論文 - 岡林 環樹
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Growth arrest of epithelial cells during measles virus infection is caused by upregulation of interferon regulatory factor 1.
Yokota S, Okabayashi T, Yokosawa N, Fujii N
Journal of virology 78 ( 9 ) 4591 - 8 2004年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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[Diversity of suppression mechanisms of JAK/STAT pathway by virus infection].
Yokota S, Yokosawa N, Okabayashi T, Fujii N
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 49 ( 4 ) 517 - 25 2004年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Diversity of suppression mechanisms of JAK/STAT pathway by virus infection
Yokota S., Yokosawa N., Okabayashi T., Fujii N.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 49 ( 4 ) 517 - 525 2004年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
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Suppression of thermotolerance in mumps virus-infected cells is caused by lack of HSP27 induction contributed by STAT-1.
Yokota S, Yokosawa N, Kubota T, Okabayashi T, Arata S, Fujii N
The Journal of biological chemistry 278 ( 43 ) 41654 - 60 2003年10月
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Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein.
Moriishi K, Okabayashi T, Nakai K, Moriya K, Koike K, Murata S, Chiba T, Tanaka K, Suzuki R, Suzuki T, Miyamura T, Matsuura Y
Journal of virology 77 ( 19 ) 10237 - 49 2003年10月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Moriishi K., Okabayashi T., Nakai K., Moriya K., Koike K., Murata S., Chiba T., Tanaka K., Suzuki R., Suzuki T., Miyamura T., Matsuura Y.
Journal of Virology 77 ( 19 ) 10237 - 10249 2003年10月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Virology
Hepatitis C virus (HCV) core protein plays an important role in the formation of the viral nucleocapsid and a regulatory protein involved in hepatocarcinogenesis. In this study, we have identified proteasome activator PA28γ (11S regulator γ) as an HCV core binding protein by using yeast two-hybrid system. This interaction was demonstrated not only in cell culture but also in the livers of HCV core transgenic mice. These findings are extended to human HCV infection by the observation of this interaction in liver specimens from a patient with chronic HCV infection. Neither the interaction of HCV core protein with other PA28 subtypes nor that of PA28γ with other Flavivirus core proteins was detected. Deletion of the PA28γ-binding region from the HCV core protein or knockout of the PA28γ gene led to the export of the HCV core protein from the nucleus to the cytoplasm. Overexpression of PA28γ enhanced the proteolysis of the HCV core protein. Thus, the nuclear retention and stability of the HCV core protein is regulated via a PA28γ-dependent pathway through which HCV pathogenesis may be exerted.
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Detection of Babesia microti-like parasite in filter paper-absorbed blood of wild rodents.
Okabayashi T, Hagiya J, Tsuji M, Ishihara C, Satoh H, Morita C
The Journal of veterinary medical science 64 ( 2 ) 145 - 7 2002年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Satoh H., Tsuneki A., Inokuma H., Kumazawa N., Jahana Y., Kiyuuna T., Okabayashi T., Muramatsu Y., Ueno H., Morita C.
Microbiology and Immunology 45 ( 1 ) 85 - 87 2001年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Microbiology and Immunology
We evaluated serum antibodies against Rickettsia japonica in 517 dogs (430 stray dogs and 87 pet dogs) and 164 humans in Okinawa, Japan, by indirect immunofluorescence assay. The seropositive rate in stray dogs was significantly higher than that in pet dogs (30.7 versus 4.6%, P<0.01). This high prevalence rate is attributed to the understandably frequent environmental exposure of stray dogs to tick infestation. Human samples obtained from Okinawa and Sapporo also showed a significant difference in seropositive antibody percentages (45.1 and 12.0%, respectively, P<0.01). This result suggests that there has been pre-exposure to spotted fever group rickettsia in humans in Okinawa.
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Prevalence of spotted fever Rickettsial antibodies in dogs and rodents in the Philippines
Camer G.A., Masangkay J., Satoh H., Okabayashi T., Norizuki S., Motoi Y., Ueno H., Morita C.
Japanese Journal of Infectious Diseases 53 ( 4 ) 162 - 163 2000年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Infectious Diseases
Antibodies against spotted fever group rickettsiae have been detected in blood samples of dogs and rodents obtained from selected areas in the Philippines. In this serosurvey, the positive percentage rates are 8.3% (11/132) in dogs and 12.2% (6/49) in rats. Positive results were read from samples tested with Rickettsia japonica antigen. No positive result was obtained in blood samples of rats and house mice using R. akari antigen. The findings of this study are the first to confirm the detection of spotted fever group rickettsial antibodies in the Philippines.
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Okabayashi T., Hasebe F., Samui K., Mweene A., Pandey S., Yanase T., Muramatsu Y., Ueno H., Morita C.
American Journal of Tropical Medicine and Hygiene 61 ( 1 ) 70 - 72 1999年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：American Journal of Tropical Medicine and Hygiene
The causative agents of rickettsial diseases (Rickettsia conorii, R. typhi, and Coxiella burnetii) have been reported throughout the African continent. However, there have been no reports on epidemiologic surveys of these infections in Zambia. This study was designed to clarify the prevalence of three rickettsioses in 377 humans in Zambia. The seroprevalence of antibodies against R. conorii, R. typhi, and C. burnetii was 16.7%, 5.0%, and 8.2%, respectively. The rates of antibody positivity against R. conorii and C. burnetii were higher in the eastern (23.1% and 11.8%) and western (16.8% and 7.4%) areas of Zambia than in the northern (3.0% and 3.0%) area of this country. There was little difference among the three areas in the distribution of antibodies against R. typhi. Since cattle breeding is more extensive in the western and eastern areas than in the northern area, it is thought that cattle-breeding areas are foci of R. conorii and C. burnetii infections in Zambia.
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Ibrahim I., Okabayashi T., Ristiyanto, Lestari E., Yanase T., Muramatsu Y., Ueno H., Morita C.
European Journal of Epidemiology 15 ( 1 ) 89 - 93 1999年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：European Journal of Epidemiology
The prevalence of antibodies against spotted fever group rickettsia (SFGR), murine typhus and Q fever were investigated in wild rats captured in Indonesia. Sera of 327 rats were collected from Jakarta and Boyolali on Java Island. The prevalences of antibodies against SFGR and murine typhus were 128 (39.1%) and 48 (14.7%), respectively. Antibodies against Q fever were not detected in these serum samples. Antibodies against SFGR were found in all species of rats (20.8-51.9%). The antibody positive rate against murine typhus in Rattus norvegicus (38.0%) was significantly higher than that in other rat species (0-4.8%,p < 0.01). The antibody positive rates against SFGR and murine typhus in rats captured in Jakarta were significantly higher than those in rats captured in Boyolali (p < 0.01). In this survey, all species of rats had antibodies against SFGR, indicating that the 4 species of tested rats (R. norvegicus, R. rattus, R. exulans, R. tiomanicus) were infected with SFGR and that SFGR may infest the whole of Java Island. Most of the rats that were antibody-positive against murine typhus were captured in Jakarta. Therefore, R. norvegicus and R. rattus are likely to be important hosts of murine typhus in Jakarta. The antibody-positive rates against SFGR and murine typhus in rats captured in the dry season were significantly higher than those in rats captured in the rainy season. This may coincide with the active periods of ticks and fleas in Indonesia.
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Detection of Coxiella burnetii from dust in a barn housing dairy cattle 査読あり
Yanase T., Muramatsu Y., Inouye I., Okabayashi T., Ueno H., Morita C.
Microbiology and Immunology 42 ( 1 ) 51 - 53 1998年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Microbiology and Immunology
We attempted to detect Coxiella burnetii in dust samples collected from a barn housing dairy cattle by the polymerase chain reaction (PCR) method. Ten dust samples (five from ventilation fans and five from crossbeams) were collected from two areas in a barn on a farm near Sapporo, Hokkaido. C. burnetii was detected in 5 of the 10 dust samples. It was believed that aerial contamination by C. burnetii occurred in the barn.
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Muramatsu Y., Yanase T., Okabayashi T., Ueno H., Morita C.
Applied and Environmental Microbiology 63 ( 6 ) 2142 - 2146 1997年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Applied and Environmental Microbiology
The use of an adequate concentration of Triton X-100 enhanced immunomagnetic separation of Coxiella burnetii from milk. PCR-enzyme-linked immunosorbent assay (PCR-ELISA) could detect coxiellas more sensitively than could conventional PCR. PCR-ELISA is therefore thought to be suitable for the simultaneous assay of a large number of samples. However, the number of cows from which raw milk tested positive for coxiellas by PCR-ELISA was inconsistent with that found with the antibody to coxiella by indirect immunofluorescence assay. The inconsistency is thought to be associated with the differences in the infectious route, infectious dose, or the timing of yielding the antibody and the period of duration of the antibody.
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Serological Survey of Spotted Fever Group Rickettsia in Wild Rats in Thailand in the 1970s
Okabayashi Tamaki, Tsutiya Kimiyuki, Muramatsu Yasukazu, UENO Hiroshi, MORITA Chiharu
Microbiology and immunology 40 ( 12 ) 895 - 898 1996年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Center for Academic Pub. Japan
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Serological survey of spotted fever group rickettsia in wild rats in thailand in the 1970s
Okabayashi T., Tsutiya K., Muramatsu Y., Ueno H., Morita C.
Microbiology and Immunology 40 ( 12 ) 895 - 898 1996年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Microbiology and Immunology
In Thailand, the first human cases of spotted fever group rickettsiosis were reported in 1994, but no serosurveys on wild rats have yet been conducted. We investigated the seroepidemiology in wild rats collected in the 1970s from two regions in Thailand, and found a 62.2% positive rate of antibodies for spotted fever group rickettsia (SFGR) by the indirect immunofluorescence antibody test. Of the antibody-positive rats, 82.2% had higher titers of antibodies against TT-118 than those against Rickettsia japonica, which suggests that Thailand is infested mainly with the TT-118 strain or its antigenically related organisms. The prevalence of antibodies in Bandicota indica was significantly higher than that in other species, which suggests that B. indica is important as a reservoir of SFGR in Thailand.
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Serological Survey of Spotted Fever Group Rickettsia in Wild Rats in Thailand in the 1970s
Okabayashi Tamaki, Tsutiya Kimiyuki, Muramatsu Yasukazu, Ueno Hiroshi, Morita Chiharu
MICROBIOLOGY and IMMUNOLOGY 40 ( 12 ) 895 - 898 1996年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Center For Academic Publications Japan
In Thailand, the first human cases of spotted fever group rickettsiosis were reported in 1994, but no serosurveys on wild rats have yet been conducted. We investigated the seroepidemiology in wild rats collected in the 1970s from two regions in Thailand, and found a 62.2% positive rate of antibodies for spotted fever group rickettsia (SFGR) by the indirect immunofluorescence antibody test. Of the antibody-positive rats, 82.2% had higher titers of antibodies against TT-118 than those against <i>Rickettsia japonica</i>, which suggests that Thailand is infested mainly with the TT-118 strain or its antigenically related organisms. The prevalence of antibodies in <i>Bandicota indica</i> was significantly higher than that in other species, which suggests that <i>B. indica</i> is important as a reservoir of SFGR in Thailand.
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Epidemiological survey of small rodents for spotted fever rickettsial antibody in Hokkaido, Japan
Okabayashi T., Miura N., Miyazaki S., Nigo T., Muramatsu Y., Ueno H., Morita C.
Japanese Journal of Medical Science and Biology 49 ( 2 ) 63 - 68 1996年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Medical Science and Biology
The prevalence of antibody against spotted fever group rickettsia (SFGR) was investigated with Rickettsia japonica antigen in small rodents captured in an area in Hokkaido, where no human cases of SFGR infection had been reported. Antibody against SFGR was found in Apodemus speciosus and Clethrionomys rufocanus but not in Apodemus argenteus. None of these rodents had antibody against R. typhi. This is the first report of the antibody against SFGR in rodents in Hokkaido.