Papers - KODAMA Yuki
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Histological severity of fetal inflammation is useful in predicting neonatal outcome
Yamada N., Sato Y., Moriguchi-Goto S., Yamashita A., Kodama Y., Sameshima H., Asada Y.
Placenta 36 ( 12 ) 1490 - 1493 2015.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Placenta
© 2015 Elsevier Ltd. Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placental findings in 272 singleton neonates born at less than 34 weeks gestation. The incidences of sepsis, intraventricular hemorrhage, chronic lung disease, and necrotizing enterocolitis increased in a stepwise fashion with severity of placental inflammation. After adjusting for gestational age, a high grade of fetal inflammation was significantly associated with chronic lung disease and necrotizing enterocolitis.
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Kodama Y., Sameshima H., Yamashita R., Oohashi M., Ikenoue T.
Journal of Obstetrics and Gynaecology Research 41 ( 11 ) 1738 - 1743 2015.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
© 2015 Japan Society of Obstetrics and Gynecology. Aim Intrapartum fetal bradycardia necessitates immediate operative delivery. Our aim was to investigate the hypothesis that some non-reassuring fetal heart rate (FHR) patterns were present before the onset of terminal bradycardia in infants who developed subsequent brain damage. Material and Methods From a population-based study of 65-197 deliveries, 190 stillbirths, 115 neonatal deaths, and 136 neurologically high-risk infants were registered by the Miyazaki Perinatal Conference. There were 15 cases of neurologically high-risk infants born at > 34-weeks of gestation exhibiting intrapartum terminal bradycardia. Focusing on the brain-damaged infants, we retrospectively analyzed FHR patterns for at least 1-h prior to the bradycardia. Results Brain damage (cerebral palsy [n-=-11] and mental retardation [n-=-2] ) was diagnosed at 2-years old in 13 out of 15 neurologically high-risk infants. Two infants had bradycardia on admission. In the remaining 11 infants, FHR patterns were reassuring in six (55%) and non-reassuring in five (45%), including late decelerations (n-=-4) and variable decelerations (n-=-2). Clinically relevant factors in the non-reassuring group included intrauterine infection (n-=-3), malpresentation with umbilical cord coiling (n-=-1), and unknown causes (n-=-1). Clinically relevant features in the reassuring group included cord prolapse (n-=-1), vaginal breech delivery (n-=-1), shoulder dystocia (n-=-1), rupture of membranes (n-=-1), and unknown causes (n-=-2). Conclusion More than half of the brain-damaged infants born at > 34-weeks of gestation who exhibited intrapartum terminal bradycardia had unremarkable FHR patterns before abrupt-onset bradycardia. For those with non-reassuring patterns preceding bradycardia, intrauterine infection was the major sentinel event.
DOI： 10.1111/jog.12797
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Maki Y., Furukawa S., Kodama Y., Sameshima H., Ikenoue T.
Early Human Development 91 ( 5 ) 333 - 337 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Early Human Development
© 2015 Elsevier Ireland Ltd. Background: It remains unclear whether performing amniocentesis to detect intra-amniotic infection is useful for improving neonatal outcomes. Aims: To determine the efficacy of amniocentesis on the neonatal outcomes in women exhibiting threatened preterm labor and intact membranes. Study design: Retrospective cohort study. Subjects: A total of 174 women with threatened preterm labor and intact membranes at 22 to 33. weeks of gestation. Women with obvious clinical chorioamnionitis, multifetal pregnancy and/or major anomalies were excluded. Outcome Measures: Neonatal short- and long-term outcomes. Results: Sixty-seven women underwent amniocentesis (Tap group), while the remaining 107 did not. The prevalence of a positive Gram stain or a positive culture result was 10% in the Tap group. The overall outcomes were not statistically different between the two groups, with the exception of borderline significance (p = 0.052) in long-term outcomes, favoring the Tap group. We performed a subgroup analysis focusing on infants born at 22-28. weeks of gestation. Consequently, the Tap group had better neonatal outcomes than the no-Tap group with respect to both short-term (OR 0.19, 95%CI 0.07-0.55) and long-term (OR 0.15, 0.05-0.46) outcomes. A multivariate analysis revealed that after adjusting confounding factors, the gestational age at delivery (OR 0.4, 0.3-0.7) and amniocentesis (OR 0.1, 0.02-0.3) remained significantly different. Conclusions: Amniocentesis is useful for improving neonatal outcomes in infants born at 22-28. weeks of gestation to women exhibiting preterm labor and intact membranes.
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Impact of Skin Lesions on Morbidity and Mortality in Extremely Premature Infants in One Tertiary Center in Southern Japan. Reviewed
Yamada N, Kodama Y, Kaneko M, Sameshima H, Ikenoue T
J Neonatal Biol 4 ( 3 ) 2015
Language：English Publishing type：Research paper (scientific journal)
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Histological severity of fetal inflammation is useful in predicting neonatal outcome. Reviewed
Yamada N, Sato Y, Moriguchi-Goto S, Yamashita A, Kodama Y, Sameshima H, Asada Y.
Placenta 36 ( 12 ) 1490 - 1493 2015
Language：English Publishing type：Research paper (scientific journal)
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Did antepartum hypoxic insult caused by fetal vessel thrombosis influence the procalcitonin level in umbilical blood? A case report. Reviewed
2) Kaneko M, Yamauchi A, Yamashita R, Sato Y, Kodama Y, Sameshima H.
J Obstet Gynecol Res 41 ( 11 ) 1839 - 1842 2015
Language：English Publishing type：Research paper (scientific journal)
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Early onset nontypable Haemophilis influenzae sepsis in a preterm newborn infant. Reviewed
○ Kaneko M, Yamashita R, Suzuki T, Kodama Y, Sameshima H, Ikenoue T
Clinical Case Reports 4 ( 7 ) 2014
Language：English Publishing type：Research paper (scientific journal)
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Prospective study of the MD-twin score for antepartum evaluation of monochorionic diamniotic twins and its correlation with perinatal outcomes. Reviewed
Oohashi M., Kaneko M., Sameshima H., Kodama Y., Ikenoue T.
J Obstet Gynecol Res 40 ( 3 ) 711 - 717 2014
Language：English Publishing type：Research paper (scientific journal)
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Kodama Y., Sameshima H., Ohashi M., Ikenoue T.
Journal of Obstetrics and Gynaecology Research 39 ( 7 ) 1242 - 1245 2013.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Obstetrics and Gynaecology Research
Aim: The aim of this study was to determine whether the new gestational diabetes mellitus (GDM) criteria increase the prevalence of diabetes-mellitus- related stillbirths by using a regional population-based approach. Material and Methods: A retrospective, population-based study was conducted to assess 114 036 deliveries from 2000 to 2010 in Miyazaki, Japan. During this period 318 stillbirths occurred after 22 weeks of gestation. Of these cases, 236 were examined to determine the cause of death. The remaining 82 cases were not fully investigated. In particular, we investigated the prevalence of pregestational diabetes mellitus and GDM among the stillbirths. We also applied new GDM criteria to evaluate the impact of these factors on stillbirth. Results: Of the 236 stillbirths, 47% were due to an explainable cause. Application of previous criteria indicated two cases of pregestational diabetes mellitus and three GDM cases in the remaining unexplained stillbirths. By applying new GDM criteria, the GDM count increased to 17. Conclusions: In an unselected population in southern Japan, the application of new GDM criteria resulted in a 5.7-fold increase (from 2.4% [3/126] to 13.5% [17/126]) in the number of GDM cases in unexplained stillbirths. Even in women with a mild degree of GDM, proper management of both mother and fetus could reduce the number of unexplained stillbirths. © 2013 The Authors.
DOI： 10.1111/jog.12055
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宮崎県の周産期医療に関するpopulation-based 研究 Invited
児玉由紀
九州連合産科婦人科学会雑誌 64 56 - 60 2013
Language：Japanese Publishing type：Research paper (scientific journal)
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Perinatal death and neurological damage as a sequential chain of poor outcome Reviewed
Doi K, Sameshima H, Kodama Y, et al.
Journal of Maternal Fetal Neonatal Medicine 25 ( 6 ) 706 - 709 2012.6
Language：English Publishing type：Research paper (scientific journal)
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Congenital infantile fibrosarcoma in a very low-birth-weight infant Reviewed
Mukai M., Sameshima H., Kodama Y., Yamashita R., Kaneko M., Ikenoue T., Matsufuji H., Kondo K., Chijiiwa K.
Journal of Pediatric Surgery 47 ( 4 ) e1 - 4 2012.4
Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Pediatric Surgery
We describe a prenatally diagnosed case with congenital infantile fibrosarcoma, which is a rare malignant tumor, of which there have been only 14 cases reported in the English literature. A giant mass on the left thigh was detected at 24 weeks' gestation by prenatal ultrasonography. Because of its rapid growth and nonreassuring fetal status in utero, the baby was delivered by cesarean delivery at 27 weeks' gestation. The case was complicated by hemorrhagic anemia, coagulopathy, and cardiac failure, and a tumor resection was performed on day 3. As of age 2.5 years, he was healthy without evidence of recurrence. Because some fetal cases with congenital infantile fibrosarcoma have a poor prognosis, termination of pregnancy at an appropriate time and postnatal early treatment are crucial for successful treatment. © 2012 Elsevier Inc.
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Intrapartum fetal heart rate patterns in infants (≥ 34 weeks) with poor neurological outcome
Kodama Y., Sameshima H., Ikeda T., Ikenoue T.
Early Human Development 85 ( 4 ) 235 - 238 2009.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Early Human Development
Background: Cases suggestive of non-acidemia related cerebral palsy (CP) are likely misdiagnosed as acidemia related CP because of the presence of nonreasuring fetal heart rate (FHR) patterns. Aims: Our purpose was to compare intrapartum FHR patterns between the cases of neurological damage and the cases without disability after severe metabolic acidemia and neonatal encephalopathy, and also to compare the FHR patterns between cases with CP due to asphyxia and cases with CP of other etiology in infants born after 34 weeks. Study design: From 1998 to 2003, our peer review conferences determined 136 infants with high-risk factors for neurological impairment in the unselected 65,197 live births. High-risk infants were chosen according to our criteria. Among them 58 were eligible infants because they were born at ≥ 34 weeks of gestation and also had legible FHR traces. Outcome measures: Incidence of nonreassuring FHR patterns. Results: Fifteen infants were acidemia related and 43 were non-acidemia related high-risk infants. Ten of the 15 acidemia infants developed CP and all had shown bradycardia ≥ 13 min with a nadir < 80 bpm. In the 43 non-acidemia infants, 35 had CP, mental retardation, epilepsy, or hearing loss and 74% (26/35) of them had shown nonreassuring FHR patterns. Incidence of severe bradycardia was significantly elevated in the acidemia related CP compared with acidotic infants without disability, and those with non-acidemia related CP. Conclusions: Even in infants with non-acidemia related CNS impairments, who were born at ≥ 34 weeks of gestation, 74% had shown intrapartum nonreassuring FHR patterns. © 2008 Elsevier Ireland Ltd. All rights reserved.
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Deaths of early-onset, invasive sepsis in full-term infants in Miyazaki: nine cases from a regional population-based analysis from 1998-2006.
Sameshima H, Kodama Y, Kaneko M, Ikenoue T, Miyazaki Perinatal Data Group.
Japanese journal of infectious diseases 61 ( 5 ) 400 - 1 2008.9
Language：Japanese Publishing type：Research paper (scientific journal)
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SAMESHIMA Hiroshi, KODAMA Yuki, IKENOUE Tsuyomu, KAJIWARA Yayoi
The Journal of obstetrics and gynaecology research 34 ( 1 ) 34 - 39 2008.2
Language：English Publishing type：Research paper (scientific journal)
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Regional population-based study on pregnancy outcomes in women with diabetes mellitus in Japan
KODAMA Yuki, SAMESHIMA Hiroshi, IKENOUE Tsuyomu
The Journal of obstetrics and gynaecology research 33 ( 1 ) 45 - 48 2007.2
Language：Japanese Publishing type：Research paper (scientific journal)