論文 - 丸山 治彦
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[Pharmacotherapy of parasitic and tropical diseases in Japan].
Maruyama H, Kimura M
Nihon rinsho. Japanese journal of clinical medicine 70 ( 12 ) 2205 - 17 2012年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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[Pharmacotherapy of parasitic and tropical diseases in Japan].
Maruyama H., Kimura M.
Nihon rinsho. Japanese journal of clinical medicine 70 ( 12 ) 2205 - 2217 2012年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Nihon rinsho. Japanese journal of clinical medicine
Parasitic and tropical diseases are relatively rare in Japan. However, physicians have to realize that a patient may visit your hospital today, who is infected with a potentially fatal parasite. This review focuses on the treatment of the domestic and imported parasitic infections in Japan. Many of the drugs against parasitic diseases, especially imported protozoan diseases, have not been approved, nor have been covered by the National Health Insurance Policy. Therefore, patients who need pharmacotherapy with an unapproved drug have to be treated in one of the hospitals of the Research Group on Chemotherapy of Tropical Diseases, which imports effective drugs against major tropical diseases.
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Efficacy and safety of atovaquone-proguanil in treating imported malaria in Japan: the second report from the research group. 査読あり
Kimura M, Koga M, Kikuchi T, Miura T, Maruyama H.
Parasitology International 61 ( 3 ) 466 - 469 2012年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Kimura M., Koga M., Kikuchi T., Miura T., Maruyama H.
Parasitology International 61 ( 3 ) 466 - 469 2012年9月
担当区分：最終著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Parasitology International
Malaria remains an important health risk among travelers to tropical/subtropical regions. However, in Japan, only 2 antimalarials are licensed for clinical use - oral quinine and mefloquine. The Research Group on Chemotherapy of Tropical Diseases introduced atovaquone-proguanil in 1999, and reported on its excellent antimalarial efficacy and safety for treating non-immune patients with uncomplicated Plasmodium falciparum malaria (20 adult and 3 pediatric cases) in 2006. In the present study, additional cases of malaria were analyzed to confirm the efficacy and safety of this antimalarial drug. Fourteen adult and 2 pediatric cases of P. falciparum malaria and 13 adult cases and 1 pediatric case of P. vivax/. ovale malaria were successfully treated with atovaquone-proguanil, including 3 P. falciparum cases in which the antecedent treatment failed. Two patients with P. vivax malaria were treated twice due to primaquine treatment failure as opposed to atovaquone-proguanil treatment failure. Except for 1 patient with P. falciparum malaria who developed a moderate liver function disturbance, no significant adverse effects were observed. Despite the intrinsic limitations of this study, which was not a formal clinical trial, the data showed that atovaquone-proguanil was an effective and well-tolerated therapeutic option; licensure of this drug in Japan could greatly contribute to individually appropriate treatment options. © 2012 Elsevier Ireland Ltd.
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A novel C-type lectin identified by EST analysis in tissue migratory larvae of Ascaris suum 査読あり
Yoshida A, Nagayasu E, Horii Y, Maruyama H.
Parasitology Research 110 ( 4 ) 1583 - 1586 2012年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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A novel C-type lectin identified by EST analysis in tissue migratory larvae of Ascaris suum. 査読あり
Yoshida A, Nagayasu E, Horii Y, Maruyama H
Parasitology Research 110 ( 4 ) 1583 - 1586 2012年4月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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術前に肝内胆管癌と診断され，抗体検査から肝蛭症が疑われた1切除例 査読あり
黒川 友博, 植田 貴徳, 榎本 剛史, 山本 雅由, 丸山 治彦, 大河内 信弘
日本消化器外科学会雑誌 45 ( 4 ) 387 - 393 2012年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：The Japanese Society of Gastroenterological Surgery
症例は51歳の男性で，全身に掻痒を伴う膨疹を主訴に受診した．血液検査でトランスアミナーゼ上昇を認めたため精査したところ，腹部超音波で肝S7，8に3cm大の腫瘤性病変を認めた．CTでは同部に早期から造影されるが内部の造影効果の弱い辺縁高吸収，内部低吸収な結節を指摘された．他に原発巣を認めず，各種腫瘍マーカー・感染症マーカー陰性であったが，CT造影パターンより肝内胆管癌と診断し，肝部分切除術を施行した．病理組織学的診断では，悪性所見は認められず，壊死を伴う肉芽腫性病変であった．異物巨細胞が目立ち，高度な好酸球浸潤により形成されるCharcot-Leyden結晶が認められたことから寄生虫の可能性が考えられたが，虫体，虫卵は指摘できなかった．血清抗体検査で，肝蛭の抗体が高値ではなかったが，ほかの抗体と比べると完全に陰性と判断できるほど低くなく末梢好酸球が高値ではないことから過去に感染した肝蛭症が強く疑われた．
DOI： 10.5833/jjgs.45.387
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A patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite 査読あり
Yamazaki H, Yamaguchi K, Iwase T, Niki T, Kusunose K, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Fukunaga Y, Nakanishi H, Maruyama H, Matsuoka H, Sata M
Journal of Cardiology Cases 4 ( 2 ) e106 - e109 2011年10月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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A patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite
Yamazaki H, Yamaguchi K, Iwase T, Niki T, Kusunose K, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Fukunaga Y, Nakanishi H, Maruyama H, Matsuoka H, Sata M
Journal of Cardiology Cases 4 ( 2 ) e106 - e109 2011年10月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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A patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite. 査読あり
Yamazaki H, Yamaguchi K, Iwase T, Niki T, Kusunose K, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Fukunaga Y, Nakanishi H, Maruyama H, Matsuoka H, Sata M
Journal of cardiology cases 4 ( 2 ) e106 - e109 2011年10月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Cardiology Cases
A 71-year-old female had worked on a farm in the mountains and noticed itching of the left 3rd toe. She visited a local hospital due to a color change to purple in this area. Attachment of a tick was observed between the left 2nd and 3rd toes, and it was extracted. However, due to persistent pain, she was referred to our department of cardiovascular medicine for close examination and treatment. Lower extremity angiography showed that vascular visualization was poor in the area supplied by the arteries distal to the tick bite site, but the other blood vessels of the toe were clearly visualized. Toe amputation was performed and pathological examination of a surgical specimen revealed that most blood vessels near the necrosis were occluded by thrombi. We speculated that tick bite reactions were associated with thrombogenic vasculopathy. This report shows a patient who developed toe necrosis due to poor blood circulation after an interdigital tick bite. © 2011 Japanese College of Cardiology.
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Izumikawa K., Kohno Y., Izumikawa K., Hara K., Hayashi H., Maruyama H., Kohno S.
Japanese Journal of Infectious Diseases 64 ( 5 ) 428 - 432 2011年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Journal of Infectious Diseases
SUMMARY: We report the case of a 62-year-old man who developed eosinophilic pneumonia due to visceral larva migrans (VLM) that was possibly caused by Ascaris suum. The patient, a resident of the middle Kyushu area who was fond of eating raw porcine liver, complained of dry cough without dyspnea. The chest radiography showed a migration of infiltrative shadow. Transbronchial lung biopsy of the right middle lobe revealed massive infiltration of eosinophils. The multi-dot enzyme-linked immunosorbent assay (ELISA) and microtiter plate ELISA showed positive results for A. suum; therefore, the patient was diagnosed with VLM caused by A. suum. The patient was administered albendazole (600 mg/day) for 28 days; he recovered successfully with no adverse effects except mild liver dysfunction. Several cases of VLM caused by A. suum have been reported in Japan, with a majority of the cases being reported in Kyushu. Careful history taking of the patient's area of residence and dietary habit is essential for the diagnosis of this parasitic disease with underestimated prevalence.
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Eosinophilic pneumonia due to visceral larva migrans possibly caused by Ascaris suum: a case report and review of recent literatures 査読あり
Izumikawa K, Kohno Y, Izumikawa K, Hara K, Hayashi H, Maruyama H, Kohno S
Japanese Journal of Infectious Diseases 64 ( 5 ) 428 - 432 2011年6月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Kawano S., Kato J., Kawano N., Yoshimura Y., Masuyama H., Fukunaga T., Sato Y., Maruyama H., Mihara K., Ueda A., Toyoda K., Imamura T., Kitamura K.
Internal Medicine 50 ( 9 ) 975 - 981 2011年5月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Internal Medicine
Background Eosinophilic myocarditis is a rare clinical entity characterized by eosinophilia and myocardial inflammation with infiltrating eosinophils. The prognosis of patients with eosinophilic myocarditis is difficult to determine due the disease's rarity and varied causes; consequently, standard treatment has not been established. Objective To elucidate the clinical characteristics and treatment outcome of eosinophilic myocarditis, we retrospectively studied 7 patients fulfilling the criteria of the Japanese Circulation Society for eosinophilic myocarditis from among 64 patients admitted to our institution with eosinophilia over a 27-year period. Results The patients' ages at diagnosis ranged from 36 to 83 years (median: 52 years). The etiologies of the eosinophilic myocarditis were found to be idiopathic (3 patients), Churg-Strauss syndrome (2 patients), parasitic infection (1 patient) and chronic eosinophilic leukemia (CEL) (1 patient). In addition to treatment for the underlying disease, we also administered prednisolone at a dose appropriate to the disease severity (6 of 7 patients). The patient who was diagnosed with a parasitic infection was treated only with albendazole, because eosinophilic myocarditis was mild. The patient with CEL was positive for the FIP1 L1-PDGFRα fusion gene and was treated with imatinib. Eosinophilic cationic protein was a useful marker for assessing disease activity and treatment efficacy. At the end of the study, of the seven patients treated, six were alive (86%), giving a mean survival time of 37 ± 40 months (mean ± SD). Conclusion Because eosinophilic myocarditis has various etiologies, it is essential to identify the etiology of the underlying disease. In the majority of eosinophilic myocarditis patients, administration of prednisolone may be an effective therapeutic modality producing a good outcome. © 2011 The Japanese Society of Internal Medicine.
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Notch2 signaling is required for proper mast cell distribution andmucosal immunity in the intestine 査読あり
Sakata-Yanagimoto M, Sakai T, Maruyama H, Nakagami-Yamaguchi E, Kumano K, Kuroakwa M, Ogawa S, Yasutomo K, Chiba S
Blood 117 128 - 134 2011年1月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Transcripts analysis of infective larvae of an intestinal nematode, Strongyloides venezuelensis 査読あり
Yoshida A, Nagayasu E, Nishimaki A, Sawaguchi A, Yanagawa S, Maruyama H
Parasitology International 60 ( 1 ) 75 - 83 2011年1月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Transcripts analysis of infective larvae of an intestinal nematode, Strongyloides venezuelensis.
Yoshida A, Nagayasu E, Nishimaki A, Sawaguchi A, Yanagawa S, Maruyama H
Parasitology international 60 ( 1 ) 75 - 83 2011年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Parasitology International
Free-living infective larvae of Strongyloides nematodes fulfill a number of requirements for the successful infection. They need to endure a long wait in harsh environmental conditions, like temperature, salinity, and pH, which might change drastically from time to time. Infective larvae also have to deal with pathogens and potentially hazardous free-living microbes in the environment. In addition, infective larvae must recognize the adequate host properly, and start skin penetration as quickly as possible. All these tasks are essentially important for the survival of Strongyloides nematodes, however, our knowledge is extremely limited in any one of these aspects. In order to understand how Strongyloides infective larvae meet these requirements, we examined transcripts of infective larvae by randomly sequencing cDNA clones constructed from S. venezuelensis infective larvae. After assembling successfully sequenced clones, we obtained 162 unique singletons and contigs, of which 84 had been significantly annotated. Annotated genes included those for respiratory enzymes, heat-shock proteins, neuromuscular proteins, proteases, and immunodominant antigens. Genes for lipase, small heat-shock protein, globin-like protein and cytochrome c oxidase were most abundantly transcribed, though genes of unknown functions were also abundantly transcribed. There were no hits found against NCBI or NEMABASE4 for 37 (22.3%) EST out of the total 162 EST. Although most of the transcripts were not infective larva-specific, the expression of respiration related proteins was most actively transcribed in the infective larva stage. The expression of astacin-like metalloprotease, small heat-shock protein, S. stercoralis L3Nie antigen homologue, and one unannotated and 2 novel genes was highly specific for the infective larva stage. © 2010 Elsevier Ireland Ltd.
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Zoonotic filariasis caused by Onchocerca dewittei japonica in a resident of Hiroshima Prefecture, Honshu, Japan
Uni S, Boda T, Daisaku K, Ikura Y, Maruyama H, Hasegawa H, Fukuda M, Takaoka H, Bain O.
Parasitology International 59 ( 3 ) 477 - 480 2010年9月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Uni S., Boda T., Daisaku K., Ikura Y., Maruyama H., Hasegawa H., Fukuda M., Takaoka H., Bain O.
Parasitology International 59 ( 3 ) 477 - 480 2010年9月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Parasitology International
A female of Onchocerca sp. was found to be the probable causative agent of a subcutaneous nodule in the left knee of a 70-year-old man in a rural area of Hiroshima Prefecture, Honshu, the main island of Japan. We compared the characteristics of the agent with the features of the four previously suspected species found in cattle and horses in various parts of the world, as well as O. lupi and O. jakutensis that were suspected or proved, respectively, in zoonotic cases in Europe. In addition, the morphologic characteristics of this parasite were compared with those of the four Onchocerca species found in wild animals in Japan. Based on such characteristics as the large triangle ridges, the considerable distance between any two adjacent ridges, and the absence of inner cuticular striae in the longitudinal sections, we found the causative agent in the present case to be identical to the female of Onchocerca dewittei japonica. All five previous cases of zoonotic onchocerciasis in Japan had been found in Oita, Kyushu, the main southern island. This human case caused by O. dewittei japonica suggests that zoonotic onchocerciasis is liable to occur in rural areas in Japan where wild boar, Simulium vectors, and humans overlap. © 2010 Elsevier Ireland Ltd.
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Enko K., Tada T., Ohgo K., Nagase S., Nakamura K., Ohta K., Ichiba S., Ujike Y., Nawa Y., Maruyama H., Ohe T., Kusano K.
Circulation Journal 73 ( 7 ) 1344 - 1348 2009年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Circulation Journal
A 19-year-old man was transferred to hospital because of myocarditis with cardiogenic shock. Echocardiography showed a left ventricular ejection fraction of 23.8% and an intermediate amount of pericardial effusion. The patient immediately received an intra-aortic balloon pump and percutaneous cardiopulmonary support. Right ventricular endomyocardial biopsy was performed in the acute phase and showed extensive eosinophilic inflammatory cell infiltration, severe interstitial edema and moderate myocardial necrosis. High-dose corticosteroids were administered. Because the patient's antibody titer against Toxocara canis was high and his symptoms had appeared after eating raw deer meat, the diagnosis was fulminant eosinophilic myocarditis caused by a hypersensitivity reaction to visceral larval migrans. After starting high-dose corticosteroids, the ejectionfraction dramatically improved, me eosinophilia decreased and the patient made a full recovery.
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Case of creeping disease treated with ivermectin
Senba Y., Tsuda K., Maruyama H., Kurokawa I., Mizutani H., Taniguchi Y.
Journal of Dermatology 36 ( 2 ) 86 - 89 2009年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Dermatology
We report a case of creeping disease treated successfully with ivermectin. A 46-year-old man presented with a 1-month history of pruriginous linear erythema on his right thigh after a visit to Indonesia. Although he had no history of eating raw fish or meat, he walked along the river and in the jungle without wearing shoes. Creeping disease caused by animal hookworm was strongly suspected. The presence of parasite larvae was not confirmed in biopsied skin specimens. In enzyme-linked immunosorbent assay, serum samples were negative for binding to hookworm antigens, including Ancylostoma canium, Necator americanus and Gnathostoma doloresi. He was treated with a single 12 mg oral dose (200 μg/kg) of ivermectin. The eruption and pruritus resolved within a few days after the administration and did not relapse. © 2009 Japanese Dermatological Association.