論文 - 田島 卓也
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Yokoe T, Tajima T, Yamaguchi N, Morita Y, Chosa E
Medicina (Kaunas, Lithuania) 58 ( 11 ) 2022年10月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Medicina (Lithuania)
Osteochondral lesion (OCL) of the patellofemoral (PF) joint is not an uncommon cause of knee pain, and surgery is needed when conservative treatment fails. However, there is a lack of evidence regarding the optimal surgical treatment for OCL of the PF joint. Fixation of OCLs using autogenous osteochondral grafts has been reported to be effective for OCL of the knee. However, in this surgical technique, the biomechanical strength of osteochondral grafts may not be sufficient in patients with open physes due to the specific quality of the cartilage and subchondral bone given their age. There is a lack of studies reporting fixation of the OCL located in the PF joint using autogenous osteochondral grafts. We herein report a case of OCL of the femoral intercondylar groove where autogenous osteochondral grafts augmented with bioabsorbable pins were used to fix the lesion in a 14-year-old patient with open physes. Preoperative MRI revealed a completely detached OCL of the intercondylar groove (36 mm × 20 mm). Although a total of four osteochondral grafts were harvested from the non-weightbearing area of the lateral femoral condyle, cartilage detached from one of the grafts. The quality of the osteochondral grafts was considered to be insufficient for stabilization of the OCL; thus, two bioabsorbable pins were additionally inserted following fixation of the lesion using three osteochondral grafts. After two years of follow-up, postoperative functional scores were favorable without knee pain. The present case suggests that fixation of the OCL using autogenous osteochondral grafts may not be appropriate for young patients with open physes.
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Fixation of an Osteochondral Lesion of the Femoral Intercondylar Groove Using Autogenous Osteochondral Grafts and Bioabsorbabale Pins in a Patient with Open Physes:A Case Report 査読あり
Takuji Yokoe,Takuya Tajima,Nami Yamaguchi,Yudai Morita and Etsuo Chosa
medicina 2022年10月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：MDPI
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足部びまん性色素性絨毛結節性滑膜炎に対し，関節鏡下腫瘍切除術を施行した一例
外山 宗樹, 横江 琢示, 田島 卓也, 山口 奈美, 大田 智美, 長澤 誠, 森田 雄大, 川越 秀一, 帖佐 悦男
整形外科と災害外科 71 ( 4 ) 725 - 729 2022年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：西日本整形・災害外科学会
【背景】色素性絨毛結節性滑膜炎（Pigmented villonodular Synovitis, PVS）は関節滑膜や腱鞘に発生する比較的稀な良性腫瘍である．多くは膝関節周囲に発生し，足関節発生症例は稀である．今回，足部びまん性PVSに対して関節鏡下腫瘍切除術を行い，良好な短期成績を得た一例を経験したので報告する．【症例】23歳女性．数年前から左足部外側に腫瘤を自覚していたが，放置していた．しかしながら，腫瘤の消退を認めず前医を受診し，PVSの疑いで当科紹介となった．当科では関節鏡下腫瘍切除術を施行した．足関節前方および後足部鏡視下併用で足関節，足関節周囲，距骨下に病変を認め，関節鏡視下に腫瘍を切除した．術後病理診断ではびまん性PVSの診断であった．術後26ヶ月経過し，再発なく経過している．【結語】足部びまん性PVSに対し，足関節前方および後足部鏡視下併用での関節鏡下腫瘍切除術を施行し，良好な短期成績を得た一例を経験した．
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足部びまん性色素性絨毛結節性滑膜炎に対し，関節鏡下腫瘍切除術を施行した一例 査読あり
外山 宗樹,横江 琢示,田島 卓也,山口 奈美,大田 智美,長澤 誠,森田 雄大,川越 秀一,帖佐 悦男
整形外科と災害外科 71 ( 4 ) 725 - 729 2022年9月
記述言語：日本語 掲載種別：研究論文（その他学術会議資料等） 出版者・発行元：西日本整形・災害外科学会
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Head Injury Assessment in the Elite Level Rugby Union in Japan: Review of 3 Seasons 査読あり
Tajima T., Ota O., Nagayama M., Takahashi M., Yamada M., Ishiyama N., Yoshida I., Takemura M., Hara K., Akama T., Mitsumori N., Higashihara J., Toyama Y., Furuya M., Chosa E., Nakamura A.
International Journal of Sports Medicine 43 ( 10 ) 889 - 894 2022年9月
担当区分：筆頭著者 記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：International Journal of Sports Medicine
Head Injury Assessment (HIA) is the screening tool for head injury during a rugby game. The purpose of this study was to investigate the epidemiology of HIA in the Japan Rugby Top League (JRTL). The incidences of HIA, defined concussion (per 1,000 player-hours) and repeated concussions were evaluated in three seasons (2016-17, 2017-18, 2018-19; total 360 games). The HIA incidence rates were 12.7 (95% confidence interval 9.5-15.9), 20.8 (16.8-24.9), and 25.0 (20.5-29.5) in each season. HIA-1 criteria 2, which is applied for suspected concussion cases, was performed for 46 cases in the 2016-17 season, 81 cases in the 2017-18 season, and 88 cases in the 2018-19 season. The concussion incidence rates were significantly greater in the 2017-18 season (9.6/1000 player-hours, 95% confidence interval 6.8-12.4) and the 2018-19 season (14.4, 11-17.8) compared to the 2016-17 season (4.8, 2.8-6.8). The number of repeated concussion cases in the same season was 1 in the 2016-17 season and 4 in both the 2017-18 and 2018-19 seasons. This study confirmed significantly higher HIA and concussion incidence rates over time. Although the HIA system might have been established in the three seasons in JRTL, comprehensive management needs to be improved to prevent repeated concussions.
DOI： 10.1055/a-1810-6509
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健常者スポーツ，パラスポーツの相互理解を目指して‐合同メディカルチェックの試み- 査読あり
喜多恒允，田島卓也，横江琢示，森田雄大，長澤誠，山口奈美，帖佐悦男
日本臨床スポーツ医学会誌 30 ( 3 ) 695 - 702 2022年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本臨床スポーツ医学会
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宮崎県の高校ラグビーにおけるメディカルサポート－３年間の外傷調査－ 査読あり
森田 恭史,今里 浩之,岩佐 一真,横江 琢示,森田 雄大,比嘉 聖,山口 奈美,中村 嘉宏,田島 卓也,帖佐 悦男,吉川 大輔
九州・山口スポーツ医・科学研究会誌 33 37 - 40 2022年7月
記述言語：日本語 掲載種別：研究論文（研究会，シンポジウム資料等） 出版者・発行元：九州・山口スポーツ医・科学研究会
我々は宮崎県で開催されるラグビーの公式戦で要請のあった全試合にマッチデイドクター配備および後方支援病院を整備している．今回，15人制高校ラグビー宮崎県大会の外傷調査を行ったため報告する．
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サーフィン競技会における医療体制の向上と重症事故発生予防を目的とした安全評価法の作成 査読あり
石田 翔太郎,小島 岳史,帖佐 悦男,田島 卓也
九州・山口スポーツ医・科学研究会誌 33 6 - 11 2022年7月
記述言語：日本語 掲載種別：研究論文（研究会，シンポジウム資料等） 出版者・発行元：九州・山口スポーツ医・科学研究会
サーフィンは海上競技であり，陸上競技では助かる脳震盪でさえも死亡事故につながってしまう．そのため安全に競技会を開催するためにはドクター派遣だけではなくライフセーバー，救急車や後方支援病院との連携，AEDの設置が必要となる．しかし現在このような安全対策ができている競技会は少ない．今回安全度向上を目的としてサーフィン競技会専用の宮崎式安全評価法を作成した．
宮崎県では過去10年間で12例のサーフィン中（競技会外）の死亡例が発生しており，競技会中も重大事故が発生しうる．今回作成した評価法を今後の競技会で継続的に使用し、医療体制の向上に努める必要があると考える． -
Miyazaki S, Funamoto T, Sekimoto T, Kurogi S, Ohta T, Nagai T, Tajima T, Imasaka M, Yoshinobu K, Araki K, Araki M, Choijookhuu N, Hishikawa Y, Chosa E
Acta histochemica et cytochemica 55 ( 3 ) 99 - 110 2022年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：日本組織細胞化学会
Epithelial protein lost in neoplasm (EPLIN) is an actin-associated cytoskeletal protein that plays an important role in epithelial cell adhesion. EPLIN has two isoforms: EPLINα and EPLINβ. In this study, we investigated the role of EPLINβ in osteoblasts using EPLINβ-deficient (<i>EPLINβ<sup>GT/GT</sup></i>) mice. The skeletal phenotype of <i>EPLINβ<sup>GT/GT</sup></i> mice is indistinguishable from the wildtype (WT), but bone properties and strength were significantly decreased compared with WT littermates. Histomorphological analysis revealed altered organization of bone spicules and osteoblast cell arrangement, and decreased alkaline phosphatase activity in <i>EPLINβ<sup>GT/GT</sup></i> mouse bones. Transmission electron microscopy revealed wider intercellular spaces between osteoblasts in <i>EPLINβ<sup>GT/GT</sup></i> mice, suggesting aberrant cell adhesion. In <i>EPLINβ<sup>GT/GT</sup></i> osteoblasts, α- and β-catenins and F-actin were observed at the cell membrane, but OB-cadherin was localized at the perinuclear region, indicating that cadherin-catenin complexes were not formed. EPLINβ knockdown in MC3T3-e1 osteoblast cells showed similar results as in calvaria cell cultures. Bone formation markers, such as <i>RUNX2</i>, <i>Osterix</i>, <i>ALP</i>, and <i>Col1a1</i> mRNA were reduced in EPLINβ knockdown cells, suggesting an important role for EPLINβ in osteoblast formation. In conclusion, we propose that EPLINβ is involved in the assembly of cadherin-catenin complexes in osteoblasts and affects bone formation.
DOI： 10.1267/ahc.22-00027
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EPLINβ Is Involved in the Assembly of Cadherin-catenin Complexes in Osteoblasts and Affects Bone Formation 査読あり
Shihoko Miyazaki, Taro Funamoto, Tomohisa Sekimoto, Syuji Kurigi, Tomomi Ohta, Takuya Nagai, Takuya Tajima, Mai Imasaka, Kumiko Yoshinobu, Kimi Araki, Masatake Asaki, Narantsog Choijookhuu, Yoshitaka Hishikawa, Etsuo Chosa
ACTA HISTOCHEMICA ET CYTOCHEMICA 55 ( 3 ) 99 - 110 2022年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japan Society of Histochemistry and Cytochemistry
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Remnant-Rreserved Single-Bundle Anterior Cruciate Ligament Augmentation in Multi-ligamentous Knee Reconstruction 査読あり
Takuya Tajima,MD, PhD NamiYamaguchi,MD,PhD Yudai Morita,MD Takuji Yokoe,MD Makotot Nagasawa,MD Tomomi Ota,MD Shuichi Kawagoe,MD Yoshihiro Nakamura, MD Etsuo Chosa,MD,PhD
The Journal of Knee Surgery 2022年6月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Thieme Medical Publishers,Inc.
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特集 スポーツ外傷･障害の予防と治療--TOKYO 2020が終了して 成長期のスポーツ障害の予防と早期発見のポイント 査読あり
田島 卓也, 帖佐 悦男
医学のあゆみ 281 ( 8 ) 812 - 814 2022年5月
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Elective one-stage all four-ligament reconstruction after open knee dislocation: A case report 査読あり
Takuji Yokoe, Takuya Tajima, Nami Yamaguchi, Etsuo Chosa
Journal of Orthopaedic Science 27 ( 3 ) 743 - 749 2022年5月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Elsevier
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A longer duration from injury to surgery is associated with preoperative deterioration of an isolated meniscal tear in patients aged 40 years or older 査読あり
Takuji Yokoe, Takuya Tajima, Nami Yamaguchi, Yudai Morita, Etsuo Chosa
Journal of Orthopaedic Surgery (Hong Kong) 30 ( 2 ) 10225536221101692 2022年5月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：SAGE Publishing
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Journal of Orthopaedic Surgery 30 ( 2 ) 2022年5月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Orthopaedic Surgery
Purpose: To evaluate the preoperative deterioration of an isolated meniscal tear in patients aged 40 years or older, and whether time from injury to surgery is associated with worsening of a meniscal tear. Methods: Patients aged 40 years or older who underwent arthroscopic surgery for isolated meniscal tear between 2014 and 2019 were retrospectively reviewed. The diagnostic magnetic resonance imaging (MRI) findings and arthroscopic findings were compared to evaluate the deterioration of meniscal tears. Predictors of the development of meniscal tears; patient demographic factors, duration from injury to surgery (injury to MRI and MRI to surgery), and image findings were assessed. Results: A total of 58 patients (58 knees) were included (mean age, 55.9 ± 8.5 years; male/female, 31/27). An isolated meniscal tear deteriorated in 28 (48.3%). Compared patients with and without deteriorated meniscal tear, significant differences were found in the MRI grade of meniscal tear (p = 0.03), duration from injury to MRI (164.2 ± 167.9 vs 45.2 ± 48.7 days, p < 0.001), and from MRI to surgery (148.8 ± 91.1 vs 67.6 ± 56.7 days, p < 0.001). A multivariate regression analysis showed that the duration from injury to MRI (odds ratio [OR], 1.03; p < 0.001) and from MRI to surgery (OR, 1.02; p < 0.001) were independent predictors. Conclusion: Approximately 50% of isolated meniscal tears deteriorated preoperatively in patients aged 40 years or older. The duration from injury to surgery was an independent predictor of worsening of an isolated meniscal tear.
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Journal of Clinical Medicine 11 ( 7 ) 2022年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Clinical Medicine
The Beighton score (BS) is widely used to evaluate generalized joint laxity. However, the association between the BS and lateral ankle laxity is unclear. This study compared the ultrasono-graphic (US) findings of the anterior talofibular ligament (ATFL) between high-(≥6) and low-(≤3) BS groups of healthy young women. The ATFL lengths of healthy young women were measured in the stress and nonstress positions using the previously reported technique from March 2021 to January 2022. The ATFL ratio (ratio of stress to nonstress ATFL length) was used as an indicator of lateral ankle laxity. The anterior drawer test (ADT) was performed. The correlation between the BS and US findings was also examined. A total of 20 (high-BS group) and 61 (low-BS group) subjects with a mean age of 23.8 ± 1.0 years were included. The high-BS group showed a higher grade of ADT than the low-BS group. No significant differences were found in the nonstress and stress ATFL lengths and ATFL ratio (1.10 ± 0.05 vs. 1.09 ± 0.05, p = 0.19) between the groups. No correlation was found between the BS and US findings. In conclusion, this study did not detect significant differences in the US findings of the ATFL between the high-and low-BS groups.
DOI： 10.3390/jcm11071759
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Symptomatic discoid lateral meniscus shows a relationship between types and tear patterns, and between causes of clinical symptom onset and the age distribution 査読あり
Nami Yamaguchi, Etsuo Chosa, Takuya Tajima, Yudai Morita, Takuji Yokoe
Knee Surgery, Sports Traumatology, Arthroscopy 30 ( 4 ) 1436 - 1442 2022年4月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：European Society of Sports Traumatology, Knee Surgery and Arthroscopy
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Effect of total hip arthroplasty on improving locomotive syndrome in hip disease patients: A prospective cohort study focused on total clinical decision limits stage 3
Miyazaki S, Tsuruta K, Yoshinaga S, Yamaguchi Y, Fujii Y, Arakawa H, Ochiai M, Kawaguchi T, Unoki A, Sakamoto T, Tajima T, Nakamura Y, Funamoto T, Hiyoshi M, Chosa E
Journal of Orthopaedic Science 2022年3月
掲載種別：研究論文（学術雑誌）
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Knee Surgery, Sports Traumatology, Arthroscopy 31 ( 5 ) 1994 - 2000 2022年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Knee Surgery, Sports Traumatology, Arthroscopy
Purpose: This study aimed to evaluate the relationship between generalized joint laxity (GJL) and stress ultrasonographic (US) findings of the anterior talofibular ligament (ATFL) of healthy young men. Methods: The ATFL lengths of healthy young men were consecutively measured in the stress and nonstress positions. The ATFL ratio was calculated as an indicator of lateral ankle laxity. GJL was evaluated using the Beighton score (BS), and a BS of ≥ 5 was considered GJL. The manual anterior drawer test (ADT) was also performed. The results of stress US and ADT were compared between subjects with and without GJL, and the correlation between GJL and US findings was examined. Results: A total of 13 subjects with GJL and 95 without GJL were included in the study. The mean BSs in the GJL and no-GJL groups were 5.9 ± 0.9 and 1.1 ± 1.3, respectively (p < 0.0001). The GJL group showed a higher grade of ADT than the no-GJL group (p < 0.0001). Significant differences were found in the stress ATFL length (23.6 ± 1.8 mm vs. 21.7 ± 1.8 mm, p = 0.002) and ATFL ratio (1.15 ± 0.06 vs. 1.07 ± 0.03, p < 0.0001) between the GJL and no-GJL groups. Spearman’s correlation coefficients showed a moderate correlation between the BS and ATFL ratio (r = 0.45, p < 0.0001). Conclusion: The present study showed significant differences in the ATFL ratio and stress ATFL length between young men with and without GJL. The BS was moderately correlated with the lateral ankle laxity in this population. Level of evidence: Level IV.
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Yokoe T., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Journal of Knee Surgery 36 ( 13 ) 1365 - 1373 2022年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Journal of Knee Surgery
The loss of knee range of motion (ROM) is not an uncommon complication after anterior cruciate ligament reconstruction (ACLR). However, the risk factors of loss of knee ROM remain debatable. The purpose of this study was to evaluate the incidence and risk factors of loss of knee ROM at 12 months after primary ACLR performed after regaining full knee ROM preoperatively. Consecutive patients who underwent primary ACLR after regaining full ROM between January 2014 and January 2020 were retrospectively reviewed. Patients who received a surgical arthrolysis within 12 months after ACLR or those who had a loss of knee ROM at 12 months postoperatively were defined as the loss of ROM group. Possible risk factors of loss of knee ROM, including patient demographic, preoperative, surgical, and postoperative factors, were assessed. The notch wide index and radiographic parameters of the tibial spines; medial tibial spine height (MTSH)/tibial length (TL), lateral tibial spine height (LTSH)/TL, and tibial spine width (TSW)/TL, were also assessed. A total of 141 patients (141 knees) were included (mean age, 25.8 ± 11.4 years; male/female, 56/85). Of the 141 patients, 3 received surgical arthrolysis within 12 months, and 23 had a loss of knee ROM at 12 months after ACLR. Compared patients with and without loss of knee ROM, significant differences were found in the age (p = 0.04), LTSH/TL (p = 0.02), and TSW/TL (p = 0.02). A multivariate regression analysis showed that the age (odds ratio [OR]; 1.05, 95% confidence interval [CI]: 1.01-1.09, p = 0.02), LTSH/TL (OR: 1.44, 95% CI: 1.01-2.1, p = 0.04), and TSW/TL (OR: 0.79, 95% CI: 0.65-0.97, p = 0.02) were identified as significant independent risk predictors of loss of knee ROM. This study showed that the incidence of loss of knee ROM at 12 months after primary ACLR was 18.4% (26/141). An older age, a higher LTSH/TL and a smaller TSW/TL may be associated with loss of knee ROM at 12 months after ACLR.
DOI： 10.1055/a-1934-0776