Papers - IKEDA Masahiro
-
Honda N., Honda N., Ohnishi K., Fujishiro T., Ikeda M., Ito K.
American Journal of Veterinary Research 68 ( 12 ) 1399 - 1406 2007.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：American Journal of Veterinary Research
Objective - To compare the interaction of endogenous ADP with collagen and thromboxane A2 (TXA2) during collagen-induced platelet aggregation between platelets from healthy cattle and those with Chediak-Higashi syndrome (CHS). Population Sample - Platelets harvested from blood samples from healthy Japanese Black cattle and those with CHS. Procedures - Aggregation of gel-filtered platelets; release of ATP-ADP; and generation of thromboxane B2 (TXB2), a metabolite of TXA2, were measured. Results - The potency of collagen to induce aggregation in platelets of cattle with CHS (ie, CHS platelets) was less than a tenth of that in platelets of healthy cattle (ie, control platelets). Platelet aggregation induced by collagen at an intermediate concentration depended on the coexistence of ADP and TXA2, suggesting that released ADP cannot cause platelet aggregation by itself. Collagen-induced ADP release was markedly decreased, whereas TXB2 production was slightly low in CHS platelets, compared with that in control platelets. A combination of subthreshold amounts of ADP and 9,11-dideoxy-9α,11α-methanoepoxy-prostaglandin F2α (U46619), a TXA2 analogue, caused platelet aggregation. Similarly, a combination of subthreshold amounts of collagen and ADP caused platelet aggregation, whereas collagen and U46619 were not synergistic. Conclusions and Clinical Relevance - Deficient ADP release ensuing from the δ-storage pool deficiency in platelets from cattle with CHS resulted in reduction of collagen-induced platelet aggregation, through attenuation of synergism between TXA2 and ADP and between ADP and collagen. Furthermore, results of the study reported here indicated that TXA2 was important for aggregation of bovine platelets.
-
Characterization of functional P2X1 receptors in mouse megakaryocytes Reviewed
Ikeda, M.
Thromb. Res. 119 343 - 353 2007.3
Language：English Publishing type：Research paper (scientific journal)
-
Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death Reviewed
Ikeda, M., Gunji, Y., Sonoda, H., Oshikawa, S., Shimono, M., Horie, A., Ito, K., Yamasaki, S.
Eur. J. Pharmacol. 546 36 - 39 2006.9
Language：English Publishing type：Research paper (scientific journal)
-
A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression Reviewed
Ikeda, M., Fong, P., Cheng, J., Boletta, A., Qian, F., Zhang, X.M., Cai, H., Germino, G.G., Guggino, W.B.
Cell. Physiol. Biochem. 18 9 - 20 2006.8
Language：English Publishing type：Research paper (scientific journal)
-
Ischemic acute tubular necrosis models and drug discovery: a focus on cellular inflammation Reviewed
Ikeda, M., Prachasilchai, W., Burne-Taney, M., Rabb, H., Yokota-Ikeda, N.
Drug Discov. Today 11 364 - 370 2006.4
Language：English Publishing type：Research paper (scientific journal)
-
Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells Reviewed
Beitz, E., Liu, K., Ikeda, M., Guggino, W.B., Agre, P., Yasui, M.
Biol. Cell 98 101 - 109 2006.2
Language：English Publishing type：Research paper (scientific journal)
-
Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule Reviewed
Morishita, Y., Matsuzaki, T., Hara-Chikuma, M., Andoo, A., Shimono, M., Matsuki, A., Kobayashi, K., Ikeda, M., Yamamoto, T., Verkman, A., Kusano, E., Ookawara, S., Takata, K., Sasaki, S., Ishibashi, K.
Mol. Cell. Biol. 25 7770 - 7779 2005.9
Language：English Publishing type：Research paper (scientific journal)
-
Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta Reviewed
Shimomura, E., Shiraishi, M., Iwanaga, T., Seto, M., Sasaki, Y., Ikeda, M., Ito, K.
Naunyn-Schmiedeberg's Arch. Pharmacol. 370 414 - 422 2004.11
Language：English Publishing type：Research paper (scientific journal)
-
The cytoplasmic tail of large conductance, voltage- and Ca2+-activated K+ (MaxiK) channel is necessary for its cell surface expression Reviewed
Wang, S.X., Ikeda, M., Guggino, W.B.
J. Biol. Chem. 278 2713 - 2722 2003.1
Language：English Publishing type：Research paper (scientific journal)
-
Characterization of aquaporin-6 as a nitrate channel in mammalian cells: Requirement of pore-lining residue threonine 63 Reviewed
Ikeda, M., Beitz, E., Kozono, D., Guggino, W.B., Agre, P., Yasui, M.
J. Biol. Chem. 277 39873 - 39879 2002.10
Language：English Publishing type：Research paper (scientific journal)
-
Do polycystins function as cation channels? Invited Reviewed
Ikeda, M., Guggino, W.B.
Curr. Opin. Nephrol. Hypertens. 11 539 - 545 2002.9
Language：English Publishing type：Research paper (scientific journal)
-
Platelet dysfunction in Chediak-Higashi syndrome-affected cattle Reviewed
Shiraishi, M., Ogawa, H., Ikeda, M., Kawashima, S., Ito, K.
J. Vet. Med. Sci. 54 751 - 760 2002.9
Language：English Publishing type：Research paper (scientific journal)
-
Shiraishi M., Kawashima S., Moroi M., Shin Y., Morita T., Horii Y., Ikeda M., Ito K.
Thrombosis and Haemostasis 87 ( 2 ) 334 - 341 2002.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Thrombosis and Haemostasis
Decreased platelet aggregation to collagen is a cause for bleeding diathesis of Chediak-Higashi syndrome (CHS). We investigated whether the collagen receptor-Ca2+ signaling system was impaired in platelets from cattle affected with CHS. A collagen-induced increase in cytosolic Ca2+ ([Ca2+]i) was depressed in CHS platelets, which was accompanied by a decrease in the production of inositol 1,4,5-trisphosphate. When the influences of endogenous arachidonic acid metabolites and ADP were excluded, convulxin or collagen-related peptide, which are specific agonists for the collagen receptor GPVI, increased [Ca2+]i in both normal and CHS platelets. In contrast, rhodocytin, which was thought to activate another collagen receptor GPIa/IIa, increased [Ca2+]i in CHS platelets to a lesser extent than in normal ones. Cytochalasin D, an actin polymerization inhibitor, depressed the response to collagen or rhodocytin but not the response to convulxin. Adhesion of CHS platelets to acid soluble type I collagen, which was mediated by GPIa/IIa, was similar to that of normal platelets. These results suggest that a defect in the rhodocytin-sensitive pathway is responsible for decreasing the response to collagen in CHS platelets. It remains to be determined which receptor is associated with the mechanism.
-
A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression Reviewed
Cheng, J., Moyer, B. D., Milewski, M., Loffing, J., Ikeda, M., Mickle, J. E., Cutting, G. R., Li, M., Stanton, B. A., Guggino, W. B.
J. Biol. Chem. 277 3520 - 3529 2002.2
Language：English Publishing type：Research paper (scientific journal)
-
Inhibitory effect of pentalenolactone on vascular smooth muscle cell proliferation Reviewed
Ikeda, M., Fukuda, A., Takagi, M., Morita, M., Shimada, Y.
Eur. J. Pharmacol. 411 45 - 53 2001.1
Language：English Publishing type：Research paper (scientific journal)
-
Inhibitory effects of ruthenium red on inositol 1,4,5-trisphosphate-induced responses in rat megakaryocytes Reviewed
Ikeda, M., Maruyama, Y.
Biochem. Pharmacol. 61 7 - 13 2001.1
Language：English Publishing type：Research paper (scientific journal)
-
Shiga toxin activates p38 MAP kinase through cellular Ca2+ increase in Vero cells Reviewed
Ikeda, M., Gunji, Y., Yamasaki, S., Takeda, Y.
FEBS Lett. 485 94 - 98 2000.11
Language：English Publishing type：Research paper (scientific journal)
-
Characteristics of collagen-induced Ca2+ mobilization in bovine platelets Reviewed
Shiraishi, M., Ikeda, M., Fujishiro, T., Fukuyama, K., Ito, K.
Cell Calcium 27 53 - 60 2000.1
Language：English Publishing type：Research paper (scientific journal)
-
Characterization of a palytoxin-induced non-selective cation channel in mouse megakaryocytes Reviewed
Ichida, K., Ikeda, M., Goto, K., Ito, K.
Jpn. J. Pharmacol. 81 200 - 208 1999.10
Language：English Publishing type：Research paper (scientific journal)
-
Detection of an autoantibody from Pug dogs with necrotizing encephalitis (Pug dog encephalitis) Reviewed
Uchida, K., Hasegawa, T., Ikeda, M., Yamaguchi, R., Tateyama, S.
Vet. Pathol. 36 301 - 307 1999.7
Language：English Publishing type：Research paper (scientific journal)