論文 - 菅本 和寛
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Sasaki S., Tozawa T., Sugamoto K., Matsushita Y., Satoh T.
Neuroscience Letters 548 132 - 136 2013年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Neuroscience Letters
Green plant-origin electrophilic compounds are a newly recognized class of neuroprotective compounds that provide neuroprotection through activation of the Nrf2/ARE pathway. Electrophilic hydroquinones are of particular interest due to their ability to become electrophilic quinones upon auto-oxidation. Although green plants frequently produce a variety of electrophilic compounds, the detailed mechanisms of action of these compounds remain unknown. Here, we focused on the neuroprotective effects of 11,14-dihydroxy-8,11,13-abietariene (DA1), derived from a para-hydroquinone-type pro-electrophilic compound from the cryptoquinone. DA1 activated the Nrf2/ARE pathway, induced phase 2 enzymes, and increased glutathione, thus protecting neuronal cells from oxidative stress. DA1 had a very broad safety zone (199.41 fold) at least in our system. Thus, DA1 is a novel neuroprotective pro-electrophilic diterpene from green plant. © 2013 Elsevier Ireland Ltd.
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Arung E., Furuta S., Sugamoto K., Shimizu K., Ishikawa H., Matsushita Y., Kondo R.
Natural Product Communications 7 ( 8 ) 1007 - 1010 2012年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Natural Product Communications
In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.
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Sugamoto K., Matsushita Y., Matsui T.
Letters in Organic Chemistry 9 ( 4 ) 263 - 266 2012年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Letters in Organic Chemistry
Abstract: The hydrotalcite-like compound having ruthenium ions, cobalt ions, and iron ions in the Brucite layer and CO3 anions in the interlayer (Ru-Co-Fe-CO3HTLC) was found to be effective heterogeneous catalyst for the solvent-free oxidative coupling of 2-naphthols in aerobic conditions. The catalyst could be easily recovered and reused repeatedly for the reaction. © 2012 Bentham Science Publishers.
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Sugamoto K., Matsusita Y., Matsui K., Kurogi C., Matsui T.
Tetrahedron 67 ( 29 ) 5346 - 5359 2011年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Tetrahedron
Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin (1a), xanthoangelol (1e), xanthoangelol F (1f), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone (1b), 1e, 1f, bavachalcone (5a), and broussochalcone B (5b) were found to inhibit Gram-positive bacteria. © 2011 Elsevier Ltd. All rights reserved.
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Microwave-assisted Beckmann rearrangement of aryl ketoximes catalyzed by in(OTf)3 in ionic liquid
Sugamoto Kazuhiro,Matsushita Yoh-Ichi,Matsui Takanao
Synthetic Communications 41 ( 6 ) 879 - 884 2010年12月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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松下 洋一, 塩盛 弘一郎, 菅本 和寛, 宮武 宗利, 倉内 誠尚, 中原 重弘
工学教育 58 ( 5 ) 44 - 49 2010年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本工学教育協会
The creative program for chemical experiments in high school has been developed for five years by cooperation between Faculty of Engineering, University of Miyazaki and Miyakonojo Izumigaoka Senior High School through the science partnership program (SPP) planed by the Ministry of Education and Science. Practical experiments of the formation of organic gel and then evaluation of its properties were mainly selected for the program. Although the students learned the gel formation for the first time in this program, they felt great interest in exciting behavior of the gel. The useful educational materials to the high school students was established in the SPP.
DOI： 10.4307/jsee.58.5_44
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Matsushita Y., Sugamoto K., Iwakiri Y., Yoshida S., Chaen T., Matsui T.
Tetrahedron Letters 51 ( 30 ) 3931 - 3934 2010年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Tetrahedron Letters
Methyl 8,11,13-abietatriene-18-oate (1b) and 7-oxo-8,11,13-abietatrienes 10 and 15 were converted into 15-hydroperoxy-7-oxo-8,11,13-abietatrienes 13 and 16 by aerobic oxidation catalyzed by N-hydroxyphthalimide (NHPI) combined with 2,2′-azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) at room temperature, and several abietane and podocarpane terpenes were synthesized from 13 and 16. © 2010 Elsevier Ltd. All rights reserved.
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Aerobic oxidation of 8,11,13-abietatrienes catalyzed by N-hydroxyphthalimide combined with 2,20-azobis(4-methoxy-2,4-dimethylvaleronitrile) and its application to synthesis of naturally occurring diterpenes「(共著)」 査読あり
Yoh-ichi Matsushita, Kazuhiro Sugamoto, Yoshihisa Iwakiri, Satoru Yoshida, Takehito Chaen, Takanao Matsui,
Tetrahedron Letters 51 3931 - 3934 2010年7月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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菅本 和寛, 斎藤 泰男, 松井 佳菜, 松下 洋一
化学と教育 58 ( 9 ) 2010年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：公益社団法人 日本化学会
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オビスギ精油の成分について「(共著)」 招待あり
菅本和寛，松下洋一，松井隆尚，藤本英人
aromatopia 18 ( 6 ) 14 - 17 2009年11月
記述言語：日本語 掲載種別：研究論文（その他学術会議資料等）
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蒸煮処理により生成するスギ材蒸煮水溶液の成分分析「(共著)」
松井隆尚，松下洋一，菅本和寛，土井良俊輔
宮崎大学工学部紀要 ( 38 ) 79 - 86 2009年9月
記述言語：日本語 掲載種別：研究論文（大学，研究機関等紀要）
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アシタバ (Angelica keiskei Koidzumi)根，茎，および葉部の成分の分離および分析「(共著)」
菅本和寛，松下洋一，松井隆尚，比喜多宏，朴鍾喆
宮崎大学工学部紀要 ( 38 ) 91 - 96 2009年9月
記述言語：日本語 掲載種別：研究論文（大学，研究機関等紀要）
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ヒュウガトウキ(Angelica furcijuga Kitagawa) 葉および茎の分離・分析「(共著)」
松下洋一，菅本和寛，松井隆尚，藤原将智
宮崎大学工学部紀要 ( 38 ) 87 - 90 2009年9月
記述言語：日本語 掲載種別：研究論文（大学，研究機関等紀要）
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Residual of 17β-estradiol in digestion liquid generated from a biogas plant using livestock waste
Suzuki Y., Kubota A., Furukawa T., Sugamoto K., Asano Y., Takahashi H., Sekito T., Dote Y., Sugimoto Y.
Journal of Hazardous Materials 165 ( 1-3 ) 677 - 682 2009年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Hazardous Materials
A biogas plant using livestock waste in which a methane fermentation process is applied is a useful facility for generating energy. The digestion liquid generated from the biogas plant as a residue has high potential for use as a crop fertilizer. However, high-density estrogens such as 17β-estradiol (E2) are included in livestock waste, and there is little information on the behavior of E2 in the digestion liquid. In this study, a survey of E2 concentration at each process in a biogas plant using livestock waste was carried out. In addition, the efficiencies of E2 removal from the digestion liquid by activated carbon adsorption and soil infiltration were examined. The total concentration of E2 in raw livestock waste was reduced to 2 μg/l after treatment, and the removal efficiency of E2 was about 80% for the plant. The methane fermentation process is important not only for the generation of methane but also for the removal of E2. The proportion of E2 conjugates comprising the total E2 concentration was 10% or less in all treated samples. In the plant, there is no likelihood of an increase in estrogen activity by the cleaving of E2 conjugates. By carrying out activated carbon adsorption to remove E2 from the digestion liquid, a large portion of E2 was removed from the digestion liquid, but an E2 concentration of 0.5 μg/l still remained in the treated digestion liquid. In contrast, it was possible to purify the digestion liquid to an E2 concentration of less than 0.002-0.011 μg/l by soil infiltration. It is thus possible to utilize the digestion liquid as a fertilizer without causing aquatic environmental pollution, but factors such as application rate, soil characteristics, and the E2 concentration of digestion liquid should be considered first. © 2008 Elsevier B.V. All rights reserved.
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Residual of 17β-estadiol in digestion liquid generated from a biogas plant using livestock waste「(共著)」 査読あり
Y. Suzuki, A. Kubota, T. Furukawa, K. Sugamoto, Y. Asano, H. Takahashi, T. Sekito, Y. Dote, Y. Sugimoto
Journal of Hazardous Materials 165 677 - 682 2009年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Synthesis of Alkyl β-Glucosides by Transglucosylation Using Pyrococcus furiosus β-Glucosidase Immobilized onto Gelatin Gel 査読あり
Yoh-ichi Matsushita, Hidetaka Nagatomo, Kazuhiro Sugamoto, Takanao Matsui
Letters in Organic Chemistry 6 115 - 119 2009年3月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Matsushita Y., Nagatomo H., Sugamoto K., Matsui T.
Letters in Organic Chemistry 6 ( 2 ) 115 - 119 2009年3月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Letters in Organic Chemistry
Synthesis of alkyl β-glucosides such as p-anisyl β-D- glucopyranoside, phenethyl β-D-glucopyranoside, salidroside, cinnamyl β-D-glucopyranoside, citrusin D, 3-methylbutyl β-D-glucopyranoside, 3-methyl-2-butenyl β-Dglucopyranoside, geranyl β-D-glucopyranoside, perilloside A, and cyclohexyl β-D-glucopyranoside was accomplished in moderate yields by transglucosylation using hyperthermostable Pyrococcus furiosus β-glucosidase immobilized onto gelatin gel. Recovered immobilisate was reusable on successive runs in transglucosylation. © 2009 Bentham Science Publishers Ltd.
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Matsushita Yoh-ichi, Sugamoto Kazuhiro, Miyakubo Kenji, KUROGI Chiaki, MATSUI Takanao, ODA Hisato, FUJIMOTO Hideto
Journal of wood science 54 ( 6 ) 476 - 482 2008年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Springer
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Chemical changes in terpenes of sugi (Cryptomeria japonica) wood during steam drying in kiln at high temperature 査読あり
3) Yoh-ichi Matsushita, Kazuhiro Sugamoto, Kenji Miyakubo, Chiaki Kurogi, Takanao Matsui, Hisato Oda, Hideto Fujimoto
Journal of Wood Science 54 476 - 182 2008年12月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Matsushita Y., Sugamoto K., Miyakubo K., Kurogi C., Matsui T., Oda H., Fujimoto H.
Journal of Wood Science 54 ( 6 ) 476 - 482 2008年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Wood Science
Sawdusts of sugi (Cryptomeria japonica) wood prepared before and after steam drying at 120°C in a kiln were extracted with n-hexane and ethyl acetate to give n-hexane extracts and ethyl acetate extracts. From gas chromatography-mass spectrometry analysis of the ethyl acetate extracts from woods before and after steam drying, the components of 4-epi-cubebol, cubebol, and 2,7(14),10-bis-abolatrien-1-ol-4-one, which existed in the raw sugi wood, were proved to disappear in the steam-dried wood. These components were also absent in the ethyl acetate extract of the steam-condensed solution of waste steam from the kiln outlet. When these three components were treated with 0.2% (v/v) acetic acid solution at 120°C, δ-cadinene was produced as a major product from both 4-epi-cubebol and cubebol by dehydration and cleavage of the cyclopropane ring, and cryptomerone from 2,7(14),10-bisabolatrien-1-ol-4- one by hydration. The chemical changes of the three components presumably occur during steam drying of the sugi wood. © 2008 The Japan Wood Research Society.