論文 - 田島 卓也
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Miyazaki S, Funamoto T, Sekimoto T, Kurogi S, Ohta T, Nagai T, Tajima T, Imasaka M, Yoshinobu K, Araki K, Araki M, Choijookhuu N, Hishikawa Y, Chosa E
Acta histochemica et cytochemica 55 ( 3 ) 99 - 110 2022年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本組織細胞化学会
Epithelial protein lost in neoplasm (EPLIN) is an actin-associated cytoskeletal protein that plays an important role in epithelial cell adhesion. EPLIN has two isoforms: EPLINα and EPLINβ. In this study, we investigated the role of EPLINβ in osteoblasts using EPLINβ-deficient (<i>EPLINβ<sup>GT/GT</sup></i>) mice. The skeletal phenotype of <i>EPLINβ<sup>GT/GT</sup></i> mice is indistinguishable from the wildtype (WT), but bone properties and strength were significantly decreased compared with WT littermates. Histomorphological analysis revealed altered organization of bone spicules and osteoblast cell arrangement, and decreased alkaline phosphatase activity in <i>EPLINβ<sup>GT/GT</sup></i> mouse bones. Transmission electron microscopy revealed wider intercellular spaces between osteoblasts in <i>EPLINβ<sup>GT/GT</sup></i> mice, suggesting aberrant cell adhesion. In <i>EPLINβ<sup>GT/GT</sup></i> osteoblasts, α- and β-catenins and F-actin were observed at the cell membrane, but OB-cadherin was localized at the perinuclear region, indicating that cadherin-catenin complexes were not formed. EPLINβ knockdown in MC3T3-e1 osteoblast cells showed similar results as in calvaria cell cultures. Bone formation markers, such as <i>RUNX2</i>, <i>Osterix</i>, <i>ALP</i>, and <i>Col1a1</i> mRNA were reduced in EPLINβ knockdown cells, suggesting an important role for EPLINβ in osteoblast formation. In conclusion, we propose that EPLINβ is involved in the assembly of cadherin-catenin complexes in osteoblasts and affects bone formation.
DOI： 10.1267/ahc.22-00027
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EPLINβ Is Involved in the Assembly of Cadherin-catenin Complexes in Osteoblasts and Affects Bone Formation 査読あり
Shihoko Miyazaki, Taro Funamoto, Tomohisa Sekimoto, Syuji Kurigi, Tomomi Ohta, Takuya Nagai, Takuya Tajima, Mai Imasaka, Kumiko Yoshinobu, Kimi Araki, Masatake Asaki, Narantsog Choijookhuu, Yoshitaka Hishikawa, Etsuo Chosa
ACTA HISTOCHEMICA ET CYTOCHEMICA 55 ( 3 ) 99 - 110 2022年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japan Society of Histochemistry and Cytochemistry
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Remnant-Rreserved Single-Bundle Anterior Cruciate Ligament Augmentation in Multi-ligamentous Knee Reconstruction 査読あり
Takuya Tajima,MD, PhD NamiYamaguchi,MD,PhD Yudai Morita,MD Takuji Yokoe,MD Makotot Nagasawa,MD Tomomi Ota,MD Shuichi Kawagoe,MD Yoshihiro Nakamura, MD Etsuo Chosa,MD,PhD
The Journal of Knee Surgery 2022年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Thieme Medical Publishers,Inc.
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特集 スポーツ外傷･障害の予防と治療--TOKYO 2020が終了して 成長期のスポーツ障害の予防と早期発見のポイント 査読あり
田島 卓也, 帖佐 悦男
医学のあゆみ 281 ( 8 ) 812 - 814 2022年5月
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Elective one-stage all four-ligament reconstruction after open knee dislocation: A case report 査読あり
Takuji Yokoe, Takuya Tajima, Nami Yamaguchi, Etsuo Chosa
Journal of Orthopaedic Science 27 ( 3 ) 743 - 749 2022年5月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Elsevier
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A longer duration from injury to surgery is associated with preoperative deterioration of an isolated meniscal tear in patients aged 40 years or older 査読あり
Takuji Yokoe, Takuya Tajima, Nami Yamaguchi, Yudai Morita, Etsuo Chosa
Journal of Orthopaedic Surgery (Hong Kong) 30 ( 2 ) 10225536221101692 2022年5月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：SAGE Publishing
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Journal of Orthopaedic Surgery 30 ( 2 ) 2022年5月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Orthopaedic Surgery
Purpose: To evaluate the preoperative deterioration of an isolated meniscal tear in patients aged 40 years or older, and whether time from injury to surgery is associated with worsening of a meniscal tear. Methods: Patients aged 40 years or older who underwent arthroscopic surgery for isolated meniscal tear between 2014 and 2019 were retrospectively reviewed. The diagnostic magnetic resonance imaging (MRI) findings and arthroscopic findings were compared to evaluate the deterioration of meniscal tears. Predictors of the development of meniscal tears; patient demographic factors, duration from injury to surgery (injury to MRI and MRI to surgery), and image findings were assessed. Results: A total of 58 patients (58 knees) were included (mean age, 55.9 ± 8.5 years; male/female, 31/27). An isolated meniscal tear deteriorated in 28 (48.3%). Compared patients with and without deteriorated meniscal tear, significant differences were found in the MRI grade of meniscal tear (p = 0.03), duration from injury to MRI (164.2 ± 167.9 vs 45.2 ± 48.7 days, p < 0.001), and from MRI to surgery (148.8 ± 91.1 vs 67.6 ± 56.7 days, p < 0.001). A multivariate regression analysis showed that the duration from injury to MRI (odds ratio [OR], 1.03; p < 0.001) and from MRI to surgery (OR, 1.02; p < 0.001) were independent predictors. Conclusion: Approximately 50% of isolated meniscal tears deteriorated preoperatively in patients aged 40 years or older. The duration from injury to surgery was an independent predictor of worsening of an isolated meniscal tear.
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Journal of Clinical Medicine 11 ( 7 ) 2022年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Clinical Medicine
The Beighton score (BS) is widely used to evaluate generalized joint laxity. However, the association between the BS and lateral ankle laxity is unclear. This study compared the ultrasono-graphic (US) findings of the anterior talofibular ligament (ATFL) between high-(≥6) and low-(≤3) BS groups of healthy young women. The ATFL lengths of healthy young women were measured in the stress and nonstress positions using the previously reported technique from March 2021 to January 2022. The ATFL ratio (ratio of stress to nonstress ATFL length) was used as an indicator of lateral ankle laxity. The anterior drawer test (ADT) was performed. The correlation between the BS and US findings was also examined. A total of 20 (high-BS group) and 61 (low-BS group) subjects with a mean age of 23.8 ± 1.0 years were included. The high-BS group showed a higher grade of ADT than the low-BS group. No significant differences were found in the nonstress and stress ATFL lengths and ATFL ratio (1.10 ± 0.05 vs. 1.09 ± 0.05, p = 0.19) between the groups. No correlation was found between the BS and US findings. In conclusion, this study did not detect significant differences in the US findings of the ATFL between the high-and low-BS groups.
DOI： 10.3390/jcm11071759
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Symptomatic discoid lateral meniscus shows a relationship between types and tear patterns, and between causes of clinical symptom onset and the age distribution 査読あり
Nami Yamaguchi, Etsuo Chosa, Takuya Tajima, Yudai Morita, Takuji Yokoe
Knee Surgery, Sports Traumatology, Arthroscopy 30 ( 4 ) 1436 - 1442 2022年4月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：European Society of Sports Traumatology, Knee Surgery and Arthroscopy
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Effect of total hip arthroplasty on improving locomotive syndrome in hip disease patients: A prospective cohort study focused on total clinical decision limits stage 3
Miyazaki S, Tsuruta K, Yoshinaga S, Yamaguchi Y, Fujii Y, Arakawa H, Ochiai M, Kawaguchi T, Unoki A, Sakamoto T, Tajima T, Nakamura Y, Funamoto T, Hiyoshi M, Chosa E
Journal of Orthopaedic Science 2022年3月
掲載種別：研究論文（学術雑誌）
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Knee Surgery, Sports Traumatology, Arthroscopy 31 ( 5 ) 1994 - 2000 2022年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Knee Surgery, Sports Traumatology, Arthroscopy
Purpose: This study aimed to evaluate the relationship between generalized joint laxity (GJL) and stress ultrasonographic (US) findings of the anterior talofibular ligament (ATFL) of healthy young men. Methods: The ATFL lengths of healthy young men were consecutively measured in the stress and nonstress positions. The ATFL ratio was calculated as an indicator of lateral ankle laxity. GJL was evaluated using the Beighton score (BS), and a BS of ≥ 5 was considered GJL. The manual anterior drawer test (ADT) was also performed. The results of stress US and ADT were compared between subjects with and without GJL, and the correlation between GJL and US findings was examined. Results: A total of 13 subjects with GJL and 95 without GJL were included in the study. The mean BSs in the GJL and no-GJL groups were 5.9 ± 0.9 and 1.1 ± 1.3, respectively (p < 0.0001). The GJL group showed a higher grade of ADT than the no-GJL group (p < 0.0001). Significant differences were found in the stress ATFL length (23.6 ± 1.8 mm vs. 21.7 ± 1.8 mm, p = 0.002) and ATFL ratio (1.15 ± 0.06 vs. 1.07 ± 0.03, p < 0.0001) between the GJL and no-GJL groups. Spearman’s correlation coefficients showed a moderate correlation between the BS and ATFL ratio (r = 0.45, p < 0.0001). Conclusion: The present study showed significant differences in the ATFL ratio and stress ATFL length between young men with and without GJL. The BS was moderately correlated with the lateral ankle laxity in this population. Level of evidence: Level IV.
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Journal of Knee Surgery 36 ( 13 ) 1365 - 1373 2022年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Knee Surgery
The loss of knee range of motion (ROM) is not an uncommon complication after anterior cruciate ligament reconstruction (ACLR). However, the risk factors of loss of knee ROM remain debatable. The purpose of this study was to evaluate the incidence and risk factors of loss of knee ROM at 12 months after primary ACLR performed after regaining full knee ROM preoperatively. Consecutive patients who underwent primary ACLR after regaining full ROM between January 2014 and January 2020 were retrospectively reviewed. Patients who received a surgical arthrolysis within 12 months after ACLR or those who had a loss of knee ROM at 12 months postoperatively were defined as the loss of ROM group. Possible risk factors of loss of knee ROM, including patient demographic, preoperative, surgical, and postoperative factors, were assessed. The notch wide index and radiographic parameters of the tibial spines; medial tibial spine height (MTSH)/tibial length (TL), lateral tibial spine height (LTSH)/TL, and tibial spine width (TSW)/TL, were also assessed. A total of 141 patients (141 knees) were included (mean age, 25.8 ± 11.4 years; male/female, 56/85). Of the 141 patients, 3 received surgical arthrolysis within 12 months, and 23 had a loss of knee ROM at 12 months after ACLR. Compared patients with and without loss of knee ROM, significant differences were found in the age (p = 0.04), LTSH/TL (p = 0.02), and TSW/TL (p = 0.02). A multivariate regression analysis showed that the age (odds ratio [OR]; 1.05, 95% confidence interval [CI]: 1.01-1.09, p = 0.02), LTSH/TL (OR: 1.44, 95% CI: 1.01-2.1, p = 0.04), and TSW/TL (OR: 0.79, 95% CI: 0.65-0.97, p = 0.02) were identified as significant independent risk predictors of loss of knee ROM. This study showed that the incidence of loss of knee ROM at 12 months after primary ACLR was 18.4% (26/141). An older age, a higher LTSH/TL and a smaller TSW/TL may be associated with loss of knee ROM at 12 months after ACLR.
DOI： 10.1055/a-1934-0776
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Objective detection of high-risk tackle in rugby by combination of pose estimation and machine learning
NISHIO Monami, NONAKA Naoki, FUJIHIRA Ryo, MURAKAMI Hidetaka, TAJIMA Takuya, YAMADA Mutsuo, MAEDA Akira, SEITA Jun
人工知能学会全国大会論文集 JSAI2022 ( 0 ) 1S5IS2a05 - 1S5IS2a05 2022年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 人工知能学会
To provide suitable care for concussion, objective and timely detection of high-risk tackle is crucial in the field of contact sports, such as rugby. Currently it depends on monitoring by match officials, and there is a certain risk of missing high-risk events. A few attemps introducing video analysis have been reported, but those approaches require labeling by experts, which is skill-dependent, and also time and cost consuming. To achieve objective and timely detection of high-risk tackle, we developed a method combining pose estimation by deep-learning and pose evaluation by machine learning. From match videos of Japan Rugby Top League in 2016~2018 seasons, 238 low-risk tackle and 155 high-risk tackle were extracted. Poses of tackler and ball carrier were estimated by deep learning, then were evaluated by machine learning. The proposed method resulted AUROC-score 0.85 and outperformed the previously reported rule-based method. Also, the features extracted by the machine learning model, such as upright positions of tackler/ball carrier, tackler's arm dropped in extended position, were consistent with the known risk factors. This result indicates that our approach combining deep-learning and machine learning opens the way for objective and real-time detection of high-risk tackle in rugby and other contact sports.
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End-to-End High-Risk Tackle Detection System for Rugby 査読あり
Nonaka N., Fujihira R., Nishio M., Murakami H., Tajima T., Yamada M., Maeda A., Seita J.
IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops 2022-June 3549 - 3558 2022年
掲載種別：研究論文（学術雑誌） 出版者・発行元：IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops
Reducing risk of severe injury such as concussion is a high priority for any contact sports. In rugby, Head Injury Assessment (HIA) protocol has been introduced to identify and protect players showing symptoms of concussion and having potential risk of concussion. However, on-field decisions by officials are sometimes difficult and subjective, and HIA is affordable only for elite leagues since it requires medical specialists. To make rugby matches more safe, we aim to develop a system to detect high-risk tackles, potential triggers of concussion, based on deep learning models. Our system takes rugby match video, then first identifies frame with tackle, subsequently detects location of tackle and estimate pose of the ball carrier and the tackler, and finally evaluate the risk of tackle using posture pair of players. Among the model combinations we have examined, the best performance was achieved with the combination of ResNet (2+1)D as tackle frame selection model, RetinaNet as tackle detection model and CenterTrack as pose estimation model. Evaluation using test data, a set of short clips from broadcasted rugby match videos, showed our system was able to detect 50% of high-risk tackles without any human intervention. This result opens a path for automated systems to detect high-risk events, leading to less expensive and more objective monitoring not only for rugby but also for any contact sports.
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End-to-End High-Risk Tackle Detection System for Rugby. 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW), New Orleans, LA, USA, 2022 査読あり
Nonaka N, Fujihira R, Nishio M, Murakami H, Tajima T, Yamada M, Maeda A, Seita J
CVPR 2022年
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Head Injury Assessment in the Elite Level Rugby Union in Japan:Review of 3 Seasons 査読あり
Takuya Tajima,Osamu Ota,Masataka Nagayama,Masayasu Takahashi,Mutsuo Yamada,Nobuo Ishiyama,Ichiro Yoshida,Masahiro Takemura,Kenji Hara,et al
International Journal of Sports Medicine 2022年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Thieme
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Does the contralateral healthy ankle of patient with ipsilateral mechanical lateral ankle laxity show greater lateral ankle laxith? Evaluation of the anterior talofibular ligament by stress ultrasonography 査読あり
Takuji Yokoe,Takuya Tajima,Shuichi Kawagoe,Nami Yamaguchi,Yudai Morita and Etsuo Chosa
BMC Musculoskeletal Disorders 23 ( 1 ) 887 2022年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：BMC
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Clinical and Radiographic Outcomes of Double-Bundle Anterior Cruciate Ligament Reconstruction for Asian Patients with Bone-Patellar Tendon-Bone and Gracilis Tendon Grafts: A Matched-Control Comparison
Takuya Tajima, Nami Yamaguchi, Yudai Morita, Makoto Nagasawa, Tomomi Ota, Yoshihiro Nakamura, Takuji Yokoe, Etsuo Chosa
Journal of Knee Surgery 2021年12月
掲載種別：研究論文（学術雑誌）
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Turner’s syndrome associated with discoid lateral meniscus and Blount’s disease: a case report 査読あり
Kita T., Tajima T., Chosa E.
BMC Musculoskeletal Disorders 22 ( 1 ) 449 2021年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：BMC Musculoskeletal Disorders
Background: Turner’s syndrome, discoid meniscus, and Blount’s disease have all been studied in isolation, but, to the best of our knowledge, there have been no studies reporting a patient with all three. Thus, the first case of Turner’s syndrome with discoid meniscus and Blount’s disease is presented. Case presentation: A 5-year-old Japanese girl with a history of Turner’s syndrome and Blount’s disease complained of pain in her left knee. Magnetic resonance imaging showed a discoid lateral meniscus tear, and arthroscopic partial meniscectomy was performed, providing a good outcome. Conclusions: In this report, some possible explanations regarding the concomitant presence of these three diseases are discussed. A possible explanation in this case is that the patient with Turner’s syndrome had a discoid lateral meniscus that might have been induced by some genetic factors associated with Turner’s syndrome, and then the discoid lateral meniscus might have been the mechanical stress that caused Blount’s disease.
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
BMC Musculoskeletal Disorders 22 ( 1 ) 636 2021年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：BMC Musculoskeletal Disorders
Background: Lateral ankle sprain (LAS) is one of the most common musculoskeletal injuries. Numerous studies regarding LAS have been performed. However, there are few studies evaluating the current clinical practice of orthopaedic surgeons regarding LAS. The purpose of this study was to evaluate the current clinical practice of general orthopaedic surgeons in the treatment of LAS. Methods: A questionnaire survey was conducted from September 2020 to December 2020 in Miyazaki, Japan, to evaluate the clinical practice of general orthopaedic surgeons in the treatment of LAS. The survey was composed of 12 questions that were developed with consideration of the recommendations in the current clinical practice guidelines (CPGs) published by the Dutch orthopaedic society. The questions in this study were focused on the diagnosis, conservative treatment, rehabilitation, and the criteria for return to sports (RTS). Results: The survey response rate was 82.7% (129/156). Among the respondents, 95.3% did not consider the Ottawa Ankle Rules in the decision to perform plain radiography for patients. Rehabilitation following LAS was performed in 58.9% of patients. Eighty-five (65.9%) of the surgeons used only one factor as the criterion for RTS. The absence of pain was the most frequently used criterion (45.7%). No objective criteria were used for the RTS decision in athletes with LAS. Conclusions: The present study suggested that most general orthopaedic surgeons do not provide the care for patients with LAS recommended by the current CPGs. No objective criteria for the RTS decision are used for athletes with LAS.