論文 - 綾部 貴典
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The usefulness of FDG-PET/CT in diagnosing recurrence of post-operative primary lung cancer
Terada T., Nagamachi S., Nisii R., Mizutani Y., Nakada H., Tamura S., Shimizu T., Ayabe T., Tomita M., Nakamura K.
Japanese Journal of Clinical Radiology 59 ( 1 ) 165 - 172 2014年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Clinical Radiology
Differential diagnosis by the FDG PET/CT between recurrence of primary lung cancer and the postoperative change is difficult. The results of our study, favorable diagnostic accuracy as higher 70% were obtained by setting the optimal cutoff value of SUVmax except for pleural lesions. Diagnostic performance was further improved by adding delayed image. The usefulness of FDG PET/CT was confirmed in diagnosing recurrence of NSCLC after surgery.
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Yorita K., Yonei A., Ayabe T., Nakada H., Nakashima K., Fukushima T., Kataoka H.
Journal of Medical Case Reports 8 ( 1 ) 345 2014年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Medical Case Reports
© 2014 Al-Kandari et al.; licensee BioMed Central Ltd. Introduction: Ganglioneuroma is a rare tumor in the posterior mediastinum; fat-containing ganglioneuromas are rarely reported. The present case report documents a brown fat-containing, posterior mediastinal ganglioneuroma, which has not been reported previously. Radiological examination, in particular 18F-2-fluoro-2-deoxyglucose-positron emission tomography, suggested that the tumor had low-grade malignant potential. This led to uncertainty at preoperative diagnosis. Case presentation: An asymptomatic 66-year-old Japanese woman with no significant past medical history was referred for the evaluation of a posterior mediastinal mass. Although its size had not changed in the past 5 years, a malignant lipomatous tumor could not be excluded due to the presence of intratumoral fat and increased 18F-2-fluoro-2-deoxyglucose uptake observed by positron emission tomography imaging. A computed tomography-guided core-needle biopsy revealed a mixture of mature adipocytes, spindle-shaped cells, and fibrotic stroma. Definite diagnosis was not possible, and surgical resection was performed. Three years after the surgery, she remains disease-free. Conclusions: Histological diagnosis of the surgically resected mass confirmed ganglioneuroma with substantial amounts of white and brown adipose tissues in peripheral areas. The existence of both ganglion cells and brown fat tissue intensified the accumulation of 18F-2-fluoro-2-deoxyglucose, resulting in a false-positive result by positron emission tomography. Considering this, ganglioneuroma should not be excluded either clinically or pathologically in fat-containing, posterior mediastinal tumors.
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Epidermal growth factor receptor mutations in Japanese men with lung adenocarcinomas
Tomita M., Ayabe T., Chosa E., Kawagoe K., Nakamura K.
Asian Pacific Journal of Cancer Prevention 15 ( 24 ) 10627 - 10630 2014年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Asian Pacific Journal of Cancer Prevention
Background: Epidermal growth factor receptor (EGFR) mutations play a vital role in the prognosis of patients with lung adenocarcinoma. Such somatic mutations are more common in women who are non-smokers with adenocarcinoma and are of Asian origin. However, to our knowledge, there are few studies that have focused on men. Materials and Methods: One hundred and eighty-four consecutive patients (90 men and 94 women) of resected lung adenocarcinoma were studied retrospectively. Results: EGFR mutations were positive in 48.9% and negative (wild type) in 51.1%. Overall mutation was significant in women (66.0% vs. 32.2%) compared with men (p < 0.001). For overall patients, EGFR mutation status was associated with gender, pStage, pT status, lepidic dominant histologic subtype, pure or mixed ground-glass nodule type on computed tomography and smoking status. However, in men, EGFR mutation status was only associated with lepidic dominant histologic subtype and not the other variables. Interestingly, the Brinkman index of men with mutant EGFR also did not differ from that for the wild type (680.0±619.3 vs. 813.1±552.1 p=0.1077). Conclusions: The clinical characteristics of men with lung adenocarcinoma related to EGFR mutation are not always similar to that of overall patients. Especially we failed to find the relationship between EGFR mutations and smoking status in men.
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Neurofibromatosis type 1に合併した迷走神経由来の頚胸部発生神経線維腫の1切除例
綾部 貴典, 富田 雅樹, 丸塚 浩助, 清水 哲哉, 中村 都英
日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery 27 ( 6 ) 712 - 718 2013年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：特定非営利活動法人 日本呼吸器外科学会
頚胸部境界に発生した迷走神経由来の腫瘍はまれであり，その手術法に関する報告は少ない．症例はNeurofibromatosis type 1を合併した25歳・男性．2010年11月職場で左頚部腫脹を指摘された．頚胸部CTでは，左頚部から鎖骨上窩，上縦隔の大動脈弓レベルまで，22×5.5 cmの腫瘤を認めた．左頚部の腫瘍は急速に増大し，悪性の可能性が疑われた．手術は，左頚部皮膚を斜切開し胸骨柄頚切痕で正中切開に移行した．腫瘍は被膜に覆われ周囲組織から容易に剥離できた．大胸筋を骨付着部より剥離し，胸骨L字切開（胸骨正中切開，左第1肋間で横切）を追加した．上縦隔部の腫瘍は大動脈弓部レベルで切離し摘出した．術後に嗄声（左反回神経麻痺）を認め，当院耳鼻科で甲状軟骨形成術を行った．鎖骨上窩＋胸骨L字切開アプローチは，頚胸部境界に発生した腫瘍の摘出に，十分な視野展開と安全な手術操作が可能となり有用と思われた．
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Takanori Ayabe, Masaki Tomita, Kunihide Nakamura
Journal of Cancer Therapy 4 15 - 23 2013年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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メチシリン耐性黄色ブドウ球菌(MRSA)アウトブレイク時の感染対策とチーム医療 査読あり
綾部貴典、西村征憲、幸森千晶、上森しのぶ、福田真弓、富田雅樹、岡山昭彦、中村都英
宮崎医会誌 37 187 - 194 2013年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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胸腔鏡下緊急手術を施行した特発性血気胸の3例 査読あり
阪口修平、富田雅樹、白崎幸枝、綾部貴典、清水哲哉、中村都英
宮崎県医師会医学会会誌 37 160 - 163 2013年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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肺癌術後再発・転移に対する化学療法(GEM+CBDCA vs PTX+CBDCA) 査読あり
綾部貴典、富田雅樹、原政樹、鬼塚敏男、中村都英
宮崎医会誌 37 97 - 105 2013年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Neurofibromatosis type 1に合併した迷走神経由来の頚胸部発生神経線維腫の1切除例 査読あり
綾部貴典、富田雅樹、丸塚浩助、清水哲哉、中村都英
日本呼吸器外科学会雑誌 27 ( 6 ) 44 - 50 2013年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Tomita M., Ayabe T., Chosa E., Nakamura K.
Annals of Cancer Research and Therapy 21 ( 1 ) 31 - 35 2013年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Annals of Cancer Research and Therapy
Some previous studies reported the relationship between the mutation status of epidermal growth factor receptor (EGFR) gene and serum carcinoembryonic antigen (CEA) level in advanced or recurrent lung adenocarcinomas. In the present study, this relationship was examined in resected lung adenocarcinomas. One hundred thirty five resected lung adenocarcinoma patients were reviewed retrospectively. Mutations of the EGFR gene were detected in 64 of the 135 patients, the most common being deletions in exon 19 and the L858R mutations in exon 21. The patients with normal serum CEA level had favorable prognosis, whereas those with high had poor prognosis. The 5-year survival of the patients with EGFR mutation-negative was significantly worse than that of the patients with EGFR mutation-positive. Both univariate and multivariate analyses indicated an independent prognostic impact of the combined use of serum CEA level and the status of EGFR mutation. There was no difference in the rate of EGFR gene mutations according to the serum CEA level. Furthermore we also failed to find the differences in the serum CEA level based on the EGFR mutation status. The rate of deletions in exon 19 and/or the L858R mutation in exon 21 was not also related to the serum CEA level. In conclusions we failed to find the relationship between the serum CEA level and the EGFR mutation status in resected lung adenocarcinomas. © 2013, The Japanese Society of Strategies for Cancer Research and Therapy. All rights reserved.
DOI： 10.4993/acrt.21.31
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Preoperative Total Serum Cholesterol and Patients' Survival in Resected Nonsmall Cell Lung Cancer 査読あり
Masaki Tomita, Takanori Ayabe, Tetsuya Shimizu, and Kunihide Nakamura
Lung Cancer International 2012 ( 463520 ) 4 2012年12月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1155/2012/463520
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(Anticancer Research 32, 8 (3535))
Tomita M., Shimizu T., Ayabe T., Nakamura K., Onitsuka T.
Anticancer Research 32 ( 12 ) 2012年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Anticancer Research
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Takanori Ayabe, Tetsuya Shimizu, Masaki Tomita, Masaki Hara, Mitsuhiro Yano, and Kunihide Nakamura
Ann. Cancer Res. Ther. 20 ( 1 ) 24 - 31 2012年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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非小細胞肺癌術後のCBDCA＋GEM化学療法の検討 査読あり
綾部貴典、富田雅樹、原政樹、清水哲哉、中村都英、鬼塚敏男
宮崎医会誌 36 116 - 124 2012年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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(Anticancer Research 32, 8, (3535))
Tomita M., Shimizu T., Ayabe T., Nakamura K., Onitsuka T.
Anticancer Research 32 ( 9 ) 2012年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Anticancer Research
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Tomita M., Shimizu T., Ayabe T., Onitsuka T.
Asia-Pacific Journal of Clinical Oncology 8 ( 3 ) 244 - 247 2012年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Asia-Pacific Journal of Clinical Oncology
Aims: The relationship between the maximum standardized uptake values (SUVmax) on positron emission tomography (PET) and serum carcinoembryonic antigen (CEA) level in non-small cell lung cancer (NSCLC) patients was investigated. Methods: Consecutively, 197 surgically resected NSCLC patients with preoperative staging including serum CEA and PET were reviewed retrospectively. Results: When patients were subdivided into two groups based on the median value of the SUVmax (6.6), the 5-year survival of patients with a high SUVmax was 63.20%, which was significantly worse than patients with a low SUVmax (87.29%, P=0.0004). The 5-year survival of patients with normal and high serum CEA level was 82.70 and 51.08%, respectively (P<0.0001). Univariate and multivariate analyses indicated the independent prognostic impact of the SUVmax and serum CEA level. Patients with both low SUVmax and normal serum CEA level had favorable prognosis, whereas those with both high SUVmax and high serum CEA level had poor prognosis. Conclusion: Preoperative SUVmax and serum CEA level are independent prognostic factors for survival in NSCLC. The combined use of preoperative SUVmax and serum CEA level might be a better prognostic indicator. © 2012 Wiley Publishing Asia Pty Ltd.
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Elevated Preoperative Inflammatory Markers Based on Neutrophil-to-Lymphocyte Ratio and C-Reactive Protein Predict Poor Survival in Resected Non-small Cell Lung Cancer. 査読あり
Tomita M, Shimizu T, Ayabe T, Onitsuka T.
Anticancer Res 32 ( 8 ) 3535 - 3538 2012年8月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Tomita M, Shimizu T, Ayabe T, Onitsuka T.
Asia Pac J Clin Oncol. 8 244 - 247 2012年8月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Elevated preoperative inflammatory markers based on neutrophil-to-lymphocyte ratio and C-reactive protein predict poor survival in resected non-small cell lung cancer.
Tomita M, Shimizu T, Ayabe T, Nakamura K, Onitsuka T
Anticancer research 32 ( 8 ) 3535 - 8 2012年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Tomita M., Shimizu T., Ayabe T., Onitsuka T.
Anticancer Research 32 ( 8 ) 3535 - 3538 2012年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Anticancer Research
Background: Previous studies showed the prognostic impact of inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP), in resected non-small cell lung cancer (NSCLC). However, there are no studies that examined both of these markers simultaneously. Patients and Methods: Three hundred and one consecutive cases of resected NSCLC with a follow-up period of more than 5 years were reviewed retrospectively. Results: A significant association was only observed between NLR and patients ' survival (p<0.0001). High CRP also led to a higher 5-year survival rate than low CRP (38.71% vs. 70.71%, p<0.0001). We evaluated the prognostic significance of the use of NLR and CRP combined. The 5-year survival of patients with both low NLR and low CRP was 74.18%. On the other hand, that of patients with both of these at a low level was significantly poor (20.00%, p<0.0001). Univariate and multivariate analyses of the clinicopathological factors affecting survival revealed that the combined use of preoperative NLR and CRP was an independent prognostic determinant. Conclusion: The combined use of preoperative NLR and CRP might be useful to predict the prognosis of patients with NSCLC.