研究者詳細 - 河上　洋

Complete remission of colon cancer with ipilimumab monotherapy

Suzuki S, Kawakami H, Miike T, Yamamoto S

Internal Medicine 60 ( 6 ) 957 - 958 2021年

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Internal Medicine

DOI： 10.2169/internalmedicine.6024-20

遠位胆管癌に対する術前診断のポイント―内視鏡関連手技を中心に―

河上　洋

日本消化器内視鏡学会雑誌 2020年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Preoperative diagnosis of distal cholangiocarcinoma: Focusing on the role of endoscopic-related procedures in its evaluation and management

KAWAKAMI H.

Gastroenterological Endoscopy 62 ( 12 ) 3090 - 3104 2020年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Gastroenterological Endoscopy

In cholangiocarcinoma, preoperative diagnosis of local extension including invasion of the vessels and proximal and/or distal intraepithelial tumor spread (ITS) is important. The mode of local extension of cholangiocarcinoma greatly differs depending on the gross type of the main tumor. In general, the mode of local extension of cholangiocarcinoma is classified into two types: I) papillary and nodular type and ii) infiltrating type. The papillary and nodular type grossly appears as an elevated lesion with a relatively clearly formed border. In the papillary and nodular type, the incidence of extensive ITS, which is continuous with the main tumor and extends ≥ 2cm into the mucosal epithelium, is 25-36%. On the other hand, extramural invasion and submucosal intramural spread are common in the infiltrating type. In the infiltrating type, the incidence of extensive ITS is approximately 3-4%. Therefore, in order to perform curative resection, the extent of ITS into the bile duct mucosal epithelia must be accurately diagnosed in the papillary and nodular type, and the extent of submucosal intramural and extramural spread must be evaluated in the infiltrating type. In this article, the role of endoscopy in the evaluation and management of distal cholangiocarcinoma will be discussed.

DOI： 10.11280/gee.62.3090

特集進化するEUS 診断的EUS　超音波内視鏡下穿刺吸引法　細胞診から生検への新たな展開

河上洋, 内山尚美, 小川宗一郎, 畑田紘志, 久保田良政, 坂哲臣

消化器内視鏡 32 ( 11 ) 1657 - 1664 2020年11月

掲載種別：研究論文（学術雑誌）出版者・発行元：(株)東京医学社

DOI： 10.24479/j02312.2021056141

消化管T細胞リンパ腫

三池　忠，山本章二朗，河上　洋

消化器内視鏡 2020年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）

超音波内視鏡ガイド下穿刺吸引法－細胞診から生検への新たな展開

河上　洋，内山尚美，小川宗一郎，畑田紘志，久保田良政，坂　哲臣

消化器内視鏡 2020年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）

ERCP後膵炎発生率の低減を目的としたearlyとprimary precutの無作為化比較試験

河上　洋

日本消化器内視鏡学会雑誌 2020年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Clinical characteristics of adult T-cell leukemia/lymphoma infiltration in the gastrointestinal tract 査読あり

Tadashi Miike, Hiroshi Kawakami, Takuro Kameda, Shojiro Yamamoto, Yoshihiro Tahara, Tomonori Hidaka, Yoko Kubuki, Kenji Yorita, Yutaka Akiyama, Yasuji Arimura, Yoshimasa Kubota, Hiroaki Kataoka, Kazuya Shimoda

BMC Gastroenterology 20 ( 1 ) 298 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMC Gastroenterology

Background: Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type 1. The clinical course of ATLL is very heterogeneous, and many organs, including the gastrointestinal (GI) tract, can be involved. However, there are few detailed reports on ATLL infiltration in the GI tract. We investigated the clinical characteristics of ATLL infiltration in the GI tract. Methods: This retrospective observational single-center study included 40 consecutive ATLL patients who underwent GI endoscopy. The patients' demographic and clinical characteristics and endoscopic findings were analyzed retrospectively. Patients with ATLL who were diagnosed by histological examination were divided into two groups based on GI tract infiltration. Results: Multivariate analysis revealed that the absence of skin lesions was significantly associated with GI infiltration (P < 0.05). Furthermore, the infiltration group tended to have similar macroscopic lesions in the upper and lower GI tracts, such as diffuse type, tumor-forming type, and giant-fold type. Conclusions: GI endoscopy may be considered for ATLL patients without skin lesions.

DOI： 10.1186/s12876-020-01438-1

Multicenter randomized trial of endoscopic papillary large balloon dilation without sphincterotomy versus endoscopic sphincterotomy for removal of bile duct stones: MARVELOUS trial

Kogure H., Kawahata S., Mukai T., Doi S., Iwashita T., Ban T., Ito Y., Kawakami H., Hayashi T., Sasahira N., Kubota K., Togawa O., Kato H., Okabe Y., Matsubara S., Yagioka H., Saito T., Nakai Y., Isayama H.

Endoscopy 52 ( 9 ) 736 - 744 2020年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Endoscopy

Background Endoscopic papillary large balloon dilation (EPLBD) has been increasingly used for the management of large common bile duct (CBD) stones. Although EPLBD is often preceded by endoscopic sphincterotomy (EST), EPLBD alone without EST has been increasingly reported as an alternative to EST for large CBD stones. Methods This multicenter randomized trial was conducted at 19 Japanese institutions to compare the efficacy and safety of EPLBD alone versus EST for the removal of large (≥ 10 mm) CBD stones. The primary end point was complete stone removal in a single session. The secondary end points included: Overall complete stone removal, lithotripsy use, procedure time, adverse events, and cost. Results 171 patients with large CBD stones were included in the analysis. The rate of single-session complete stone removal was significantly higher in the EPLBD-alone group than in the EST group (90.7 % vs. 78.8 %; P = 0.04). Lithotripsy use was significantly less frequent in the EPLBD group than in the EST group (30.2 % vs. 48.2 %; P = 0.02). The rates of early adverse events were comparable between the two groups: Rates of overall adverse events were 9.3 % vs. 9.4 % and of pancreatitis were 4.7 % vs. 5.9 % in the EPLBD and EST groups, respectively. The procedure costs were $1442 vs. $1661 in the EPLBD and EST groups, respectively (P = 0.12). Conclusion EPLBD without EST for the endoscopic treatment of large CBD stones achieved a significantly higher rate of complete stone removal in a single session compared with EST, without increasing adverse events.

DOI： 10.1055/a-1145-3377

Diarrhea, Fever, and Polyarthralgia with Colitis

Yamamoto S, Miike T, Kawakami H

American Journal of Gastroenterology 115 ( 8 ) 1161 2020年8月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Journal of Gastroenterology

DOI： 10.14309/ajg.0000000000000419

膵・胆管合流異常症

河上　洋

Medical Practice 2020年8月

記述言語：日本語掲載種別：学位論文（その他）

今月の主題 H. pylori未感染胃の上皮性腫瘍主題 H. pylori未感染胃上皮性腫瘍の臨床的特徴

鈴木翔, 上堂文也, 河上洋, 石原立

胃と腸 55 ( 8 ) 981 - 987 2020年7月

掲載種別：研究論文（学術雑誌）出版者・発行元：株式会社医学書院

DOI： 10.11477/mf.1403202088

Planned limited resection of the extrahepatic bile duct in a case of intraductal papillary neoplasm of the bile duct based on preoperative examinations. 査読あり

Nanashima, A., Imamura, N., Hiyoshi, M., Hamada, T., Yano, K., Wada, T., Kawakami, H., Ban, T., Kubota ,Y., Sato, Y. and Harada, K.

Clinical Journal of Gastroenterology 13 ( 2 ) 233 - 239 2020年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Journal of Gastroenterology

Intraductal papillary neoplasm of the bile duct (IPNB) is defined as a non-invasive malignancy; however, since there are disparities in its histological diagnosis, the operative strategy for typical IPNB has not yet been established. A 69-year-old male was diagnosed with a bile duct mass lesion at the confluence of the cystic duct by ultrasonography without clinical symptoms. Liver functional parameters and tumor markers were within normal ranges. Computed tomography showed an enhanced tumor with no findings of ductal invasion or node metastasis. The tumor was exposed in the hepatic duct lumen and biopsy via SpyGlass DS cholangiography revealed that it was a low-grade papillary lesion, indicating type 1 IPNB. Under preoperative diagnostic modalities, limited resection of the extrahepatic bile duct with D2 lymphadenectomy was planned and R0 resection was achieved. The postoperative histological diagnosis was type 1 IPNB without node metastasis. The postoperative course was uneventful and a good prognosis is expected at this stage. In the field of biliary surgery, although extended resection is generally performed for bile duct carcinomas, satisfactory limited surgical resection is possible for type 1 IPNB with lower malignant behavior.

DOI： 10.1007/s12328-019-01049-8

Single rectal neuroendocrine tumor associated with multiple endocrine cell micronests: A case report. 査読あり

Hiroshi Kawakami, Tadashi Miike, Shojiro Yamamoto, Hiroo Abe, Kazuya Shimoda, Shinya Ashizuka, Haruhiko Inatsu, Yoshimasa Kubota, Tesshin Ban, Kenji Yorita, Hiroaki Kataoka

Internal Medicine 30 ( 3 ) 400 - 402 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Internal Medicine

Although a few reports of neuroendocrine tumor (NET) in the stomach or appendix with surrounding micronests have been published, cases of rectal NET are rare. We herein report a unique case of a patient with single rectal NET treated endoscopically. A pathological examination revealed multiple endocrine cell micronests (ECMs) in the submucosal layer around the main NET lesion. Neither lymph node metastasis nor distant metastasis in computed tomography was observed six years after the treatment. Because case reports of multiple ECM are very rare, the significance of malignancy is unclear. It therefore appears to be necessary to accumulate similar cases.

DOI： 10.2169/internalmedicine.3582-19

A novel integrated inside biliary stent and nasobiliary drainage catheter system for biliary drainage (with video)

Kawakami H., Itoi T.

Journal of Hepato-Biliary-Pancreatic Sciences 27 ( 3 ) 149 - 150 2020年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Hepato-Biliary-Pancreatic Sciences

DOI： 10.1002/jhbp.693

Two cases of bile duct carcinoma patients who underwent the photodynamic therapy using talaporfin sodium (Laserphyrin®)

A novel integrated inside biliary stent and nasobiliary drainage catheter system for biliary drainage (with video). 査読あり

Kawakami H, itoi T.

J Hepatobiliary Pancreat Sci 27 ( 3 ) 149 - 150 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Nanashima A., Hiyoshi M., Imamura N., Hamada T., Nishida T., Kawakami H., Ban T., Kubota Y., Nakashima K., Yano K., Wada T., Takeno S., Kai M.

Clinical Journal of Gastroenterology 13 ( 1 ) 102 - 109 2020年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Clinical Journal of Gastroenterology

The efficacy of adjuvant photodynamic therapy (PDT) using the new photosensitizer, talaporfin sodium (TPS) has been clinically examined in some patients with bile duct carcinoma (BDC). Based on our previous cohorts, a prospective clinical trial was attempted; however, only two cases were ultimately enrolled in 27 months. A 664-nm semiconductor laser (100 J/cm2) was applied through an endoscope to the tumor lesion within 6 h of an intravenous injection of 40 mg/m2 TPS according to the protocol for lung cancer. Case 1 was an 82-y.o. female patient with BDC at the left hepatic duct with biliary obstruction, percutaneous transhepatic biliary drainage (PTBD) was achieved, and the patient did not consent to surgery. She was followed up for 15 months to search for non-surgical treatments and eventually received PDT. Although mild photosensitivity occurred, she was discharged without severe adverse events. Biliary stenosis markedly extended and a PTBD tube was scheduled at 1 month. However, cancer immediately metastasized to the liver and she died 155 days after PDT. Case 2 was a 70-y.o. female with perihilar BDC and multiple biliary stenoses. Multiple biliary stenting was considered to be difficult. She received PDT and no adverse events were observed. Biliary stenoses markedly improved and multiple stenting was successfully performed. On day 132, she died of cancer progression. These two cases demonstrated the safety and efficacy of biliary malignant stenosis soon after PDT; however, long-term survival and a sufficient quality of life were not achieved. The combination of the PDT protocol and system chemotherapy or brachytherapy needs to be examined in clinical trials for advanced stage BDC.

DOI： 10.1007/s12328-019-01006-5