論文 - 田島 卓也
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Yokoe T., Yang F., Tajima T., Yamaguchi N., Morita Y., Chosa E.
Foot and Ankle Surgery 30 ( 7 ) 608 - 611 2024年10月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Foot and Ankle Surgery
Background: This study aimed to evaluate the shape of the retromalleolar groove of the tibialis posterior tendon (TPT) using computed tomography (CT). Methods: CT images of patients with foot or ankle pathologies were retrospectively reviewed. The morphology of the retromalleolar groove of the TPT was assessed at two different levels: the ankle joint and 10 mm above the ankle joint. The groove shape was classified into three types; concave, flat, or irregular. In cases with concave grooves, the width and depth of the grooves were measured. Results: Of the 116 ankles from 116 subjects included in this study, 80.2 % showed a shallow concave shape (mean depth, 1.6 mm) at the two scan levels. The shape and width of the groove differed significantly by gender, although there was no significant difference in the groove depth. Conclusion: Approximately 80% showed a shallow concave groove of the TPT. The groove characteristics differed by gender, although there was no significant difference in the groove depth. Level of evidence: Cross-sectional cohort study; Level of evidence, Ⅳ
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リファンピシン使用によりステロイド作用が減弱し治療に難渋した手関節非結核性抗酸菌症の1例 査読あり
松永 美穂, 大田 智美, 田島 卓也, 山口 奈美, 長澤 誠, 森田 雄大, 横江 琢示, 帖佐 悦男
整形外科と災害外科 73 ( 3 ) 602 - 605 2024年9月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：西日本整形・災害外科学会
【はじめに】ステロイド薬は他薬との薬物相互作用が比較的少なく汎用されるが，抗結核薬のリファンピシン（以下RFP）との相互作用はあまり知られていない．ネフローゼ症候群加療中に非結核性抗酸菌症（以下NTM）を合併し，ステロイドとRFPの併用で原疾患およびNTMの治療に難渋した1例を経験した．【症例】41歳男性，21歳時にネフローゼ症候群と診断され，ステロイドを内服中に手関節掌背側の腫脹を認め，滑膜切除術後に非結核性抗酸菌性滑膜炎の診断となった．RFPを含む抗結核薬3剤を開始したところ，ネフローゼ症候群が悪化しステロイドを増量，尿蛋白は改善するも手関節腫脹が再発し，2回目の滑膜切除術施行後，高気圧酸素療法で感染は鎮静化した．【考察】NTMにはRFPが汎用されるが，ステロイドとの相互作用により治療に難渋することがある．薬物の相互作用を十分に熟知し，NTMの治療にあたる必要がある．
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特集 大規模レジストリーによる整形外科リアルワールドエビデンス構築 関節鏡およびスポーツ整形外科関連手術に対するレジストリー-JOSKAS eNOTEからJSOAレジストリーへ 査読あり
田島 卓也, 鈴木 朱美
臨床整形外科 59 ( 7 ) 891 - 895 2024年7月
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Ureter position and risk of ureteral injury during lateral lumbar interbody fusion 査読あり
Hamanaka H., Tajima T., Kurogi S., Higa K., Nagai T., Kuroki T., Takamori H., Mukai S., Kamoto T., Chosa E.
Journal of Orthopaedic Science 2024年5月
担当区分：責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Differences in Retromalleolar Fibular Groove Morphology According to Level of Axial Computed Tomography Scans 査読あり
Takuji Yokoe, Takuya Tajima, Koki Ouchi, Nami Yamaguchi, Yudai Morita, and Etsuo Chosa
The Orthopaedic Journal of Sports Medicine 12 ( 3 ) 2024年3月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Screening of Undiagnosed Increased Lateral Ankle Laxity Using Stress Ultrasonography 査読あり
Yokoe T., Tajima T., Chosa E., Yamaguchi N., Morita Y.
Orthopaedic Journal of Sports Medicine 12 ( 4 ) 23259671241235162 2024年3月
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Orthopaedic Journal of Sports Medicine
Background: Some patients with lateral ankle sprain (LAS) will experience chronic lateral ankle instability (CLAI). However, not all of those with residual increased lateral ankle laxity (ILAL) become symptomatic. There is a lack of evidence regarding the prevalence of undiagnosed ILAL in the general population. Purpose: To evaluate the prevalence of undiagnosed ILAL with the use of stress ultrasonography (US) and to investigate the percentage of ankle sprain copers (ASCs) with ILAL. Study Design: Cross-sectional study; Level of evidence, 3. Methods: The anterior talofibular ligament (ATFL) lengths in college students without diagnosis of CLAI were measured consecutively in stress and nonstress positions. The ATFL ratio was calculated as an indicator of lateral ankle laxity according to a previously reported method. The manual anterior drawer test was also performed. The Cumberland Ankle Instability Tool (CAIT) and Ankle Instability Instrument (AII) were used to assess subjective impairments related to CLAI. The correlation between the ATFL ratio and CAIT score was evaluated. Results: A total of 207 ankles from 106 participants (mean age, 23.9 ± 2.2 years; male/female, 64/42) were included. Overall, 38 participants (35.8%; 50 ankles [24.2%]) were classified as having undiagnosed ILAL. Of the ankles with no history of LAS, 8% showed ILAL. Overall, 53 participants (50%) had a history of LAS and were all classified as ASCs. Of the 82 ankles from these ASCs, 40 (48.8%) were regarded as having undiagnosed ILAL. There was no correlation between the ATFL ratio and CAIT scores (r = -0.09, P =.414). Conclusion: The prevalence of undiagnosed ILAL by stress US screening was approximately one-third in young adults. In this study, 48.8% of the ankles from ASCs showed ILAL.
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Risk of Skull Perforation with Halo Vest Skull Pins 査読あり
Hamanaka H., Tajima T., Kurogi S., Higa K., Nagai T., Takahashi T., Matsumoto T., Chosa E.
Spine Surgery and Related Research 8 ( 5 ) 480 - 484 2024年
担当区分：責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Spine Surgery and Related Research
Introduction: A halo vest is an immobilization device widely used to stabilize the cervical spine. Pain and infection at the skull pin insertion site are common complications, but skull perforation is rare, and most published studies are case reports. This study aimed to identify risk factors for skull perforation by comparing patients who did and did not develop perforation. Methods: Overall thickness and the thicknesses of the internal and external laminae of the skull at the skull pin insertion sites were measured on cranial computed tomography scans of 66 patients fitted with a halo vest. The results were compared between patients who did and did not develop perforation. Results: Four patients developed perforations. All patients with perforation were older women, and their external and internal laminae were significantly thinner than those of patients who did not develop perforation. Conclusions: The reported causes of skull pin perforation include infection around the pin, osteoporosis, and an enlarged frontal sinus. However, most patients with perforation in the present study were older women, and the cause was the thinning of the external and external laminae.
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3．ジャパンラグビーリーグワンにおける外傷・障害調査 査読あり
田島 卓也, 帖佐 悦男, 中村 明彦
日本臨床スポーツ医学会誌 32 ( 3 ) 342 - 344 2024年
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スポーツ現場における外傷・障害・疾病調査の標準化フォーマットの実現化に向けて. ジャパンラグビーリーグワンにおける外傷・障害調査. 招待あり 査読あり
田島卓也、帖佐悦男、中村明彦
日本臨床スポーツ医学会誌 32 ( 3 ) 342 - 344 2024年
担当区分：筆頭著者, 責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌）
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特集 その痛みはどこから？‐スポーツによる外傷・障害‐. 筋損傷の痛みと治療のアプローチ. 招待あり 査読あり
田島卓也
臨床スポーツ医学 41 ( 12 ) 1314 - 1319 2024年
担当区分：筆頭著者, 責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌）
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Miyazaki S., Fujii Y., Tsuruta K., Yoshinaga S., Hombu A., Funamoto T., Sakamoto T., Tajima T., Arakawa H., Kawaguchi T., Nakatake J., Chosa E.
Peerj 12 ( 10 ) e18351 2024年
担当区分：筆頭著者, 最終著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Peerj
Background. Understanding the gait pattern of patients eligible for total hip arthroplasty (THA) due to hip osteoarthritis (OA) offers valuable information for improving locomotive syndrome (LS). This study aims to measure the gait patterns of THA-eligible patients using an optical motion capture system and to analyze these patterns using principal component analysis (PCA). Additionally, this study examines the relationship between THA-induced gait patterns and LS. Methods. This before-after study included 237 patients who underwent unilateral primary THA due to hip OA. The primary outcome measures were spatiotemporal gait parameters. Secondary outcome measures included three LS risk tests: a stand-up test, a two-step test, a 25-question Geriatric Locomotive Function Scale (GLFS-25), and total clinical decision limits stages. PCA was performed using 16 spatiotemporal gait parameters collected before and three months after THA. Principal components (PC) were selected to achieve a cumulative contribution rate of 90% (0.9) or higher. Each summarized PC was compared using a paired t-test before and three months after THA. Furthermore, multiple regression analysis was conducted to determine how changes in each PC between before and three months after THA related to changes in the four LS evaluation items. Results. PCA identified three principal components (PC1, PC2, PC3) that accounted for a cumulative contribution rate of 0.910 using 16 spatiotemporal gait parameters. When comparing before and three months after THA for all three PCs, significant differences were observed in each PC (p < 0.001), with overall walking ability and stance phase being higher three months after THA than before THA, while the asymmetry of support time was lower three months after THA. The results of multiple regression analysis revealed that PC1, PC2, and PC3 were the most influential factors in total clinical decision limits stage. For each LS risk test, the factors related to the stand-up test were identified as PC1, PC2, and PC3, while the factors related to the two-step test were identified as PC1 and PC2. The factors related to the GLFS-25 were also identified as PC1 and PC2. Conclusions. The most important findings of this study indicate that the three PCs represent over 90% of the 16 spatiotemporal gait parameters, which are associated with total clinical decision limits stage and LS risk tests. The present results suggest that PC1 represents overall walking ability, PC2 represents the stance phase, and PC3 represents asymmetry of support time. Gait pattern characteristics, such as overall walking ability, stance phase, and asymmetry of support time, were clearly defined by these PCs. Regarding the relationship between PC and LS, all three PCs are related to total clinical decision limits stage. In addition, PC1 and PC2 related to all three LS risk tests, and PC3 related only to the stand-up test.
DOI： 10.7717/peerj.18351
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Age- and sex-related differences in upper-body joint and endpoint kinematics during a drinking task in healthy adults. 査読あり
Jun Nakatake, Hideki Arakawa, Takuya Tajima, Shigeaki Miyazaki, Etsuo Chosa
PeerJ 2023年12月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.7717/peerj.16571
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Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway 査読あり
Nagai T., Sekimoto T., Kurogi S., Ohta T., Miyazaki S., Yamaguchi Y., Tajima T., Chosa E., Imasaka M., Yoshinobu K., Araki K., Araki M., Choijookhuu N., Sato K., Hishikawa Y., Funamoto T.
Scientific Reports 13 ( 1 ) 14639 2023年12月
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Scientific Reports
Bone remodeling is an extraordinarily complex process involving a variety of factors, such as genetic, metabolic, and environmental components. Although genetic factors play a particularly important role, many have not been identified. In this study, we investigated the role of transmembrane 161a (Tmem161a) in bone structure and function using wild-type (WT) and Tmem161a-depleted (Tmem161aGT/GT) mice. Mice femurs were examined by histological, morphological, and bone strength analyses. Osteoblast differentiation and mineral deposition were examined in Tmem161a-overexpressed, -knockdown and -knockout MC3T3-e1 cells. In WT mice, Tmem161a was expressed in osteoblasts of femurs; however, it was depleted in Tmem161aGT/GT mice. Cortical bone mineral density, thickness, and bone strength were significantly increased in Tmem161aGT/GT mice femurs. In MC3T3-e1 cells, decreased expression of alkaline phosphatase (ALP) and Osterix were found in Tmem161a overexpression, and these findings were reversed in Tmem161a-knockdown or -knockout cells. Microarray and western blot analyses revealed upregulation of the P38 MAPK pathway in Tmem161a-knockout cells, which referred as stress-activated protein kinases. ALP and flow cytometry analyses revealed that Tmem161a-knockout cells were resistant to oxidative stress. In summary, Tmem161a is an important regulator of P38 MAPK signaling, and depletion of Tmem161a induces thicker and stronger bones in mice.
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Diagnostic utility of anteroposterior measurements of the median nerve on sagittal ultrasonographic images and their correlation with clinical findings in carpal tunnel syndrome. 査読あり
Okura T, Tajima T, Fukuda H, Matsuoka T, Chosa E
Journal of clinical ultrasound : JCU 2023年10月
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Remnant-Preserved Single-Bundle Anterior Cruciate Ligament Augmentation in Multi-ligamentous Knee Reconstruction. 査読あり
Tajima T, Yamaguchi N, Morita Y, Yokoe T, Nagasawa M, Ota T, Kawagoe S, Nakamura Y, Chosa E.
J Knee Surg 36 ( 10 ) 1095 - 1101 2023年10月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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第2趾DIP関節脱臼に対する観血的整復術後の早期スポーツ復帰の一例 査読あり
川越 亮, 田島 卓也, 山口 奈美, 大田 智美, 長澤 誠, 森田 雄大, 横江 琢示, 帖佐 悦男
整形外科と災害外科 72 ( 3 ) 485 - 487 2023年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：西日本整形・災害外科学会
【はじめに】観血的整復術を必要とした第2趾のDIP関節脱臼の1例を経験した．【症例】16歳男性．空手中に受傷．第2趾DIP関節脱臼で徒手整復を行ったが整復不能であったため，観血的整復術を行った．整復阻害因子は長趾屈筋腱であり，蹠側板の嵌頓は認めなかった．術後早期の競技復帰希望があったため母趾とのbuddy tapingを指示し復帰とした．術後6か月が経過し特に問題なく競技継続している．【考察】DIP関節脱臼の整復阻害因子は蹠側板や長趾屈筋腱の報告があり，本症例では長趾屈筋腱であった．また，術後のスポーツ復帰について，競技によっては症状次第で早期復帰が見込めると考えられた．
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Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway 査読あり
Takuya Nagai,Tomohisa Sekimoto,Syuji Kurogi,Tomomi Ohta, Shihoko Miyazaki,Yoichiro Yamaguchi,Takuya Tajima, Etsuo Chosa,Mai Imasaka,Kumiko Yoshinobu,Yoshitaka Hishikawa,Taro Funamoto
Scientific reports ( 14639 ) 2023年9月
記述言語：英語 掲載種別：研究論文（大学，研究機関等紀要）
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私論 学会で発表することの意義 査読あり
田島 卓也
整形外科 74 ( 10 ) 1072 - 1072 2023年9月
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Is the Small Ossicle of Type 1 Accessory Navicular a Cause of Foot Pain?-A Case Report. 査読あり
Yokoe T, Uemichi K, Tajima T, Chosa E
Medicina (Kaunas, Lithuania) 59 ( 9 ) 2023年8月
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Is the Small Ossicle of Type 1 Accessory Navicular a Cause of Foot Pain?—A Case Report 査読あり
Takuji Yokoe,Kazushi Uemichi,Takuya Tajima,Etsuo Chosa
medicina 59 ( 9 ) 1562 2023年8月
記述言語：英語 掲載種別：研究論文（大学，研究機関等紀要）