論文 - 岡林 環樹
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The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
Yokota S, Okabayashi T, Fujii N
Mediators of inflammation 2010 184328 2010年
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Efficacy of polarized hydroxyapatite and silk fibroin composite dressing gel on epidermal recovery from full-thickness skin wounds.
Okabayashi R, Nakamura M, Okabayashi T, Tanaka Y, Nagai A, Yamashita K
Journal of biomedical materials research. Part B, Applied biomaterials 90 ( 2 ) 641 - 6 2009年8月
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Fosfomycin suppresses chemokine induction in airway epithelial cells infected with respiratory syncytial virus.
Okabayashi T, Yokota S, Yoto Y, Tsutsumi H, Fujii N
Clinical and vaccine immunology : CVI 16 ( 6 ) 859 - 65 2009年6月
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Okabayashi R., Nakamura M., Okabayashi T., Tanaka Y., Nagai A., Yamashita K.
8th World Biomaterials Congress 2008 4 2008年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：8th World Biomaterials Congress 2008
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Occurrence of norovirus infections unrelated to norovirus outbreaks in an asymptomatic food handler population.
Okabayashi T, Yokota S, Ohkoshi Y, Ohuchi H, Yoshida Y, Kikuchi M, Yano K, Fujii N
Journal of clinical microbiology 46 ( 6 ) 1985 - 8 2008年6月
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[Molecular mechanisms for suppression of TLR signaling pathway by virus infection].
Fujii N, Yokota S, Yokosawa N, Okabayashi T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 53 ( 6 ) 710 - 9 2008年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Molecular mechanisms for suppression of TLR signaling pathway by virus infection
Fujii N., Yokota S., Yokosawa N., Okabayashi T.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 53 ( 6 ) 710 - 719 2008年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
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Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
Yokota S, Okabayashi T, Yokosawa N, Fujii N
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22 ( 1 ) 74 - 83 2008年1月
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Suppression of NF-kappaB and AP-1 activation in monocytic cells persistently infected with measles virus.
Indoh T, Yokota S, Okabayashi T, Yokosawa N, Fujii N
Virology 361 ( 2 ) 294 - 303 2007年5月
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Single nucleotide polymorphisms and functional analysis of MxA promoter region in multiple sclerosis.
Furuyama H, Chiba S, Okabayashi T, Yokota S, Nonaka M, Imai T, Fujii N, Matsumoto H
Journal of the neurological sciences 249 ( 2 ) 153 - 7 2006年11月
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Cytokine regulation in SARS coronavirus infection compared to other respiratory virus infections.
Okabayashi T, Kariwa H, Yokota S, Iki S, Indoh T, Yokosawa N, Takashima I, Tsutsumi H, Fujii N
Journal of medical virology 78 ( 4 ) 417 - 24 2006年4月
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[Molecular mechanisms for suppression of interferon system by HSV-1 infection].
Fujii N, Yokota S, Yokosawa N, Okabayashi T
Nihon rinsho. Japanese journal of clinical medicine 64 Suppl 3 171 - 7 2006年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Molecular mechanisms for suppression of interferon system by HSV-1 infection
Fujii N., Yokota S., Yokosawa N., Okabayashi T.
Nippon rinsho. Japanese journal of clinical medicine 64 Suppl 3 171 - 177 2006年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Nippon rinsho. Japanese journal of clinical medicine
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Serum-dependent expression of promyelocytic leukemia protein suppresses propagation of influenza virus.
Iki S, Yokota S, Okabayashi T, Yokosawa N, Nagata K, Fujii N
Virology 343 ( 1 ) 106 - 15 2005年12月
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Viral strategies for escape from host innate immune system
Yokota S., Yokosawa N., Okabayashi T., Fujii N.
Sapporo Medical Journal 74 ( 3-4 ) 17 - 22 2005年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Sapporo Medical Journal
In order to establish infection to host cells, viruses suppress or escape from the host immune response against microorganisms by various strategies. Interferon (IFN) system is an important contributor of innate immunity. IFN is induced by viral infection, and it promotes antiviral state through induction and/or activation of the effector molecules. Many viruses possess the suppression mechanisms for the anti-viral effector molecules, whereas they also perform inhibition of IFN signaling pathway, JAK/STAT pathway. We consider that latter is a most effective strategy counteracting IFN function, because the signaling pathway is an entrance of the system. The strategies counteracting JAK/STAT pathway are varied among virus species. Viruses perform (i) degradation of JAK/STAT components, (ii) suppression of activation (phosphorylation) of the components, (iii) inhibition of nuclear translocation of activated transcription factor, and (iv) induction of host JAK/STAT negative regulator. In this review, we describe details of these strategies, especially our recent results of HSV-1, measles virus and mumps virus.
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication.
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Fujii N
Virology 338 ( 1 ) 173 - 81 2005年7月
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Nuclear localization of Japanese encephalitis virus core protein enhances viral replication.
Mori Y, Okabayashi T, Yamashita T, Zhao Z, Wakita T, Yasui K, Hasebe F, Tadano M, Konishi E, Moriishi K, Matsuura Y
Journal of virology 79 ( 6 ) 3448 - 58 2005年3月
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[Molecular mechanisms for suppression of interferon signal transduction pathways caused by viral infections].
Fujii N, Yokota S, Yokosawa N, Okabayashi T
Uirusu 54 ( 2 ) 169 - 78 2004年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Fujii N., Yokota S.I., Yokosawa N., Okabayashi T.
Uirusu. Journal of virology 54 ( 2 ) 169 - 178 2004年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Uirusu. Journal of virology
In order to establish infection to host cells, viruses suppress or escape from the host immune response against microorganisms by various strategies. Interferon (IFN) system is an important contributor of innate immunity. IFN is induced by viral infection, and it promotes antiviral state through induction and/or activation of the effector molecules. Many viruses possess the suppression or inhibition mechanisms for the anti-viral effector molecules, whereas they also perform inhibition of IFN signaling pathway, JAK/STAT pathway. We consider that latter is a most effective strategy counteracting IFN function, because the signaling pathway is an entrance of the system. The strategies counteracting JAK/STAT pathway are varied among virus species. Viruses perform (i) production of IFN-binding protein, (ii) degradation of JAK/STAT components, (iii) suppression of activation (phosphorylation) of the components, (iv) inhibition of nuclear translocation of activated transcription factor, and (v) induction of host JAK/STAT negative regulator. Here, we present these strategies, especially our recent resulta of HSV1, mumps virus, and measles virus. For example, HSV1 induces a host JAK/STAT negative regulator SOCS3 (suppressor of cytokine signaling-3). Mumps virus V protein promotes degradation of both STAT-1 and STAT-3. Measles virus freezes the flexibility of IFN-alpha receptor complex by the action of viral proteins, C and V.
DOI： 10.2222/jsv.54.169
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Journal of virology 78 ( 12 ) 6282 - 6 2004年6月