論文 - 河上 洋
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Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer 査読あり
Kobayashi T., Ishida J., Shimizu Y., Kawakami H., Suda G., Muranaka T., Komatsu Y., Asaka M., Sakamoto N.
Tumor Biology 39 ( 3 ) 2017年3月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Tumor Biology
© 2017, © The Author(s) 2017. RNA-binding motif 5 is a putative tumor suppressor gene that modulates cell cycle arrest and apoptosis. We recently demonstrated that RNA-binding motif 5 inhibits cell growth through the p53 pathway. This study evaluated the clinical significance of RNA-binding motif 5 expression in gastric cancer and the effects of altered RNA-binding motif 5 expression on cancer biology in gastric cancer cells. RNA-binding motif 5 protein expression was evaluated by immunohistochemistry using the surgical specimens of 106 patients with gastric cancer. We analyzed the relationships of RNA-binding motif 5 expression with clinicopathological parameters and patient prognosis. We further explored the effects of RNA-binding motif 5 downregulation with short hairpin RNA on cell growth and p53 signaling in MKN45 gastric cancer cells. Immunohistochemistry revealed that RNA-binding motif 5 expression was decreased in 29 of 106 (27.4%) gastric cancer specimens. Decreased RNA-binding motif 5 expression was correlated with histological differentiation, depth of tumor infiltration, nodal metastasis, tumor–node–metastasis stage, and prognosis. RNA-binding motif 5 silencing enhanced gastric cancer cell proliferation and decreased p53 transcriptional activity in reporter gene assays. Conversely, restoration o f RNA-binding motif 5 expression suppressed cell growth and recovered p53 transactivation in RNA-binding motif 5–silenced cells. Furthermore, RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer.
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Peroral video cholangioscopic findings in a biliary intraductal mucinous cystic neoplasm 査読あり
Kawakami H, Kubota Y, Kubo K, Sato D, Mitsuhashi T, Hirano S, Sakamoto N
Endoscopy 2017年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Rescue technique using a diathermic dilator for an unremovable stent in malignant perihilar biliary obstruction 査読あり
Sugiura R, Kawakami H, Ehira N, Iwanaga I, Uebayashi M, Kuwatani M, Sakamoto N
Endoscopy 2017年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Novel wire-guided fine-gauge bougie dilator for transpapillary or endoscopic ultrasonography-guided biliary drainage 査読あり
Kawakami H, Kubota Y
Endoscopy 2017年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Balloon enteroscopy-assisted biliary drainage using a diathermic dilator followed by placement of a novel ultra-slim metallic stent 査読あり
Kawakami H, Kubota Y, Ashizuka S, Haraguchi M, Sannomiya I.
Endoscopy 2017年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Endoscopic ultrasonography-guided antegrade stenting combined with hepaticogastrostomy/hepaticojejunostomy using ultraslim instruments 査読あり
Kawakami H, Kubota Y
Endoscopy 2017年2月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Nursing care management of photodynamic therapy in digestive tract carcinomas at a single cancer center. 査読あり
Nanashima A, Nakashima K, Kawakami H, Ashizuka S, Kubota Y.
Photodiagnosis and Photodynamic Therapy 2017年1月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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非切除悪性遠位胆管閉塞に対する大口径fully‒covered self‒expandable metallic stentの多施設共同観察研究 査読あり
向井 強，安田 一朗，伊佐山 浩通，岩下 拓司，糸井 隆夫，河上 洋，木暮 宏史，中井 陽介
日本消化器内視鏡学会雑誌 59 ( 10 ) 2546 - 2556 2017年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本消化器内視鏡学会
目的：非切除悪性遠位胆管閉塞に対するcovered self-expandable metallic stent（CSEMS）はtumor ingrowthを予防できるため，uuncovered self-expandable metallic stentより長期の開存期間が期待できる．また，CSEMSのrecurrent biliary obstruction（RBO）の主因であるsludgeによるステント閉塞は，ステント径が大きいほど低率になると報告されている．そこで，われわれは12mm径のfully-covered SEMS（FCSEMS-12）を開発し，臨床的安全性および有用性に関する前向きの多施設共同観察研究を行った．方法：2011年６月から2012年11月の期間に非切除悪性遠位胆管閉塞38例に対してFCSEMS-12を留置した．主要評価項目はステント留置から６カ月後のnon-RBO率とした．結果：手技的および臨床的成功率ともに100％であり，ステント留置６カ月後のnon-RBO率は50％であった．TRBO中央値は184日，生存期間中央値は241日であり，６カ月以内にRBOなく死亡されたのは12例（32％）であった．RBOは10例（26％）で認められ，ステント閉塞は７例（18％），migration ３例（８％）であり，30日以内の早期偶発症を６例（16％；胆嚢炎１例，膵炎１例，高アミラーゼ血症１例，膵管炎１例，腹痛２例）に認めた．reinterventionの際にステント抜去を試みた８例全例で抜去に成功した．結語：われわれが開発したFCSEMS-12の使用は安全で有効性も高く，偶発症発生率も容認できると考える．（Clinical trial registration number：UMIN000007061）
DOI： 10.11280/gee.59.2546
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Ishii M., Takeno S., Nishida T., Nanashima A., Kubota Y., Kawakami H., Umekita Y., Akiyama Y.
International Journal of Surgery Case Reports 34 49 - 55 2017年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：International Journal of Surgery Case Reports
© 2017 The Authors Introduction We report a relatively rare case of esophageal leiomyoma in the upper thoracic esophagus enucleated by thoracoscopic procedures. The usefulness of preoperative diagnosis and an adequate surgical approach are described along with a review of the relevant literature. Presentaion of case A submucosal tumor 45 mm in diameter was detected in the upper thoracic esophagus of a 69-year-old man. The tumor was preoperatively diagnosed from histopathological biopsy under endoscopic ultrasound-guided fine needle aspiration. Thoracoscopic enucleation was therefore preoperatively scheduled under the left decubitus position in consideration of the low risk of malignant disease. Histopathological diagnosis of the resected specimen was benign leiomyoma and patient outcomes were good. Discussion The need for preoperative biopsy of esophageal submucosal tumor is a controversial issue. However, preoperative biopsy provided the benefits to decide the operative procedure or confirm adequate resection, and our experience suggested that preoperative biopsy did not adversely influence subsequent enucleation. Conclusion Precise preoperative diagnosis is necessary to avoid excessive surgery when managing esophageal submucosal tumor.
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No Benefit of Oral Diclofenac on Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis 査読あり
Ishiwatari H, Urata T, Yasuda I, Matsusaki S, Hisai H, Kawakami H, Ono M, Iwashita T, Doi S, Kawakubo K, Hayashi T, Sonoda T, Sakamoto N, Kato J.
Ｄｉｇｅｓｔｉｖe disease and sciences 2016年11月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Kubo K., Kawakami H., Kuwatani M., Nishida M., Kawakubo K., Kawahata S., Taya Y., Kubota Y., Amano T., Shirato H., Sakamoto N.
BMC Gastroenterology 16 ( 1 ) 116 2016年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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The Asian consensus statements on endoscopic management of walled-off necrosis Part2: Endoscopic management. 査読あり
Isayama H, Nakai Y, Perknimitr R, Kohr C, Lau J, Wang HP, Seo DW, Ratanachu-ek T, Lakhtakia S, Ang TL, Ryozawa S, Hayashi T, Kawakami H, Yamamoto N, Iwashita T, Itokawa F, Kuwatani M, Kitano M, Hanada K, Ponnudurai R, Moon JH, Itoi T, Yasuda I, Irisawa A,
Journal of Gastroenterology and Hepatology 2016年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1111/jgh.13398
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The Asian consensus statements on endoscopic management of walled-off necrosis Part1: Epidemiology, diagnosis and treatment. 査読あり
Isayama H, Nakai Y, Perknimitr R, Kohr C, Lau J, Wang HP, Seo DW, Ratanachu-ek T, Lakhtakia S, Ang TL, Ryozawa S, Hayashi T, Kawakami H, Yamamoto N, Iwashita T, Itokawa F, Kuwatani M, Kitano M, Hanada K, Ponnudurai R, Moon JH, Itoi T, Yasuda I, Irisawa A,
Journal of Gastroenterology and Hepatology 2016年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1111/jgh.13394
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Reply to Kadayifci et al 査読あり
Ishiwatari H, Kawakami H, Hisai H, Yane K, Onodera M, Eto K, Haba S, Okuda T, Ihara H, Kukitsu T, Matsumoto R, Kitaoka K, Sonoda T, Hayashi T
Endoscopy 2016年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Kubo K., Kawakami H., Kuwatani M., Nishida M., Kawakubo K., Kawahata S., Taya Y., Kubota Y., Amano T., Shirato H., Sakamoto N.
BMC Gastroenterology 16 ( 1 ) 65 2016年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：BMC Gastroenterology
© 2016 The Author(s). Background: Obstructive jaundice has been reported to influence liver elasticity, independent of liver fibrosis. The aim of our prospective study was to evaluate the changes in liver elasticity, before and after biliary drainage, in patients with obstructive jaundice, and to evaluate the correlation between elasticity measures and serum markers of liver fibrosis. Methods: This is a prospective cohort study of 20 patients with obstructive jaundice. Liver elasticity was assessed by Transient Elastography (TE) and Virtual Touch™ Quantification (VTQ). Serum total bilirubin (T-Bil) level was measured before biliary drainage (Day 0), with measures repeated at 2 days (Day 2) and 7 days (Day 7) after biliary drainage. Serum levels of the following markers of liver fibrosis were also obtained on Day 0 and Day 7: hyaluronic acid (HA), procollagen-III-peptide (P-III-P). Results: T-Bil, TE, and VTQ for the left (VTQ-L) and right (VTQ-R) lobes of the liver were all elevated before biliary drainage, with respective levels, measured at Day 0, of 11.9 ± 1.5 mg/dl, 12.1 ± 0.9 kPa, 2.23 ± 0.10 m/s, and 1.85 ± 0.10 m/s. All values decreased on Day 7 after drainage: T-Bil, 4.7 ± 1.0 mg/dl (P < 0.001); TE, 7.6 ± 0.6 kPa (P < 0.001); VTQ-L, 1.53 ± 0.08 m/s (P < 0.001); and VTQ-R, 1.30 ± 0.05 m/s (P < 0.001). Similar changes were observed in serum markers of liver fibrosis. Liver elasticity measures correlated with serum levels of T-Bil, P-III-P, and HA (r = 0.35-0.67, P < 0.001). Conclusions: This study confirmed decreases in liver elasticity, measured by TE and VTQ, after biliary drainage. Measures of liver elasticity correlated to levels of T-Bil and serum markers of liver fibrosis. (UMIN ID: UMIN00001284313). Trial registration: Registration number: University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN00001284313); Registration date: 2014-01-14.
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Reply to Rimbas, Kunda 査読あり
Kawakami H, Kawakubo K, Kubota Y, Kuwatani M, Sakamoto N
Endoscopy 2016年7月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Reply to Saritas, Ulku
Kawakami H, Kawakubo K, Kubota Y, Kuwatani M, Sakamoto N
Endoscopy 2016年7月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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A pilot study of a novel, large-bore, fully covered self-expandable metallic stent for unresectable distal biliary malignancies 査読あり
Mukai T, Yasuda I, Isayama H, Iwashita T, Kawakami H, Itoi T, Kogure H, Nakai Y.
Digestive Endoscopy 2016年6月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1111/den.12643
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Balloon catheter versus basket catheter for endoscopic bile duct stone extraction: a multicenter randomized trial 査読あり
Ishiwatari H, Kawakami H, Hisai H, Yane K, Onodera M, Eto K, Haba S, Okuda T, Ihara H, Kukitsu T, Matsumoto R, Kitaoka K, Sonoda T, Hayashi T; Hokkaido Interventional EUS/ERCP Study (HONEST) Group
Endoscopy 2016年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Transpapillary selective bile duct cannulation technique: Review of Japanese randomized controlled trials since 2010 and an overview of clinical results in precut sphincterotomy since 2004. 査読あり
Kawakami H, Kubota Y, Kawahata S, Kubo K, Kawakubo K, Kuwatani M, Sakamoto N.
Digestive Endoscopy 2016年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1111/den.12621