論文 - 綾部 貴典
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急性虫垂炎発症を契機に発見された盲腸癌の１例. 査読あり
綾部貴典, 土田裕一, 井上正邦, 中島清美, 小坂裕之, 鬼塚敏男
宮崎県医師会医学会会誌 27 120 - 123 2003年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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私の医療情報伝達法. 査読あり
綾部貴典
胸部外科 56 ( 10 ) 861 - 866 2003年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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重度多発外傷を合併した外傷性横隔膜破裂の1救命治験例. 査読あり
綾部貴典, 吉岡 誠, 福島靖典, 櫻井俊孝, 鬼塚敏男
宮崎県医師会医学会会誌, 27： 39-43, (2003) 27 39 - 43 2003年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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大動脈弁と肺動脈弁に感染性心内膜炎を伴ったValsalva洞動脈瘤破裂の外科的治療例. 査読あり
綾部貴典, 福島靖典, 帖佐英一, 吉岡 誠, 鬼塚敏男
日本心臓血管外科学会雑誌 31 ( 1 ) 61 - 64 2002年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Adenylate Kinase, Wiley Encyclopedia of Molecular Medicine, 5 Vol. Set, Edited by Thomas Creighton, John Wiley & Sons, Inc., New York, NY, 76-77, (2002) 査読あり
Ayabe T. and Hamada M.
Wiley Encyclopedia of Molecular Medicine 76 - 77 2002年5月
記述言語：英語 掲載種別：研究論文（その他学術会議資料等）
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緊急冠状動脈バイパス術後生じた呼吸不全に対しveno- venous ECMOを用い救命した１例. 査読あり
福島靖典, 綾部貴典, 中村栄作, 吉岡 誠, 松尾由美子, 鬼塚敏男
胸部外科, 55(3): 203-206, (2002) 55 ( 3 ) 203 - 206 2002年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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機能的内胸動脈グラフト症例の右側開胸到達法による僧帽弁再手術. 査読あり
綾部貴典, 福島靖典, 帖佐英一, 吉岡 誠, 鬼塚敏男
宮崎県医師会医学会会誌, 26(2) : 147-150, (2002) 26 ( 2 ) 147 - 150 2002年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Veno-venous ECMO for the respiratory failure after coronary artery bypass grafting
Fukushima Y., Ayabe T., Nakamura E., Yoshioka M., Matsuo Y., Onitsuka T.
Kyobu geka. The Japanese journal of thoracic surgery 55 ( 3 ) 203 - 206 2002年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Kyobu geka. The Japanese journal of thoracic surgery
We encountered a 60-year-old man with severe respiratory failure after CABG. The patient received veno-venous extracorporeal membrane oxygenation (ECMO) in which blood was drained from the right atrium through a cannula and was returned via a cannula in the left femoral vein. During ECMO, the flow rate was 2.8-3.0 l/min (about 40 ml/kg/min) and the assist was needed for 5 years. Veno-venous ECMO is a simple and effective therapy for acute respiratory failure unresponsive to conventional treatment.
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Anti-bleeding effect of nafamostat mesilate for the surgery of thoracic ascending aorta
Ayabe T., Nakamura K., Nakajima S., Yano Y., Matsuzaki Y., Onitsuka T.
Kyobu geka. The Japanese journal of thoracic surgery 54 ( 9 ) 773 - 776 2001年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Kyobu geka. The Japanese journal of thoracic surgery
During extracorporeal cardiopulmonary bypass (ECB), the activated coagulation and fibrinogenolysis system causes bleeding and postoperative multiple organ failures. We studied the effect of an anti-bleeding agent, nafamostat mesilate (NM) during the surgery of thoracic ascending aorta to decrease a side effect of bleeding. From March 1980 to January 1998, for thoracic ascending aorta operations in our department (true aneurysm, 16-, psudoaneurysm, 2-, and dissection, 11 cases, in 29 cases, respectively), age from 16 to 79 (mean 62.9 +/- 9.5 year of age), we classified the objects in two groups, NM group (intraoperative infusion with NM of 60 mg/hr and with heparin 300 IU/kg) and C group (only with heparin treated, 500 IU/kg). We investigated the preoperative factors (age and aneurysmal diameter), the intraoperative factors (ACT, hematcrit, platelet, aorta clamping time, operative time, ECB time, bleeding volume, and blood transfusion), and the postoperative factors (bleeding and blood transfusion) after the administration of NM. RESULTS: There was no significance for the protection effect of NM infusion on the preoperative and the postoperative factors. However, intraoperative bleeding and blood transfusion volume in NM group were significantly lesser than those in group C. CONCLUSIONS: It might be useful for NM infusion during the surgery of thoracic ascending aorta due to the decrease of volume of intraoperative bleeding and blood transfusion amount with the remarkable anti-bleeding effect.
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Expression of nm23-H1 gene product in mediastinal lymph nodes from lung cancer patients
Tomita M., Ayabe T., Matsuzaki Y., Onitsuka T.
European Journal of Cardio-thoracic Surgery 19 ( 6 ) 904 - 907 2001年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：European Journal of Cardio-thoracic Surgery
Objective: Although numerous studies have shown that nm23-H1 gene product expression is inversely related to metastatic potential in some cancers, the expression in lymph nodes has not been studied in detail. An analysis of nm23-H1 gene product expression in mediastinal lymph nodes from lung cancer patients is reported. Methods: One hundred and thirty-four, randomly selected lymph nodes (63 with positive pathological lymph node status) from 39 surgically treated lung cancer patients were examined. Expression of nm23-H1 gene product was determined using specific monoclonal antibodies. Metastatic cancer cells were highlighted using anti-cytokeratin antibody. Results: Expression of nm23-H1 gene product in patients with less and more than 50% nodes-positive was 12/23 (52.2%) and 15/16 (93.8%) cases, respectively. Immunohistochemical studies with cytokeratin revealed micrometastasis in 6/39 (15.4%) patients and 9/71 (12.7%) nodes previously reported as cancer negative. Expression of nm23-H1 gene product in micrometastasis and metastasis-positive nodes was 5/9 (55.6%) and 55/63 (87.3%), respectively. We also found nm23-H1 gene product expression in germinal center cells. However, we found no relationship between expression of nm23-H1 gene product in germinal center cells and extent of metastasis. Conclusions: Our study demonstrates a positive relationship between expression of nm23-H1 gene product and extent of metastasis in mediastinal lymph nodes from lung cancer patients. Our data for normal germinal center cells suggests that nm23-H1 gene product expression does not play a specific biological role in suppressing tumor metastasis in lung cancer. Copyright © 2001 Elsevier Science B.V.
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破裂性腹部大動脈瘤耐術症例の遠隔期予後の検討. 査読あり
綾部貴典, 福島靖典,帖佐英一, 吉岡 誠, 鬼塚敏男
外科 63 ( 10 ) 1231 - 1236 2001年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Tomita M., Ayabe T., Matsuzaki Y., Edagawa M., Maeda M., Shimizu T., Hara M., Onitsuka T.
BMC Cancer 1 2001年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：BMC Cancer
Background: We assessed the nm23-H1 gene product expression and its relationship with lymphatic and blood vessel invasion in patients with esophageal squamous cell carcinoma. Methods: Formalin-fixed and paraffin-embedded tissue sections from 45 patients who were treated surgically were used in this study. Pathologists graded lymphatic and blood vessel invasion in each of the tissue samples. Expression of nm23-Hl gene product was determined using a specific monoclonal antibody. Results: Expression of nm23-H1 gene product was present in 17 (37.8%) cases. We found an inverse correlation between nm23-H1 gene product expression and lymphatic vessel invasion, whereas no correlation between nm23-H1 gene product expression and blood vessel invasion. Overall survival rate was not different between nm23-H1 gene product positive and negative patients (p = 0.21). However, reduced expression of nm23-H1 gene product was associated with shorter overall survival in patients with involved lymph nodes (p < 0.05), but not in patients without involved lymph nodes (p = 0.87). Conclusions: In patients with esophageal squamous cell carcinoma, there appears to be an inverse relationship between nm23-H1 gene product expression and lymphatic vessel invasion. Furthermore, nm23-H1 gene product expression might be a prognostic marker in patients with involved lymph nodes. Our data does not demonstrate any correlation between nm23-H1 gene product expression and blood vessel invasion. © 2001 Tomita et al; licensee BioMed Central Ltd.
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Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival. 査読あり
72. Tomita M., Ayabe T., Matsuzaki Y., Edagawa M., Maeda M., Shimizu T., Hara M., Onitsuka T.
BMC Cancer, 1 : 3, (2001) 1 3 2001年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Expression of nm23-H1 gene product in mediastinal lymph nodes from lung cancer patients. 査読あり
Tomita M., Ayabe T., Matsuzaki Y., Onitsuka T.
Eur.J. Cardiothorac. Surg., 19(6): 904-907, (2001) 19 ( 6 ) 904 - 907 2001年3月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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橈骨動脈グラフトに対するニトログリセリン経皮剤の血管拡張作用に関する検討. 査読あり
綾部貴典, 福島靖典,帖佐英一, 吉岡 誠, 鬼塚敏男
宮崎県医師会医学会誌, 25(2): 114-117, (2001) 25 ( 2 ) 114 - 117 2001年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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開腹手術の既往を有する腹部大動脈瘤手術症例の検討. 査読あり
綾部貴典, 中村都英, 矢野光洋, 鬼塚敏男
日本血管外科学会雑誌 10 ( 6 ) 601 - 605 2001年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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胸部下行大動脈手術におけるnafamostat mesilateの出血防止効果 査読あり
綾部貴典、中村都英、中嶋誠司、矢野義和、松崎泰憲、鬼塚敏男
胸部外科 54 773 - 776 2001年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Ayabe Takanori, Park Seung Kyu, Takenaka Hitoshi, TAKENAKA Osamu, MARUYAMA Hideharu, SUMIDA Michihiro, ONITSUKA Tochio, HAMADA Minoru
The journal of biochemistry 128 ( 2 ) 181 - 187 2000年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Biochemical Society
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Surgical management of ductus arteriosus aneurysm in adults.
Ayabe T., Nakamura K., Nakajima S., Yano Y., Matsuzaki Y., Onitsuka T.
The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi 48 ( 5 ) 304 - 306 2000年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
Aneurysm of the ductus arteriosus is rare, especially in adults, and preoperative diagnosis is very difficult, requiring intraoperative diagnosis. A 71-year-old man was preoperatively diagnosed with ductus arteriosus aneurysm by computed tomographic scanning, magnetic resonance imaging, and aortography, which demonstrated a saccular aneurysm of the distal aortic arch. Under partial extracorporeal circulation, the aneurysm was replaced by an artificial vascular graft. The location and morphology of the aneurysm confirmed the preoperative diagnosis. The postoperative course was uneventful. Surgery for this condition is safe and is recommended the same as for common thoracic aortic aneurysm.
DOI： 10.1007/BF03218144
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Takanori Ayabe, Seung Kyu Park, Osamu Takenaka, Hideharu Maruyama, Michihiro Sumida, Toshio Onitsuka, and Minoru Hamada
Journal of Biochemistry 128 181 - 187 2000年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）