Details of a Researcher

Association between fetal vascular malperfusion and gestational diabetes Reviewed

Goto T., Sato Y., Kodama Y., Tomimori K., Sameshima H., Aman M., Maekawa K., Yamashita A., Asada Y.

Journal of Obstetrics and Gynaecology Research 48 ( 1 ) 80 - 86 2022.1

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research

Aim: Diabetes mellitus (DM) is a major complication in pregnancy. Placental lesions with DM remain unclear and controversial. Recently, the terms of placental pathological findings, such as maternal and fetal vascular malperfusions (MVM and FVM, respectively) were introduced by the Amsterdam Placental Workshop Group Consensus Statement (APWGCS). FVM cases were classified as the partial obstruction type (global FVM) and the complete obstruction type (segmental FVM). The aim of this study was to clarify the pathological characteristics of the placenta with pregestational DM/gestational DM; GDM according to APWGCS. Methods: We studied the placentas of 182 DM women (27 pregestational DM and 155 GDM) and control placentas of 460 women without DM during 2011–2018. We excluded cases of intrauterine fetal death or multiple pregnancies. We reviewed microscopical findings including, MVM, FVM, chorioamnionitis with the slides according to the APWGCS. Results: Microscopically, the incidence of FVM was significantly higher in GDM patients than control (17% vs. 10%, p = 0.0138), but not significant in pregestational DM (11%, p = 0.7410). Segmental FVM (complete obstruction) was significantly more observed in GDM than control group (5% vs. 0.4%, p = 0.0013). Segmental FVM in GDM showed high incidence of light-for-dates infant (three of seven cases, 43%, p = 0.0288). In addition, several segmental FVM findings (villous stromal-vascular karyorrhexis and stem vessel occlusion) were frequently noted in 2 or 3 points positive of 75 g oral glucose tolerance test than 1 point positive GDM. Conclusion: Our placental findings suggest disorder of carbohydrate metabolism might affect the fetal vascular damage, especially complete fetal vascular obstruction.

DOI： 10.1111/jog.15046

特集周産期医学必修知識(第9版) 分娩時アスフィキシアと脳性麻痺の因果関係の判定基準

後藤智子, 児玉由紀, 鮫島浩

周産期医学 51 ( 13 ) 453 - 456 2021.12

Publishing type：Research paper (scientific journal) Publisher：(株)東京医学社

DOI： 10.24479/j00621.2022108803

Congenital tracheo-esophageal transition: A previously undescribed tracheo-esophageal malformation that showed direct transition of the trachea to the esophagus. Reviewed

Kiwaki T, Nagayasu MA, Yamada N, Kodama Y, Umekita Y, Fukushima T, Kataoka H, Tanaka H

Pathology international 2021.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/pin.13189

特集在胎22～23週の超早産をめぐる課題と展望母体の背景と管理法　切迫早産の管理 Invited International coauthorship

松澤聡史, 児玉由紀

周産期医学 51 ( 8 ) 1109 - 1112 2021.8

Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(株)東京医学社

DOI： 10.24479/j00621.2021323159

A case of facial cellulitis caused by group B streptococcus in an extremely low birthweight infant. Reviewed

Muraoka J, Kodama Y, Higashi M, Yamada N, Yamashita R, Nakame K, Kaneko M, Sameshima H

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 47 ( 3 ) 1110 - 1117 2021.5

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jiac.2021.04.021

Intrapartum fetal heart rate patterns and perinatal outcome in chorioamnionitis at or beyond 34 weeks of gestation Reviewed

Muraoka J., Kodama Y., Ohashi M., Goto T., Sameshima H.

Journal of Obstetrics and Gynaecology Research 47 ( 3 ) 1110 - 1117 2021.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research

Aim: To investigate intrapartum fetal heart rate (FHR) patterns in women with chorioamnionitis at or beyond 34 weeks of gestation in relation to neonatal outcome and to compare clinical and subclinical chorioamnionitis. Methods: A retrospective questionnaire survey on deliveries during 2015 was conducted by the Perinatology Committee of the Japan Society of Obstetrics and Gynecology from 2016 to 2018. A total of 498 singleton births complicated by chorioamnionitis delivered at ≥34 weeks of gestation without major congenital malformations were included. The subjects were divided into clinical and subclinical chorioamnionitis groups based on Lencki's criteria. Poor perinatal outcome was defined as death or brain damage. We analyzed clinical features, FHR patterns in the last 2 h before delivery, gestational age, birthweight, Apgar score, umbilical arterial blood gas analysis, and infant's outcome. Results: Incidence of chorioamnionitis at ≥34 weeks of gestation was 0.59% (522/87827). Clinical and subclinical chorioamnionitis comprised 240 and 258 cases, respectively. Abnormal FHR patterns (late deceleration or decreased baseline variability) were significantly associated with poor perinatal outcome. Combined late deceleration and decreased variability showed low positive predictive value (12.8%) and high negative predictive value (99.5%), and was significantly associated with long-term poor outcome in clinical chorioamnionitis only (odds ratio: 29.4, p < 0.01). Poor perinatal outcome showed no significant difference between the clinical and subclinical chorioamnionitis groups. Conclusions: Combined late deceleration and decreased variability could predict poor perinatal outcome in clinical chorioamnionitis. Poor perinatal outcome occurred in infants born to mothers with clinical and subclinical chorioamnionitis.

DOI： 10.1111/jog.14641

村岡純輔, 児玉由紀

周産期医学 50 ( 12 ) 2042 - 2044 2020.12

Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(株)東京医学社

DOI： 10.24479/j00621.2021085660

Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study Reviewed

Yada Y., Ohkuchi A., Otsuki K., Goishi K., Takahashi M., Yonemoto N., Saito S., Kusuda S., Ota H., Kosugiyama K., Okuyama K., Mizushima M., Negishi H., Koshida S., Kasai M., Okabe M., Sato A., Adachi H., Banzai M., Akaba K., Suzuki R., Ishibashi N., Watanabe T., Kasuga Y., Kameda T., Fujiu T., Takagi T., Maruyama K., Higashino M., Naito T., Kamei Y., Kunikata T., Iitsuka Y., Otsuka H., Yamamoto Y., Yamada M., Daigo M., Hyodo H., Sato A., Kataoka N., Yamanaka S., Okahashi A., Kojima Y., Kabashima S., Nakamura Y., Okuno R., Hirose S., Sugahara K., Okamoto S., Hara S., Shima W., Suzuki T., Kagawa H., Fujioka K., Kurasaki A., Miura A., Hokuto I., Arase T., Taguchi N., Sekiguchi K., Matsuo T., Ohnuma E., Fujiwara K., Ogawa M., Uozumi A., Yokomichi N., Hirose A., Okuda M., Fukuyama A., Ishimoto H., Mitsuzuka K., Kondo S., Kitazawa M., Kikuchi N., Miyashita Y., Tsutsumi C., Terada S., Ohki S., Kawamura T., Yasuda M., Soeno Y., Kurabayashi T., Nagayama Y., Yoneda S., Shiga T., Hayashi S., Tsuda H., Oshiro M., Ushida T., Mizutani T., Asada H., Miura R., Tanaka R., Kato N., Sasaki Y., Yokoyama T., Hirooka T., Yamada T., Maruwaka K., Nagara S.

Scientific Reports 10 ( 1 ) 2020.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports

Our aim was to evaluate the association between ritodrine and magnesium sulfate (MgSO4) and the occurrence of neonatal hyperkalemia or hypoglycemia among late preterm infants in a retrospective cohort study. We used a nationwide obstetrical database from 2014. A total of 4,622 live preterm infants born at 32–36 gestational weeks participated. Fourteen risk factors based on both clinical relevance and univariate analysis were adjusted in multivariable logistic regression analyses. Neonatal hyperkalemia and hypoglycemia occurred in 7.6% (284/3,732) and 32.4% (1,458/4,501), respectively. Occurrence of hyperkalemia was associated with concomitant usage of ritodrine and MgSO4 compared with no usage (adjusted odds ratio [aOR] 1.53, 95% confidence interval [CI] 1.09–2.15). Occurrence of hypoglycemia was associated with ritodrine alone (aOR 2.58 [CI 2.21–3.01]) and with concomitant usage of ritodrine and MgSO4 (aOR 2.59 [CI 2.13–3.15]), compared with no usage, and was associated with long-term usage (≥ 48 hours) of ritodrine and cessation directly before delivery. In conclusion, in late preterm infants, usage of ritodrine together with MgSO4 was associated with occurrence of critical neonatal hyperkalemia, and long-term usage of ritodrine and cessation directly before delivery were associated with neonatal hypoglycemia.

DOI： 10.1038/s41598-020-64687-w

特集 HTLV-1母子感染をもっと知ろうキャリアマザーから出生した児の産科施設退院までの留意点 Invited

吉本望, 児玉由紀

周産期医学 50 ( 10 ) 1741 - 1743 2020.10

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(株)東京医学社

DOI： 10.24479/j00621.2021005607

特集 [必携]専攻医と指導医のための産科診療到達目標病態･疾患編【妊娠中】胎児発育不全 Invited

土井宏太郎, 児玉由紀

周産期医学 50 ( 8 ) 1346 - 1351 2020.8

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(株)東京医学社

DOI： 10.24479/j00621.2020377214

特集経腟分娩vs帝王切開-分娩様式の選択と対応- 9.胎児異常症例 Invited

山口智子, 児玉由紀

産婦人科の実際 69 ( 6 ) 603 - 608 2020.6

Publishing type：Research paper (scientific journal) Publisher：金原出版

DOI： 10.18888/sp.0000001301

Pathologically diagnosed superficial form of placenta accreta: a comparative analysis with invasive form and asymptomatic muscular adhesion. Reviewed

Sato Y, Aman M, Maekawa K, Yamashita A, Kodama Y, Doi K, Sameshima H, Asada Y

Virchows Archiv : an international journal of pathology 2020.1

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00428-019-02723-5

Two cases of very low birth weight infants with congenital syphilis Reviewed

Tokuda Atsuko, Kodama Yuki, Kanno Chika, Goto Tomoko, Yamada Naoshi, Yamashita Rie, Doi Koutarou, Kaneko Masatoki, Sameshima Hiroshi

Journal of Japan Society of Perinatal and Neonatal Medicine 56 ( 3 ) 538 - 543 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society of Perinatal and Neonatal Medicine

Syphilis is a sexually transmitted disease caused by <i>Treponema pallidum</i>. Congenital syphilis occurs as a result of vertical transmission from a mother to the fetus. The number of congenital syphilis cases has recently been rising in both the United States and Japan. Vertical transmission of syphilis can be prevented by early detection during pregnancy and adequate treatment of the mother. Here we report two cases of very low birth weight infants with congenital syphilis, who had different clinical courses. One survived and developed normally following successful antibiotic treatment, while the other died at 14 hours of age with <i>Treponema pallidum</i> infection in the placenta and multiple organs.

DOI： 10.34456/jjspnm.56.3_538

Characteristics and influence of Mycoplasma / Ureaplasma cultures in amniotic fluid on perinatal outcomes Reviewed

Sho Takakura, Yuki Kodama, Rie Yamashita, Emi Kino, Noriko Kawano, Kayo Tominori, Yohei Maki, Koutaro Doi, Masatoki Kaneko, Hiroshi Sameshima

Journal of Obstetrics and Gynaecology Resarch 46 ( 3 ) 389 - 395 2019.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/jog.14183

過去20年の総合周産期母子医療センターにおける産科症例の変遷 Reviewed

川越靖之、大西淳仁、古川誠志、児玉由紀、金子政時、鮫島浩、池ノ上克

宮崎県医師会医学会誌 43 ( 2 ) 139 - 144 2019.11

Language：Japanese Publishing type：Research paper (scientific journal)

Intrapartum fetal asphyxia influence on blood levels of procalcitonin in neonate immediately after birth Reviewed

Journal of Japan Society of Perinatal and Neonatal Medicine 55 ( 3 ) 755 - 759 2019.9

Language：Japanese Publishing type：Research paper (scientific journal)

CD39 downregulation in chronic intervillositis of unknown etiology Reviewed

Yuichiro Sato, Kazunari Maekawa, Murasaki Aman, Atushi Yamashita, Yuki Kodama, Yohei Maki,Hiroshi Sameshima, Yujiro Asada

Virchows Archiv 475 357 - 364 2019.9

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s00428-019-02598-6