論文 - 山﨑 正夫
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Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats
Yamasaki M., Mansho K., Ogino Y., Kasai M., Tachibana H., Yamada K.
Journal of Nutritional Biochemistry 11 ( 9 ) 467 - 471 2000年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Nutritional Biochemistry
The purpose of this study was to clarify the effect of conjugated linoleic acid on lipid accumulation in adipose tissue. Sprague-Dawley rats were fed a diet containing 2% conjugated linoleic acid for 1, 3, 6, and 12 weeks. In rats fed 2% conjugated linoleic acid, the weight of perirenal white adipose tissue was comparable with that of rats fed a conjugated linoleic acid-free diet. For fatty acid composition of perirenal white adipose tissue, both 16:1/16:0 and 18:1/18:0 ratios were significantly lower in the conjugated linoleic acid-fed group than the control group. Although there was no remarkable difference in serum triglyceride, total cholesterol, and phospholipid levels between dietary groups, serum leptin level was significantly lower than the control group, and lipid content in the perirenal white adipose tissue exerted a tendency toward low compared to the control value at 1-week feeding. On the other hand, leptin level in perirenal white adipose tissue was significantly lower in the conjugated linoleic acid-fed group than the control group at 12-week feeding. In conclusion, these observations suggest dietary conjugated linoleic acid is an acute reducer of serum leptin level. This may afford an explanation of the mechanism of anti-obesity effect in conjugated linoleic acid. (C) Elsevier Science Inc. 2000.
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Effect of dietary conjugated linoleic acid on lipid peroxidation and histological change in rat liver 査読あり
M. Yamasaki, K. Mansho, H. Mishima, G. Kimura, M. Sasaki, M. Kasai, H. Tachibana, and K. Yamada
Journal of Agricultural and Food Chemistry 2000年12月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Regulation of serum leptin level by dietary conjugated linoleic acid.
M. Yamasaki, K. Mansho, Y. Ogino, M. Kasai, H. Tachibana, and K. Yamada.
Animal Cell Technology for creation of new era 12 467 - 472 2000年12月
記述言語：英語 掲載種別：研究論文（国際会議プロシーディングス）
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Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes 査読あり
M. Yamasaki, K. Kishihara, K. Mansho, Y. Ogino, M. Kasai, M. Sugano, H. Tachibana and K. Yamada
Bioscience Biotechnology Biochemistry 2000年10月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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A recommended esterification method for gas chromatographic measurement of conjugated linoleic acid. 査読あり
M. Yamasaki, K. Kishihara, I. Ikeda, M. Sugano, and K. Yamada
Journal of American Oil Chemists Society 1999年8月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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O-412 肝虚血再灌流障害 : Nutritional immunomodulationの応用 査読あり
宇都宮 徹、島田 光生、祇園 智信、長谷川 博文、山崎 正夫、加来 志保子、山田 耕路、杉町 圭蔵
日本外科学会雑誌 100 210 1999年2月
記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Yamasaki M., Mansho K., Mishima H., Kasai M., Sugano M., Tachibana H., Yamada K.
Bioscience, Biotechnology and Biochemistry 63 ( 6 ) 1104 - 1106 1999年1月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Bioscience, Biotechnology and Biochemistry
We examined the effect of dietary conjugated linoleic acid (CLA) on lipid parameters in the liver, white adipose tissue (WAT) and brown adipose tissue (BAT) of Sprague-Dawley rats and found that it reduced the levels of triglycerides and non-esterified fatty acid in the liver and WAT without significant change in the BAT lipid levels. These results suggest that CLA has an obesity-preventing action. © 1999, Taylor & Francis Group, LLC. All rights reserved.
DOI： 10.1271/bbb.63.1104
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Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats
Sugano M., Tsujita A., Yamasaki M., Noguchi M., Yamada K.
Lipids 33 ( 5 ) 521 - 527 1998年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Lipids
The effects of conjugated linoleic acid (CLA) on the levels of chemical mediators in peritoneal exudate cells, spleen and lung, and the concentration of immunoglobulins in mesenteric lymph node and splenic lymphocytes and in serum were examined in rats. After feeding diets containing either 0 (control), 0.5 or 1.0% CLA for 3 wk, there was a trend toward a reduction in the release of leukotriene B 4 (LTB 4 ) from the exudate cells in response to the dietary CLA levels. However, CLA did not appear to affect the release of histamine. A similar dose-response pattern also was observed in splenic LTB 4 , lung LTC 4 and serum prostaglandin E 2 levels, and the differences in these indices between the control and 1.0% CLA groups were all statistically significant. The reduction by CLA of the proportions of n-6 polyunsaturated fatty acids in peritoneal exudate cells and splenic lymphocyte total lipids seems to be responsible at least in part for the reduced eicosanoid levels. Splenic levels of immunoglobulin A (IgA), IgG, and IgM increased while those of IgE decreased significantly in animals fed the 1.0% CLA diet. This was reflected in the serum levels of immunoglobulins. The levels of IgA, IgG, and IgM in mesenteric lymph node lymphocytes increased in a dose-dependent manner, while IgE was reduced in those fed the higher CLA intake. However, no differences were seen in the proportion of T-lymphocyte subsets of mesenteric lymph node. These results support the view that CLA mitigates the food- induced allergic reaction.
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Lymphatic recovery, tissue distribution, and metabolic effects of conjugated linoleic acid in rats. 査読あり
M. Sugano, A. Tsujita, M. Yamasaki, K. Yamada, I. Ikeda and D. Kritchevsky
Journal of Nutritional Biochemistry 1997年1月
記述言語：英語 掲載種別：研究論文（学術雑誌）