論文 - 盛武 浩
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Kosaka Y., Koh K., Kinukawa N., Wakazono Y., Isoyama K., Oda T., Hayashi Y., Ohta S., Moritake H., Oda M., Nagatoshi Y., Kigasawa H., Ishida Y., Ohara A., Hanada R., Sako M., Sato T., Mizutani S., Horibe K., Ishii E.
Blood 104 ( 12 ) 3527 - 3534 2004年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Blood
Forty-four infants with acute lymphoblastic leukemia (ALL) characterized by MLL gene rearrangements were treated on a protocol of intensive chemotherapy followed by hematopoietic stem cell transplantation (HSCT) between November 1998 and June 2002. The remission induction rate was 91.0%, and the 3-year overall survival and event-free survival (EFS) rates, with 95% confidence intervals, were 58.2% (43.5%-72.9%) and 43.6% (28.5%-58.7%), respectively. Univariate analysis of EFS by presenting features indicated a poorer outcome in patients younger than 6 months of age with high white blood cell counts (≥ 100 × 10 9 /L; EFS rate, 9.4% versus 55.1% for all others, P = .0036) and in those with central nervous system invasion (EFS rate, 10.0% versus 56.9% for all others, P = .0073). The 3-year posttransplantation EFS rate for the 29 patients who underwent HSCT in first remission was 64.4% (46.4%-82.4%). In this subgroup, only the timing of HSCT (first remission versus others) was a significant risk factor by multivariate analysis (P < .0001). These results suggest that early introduction of HSCT, possibly with a less toxic conditioning regimen, may improve the prognosis for infants with MLL + ALL. Identification of subgroups or patients who respond well to intensified chemotherapy alone should have a high priority in future investigations. © 2004 by The American Society of Hematology.
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Residential proximity to high-voltage power lines and risk of childhood hematological malignancies 査読あり
Mizoue T., Onoe Y., Moritake H., Okamura J., Sokejima S., Nitta H.
Journal of Epidemiology 14 ( 4 ) 118 - 123 2004年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Epidemiology
Background: Epidemiologic studies of electromagnetic fields and childhood cancers have focused on home exposure. The authors investigated whether residence in districts near high-voltage power lines is associated with childhood hematological malignancies, using small area analysis. Methods: Among 50,000 children in a city in Japan, 14 cases aged younger than 15 years were diagnosed with these malignancies in the period from 1992 through 2001. A total of 294 districts constituting this city were classified according to their proximity to high-voltage power lines (either 66 kV or 220 kV). Mantel-Haenszel rate ratio is used to calculate incidence rate ratio and its 95% confidence interval (CI). Results: Compared to districts of which no area fell within 300 m of high-voltage power lines, districts in which at least 50% of the area fell within 300 m of high-voltage power lines demonstrated an increased risk (incidence rate ratio: 2.2; 95% CI: 0.5-9.0). The association was strengthened for homes in which patients had resided for the longest interval of their lives (incidence rate ratio: 3.4; 95% CI: 0.9-13.2). Point-in-time measurements showed no increase in magnetic field levels for patient homes in districts near the lines. Conclusion: An increased, albeit nonsignificant, risk of childhood hematological malignancies associated with residential proximity to high-voltage power lines warrants further investigations. Copyright © 2005 by Japan Epidemiological Association.
DOI： 10.2188/jea.14.118
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Viral infections in juvenile myelomonocytic leukemia: prevalence and clinical implications. 査読あり
Manabe A,Yoshimasu T,Ebihara Y,Yagasaki H,Wada M,Ishikawa K,Hara J,Koike K,盛武 浩,Park YD,Tsuji K,Nakahata T
J Pediatr Hematol Oncol 26 636 - 641 2004年10月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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定期フォロー中に肉眼的血尿よりWilms腫瘍が発見されたWAGR症候群の1例 査読あり
盛武 浩, 満木 ひとみ, 日高 文郎, 外山 誠也, 上村 幸代, 此元 隆雄, 園田 徹, 金子 安比古, 布井 博幸
小児がん : 小児悪性腫瘍研究会記録 41 ( 1 ) 130 - 133 2004年
担当区分：筆頭著者 記述言語：日本語 掲載種別：症例報告 出版者・発行元：がんの子供を守る会
WAGR症候群の1歳女児を報告する.3ヵ月毎の腹部超音波による定期フォロー中に肉眼的血尿があり,次いでWilms腫瘍が発見された.腫瘍組織の染色体検査で11p13領域を含む部分欠失が認められた.DNA分析で対側アレルのWT1遺伝子のエクソン7にナンセンス変異を認めた.本症例のようなWilms腫瘍合併頻度の高い症候群では,腹部超音波検査を2歳までは1ヵ月毎に実施するべきであると考えた.
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Moritake H., Sugimoto T., Kuroda H., Hidaka F., Takahashi Y., Tsuneyoshi M., Yoshida M., Cui Q., Akiyoshi K., Izumi T., Nunoi H.
Cancer Genetics and Cytogenetics 146 ( 2 ) 102 - 109 2003年10月
担当区分：筆頭著者 記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Cancer Genetics and Cytogenetics
Askin tumor is a malignant small round cell tumor that originates from the thoracopulmonary region and is a member of Ewing sarcoma family of tumors (ESFT). Only a few Askin tumor cell lines have been established. An Askin tumor cell line, designated MP-ASKIN-SA, was established from the left thoracic tumor of a 13-year-old Japanese boy. ESFT is known to have a high rate of distant metastases at diagnosis. The genes controlling the spread of ESFT cells, however, have not been elucidated. G-banding chromosome analysis revealed that the MP-ASKIN-SA cell line has complex chromosomal abnormalities including trisomy 8. The EWS/FLI1 chimeric transcript and c-myc overexpression were revealed by the reverse transcriptase-polymerase chain reaction and Northern blot analysis. Furthermore, we investigated the expression of the focal adhesion kinase (FAK) gene in the ESFT cell lines using Northern blot analysis. In addition to the MP-ASKIN-SA cell line, six Ewing sarcoma cell lines, one peripheral nerve sheath tumor cell line, and two Askin tumor cell lines were analyzed. All ESFT cell lines, including MP-ASKIN-SA, expressed five- to twenty-eight-fold-increased values of FAK, as compared with fibroblasts obtained from the bone marrow of a healthy volunteer. These results raise the possibility that the overexpression of c-myc and FAK are involved in the poor prognosis of ESFT. © 2003 Elsevier Inc. All rights reserved.
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Moritake H., Kamimura S., Akiyoshi K., Nagatoshi Y., Chuman H., Okamura J.
Medical and Pediatric Oncology 40 ( 3 ) 187 - 188 2003年3月
担当区分：筆頭著者 記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Medical and Pediatric Oncology
DOI： 10.1002/mpo.10115
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.Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene 査読あり
Moritake H, Sugimoto T, Asada Y, Yoshida MA, Maehara Y, Epstein AL, Kuroda H.Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene.Cancer Genet Cytogenet. 2002 May;135(1):48-56.[査読有]
Cancer Genetics and Cytogenetics 135 ( 1 ) 48 - 56 2002年6月
掲載種別：研究論文（学術雑誌）
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Analysis of PTEN/MMAC1 alteration in neuroblastoma 査読あり
H Moritake, Y Horii, H Kuroda, T Sugimoto
Cancer Genet Cytogenet 125 ( 2 ) 151 - 155 2001年3月
担当区分：筆頭著者 掲載種別：研究論文（学術雑誌）
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Analysis of PTEN/MMAC1 alteration in neuroblastoma 査読あり
Moritake H, Horii Y, Kuroda H, Sugimoto T
Cancer Genet Cytogenet 2001年3月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Signal Transduction Pathways through TRK-A and TRK-B Receptors in Human Neuroblastoma Cells 査読あり
SUGIMOTO Tohru, KURODA Hiroshi, HORII Yoshihiro, MORITAKE Hiroshi, TANAKA Takeo, HATTORI Seisuke
Japanese journal of cancer research : gann 92 ( 2 ) 152 - 160 2001年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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対麻痺で発症した胸椎上部aneurysmal bone cystの1例 査読あり
日高 文郎, 盛武 浩, 黒田 啓史, 堀井 由博, 杉本 徹, 藤目 憲一, 呉屋 朝和, 脇坂 信一郎, 鍋島 一樹, 河野 正
小児がん 37 ( 4 ) 516 - 519 2000年12月
記述言語：日本語 掲載種別：症例報告
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Renin producing hepatoblastoma 査読あり
Moritake H, Taketomi A, Kamimura S, Ikuno Y, Seo Y, Fukuda T, Iguchi H, Okamura J.
J Pediatr Hematol Oncol 2000年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Renin producing hepatoblastoma 査読あり
Moritake H, Taketomi A, Kamimura S, Ikuno Y, Seo Y, Fukuda T, Iguchi H, Okamura J
J Pediatr Hematol Oncol 22 ( 1 ) 78 - 80 2000年1月
担当区分：筆頭著者 掲載種別：研究論文（学術雑誌）
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Moritake H., Ikuno Y., Tasaka H., Koga H., Miyazaki S., Okamura J.
Bone Marrow Transplantation 21 ( 7 ) 725 - 726 1998年4月
担当区分：筆頭著者 記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Bone Marrow Transplantation
A 10-year-old boy with metastatic rhabdomyosarcoma had an HLA-identical sibling and received an allogeneic BMT. Recurrence was detected in the BM as the only site of treatment failure 12 months after BMT. Donor leukocyte infusion (DLI) was chosen as salvage therapy. Although sufficient cells (a total of 29.7 x 10 7 /kg) were infused, no signs of acute GVHD nor BM aplasia occurred and the patient died of disease progression 9 months after DLI.
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左アキレス腱に原発したClear cell sarcomaの13歳女児例 査読あり
河野慶一郎,澤田一美,盛武 浩,黒田啓史,堀井由博,桑原 茂,浅田祐士郎,住吉昭信,杉本 徹
小児がん 35 532 - 535 1998年
記述言語：日本語 掲載種別：症例報告
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化学療法と放射線療法が奏効した鼻咽頭癌の16歳男児例 査読あり
堀井由博,黒田啓史,児玉由紀子,紺谷幸代,河野慶一郎,盛武 浩,松田圭二,浅田祐士郎,小野誠治,杉本 徹
小児がん 35 248 - 518 1998年
記述言語：日本語 掲載種別：症例報告
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Ewing肉腫ファミリー腫瘍におけるキメラ産物の検出 査読あり
堀井由博,杉本 徹,黒田啓史,盛武 浩,紺谷幸代,江口春彦,田代 聡,宮崎澄雄
小児がん 34 191 - 195 1997年
記述言語：英語 掲載種別：研究論文（学術雑誌）
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腸重積を合併した悪性リンパ腫の6歳男児例 査読あり
盛武 浩,井上 忍,此元隆雄,山崎俊輔,杉本 徹,丸山賢幸,崎浜國治,東秀史,瀬戸口敏明,丸塚浩助,住吉昭信:
宮崎県医師会医学雑誌 20 89 - 93 1996年
記述言語：日本語 掲載種別：症例報告
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Henoch-Schonlein紫斑病の臨床像を呈した溶連菌感染後急性糸球体腎炎の1例 査読あり
清 保博,黒川聡子,盛武 浩,大野拓郎,西口俊裕,三宅和昭,浜田恵亮
日本小児科学会雑誌 99 1476 - 1480 1995年
記述言語：日本語 掲載種別：症例報告
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ヒトヘルペスウイルス6型の初感染による脳炎・脳症の臨床像 査読あり
福永一美,糸数直哉,盛武 浩,井上 忍,大庭健一,園田 徹,杉本 徹
小児科臨床 20 89 - 93 1995年
記述言語：日本語 掲載種別：研究論文（学術雑誌）