischemia-reperfusion was largely localized in proximal tubule cells. Pretreatment with tunicamycin or thapsigargin significantly ameliorated renal dysfunction and injury after ischemia-reperfusion. Taken together with these results, the unfolded protein response was activated following renal ischemia-reperfusion at sites that are susceptible to ischemia-reperfusion injury, and this activation had a protective effect against renal ischemia-reperfusion injury in vivo. Molecules involved in the unfolded protein response may offer new opportunities for pharmacological intervention against renal ischemia-reperfusion injury, which is an important cause of acute kidney injury. © 2008 Elsevier B.V. All rights reserved.
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Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway Reviewed
Sharyo, S., Yokota-Ikeda, N., Mori, M., Kumagai, K., Uchida, K., Ito, K., Burne-Taney, M., Rabb, H., Ikeda, M.
Kidney Int. 74 ( 5 ) 577 - 584 2008.9
Language：English Publishing type：Research paper (scientific journal)
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Therapeutic effects of the putative P2X(3)/P2X (2/3) antagonist A-317491 on cyclophosphamide-induced cystitis in rats. Reviewed
Ito, K., Iwami, A., Katsura, H., Ikeda, M.
Naunyn-Schmiedeberg's Arch. Pharmacol. 377 ( 4-6 ) 483 - 490 2008.6
Language：English Publishing type：Research paper (scientific journal)
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Glutamate mediates platelet activation through the AMPA receptor Reviewed
Morell, C.N., Sun, H., Ikeda, M., Beique, J.C., Swaim, A.M., Mason, E., Martin, T.V., Thompson, L.E., Gozen, O., Ampagoomian, D., Sprengel, R., Rothstein, J., Faraday, N., Huganir, R., Lowenstein, C.J.
J. Exp. Med. 205 ( 3 ) 575 - 584 2008.3
Language：English Publishing type：Research paper (scientific journal)
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Evaluation of olmesartan medoxomil in the rat monocrotaline model of pulmonary hypertension Reviewed
Kato, T., Nasu, T., Sonoda, H., Ito, K.-M., Ikeda, M., Ito, K.
J. Cardiovasc. Pharmacol. 51 18 - 23 2008.1
Language：English Publishing type：Research paper (scientific journal)
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Alteration of release and roles of ADP and thromboxane A2 during collagen-induced aggregation of platelets from cattle with Chediak-Higashi syndrome Reviewed
Honda, N., Ohnishi, K., Fujishiro, T., Ikeda, M., Ito, K.
Am. J. Vet. Res. 68 1399 - 1406 2007.12
Language：English Publishing type：Research paper (scientific journal)