論文 - 河上 洋
-
The Asian consensus statements on endoscopic management of walled-off necrosis Part2: Endoscopic management. 査読あり
Isayama H, Nakai Y, Perknimitr R, Kohr C, Lau J, Wang HP, Seo DW, Ratanachu-ek T, Lakhtakia S, Ang TL, Ryozawa S, Hayashi T, Kawakami H, Yamamoto N, Iwashita T, Itokawa F, Kuwatani M, Kitano M, Hanada K, Ponnudurai R, Moon JH, Itoi T, Yasuda I, Irisawa A,
Journal of Gastroenterology and Hepatology 2016年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1111/jgh.13398
-
The Asian consensus statements on endoscopic management of walled-off necrosis Part1: Epidemiology, diagnosis and treatment. 査読あり
Isayama H, Nakai Y, Perknimitr R, Kohr C, Lau J, Wang HP, Seo DW, Ratanachu-ek T, Lakhtakia S, Ang TL, Ryozawa S, Hayashi T, Kawakami H, Yamamoto N, Iwashita T, Itokawa F, Kuwatani M, Kitano M, Hanada K, Ponnudurai R, Moon JH, Itoi T, Yasuda I, Irisawa A,
Journal of Gastroenterology and Hepatology 2016年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1111/jgh.13394
-
Reply to Kadayifci et al 査読あり
Ishiwatari H, Kawakami H, Hisai H, Yane K, Onodera M, Eto K, Haba S, Okuda T, Ihara H, Kukitsu T, Matsumoto R, Kitaoka K, Sonoda T, Hayashi T
Endoscopy 2016年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
-
Kubo K., Kawakami H., Kuwatani M., Nishida M., Kawakubo K., Kawahata S., Taya Y., Kubota Y., Amano T., Shirato H., Sakamoto N.
BMC Gastroenterology 16 ( 1 ) 65 2016年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：BMC Gastroenterology
© 2016 The Author(s). Background: Obstructive jaundice has been reported to influence liver elasticity, independent of liver fibrosis. The aim of our prospective study was to evaluate the changes in liver elasticity, before and after biliary drainage, in patients with obstructive jaundice, and to evaluate the correlation between elasticity measures and serum markers of liver fibrosis. Methods: This is a prospective cohort study of 20 patients with obstructive jaundice. Liver elasticity was assessed by Transient Elastography (TE) and Virtual Touch™ Quantification (VTQ). Serum total bilirubin (T-Bil) level was measured before biliary drainage (Day 0), with measures repeated at 2 days (Day 2) and 7 days (Day 7) after biliary drainage. Serum levels of the following markers of liver fibrosis were also obtained on Day 0 and Day 7: hyaluronic acid (HA), procollagen-III-peptide (P-III-P). Results: T-Bil, TE, and VTQ for the left (VTQ-L) and right (VTQ-R) lobes of the liver were all elevated before biliary drainage, with respective levels, measured at Day 0, of 11.9 ± 1.5 mg/dl, 12.1 ± 0.9 kPa, 2.23 ± 0.10 m/s, and 1.85 ± 0.10 m/s. All values decreased on Day 7 after drainage: T-Bil, 4.7 ± 1.0 mg/dl (P < 0.001); TE, 7.6 ± 0.6 kPa (P < 0.001); VTQ-L, 1.53 ± 0.08 m/s (P < 0.001); and VTQ-R, 1.30 ± 0.05 m/s (P < 0.001). Similar changes were observed in serum markers of liver fibrosis. Liver elasticity measures correlated with serum levels of T-Bil, P-III-P, and HA (r = 0.35-0.67, P < 0.001). Conclusions: This study confirmed decreases in liver elasticity, measured by TE and VTQ, after biliary drainage. Measures of liver elasticity correlated to levels of T-Bil and serum markers of liver fibrosis. (UMIN ID: UMIN00001284313). Trial registration: Registration number: University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN00001284313); Registration date: 2014-01-14.
-
Reply to Rimbas, Kunda 査読あり
Kawakami H, Kawakubo K, Kubota Y, Kuwatani M, Sakamoto N
Endoscopy 2016年7月
記述言語：英語 掲載種別：研究論文（学術雑誌）
-
Reply to Saritas, Ulku
Kawakami H, Kawakubo K, Kubota Y, Kuwatani M, Sakamoto N
Endoscopy 2016年7月
記述言語：英語 掲載種別：研究論文（学術雑誌）
-
A pilot study of a novel, large-bore, fully covered self-expandable metallic stent for unresectable distal biliary malignancies 査読あり
Mukai T, Yasuda I, Isayama H, Iwashita T, Kawakami H, Itoi T, Kogure H, Nakai Y.
Digestive Endoscopy 2016年6月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1111/den.12643
-
Balloon catheter versus basket catheter for endoscopic bile duct stone extraction: a multicenter randomized trial 査読あり
Ishiwatari H, Kawakami H, Hisai H, Yane K, Onodera M, Eto K, Haba S, Okuda T, Ihara H, Kukitsu T, Matsumoto R, Kitaoka K, Sonoda T, Hayashi T; Hokkaido Interventional EUS/ERCP Study (HONEST) Group
Endoscopy 2016年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
-
Transpapillary selective bile duct cannulation technique: Review of Japanese randomized controlled trials since 2010 and an overview of clinical results in precut sphincterotomy since 2004. 査読あり
Kawakami H, Kubota Y, Kawahata S, Kubo K, Kawakubo K, Kuwatani M, Sakamoto N.
Digestive Endoscopy 2016年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1111/den.12621
-
Randomized trial comparing a side-port needle and standard needle for EUS-guided histology of pancreatic lesions. 査読あり
Ishiwatari H, Hayashi T, Kawakami H, Isayama H, Itoi T, Ono M, Kawakubo K, Yamamoto N, Tanaka M, Itokawa F, Oshiro H, Sonoda T, Hasegawa T.
Gastrointestinal Endoscopy 2016年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
-
久保 公利，河上 洋，久保田 良政，川畑 修平，川久保 和道，桒谷 将城，上野 峰，三橋 智子，坂本 直哉 査読あり
久保公利，河上 洋，久保田良政，川畑修平，川久保和道，桒谷将城，上野 峰，三橋智子，坂本直哉．
胆道学会誌 2016年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
-
IgG4-related sclerosing cholangitis: all we need to know. 招待あり 査読あり
Zen Y, Kawakami H, Kim JH
Journal of Gastroenterology 51 ( 4 ) 295 - 312 2016年4月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Springer
-
Kawakami H, Kubota Y, Sakamoto N
Digestive Diseases and Sciences 61 ( 3 ) 660 - 662 2016年3月
担当区分：筆頭著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Digestive Diseases and Sciences
-
Double penetrated duodenal wall during endoscopic ultrasound-guided choledochoduodenostomy
Kawakami H., Kuwatani M., Sakamoto N.
Gut and Liver 10 ( 2 ) 318 - 319 2016年3月
-
Kurihara T., Yasuda I., Isayama H., Tsuyuguchi T., Yamaguchi T., Kawabe K., Okabe Y., Hanada K., Hayashi T., Ohtsuka T., Oana S., Kawakami H., Igarashi Y., Matsumoto K., Tamada K., Ryozawa S., Kawashima H., Okamoto Y., Maetani I., Inoue H., Itoi T.
World Journal of Gastroenterology 22 ( 5 ) 1891 - 1901 2016年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：World Journal of Gastroenterology
© 2016 Baishideng Publishing Group Inc. All rights reserved. AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy (SOCPS) using the SpyGlass system in widespread clinical application for biliary and pancreatic diseases. METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2% (135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5% (84/89) and 88.2% (15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS (bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7% (53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5% (14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2% (23/31) and 42.9% (3/7) of the patients, respectively. Others: SOCPS using the SpyGlass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4% (8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate.
-
Kawakubo K., Kawakami H., Kuwatani M., Kubota Y., Kawahata S., Kubo K., Sakamoto N.
Endoscopy 48 ( 2 ) 164 - 169 2016年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Endoscopy
© Georg Thieme Verlag KG. Background and study aims: Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) has gained popularity as an alternative to percutaneous biliary drainage for patients in whom endoscopic retrograde cholangiopancreatography has failed. There are no previous studies comparing EUS-CDS with endoscopic transpapillary stenting (ETS) as first-line treatment for distal malignant obstruction. The aim of this study was to compare the clinical efficacy and safety of EUS-CDS and ETS as first-line treatment in patients with distal malignant biliary obstruction. Patients and methods: A total of 82 patients with distal malignant biliary obstruction underwent initial biliary drainage using self-expandable metal stents at a tertiary care university hospital. ETS was performed between June 2009 and May 2012, and EUS-CDS was performed between May 2012 and March 2014. Clinical success rates, adverse event rates, and reintervention rates were retrospectively evaluated for EUS-CDS and ETS. Results: A total of 26 patients underwent EUS-CDS and 56 underwent ETS. Clinical success rates were equivalent between the groups (EUS-CDS 96.2%, ETS 98.2%; P=0.54). The mean procedure time was significantly shorter with EUS-CDS than with ETS (19.7 vs. 30.2 minutes; P < 0.01). The rate of overall adverse events was not significantly different between the groups (EUS-CDS 26.9%, ETS 35.7%; P=0.46). Post-procedural pancreatitis was only observed in the ETS group (0% vs. 16.1%; P=0.03). The reintervention rate at 1 year was 16.6% and 13.6% for EUS-CDS and ETS, respectively (P=0.50). Conclusions: EUS-CDS performed by expert endoscopists was associated with a short procedure time and no risk of pancreatitis, and would therefore be feasible as a first-line treatment for patients with distal malignant biliary obstruction.
-
Kawakubo K., Ohnishi S., Hatanaka Y., Hatanaka K., Hosono H., Kubota Y., Kamiya M., Kuwatani M., Kawakami H., Urano Y., Sakamoto N.
Molecular Imaging and Biology 18 ( 3 ) 463 - 471 2016年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Molecular Imaging and Biology
© 2015, World Molecular Imaging Society. Purpose: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is the most reliable method for the histological diagnosis of pancreatic tumors. Rapid on-site fluorescence-guided histological diagnosis was evaluated by topically applying an enzymatically activatable probe onto the EUS-FNA samples; the probe fluoresces in the presence of γ-glutamyltranspeptidase (GGT). Procedures: We evaluated GGT expression in pancreatic cancer cell lines in vitro. EUS-FNA was performed in 10 pancreatic tumors. After topical application of the probe, signal intensity was measured using a fluorescence imaging system for 13 min. Results: GGT was expressed in Panc-1, AsPC-1, and AR42J, but not in KP4 cells. In samples from six cases, several regions of the specimens fluoresced and contained adequate tissue for pathological diagnosis. The remaining four non-fluorescent samples contained very small amounts of carcinoma, normal epithelial cells, or no epithelial cells. The signal intensity at 5 min was 25.5 ± 7.7 and 7.7 ± 0.5 in fluorescent and non-fluorescent regions, respectively (p < 0.05). Conclusions: Application of enzymatically activatable probe onto EUS-FNA samples would be feasible for the rapid evaluation of tissues suitable for histological diagnosis.
-
Kawakami H., Kubota Y., Kawahata S., Kubo K., Okabayashi S., Tatsumi R., Sakamoto N.
Endoscopy 48 E146 - E147 2016年
-
Eto K., Kawakami H., Haba S., Yamato H., Okuda T., Yane K., Hayashi T., Ehira N., Onodera M., Matsumoto R., Matsubara Y., Takagi T., Sakamoto N.
Journal of Hepato-Biliary-Pancreatic Sciences 22 ( 12 ) 825 - 830 2015年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Hepato-Biliary-Pancreatic Sciences
© 2015 Japanese Society of Hepato-Biliary-Pancreatic Surgery. Background Two-stage treatment involving stone removal after drainage is recommended for mild to moderate acute cholangitis associated with choledocholithiasis. However, single-stage treatment has some advantages. We aimed to assess the efficacy and safety of single-stage endoscopic treatment for mild to moderate acute cholangitis associated with choledocholithiasis. Methods A multicenter, non-randomized, open-label, exploratory clinical trial was performed in 12 institutions. A total of 50 patients with a naïve papilla and a body temperature ≥37 °C who were diagnosed with mild to moderate cholangitis associated with choledocholithiasis were enrolled between August 2012 and February 2014. Results Of the 50 patients, 15 had mild cholangitis and 35 had moderate cholangitis. The median number of common bile duct stones was 2 (range, 1-8), and the median diameter of the common bile duct stones was 7.5 mm (range, 1-18). The cure rate of acute cholangitis within 4 days after single-stage treatment was 90% (45/50) based on a body temperature < 37 °C for ≥24 h. The incidence of complications was 10% (5/50). Conclusion Single-stage endoscopic treatment may be effective and safe for mild to moderate acute cholangitis associated with choledocholithiasis (clinical trial registration number: UMIN000008494). Highlight Eto and colleagues demonstrated high cure rates and low complication rates in the first multicenter prospective study to verify the still controversial efficacy and safety of single-stage endoscopic treatment involving endoscopic retrograde cholangiopancreatography and sphincterotomy for mild to moderate acute cholangitis associated with choledocholithiasis according to the TG07.
DOI： 10.1002/jhbp.296
-
Abe Y., Kawakami H., Oba K., Hayashi T., Yasuda I., Mukai T., Isayama H., Ishiwatari H., Doi S., Nakashima M., Yamamoto N., Kuwatani M., Mitsuhashi T., Hasegawa T., Hirose Y., Yamada T., Tanaka M., Sakamoto N., Kawakami H., Abe Y., Kuwatani M., Kawakubo K., Haba S., Kudo T., Kawahata S., Kubo K., Kubota Y., Sakamoto N., Mitsuhashi T., Marukawa K., Moriya J., Oba K., Hayashi T., Ishiwatari Y., Ono M., Hasegawa T., Nakanishi K., Ogino J., Sanuma H., Yasuda I., Doi S., Iwashita T., Hirose Y., Mukai T., Nakashima M., Yamada T., Etori M., Isayama H., Yamamoto N., Tanaka M.
Gastrointestinal Endoscopy 82 ( 5 ) 837 - 844e1 2015年11月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Gastrointestinal Endoscopy
© 2015 American Society for Gastrointestinal Endoscopy. Background EUS-guided FNA (EUS-FNA) has become the most efficacious way to obtain specimens from a solid lesion adjacent to the GI tract. Previous reports regarding the use of a stylet during EUS-FNA were all based on cytological diagnosis and have showed no significant superiority in terms of diagnostic yield. Objective To clarify the noninferiority of EUS-FNA without a stylet (S-) compared with EUS-FNA with a stylet (S+) on histological assessment. Design A prospective, single-blind, randomized, controlled crossover study. Setting Five tertiary referral centers in Japan. Patients Patients referred for EUS-FNA of a solid lesion. Intervention EUS-FNA S+ and S- in a total of 4 alternate passes with randomization to S+ first or S- first. Main Outcome Measurements The primary endpoint was the acquisition rate of an appropriate and sufficient specimen for histological assessment. The secondary endpoints were cellularity, contamination, bloodiness, diagnostic ability, and diagnostic accuracy. Results We enrolled 107 patients (110 lesions) and analyzed 220 specimens each in the S+ and S- groups. The acquisition rate of appropriate and sufficient specimens in the S+ group was 121 of 220 (55.0%) and 122 of 220 (55.5%) in the S- group. The difference in the acquisition rate of the specimen (S- minus S+) based on the generalized estimating equation was 0.42% (95% confidence interval, -6.72% to 7.56%), which was less than 10% of the prespecified noninferiority margin of this study. With regard to cellularity, contamination, bloodiness score, diagnostic ability, and diagnostic accuracy, there were no significant differences between both groups. There were no dropouts in the study. Limitations A variety of target lesions, multiple pathologists, lack of an assessment of intraobserver and interobserver variability, and a single-blind study for the pathologists. Conclusion EUS-FNA S- is noninferior to EUS-FNA S+ on histological assessment. (Clinical trial registration number: UMIN000008695.)