Papers - NANASHIMA Atsushi
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Nanashima A., Nanashima A., Hatachi G., Tominaga T., Murakami G., Takagi K., Arai J., Wada H., Nagayasu T., Sumida Y.
Tohoku Journal of Experimental Medicine 238 ( 1 ) 9 - 16 2015.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Tohoku Journal of Experimental Medicine
© 2016 Tohoku University Medical Press.Nogo-B, located in the endoplasmic reticulum, is an isoform belonging to the reticulon protein family, which is expressed specifically in cholangiocytes and non-parenchymal cells in the liver. Nogo-B expression is down-regulated with the progression of liver fibrosis, but its distinct function in liver malignancies has not been fully clarified. We have hypothesized that Nogo-B expression may be altered in intrahepatic cholangiocarcinoma (ICC), a relatively rare type of primary liver cancer with highly malignant behavior. The present study aimed to investigate the relationship between Nogo-B expression, assessed by immunohistochemical staining, and clinicopathological factors and prognosis in 34 ICC patients. Positive expression was observed in 19 (56%) of 34 ICC specimens: 6 patients (18%) with positivity levels of 1+ (positive cells in 10-50% of cancer cells) and 13 patients (38%) with 2+ (positive cells over 50%). Importantly, the remaining 15 patients (44%) were categorized as negative expression (Nogo-B-positive cells, less than 10%). Conversely, the mass-forming type of ICC tended to express Nogo-B with the degree of 2+ positivity, compared to the periductal infiltration type (p = 0.064), and the mass-forming type showed a better 5-year survival rate (66% vs. 5%) after hepatectomy (p < 0.05). However, the degree of positivity was not associated with tumor relapse rate, disease-free and overall survival, although each of the periductal infiltration type, intrahepatic metastasis, larger tumor size, and lower microvessel counts was associated with lower survival rates. We propose that Nogo-B expression is down-regulated in ICC, the implication of which, however, remains to be investigated.
DOI： 10.1620/tjem.238.9
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Comprehensive Predictors of Portal Pressure from Functional Liver Reserve in Patients Who Underwent Hepatectomy. Reviewed
Nanashima, A., Abo, T., Arai, J., Tsucchiya, T., Miyazaki, T., Takagi, K., Chen, X. and Nagayasu, T.:
Indian Journal of Surgery. 77 ( S3 ) 923 - 929 2015.12
Language：English Publishing type：Research paper (scientific journal)
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Comprehensive Predictors of Portal Pressure from Functional Liver Reserve in Patients Who Underwent Hepatectomy.
Nanashima A, Abo T, Arai J, Tsuchiya T, Miyazaki T, Takagi K, Chen X, Nagayasu T
The Indian journal of surgery 77 ( Suppl 3 ) 923 - 9 2015.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Photodynamic Therapy using Talaporfin Sodium for the Recurrence of Cholangiocarcinoma after Surgical Resction. Reviewed
Shimizu, S., Nakazawa, T., Hayashi, K., Naitoh, I., Miyabe, K., Kondo, H., Nishi, Y., Umemura, S., Hori, Y., Kato, A., Morisaki, T., Nanashima, A., Ohara, H. and Joh, H.:
Internal Medicine. 54 ( 18 ) 221 - 2326 2015.9
Language：English Publishing type：Research paper (scientific journal)
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A favourable prognostic marker for EGFR mutant non-small cell lung cancer: immunohistochemical analysis of MUC5B.
Wakata K, Tsuchiya T, Tomoshige K, Takagi K, Yamasaki N, Matsumoto K, Miyazaki T, Nanashima A, Whitsett JA, Maeda Y, Nagayasu T
BMJ open 5 ( 7 ) e008366 2015.7
Language：Japanese Publishing type：Research paper (scientific journal)
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胃癌に対する5-アミノレブリン酸を用いたレーザー光線力学的内視鏡診断． Reviewed
磯本一, 萩原久美, 妹尾健正, 大仁田賢, 山口直之, 中尾一彦, 七島篤志:
日本レーザー医学会雑誌． 36 ( 2 ) 114 - 118 2015.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Prognostic Impact of Preoperative Lymph Node Enlargement in Intrahepatic Cholangiocaricinoma： A Multi-Institutional Study br the Kyushu Study Group of Liver Surgery Reviewed
Adachi, T., Eguchi, S., Beppu, T., Ueno, S., Shiraishi, M., Okuda, K., Yamaguchi, Y., Kondo, K., Nanashima, A., Ohta, M., Takami, Y., Noritomi, T., Kitahara, K. and Fujioka, H.:
Annals of Surgical Oncology 22 ( 7 ) 2269 - 6678 2015.7
Language：English Publishing type：Research paper (scientific journal)
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Prognostic Impact of Preoperative Lymph Node Enlargement in Intrahepatic Cholangiocarcinoma: A Multi-Institutional Study by the Kyushu Study Group of Liver Surgery.
Adachi T, Eguchi S, Beppu T, Ueno S, Shiraishi M, Okuda K, Yamashita Y, Kondo K, Nanashima A, Ohta M, Takami Y, Noritomi T, Kitahara K, Fujioka H
Annals of surgical oncology 22 ( 7 ) 2269 - 78 2015.7
Language：Japanese Publishing type：Research paper (scientific journal)
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A variant of multicystic biliary hamartoma presenting as an intrahepatic cystic neoplasm
Tominaga T., Abo T., Kinoshita N., Murakami T., Sato Y., Nakanuma Y., Harada K., Masuda J., Nagayasu T., Nanashima A., Nanashima A.
Clinical Journal of Gastroenterology 8 ( 3 ) 162 - 166 2015.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Clinical Journal of Gastroenterology
© 2015, Springer Japan.A rare case of an intrahepatic multicystic tumor is described. A 26-year-old man visited our hospital because of abdominal discomfort. Contrast-enhanced computed tomography and magnetic resonance cholangiopancreatography revealed a 10 × 7 cm multicystic tumor of the bile duct in the right side of the liver. The gross appearance of the tumor resembled an intraductal papillary neoplasm of the bile duct, and right hepatectomy with regional lymphadenectomy was performed. Histologically, these cystic lesions were composed of variably and irregularly dilated duct structures lined by columnar epithelium resembling bile duct lining. There were no atypical cells and no papillary growth of the epithelial cells. Interestingly, the dilated ducts contained inspissated bile, and the inter-cystic parenchyma contained variable but irregularly distributed and hamartomatous hepatic parenchyma with an abnormal lobular pattern. Though it had atypical features of a hamartoma in some aspects (age, smooth muscle), this case could finally be regarded as a variant of multicystic biliary hamartoma.
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A Vatiant of Multicystic Biiary Hamartoma Presenting as anIntrahepatic Custic Neoplasm. Reviewed
Tominaga, T., Abo, T., Kinoshita, N., Murakami, T., Sato, Y., Nakanuma, Y., Harada, K., Masuda, J., Nagayasu, T. and Nanashima, A.:
Clinical Journal of Gastroenteroogy 8 ( 3 ) 162 - 166 2015.6
Language：English Publishing type：Research paper (scientific journal)
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In vivo Fluorescence Navigation of Gastric and Upper Gastrointestinal Tumors by 5-Aminolevulinic Acid Mediated Photodynamic Diagnosis with a Laser-equipped Video Image Endoscope Reviewed
Isomoto, H., Nanashima, A., Senoo, T., Ogiwara, K., Hashisako, M., Ohnita, K., Yamaguchi, N., Kunizaki, M., Hidaka, S., Fukuda, H., Ishii, H., Matsumoto, K., Minami, H., Akazawa, Y., Takehima, F., Fukuoka, J., Nagayasu, T. and Nakao,K.:
Photodiagnosis and Photodynami Therapy 12 ( 2 ) 201 - 208 2015.6
Language：English Publishing type：Research paper (scientific journal)
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In vivo fluorescence navigation of gastric and upper gastrointestinal tumors by 5-aminolevulinic acid mediated photodynamic diagnosis with a laser-equipped video image endoscope. Reviewed
Isomoto H, Nanashima A, Senoo T, Ogiwara K, Hashisako M, Ohnita K, Yamaguchi N, Kunizaki M, Hidaka S, Fukuda H, Ishii H, Matsushima K, Minami H, Akazawa Y, Takeshima F, Fukuoka J, Nagayasu T, Nakao K
Photodiagnosis and Photodynamic Therapy 12 ( 2 ) 201 - 208 2015.6
Language：English Publishing type：Research paper (scientific journal)
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Current status of photodynamic therapy in digestive tract carcinoma in Japan.
Nanashima A, Nagayasu T
International journal of molecular sciences 16 ( 2 ) 3434 - 40 2015.2
Language：Japanese Publishing type：Research paper (scientific journal)
DOI： 10.3390/ijms16023434
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Abo T., Nanashima A., Tobinaga S., Hidaka S., Taura N., Takagi K., Arai J., Miyaaki H., Shibata H., Nagayasu T.
European Journal of Surgical Oncology 41 ( 2 ) 257 - 264 2015.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：European Journal of Surgical Oncology
© 2014 Elsevier Ltd. Background To improve the diagnostic accuracy for hepatic tumors on the liver surface, we investigated the usefulness of an indocyanine green-photodynamic eye (ICG-PDE) system by comparison with Sonazoid intraoperative ultrasonography (IOUS) in 117 patients. Hepatic segmentation by ICG-PDE was also evaluated. Methods ICG was administered preoperatively for functional testing and images of the tumor were observed during hepatectomy using a PDE camera. ICG was injected into portal veins to determine hepatic segmentation. Results Accurate diagnosis of liver tumors was achieved with ICG-PDE in 75% of patients, lower than with IOUS (94%). False-positive and false-negative diagnosis rates for ICG-PDE were 24% and 9%, respectively. New small HCCs were detected in 3 patients. The ICG fluorescent pattern in tumors was strong staining in 41%, weak staining in 13%, rim staining in 20% and no staining in 26%. Hepatocellular carcinoma predominantly showed strong staining (61%), while rim staining predominated in cholangiocellular carcinoma (60%) and liver metastasis (55%). Hepatic segmental staining was performed in 28 patients, proving successful in 89%. Conclusion ICG-PDE is a useful tool for detecting the precise tumor location at the liver surface, identifying new small tumors, and determining liver segmentation for liver resection.
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Current Status of Photodynamic Therapy in DIgestive Tract Carcinoma in Japan． Reviewed
Nanashima, A. and Nagayasu, T.:
International Journal of Molecular Science 16 ( 2 ) 3434 - 3440 2015.2
Language：English Publishing type：Research paper (scientific journal)
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Usefulness of Intraoperative Diagnosis of Hepatic Tumors Located at the Liver Surface and Hepatic Segmental Visualization Using Indocyanine Green-photodynamic Eye Imaging． Reviewed
Abo, T., Nanashima, A., Toibnaga, S., HIdaka, S., Taura, T., Miyaaki, H., Shibata, H. and Nagayasu, T.:
European Journal of Surgical Oncology 41 ( 2 ) 257 - 264 2015.2
Language：English Publishing type：Research paper (scientific journal)
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Clinicopathological characteristics of multiple primary cancers in hepatobiliary and pancreas malignancies.
Nanashima A, Kondo H, Nakashima M, Abo T, Arai J, Ishii M, Hidaka S, Kunizaki M, To K, Takeshita H, Yamasaki N, Tsuchiya T, Nagayasu T
Anticancer research 35 ( 2 ) 1073 - 83 2015.2
Language：Japanese Publishing type：Research paper (scientific journal)
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Short-term Outcomes of Laparoscopic Surgery for Colorectal Cancer in Japan. Reviewed
32 ( 1 ) 32 - 38 2015.1
Language：English Publishing type：Research paper (scientific journal)
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Photodynamic Therapy using Talaporfin Sodium for the Recurrence of Cholangiocarcinoma after Surgical Resection.
Shimizu S, Nakazawa T, Hayashi K, Naitoh I, Miyabe K, Kondo H, Nishi Y, Umemura S, Hori Y, Kato A, Morisaki T, Nanashima A, Ohara H, Joh T
Internal medicine (Tokyo, Japan) 54 ( 18 ) 2321 - 6 2015
Language：Japanese Publishing type：Research paper (scientific journal)
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胃癌に対する５-アミノレブリン酸を用いたレーザー光線力学的内視鏡診断
磯本 一, 荻原 久美, 妹尾 健正, 大仁田 賢, 山口 直之, 中尾 一彦, 七島 篤志
日本レーザー医学会誌 36 ( 2 ) 113 - 118 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：特定非営利活動法人 日本レーザー医学会
我々は胃癌の早期発見とスクリーニングへの応用を目指し，5-アミノレブリン酸（5-ALA）を用いたレーザー光線力学的内視鏡診断（PDD）の有用性を検討している．倫理委員会の承認を得て，当院で治療適応と判断された上部消化管腫瘍症例から本臨床研究に同意の得られた20例を対象とした．治療当日に5-ALAを経口摂取して3時間後にPDDを行った．5-ALA代謝産物のプロトポルフィリンIX（光感受性物質）を励起する特定波長レーザー光を照射可能な内視鏡を試作し，赤色蛍光の検出の有無，切除標本の病理組織像との対比を行った．胃癌23病変中19病変で赤色蛍光が確認できた．PDDに関する有害事象はなく，5-ALA/PDDの有用性と安全性を確認した．