Papers - NANASHIMA Atsushi
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Nanashima A., Pillay P., Verran D., Painter D., Nakasuji M., Crawford M., Shi L., Ross A.
Transplantation Proceedings 34 ( 4 ) 1231 - 1235 2002.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Transplantation Proceedings
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Minilaparotomy approach to terminal ileal Crohn's disease.
Nakagoe T, Sawai T, Tsuji T, Jibiki MA, Nanashima A, Yamaguchi H, Yasutake T, Ayabe H
World journal of surgery 26 ( 6 ) 721 - 5 2002.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Nakagoe T., Sawai T., Tsuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H., Arisawa K., Ishikawa H.
Anticancer Research 22 ( 1 A ) 451 - 458 2002.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research
Preoperative serum levels of sialyl Lewisa(CA19-9), sialyl Lewisx(SLX) and sialyl Tn (STN) antigens in 180 patients with gastric cancer were examined to establish predictive factors for serum levels of these antigens compared with carcino-embryonic antigen (CEA). The patients were divided into low and high antigen groups. Multivariate logistic regression analysis revealed the following independent predictive factors for high antigen levels [odds ratio]: liver metastasis for CA19-9 [4.40], SLX [9.90], STN [39.65] and CEA [5.14]; peritoneal dissemination for SLX [4.78] or STN [13.01]; venous invasion for CEA [3.56]; lymph node metastasis for CA19-9 [4.51]. In addition, high CA19-9 levels were independently related to lymph node metastasis in patients with stage I or II tumors. In conclusion, high serum levels of CA19-9, SLX and STN are associated with liver metastasis, while high serum levels of SLX and STN are associated with peritoneal dissemination. In addition, high serum CA19-9 levels may represent an independent predictor for lymph node metastasis.
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Nakagoe T., Fukushima K., Tanaka K., Sawai T., Tsuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H., Arisawa K.
Journal of Experimental and Clinical Cancer Research 21 ( 1 ) 107 - 113 2002.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Experimental and Clinical Cancer Research
This study aimed to determine whether sialyl Lewis a (Le a ), sialyl Lewisx (Le x ), or sialyl Tn antigen expression could identify a subset of node-negative colorectal cancer patients that are at high risk for recurrence after curative surgery. Tumor tissue samples from 90 patients with node-negative colorectal cancer, who had undergone surgical resection, were analyzed immunohistochemically for the expression of each antigen. Patients were classified as having low or high antigen expression depending on whether more or less than 40% of the field showed positive staining. The main outcome measure for each variable was disease-free interval. Sialyl Le a , sialyl Le x , and siaiyl Tn antigens were expressed in 53 (58.9%), 41 (45.6%), and 34 (37.8%) carcinomas, respectively. The median follow-up was 83.5 months. Patients with high sialyl Lex x expression had shorter disease-free intervals than those with low sialyl Le x expression (P=0.0041); the expression of sialyl Le x or sialyl Tn antigens did not show a significant relationship with disease-free survival. Cox's regression analysis revealed that sialyl Le x expression was an independent predictor for disease-free survival, separate from T factor or tumor location. High sialyl Le x expression may be useful in identifying a subset of node-negative colorectal cancer patients who are at high risk for recurrence.
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Nakagoe T., Sawai T., Tsuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H., Arisawa K., Ishikawa H.
Journal of Clinical Gastroenterology 34 ( 4 ) 408 - 415 2002.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Clinical Gastroenterology
Sialyl Lewis a (CA19-9) and sialyl Lewis x antigens (SLX) may play a role in tumor metastasis by serving as functional ligands in the cell adhesion system. The authors examined preoperative serum levels of CA19-9 and SLX in 218 patients who underwent resection for gastric cancer to determine their prognostic value. The patients were divided into two groups, termed the low and high antigen groups, based on a value selected as a diagnostic cutoff. Correlation between the antigen serum levels, various established clinicopathologic factors, and prognosis were studied by univariate and multivariate analysis. The disease-specific interval for high CA19-9 and SLX groups was significantly shorter than that of their respective low groups (p = 0.0024 and p < 0.0001, respectively). Patients with stage III/IV tumors who had high serum SLX levels had shorter disease-specific intervals than those with low serum levels (p = 0.0017). A Cox's regression analysis revealed a high serum SLX level as an independent factor for worse outcome. In addition, logistic regression analysis revealed that a high serum SLX level was an independent predictor for liver metastasis. In conclusion, an elevated preoperative serum SLX level was a predictor for poor outcome after resection for gastric cancer, whereas CA19-9 was not.
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Difference in prognostic value between sialyl Lewis(a) and sialyl Lewis(x) antigen levels in the preoperative serum of gastric cancer patients.
Nakagoe T, Sawai T, Tsuji T, Jibiki MA, Nanashima A, Yamaguchi H, Yasutake T, Ayabe H, Arisawa K, Ishikawa H
Journal of clinical gastroenterology 34 ( 4 ) 408 - 15 2002.4
Language：Japanese Publishing type：Research paper (scientific journal)
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[Liver transplantation for hepatocellular carcinoma: experience at an Australian transplantation unit].
Nanashima A
Nihon Geka Gakkai zasshi 103 ( 4 ) 381 - 5 2002.4
Language：Japanese Publishing type：Research paper (scientific journal)
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Liver transplantation for hepatocellular carcinoma: experience at an Australian transplantation unit Reviewed
Nanashima A.
Journal of Japan Surgical Society 103 ( 4 ) 381 - 385 2002.4
Authorship：Lead author Language：Japanese Publishing type：Case report
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A case report of intestinal perforation causing by dialysis-related amyloidosis
Takashi T., Terumitsu S., Shinichi S., Atsushi N., Masaaki J., Hiroyuki Y., Tohru Y., Tohru N., Hiroyoshi A., Kuniko A.
Japanese Journal of Gastroenterological Surgery 35 ( 2 ) 176 - 179 2002.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Gastroenterological Surgery
We experienced a case with an intestinal perforation resulting from dialysis-related amyloidosis. A fifty-six-year old women who had been receiving hemodialysis for twenty-three years underwent an operation for bilateral carpal tunnel syndrome and destructive spondyloarthropathy. She had experienced the onset of diarrhea four months earlier, and was operated on for perforative peritonitis. The middle part of the small intestine contained a 16 × 8 mm hole. Partial resection of the small bowel and end-to-end anastomosis was performed. A pathological examination revealed an amyloid deposit in a perivascular area of the submucosal layer, and immunohistochemistry for β2-microglobulin was positive. She was diagnosed as having dialysis-related amyloidosis. Anastomotic leakage occurred early during the post-operative day. She was died five months later because of a sepsis.
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Nakagoe T., Sawai T., Tuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H., Matuo T., Tagawa Y.
Digestive Diseases and Sciences 47 ( 2 ) 322 - 330 2002.2
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Digestive Diseases and Sciences
We examined the immunohistochemical expression of sialosyl-Tn antigen in the colorectal cancer tissues of 116 patients who underwent curative resection to determine the association between patient prognosis and the expression of sialosyl-Tn in two different tissues: carcinoma and transitional mucosa. Negative or positive expression of sialosyl-Tn in the carcinoma and transitional mucosal tissues were denoted as CA-or CA+and TM-or TM+, respectively. Patients were classified into one of four groups: CA-/TM-, CA-/TM+, CA+/TM-, and CA+/TM+. CA-/TM-was observed in 13 patients and CA-/TM+, CA+/TM-, or CA+/TM+was observed in 103 patients. The difference in five-year survival between the CA-/TM-group and all the other groups was statistically significant (P = 0.0457), and multivariate analysis showed that sialosyl-Tn expression in at least one of the two tissues was an independent prognostic factor. We conclude that the evaluation of sialosyl-Tn expression in carcinoma as well as transitional mucosa is useful for predicting survival in colorectal cancer patients.
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Increased expression of sialyl Lewis(x) antigen as a prognostic factor in patients with stage 0, I, and II gastric cancer.
Nakagoe T, Fukushima K, Sawai T, Tsuji T, Jibiki Ma, Nanashima A, Tanaka K, Yamaguchi H, Yasutake T, Ayabe H, Arisawa K, Ishikawa H
Cancer letters 175 ( 2 ) 213 - 21 2002.1
Language：Japanese Publishing type：Research paper (scientific journal)
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Nakagoe T., Fukushima K., Sawai T., Tsuji T., Jibiki M., Nanashima A., Tanaka K., Yamaguchi H., Yasutake T., Ayabe H., Arisawa K., Ishikawa H.
Cancer Letters 175 ( 2 ) 213 - 221 2002.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Cancer Letters
Immunohistochemically detected expression of sialyl Lewis x (Le x ) antigen was analyzed in 101 stage 0-II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Le x antigen within their tumors had shorter disease-specific intervals than those with negative- or low-expressing tumors (P < 0.0001). This difference was noted particularly in stage I-B or II disease. Multivariate Cox's regression analysis revealed sialyl Le x antigen expression to be an independent predictor of disease-specific survival (Hazard ratio=9.10). In conclusion, the increased expression of sialyl Le x antigen may serve as a prognostic factor after curative surgery for stages 0-II gastric cancer. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
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Predictive factors for preoperative serum levels of sialy Lewis(x), sialyl Lewis(a) and sialyl Tn antigens in gastric cancer patients.
Nakagoe T, Sawai T, Tsuji T, Jibiki MA, Nanashima A, Yamaguchi H, Yasutake T, Ayabe H, Arisawa K, Ishikawa H
Anticancer research 22 ( 1A ) 451 - 8 2002.1
Language：Japanese Publishing type：Research paper (scientific journal)
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Analysis of tumor morphology in metastatic colorectal cancer: does this classification have any clinical significance?
Nanashima A, Yamaguchi H, Sawai T, Shibasaki S, Yasutake T, Tsuji T, Hidaka S, Jibiki M, Nakagoe T, Ayabe H
Journal of gastroenterology 37 ( 10 ) 791 - 7 2002
Language：Japanese Publishing type：Research paper (scientific journal)
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Application of argyrophilic nucleolar organizer region (AgNOR) staining for cytology of biliary tract carcinomas.
Nanashima A, Yamaguchi H, Nishizawa-Takano JE, Hatano K, Shibasaki S, Sawai T, Yasutake T, Obatake M, Nakagoe T, Ayabe H
Journal of hepato-biliary-pancreatic surgery 9 ( 4 ) 485 - 9 2002
Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Pillay P., Crawford M., Nakasuji M., Verran D., Painter D.
Journal of Hepato-Biliary-Pancreatic Surgery 8 ( 6 ) 557 - 563 2001.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Hepato-Biliary-Pancreatic Surgery
Background/Purpose. We investigated the causes and examined patient outcomes following the postrevascularization syndrome (PRS) during orthotopic liver transplantation (OLTx). Methods. PRS was defined as a fall in the mean arterial pressure at 5 min after revascularization to less than 70% of the baseline and lasting for 5 min. Data from 100 adult patients who underwent OLTx between January 1998 and September 2000 were analyzed. Analyzed data included donor and recipient demographic data, recipient operative and postoperative courses, and recipient outcome. Results. Twenty-nine patients (29%) exhibited PRS during OLTx (PRS group). There was a higher incidence of older donors ( > 50 years) in the PRS group (48% vs 23%; P < 0.05). Postrevascularization hyperkalemia and metabolic acidosis were observed in both the PRS and non-PRS groups. Transaminase and lactate levels after revascularization were significantly higher in the PRS group (P < 0.05). Alkaline phosphatase and gamma-glutamyl transpeptidase levels on day 7 tended to be higher in the PRS group; although the difference was not significant (p ≥ 0.05). Serum creatinine was significantly elevated on day 7 in the PRS group (P < 0.01). Conclusions. Our results indicate that PRS following OLTx tended to be more common in liver allografts from older donors and was associated with posttransplantation liver and renal dysfunction.
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Colectomy for colon cancer via a 7-cm minilaparotomy
Nakagoe T., Sawai T., Tsuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H.
Surgery Today 31 ( 12 ) 1113 - 1115 2001.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Surgery Today
We herein describe our technique for performing a colectomy to resect colon cancer via a 7-cm minilaparotomy using conventional surgical techniques and instruments. By moving the minilaparotomy wound laterally as well as either caudad or cephalad, the mobilization of the relevant segment of the bowel loop was thus made possible. To ensure an adequate visualization of the operative field during a dissection of the lymph nodes, an Omni-Tract retractor system was used. The division of the colonic mesentery, transection of the affected bowel, and bowel anastomosis were performed extracorporeally or at the level of the incision. This same operation was successfully performed in 102 patients with colon cancer. We conclude that a colectomy for colon cancer via a 7-cm minilaparotomy is an attractive alternative to a conventional full laparotomy in selected patients.
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Early outcome after minilaparotomy for the treatment of rectal cancer
Nakagoe T., Sawai T., Tsuji T., Jibiki M., Nanashima A., Yamaguchi H., Yasutake T., Ayabe H.
European Journal of Surgery 167 ( 9 ) 705 - 710 2001.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：European Journal of Surgery
Objective: To compare early outcomes of the minilaparotomy approach to the resection of rectal cancer with those of conventional laparotomy. Design: Retrospective study. Setting: University hospital, Japan. Subjects: 18 patients who had complete resection through a minilaparotomy and 20 who had a conventional laparotomy served as the study and the control groups, respectively. Patients who were overweight or morbidly obese (body mass index ≥25) were excluded from the study. Interventions: Complete resection through a skin incision less than 7 cm in length, or a conventional incision. Main outcome measures: Early postoperative outcomes. Results: Postoperative time intervals to standing, walking, passing flatus, and removal of the urinary catheter, and analgesic requirements were significantly less in the minilaparotomy group (p = 0.007, p = 0.004, p = 0.02, p = 0.002, and p = 0.05, respectively). Conclusions: The minilaparotomy for complete resection of rectal cancer is less invasive than conventional laparotomy, and provides an attractive alternative in highly selected patients who are not overweight.
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Sawai T., Nanashima A., Tsuji T., Yamaguchi H., Yasutake T., Nakagoe T., Ayabe H., Tagawa Y.
Journal of Experimental and Clinical Cancer Research 20 ( 3 ) 401 - 405 2001.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Experimental and Clinical Cancer Research
Recently, two different mechanisms of genetic instability have been demonstrated in the carcinogenesis of colorectal cancer. Microsatellite instability is an important genetic event for carcinogenesis in hereditary non-polyposis colorectal cancer, proximal colon cancer, and multiple colorectal carcinoma. To examine the association among chromosomal instability and multiple primary malignancies (MPM) in colorectal cancer, fluorescence in situ hybridization using a chromosome 17-specific probe, p53 cosmid probe, and/or an alpha satellite DNA probe was performed in 184 patients with colorectal cancer. The proportion of aneusomy 17 in MPM was significantly higher than that of single cancers (SC) (46.1±8.0% and 39.0±10.3%, respectively; p < 0.01). Multiple numerical aberrations of chromosome 17 in MPM occurred more often than those of SC (64.3% and 22.9%, respectively; p < 0.01). The mean frequency of p53 deletion was also higher in MPM (70.4±16.7%) compared with SC (53.4±18.1%, p < 0.05). The frequency of chromosome 17 translocation was significantly greater in tumors with MPM (4/6; 67%) than in SC (3/23; 13%, p < 0.05). The frequency of p53 locus translocation was also significantly greater in tumors with MPM (4/6; 67%) than in SC (0/23; 0%, p < 0.01). These results suggested that numerical and structural aberrations of chromosome 17 and the p53 locus are important genetic events associated with carcinogenesis in non-familial colorectal cancer with MPM.
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Minilaparotomy wound edge protector (Lap-Protector): A new device
Nakagoe T., Sawai T., Tsuji T., Nanashima A., Jibiki M., Yamaguchi H., Yasutake T., Ayabe H., Shimomura K.
Surgery Today 31 ( 9 ) 850 - 852 2001.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Surgery Today
Laparoscopic-assisted or minimally invasive surgery involving minilaparotomy is occasionally complicated by infection of the minilaparotomy wound caused by intestinal bacteria. Furthermore, when this procedure is performed to excise colorectal or gastric cancer, tumor recurrence may develop in the minilaparotomy wound. In an attempt to minimize the risk of these complications, we developed a new, easy-to-use device which we named the "Lap-Protector." Minilaparotomy was performed using the Lap-Protector in 28 patients with colon cancer and eight patients with early gastric cancer who underwent minimally invasive surgery between January and September, 1999. During a median follow-up period of 15.9 (range 12.4-21.0) months, none of the 36 patients showed any sign of wound infection or tumor recurrence in the minilaparotomy wound. These results indicated that the Lap-Protector is a safe and useful device that may help to prevent infections and cancer cell contamination of the minilaparotomy wound.