論文 - 田島　卓也

肩関節脱臼後に腋窩神経麻痺を伴った腱板広範囲断裂の治療経験

石田 康行, 帖佐 悦男, 矢野 浩明, 山本 恵太郎, 河原 勝博, 田島 卓也, 小牧 ゆか, 樋口 誠二, 酒井 健, 海田 博志

整形外科と災害外科   56 ( 4 )   525 - 528   2007年9月

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：西日本整形・災害外科学会  

【目的】神経麻痺を伴った腱板断裂の治療法は見解が分かれる．我々は肩関節脱臼後に腋窩神経麻痺を伴った腱板広範囲断裂2例に対し鏡視下腱板修復術を行い良好な成績を得たので報告する．【症例1】60歳，男性．転倒し右肩関節受傷．右肩自力挙上困難にて受傷後6週で初診．右三角筋に筋萎縮，右肩外側に痺れ感を認めた．受傷後3ヶ月で鏡視下腱板修復術施行した．JOA scoreは術前31点が術後1年で94点に改善した．【症例2】47歳，男性．転倒し右肩関節受傷．右肩自力挙上困難にて受傷後3週で初診．右三角筋の筋萎縮，右肩外側に痺れ感を認め，EMGにて右三角筋に安静時脱神経電位を認めた．受傷後1ヶ月で鏡視下腱板修復術を施行した．JOA scoreは術前45点が術後6ヶ月で93点に改善した．【考察】腱板の変性を考えると断裂が大きい場合は神経の回復傾向がみられたら早期に手術を考慮していいのではと考える．

DOI： 10.5035/nishiseisai.56.525

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Hemoglobin stimulates the expression of matrix metalloproteinases, MMP-2 and MMP-9 by synovial cells: A possible cause of joint damage after intra-articular hemorrhage

Tajima T., Yoshida E., Yamashita A., Ohmura S., Tomitaka Y., Sugiki M., Asada Y., Maruyama M.

Journal of Orthopaedic Research   23 ( 4 )   891 - 898   2005年7月

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Orthopaedic Research  

Intra-articular bleeding causes degradation of articular cartilage leading to joint disorders, but the mechanisms is not well understood. The present study examined the effect of hemoglobin on the ability of synovial tissues to produce plasminogen activators and matrix metalloproteinases that play important roles in the degradation of articular cartilage. Human Hb added to primary cultures of human knee synovial cells markedly increased fibrinolytic activity and gelatinolytic activity. The fibrinolytic activity was due to an increase in uPA activity. Western blot analysis and gelatin zymography indicated that the increased gelatinolytic activity was due to increased MMP-2 and -9. In order to know whether the effect of Hb on cultured synovial tissue is also true in in vivo system or not, rabbit hemoglobin was injected into rabbit knee joints. Coinciding with in vitro study, hemoglobin elicited considerable increase in fibrinolytic and gelatinolytic activity. The level of proteoglycan fragments in the hemoglobin-treated joint fluid was significantly elevated, indicating cartilage matrix degradation. Cartilage damage after hemoglobin treatment was also confirmed by histological study. These findings suggest that hemoglobin stimulates the secretion of uPA, MMP-2 and MMP-9 by synovial tissues, and raise a possible role of hemoglobin in joint damage after intra-articular bleeding. © 2005 Published by Elsevier Ltd. on behalf of Orthopaedic Research Society.

DOI： 10.1016/j.orthres.2005.01.003

Scopus

PubMed

ラグビー競技会における安全評価法の活用

田島 卓也, 柏木 輝行, 矢野 良英, 帖佐 悦男, 山本 恵太郎, 吉川 大輔, 吉川 教恵

日本整形外科スポーツ医学会雑誌 = Japanese journal of orthopaedic sports medicine   25 ( 1 )   2005年6月

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記述言語：日本語   掲載種別：研究論文（学術雑誌）  

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