論文 - 河上 洋
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Kato M., Asaka M., Ono S., Nakagawa M., Nakagawa S., Shimizu Y., Chuma M., Kawakami H., Komatsu Y., Hige S., Takeda H.
Journal of Gastroenterology 42 ( SUPPL.17 ) 16 - 20 2007年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Gastroenterology
Because most gastric cancers develop from a background of Helicobacter pylori-infected gastric mucosa, H. pylori plays an important role in gastric carcinogenesis. Therefore, eradication of H. pylori may inhibit the incidence of gastric cancers. In experimental studies, H. pylori eradication has proved to act as a prophylaxis against gastric cancer. However, the results of recent randomized controlled studies are absolutely contradictory. In Japan, mucosal gastric cancer is usually resected by endoscopic treatment. As only a small part of the gastric mucosa is resected, secondary gastric cancer after endoscopic resection of the primary gastric cancer often develops at another site in the stomach. A nonrandomized Japanese study involving 132 early gastric cancer patients reported that eradication of H. pylori after endoscopic resection tended to reduce the development of secondary gastric cancer. Also, a retrospective multicenter survey indicated that the incidence rate of secondary gastric cancer in H. pylori-eradicated patients was about one-third that among patients in the noneradication group. We conducted a large-scale multicenter randomized trial to confirm the effect of H. pylori eradication on secondary and residual gastric cancer after endoscopic resection. This study was begun in 2003 and is ongoing at present. Diagnosis of a new carcinoma at another site of the stomach is defined as the primary end point, and recurrence of tumors at the resection site as a secondary end point. A total of 542 subjects have been enrolled in the study. This study will have the statistical power to demonstrate whether H. pylori eradication decreases the incidence and recurrence of gastric cancer. © Springer-Verlag Tokyo 2007.
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Neutrophils secrete MIP-1β after adhesion to laminin contained in basement membrane of blood vessels
Chiba K., Zhao W., Chen J., Wang J., Cui H., Kawakami H., Miseki T., Satoshi H., Tanaka J., Asaka M., Kobayashi M.
British Journal of Haematology 127 ( 5 ) 592 - 597 2004年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：British Journal of Haematology
We have recently demonstrated that granulocyte colony-stimulating factor (G-CSF) stimulated the production of epithelial-cell-derived-neutrophil attractant-78 (ENA-78) by neutrophils and that ENA-78 might promote the accumulation of neutrophils that had migrated from the intravascular space into inflammatory tissues. In this study, we examined whether other chemokines could be secreted by neutrophils that had accumulated after migrating from the intravascular space into the inflammatory tissues. We demonstrated that adhesion to laminin contained in the basement membrane and Matrigel, which is an artificial basement membrane model, induced macrophage inflammatory protein-1β (MIP-1β) in neutrophils and that MIP-1β secreted by neutrophils induced the chemotaxis of dendritic cells. These findings suggest that neutrophils transmigrating through the basement membrane are stimulated to secrete MIP-1β by the basement membrane, inducing the transmigration of dendritic cells from the intravascular space into inflammatory tissues. We propose that neutrophils intervene between innate immune response and specific immune response by secreting MIP-1β during the transmigration through the basement membrane.
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Osanai M., Maguchi H., Katanuma A., Kawakami H., Amizuka H., Itoh H., Takahashi K., Koizumi K., Mitsui S., Izumi S., Watanabe S., Nomura M., Yoshida H., Sakurai Y., Tsuji K., Jong-Hong K.
Gastroenterological Endoscopy 44 ( 5 ) 904 - 911 2002年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Gastroenterological Endoscopy
A 46-year-old man was admitted to the hospital with alcoholic chronic pancreatitis complicated by infectious pseudocysts. As multiple pseudocysts were seen, both transduodenal and percutaneous drainage of the cysts were performed to improve the general condition. The ERCP finding revealed some strictures of the main pancreatic duct in the head. It was highly suspected that multiple pseudocysts were caused by those pancreatic ductal strictures. Then we performed endoscopic transpapillary stenting of the pancreatic duct. The postoperative course was uneventful without recurrence of the pseudocysts.
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特発性筋肉内血腫を発症したアルコール性肝硬変の2例 査読あり
Yoshida H., Tsuji K., Kawakami H., Katanuma A., Sakurai Y., Jong-Hon K., Koizumi K., Mitsui S., Gotoh M., Yoshida A., Hayashi T., Tanaka Y., Izumi S., Watanabe S., Takahashi K., Nomura M., Maguchi H., Shinohara T.
Japanese Journal of Gastroenterology 99 ( 11 ) 1350 - 1354 2002年11月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Gastroenterology
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Kawakami H., Nomura M., Amizuka H., Haruyama Y., Izumi S., Watanabe S., Osanai M., Katanuma A., Itoh H., Takahashi K., Yoshida H., Sakurai Y., Tsuji K., Kang J., Maguchi H., Nakamura F., Dohke M., Shinohara T.
Japanese Journal of Gastroenterology 99 ( 9 ) 1063 - 1068 2002年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Gastroenterology
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Kawakami H., Maguchi H., Takahashi K., Itoh H., Katanuma A., Osanai M., Amizuka H., Yoshida H., Hayashi T.
Gastroenterological Endoscopy 44 ( 10 ) 1843 - 1849 2002年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Gastroenterological Endoscopy
We report a case in which endoscopic pancreatic stenting was effective for the postoperative stricture of the anastomosis of the main pancreatic duct and the duodenal bulb. A 32-year -old Japanese male with a history of reccurent acute pancreatitis was admitted to our hospital with severe abdominal pain and back pain, and the serum level of pancreatic enzymes was elevated. He had been injured by traffic accident and undergone operation of the pancreas twice at the age 20. He was treated by the conservative therapy, and the condition was improved biochemically. However, endoscopic retrograde pancreatography showed a stricture of the anastomosis of the main pancreatic duct and the duodenal bulb, and dilatation of the distal pancreatic duct. The stricture was considered to be the cause of recurrent acute pancreatitis and endoscopic pancreatic stent placing was performed. General condition got better after treatment, and the serum level of pancreatic enzymes was normalized. The stent was naturally removed after 3 months with no recurrence. MRCP revealed no recurrence of the stricture. He has been free from complications after the stent removal. In conclusion, endoscopic pancreatic stenting can be one of the therapeutic alternatives for the postoperative stricture of the anastomosis of the main pancreatic duct and digestive tract. © 2002, Japan Gastroenterological Endoscopy Society. All rights reserved.
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短期間にIs型からIIa+IIc型へと肉眼形態が変化したS状結腸sm癌の1例 査読あり
Izumi S., Nomura M., Kawakami H.
Stomach and Intestine 36 ( 13 ) 2001年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Stomach and Intestine
A 49-year-old woman was referred to our center for positive fecal occult blood. Colonoscopic examination revealed a sessile lesion (Is type), approximately 10 mm in size, in the sigmoid colon. Morphologically, it was considered to be an elevated lesion due to massive submucosal invasion. Colonoscopic examination 30 days later revealed that the lesion had metamorphosed to a flat lesion with disappearance of the elevation in the center. In the area where the elevation had disappeared, an irregular shallow depression with uneven surface was observed. From these colonoscopic findings, it was diagnosed as a superficial depressed cancer (IIa + IIc type) with massive submucosal invasion. Barium enema radiograph revealed a round radiolucent lesion with a thin, irregular barium collection in the center, 10 mm in size. The profile view showed a semilunar deformity. From these findings combined with high-frequency ultrasound probe findings, the lesion was finally diagnosed as IIa + IIc type cancer with massive submucosal invasion at the center. Laparoscopic sigmoidectomy was perfomed. In the resected specimen, there was a IIa + IIc type lesion measuring 8×8 mm in size. Histologically, it was a well differentiated adenocarcinoma with massive submucosal invasion at the center. The tumor border was covered with normal mucosa. The case was thought to be noteworthy for considering the natural course of colorectal cancer.
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Bone marrow dysplasia with basophilic cells in a patient with angiocentric lymphoma
Mori A., Hashino S., Imamura M., Kahata K., Kawakami H., Kobayashi S., Tanaka J., Musashi M., Asaka M.
Acta Haematologica 99 ( 2 ) 98 - 101 1998年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Acta Haematologica
We report a 46-year-old man suffering from angiocentric lymphoma of the skin. On admission, he had atypical cells rich in basophilic granules in the bone marrow and peripheral blood, in addition to skin eruptions and bone marrow dysplasia. Immediately after diagnosis, the patient was treated with multidrug combination chemotherapy. At first, the chemotherapy markedly relieved the skin eruption and bone marrow dysplasia, and atypical cells in the bone marrow and peripheral blood disappeared rapidly. However, the disease gradually became resistant to chemotherapy, resulting in a gradual deterioration of the skin eruption and bone marrow dysplasia, and reappearance of atypical cells. The levels of serum cytokines such as interleukin-4 and interleukin-6, and of soluble interleukin-2 receptor correlated well with the disease states. These results suggest that the lymphoma cells directly or indirectly induce the production of these cytokines and that a dysregulated cytokine network, which might be caused by lymphoma cells, induces an increase in atypical cells.
DOI： 10.1159/000040820
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Mori A., Hashino S., Imamura M., Kahata K., Kawakami H., Shibata M., Kobayashi S., Tanaka J., Asaka M.
Bone Marrow Transplantation 21 ( 6 ) 615 - 617 1998年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Bone Marrow Transplantation
We report a case of bone marrow infarction in a 20-year-old woman with acute lymphocytic leukemia (ALL) who underwent unrelated bone marrow transplantation (BMT). Hematopoietic engraftment occurred on day 9 and, thereafter, the patient developed acute dermal and hepatic graft-versus-host disease (GVHD). She also experienced severe arthralgia in her knee joints on day 21. Immunosuppressive therapy with prednisolone (PSL) for acute GVHD was given, and the arthralgia improved rapidly, correlating with the improvement in dermal and hepatic GVHD. Based on the laboratory findings and analysis of magnetic resonance images, she was diagnosed as having bone marrow infarction. The cause of the bone marrow infarction was thought to be acute CVHD-related microangiopathy.