Papers - NANASHIMA Atsushi
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Nanashima A., Takeshita H., Sawai T., Sumida Y., Abo T., Tanaka K., Nonaka T., Sengyoku H., Hidaka S., Yasutake T., Nagayasu T.
Hepato-Gastroenterology 55 ( 86-87 ) 1750 - 1753 2008.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Hepato-Gastroenterology
Background/Aims: Recently, early detection of liver tumors has been possible with improvement of various imaging techniques, and practical selection of imaging is clinically necessary to distinguish metastatic liver carcinoma (MLC) from colorectal carcinoma. Methodology: We retrospectively examined the diagnostic accuracy of enhanced computed tomography (eCT) and super paramagnetic iron oxide particles magnetic resonance imaging (SPIO-AMI) for 110 MLC lesions in 47 patients who underwent hepatic resection at a single Japanese cancer institute between 2000 and 2006, Sensitivity and positive predictive value (PPV) of both imaging techniques in comparison with resected specimens were analyzed. Fourteen cases were synchronous liver metastasis, which were resected simultaneously. Results: On a per patient basis, both eCT and SPIO-MRI showed a sensitivity of 85.1% 1 (40 of 47 patients) and PPV was 100%, respectively. On a per lesion basis, a sensitivity of SPIO-MRI (98/110 lesions; 89%) tended to be higher than that of eCT (92 of 110 lesions; 84%), but not statistically different (p=0.32). PPV, of SPIO-MRI (98 of 99 lesions; 99%) was not different from that of eCT (92 of 93; 99%). Twelve lesions in 7 patients that were not detected by both imaging methods were small lesions. PPV for liver cyst and non-timorous lesions was 99% by both imaging methods. Two liver cysts could be clearly diagnosed by SPIO-MRI only. Conclusions, We found no superiority of diagnosis with SPIO-MRI, which may not be conceptually useful for preoperative screening for MLC from colorectal carcinomas. SPIO-MRI may be useful to detect non-cancerous lesions as an adjuvant diagnostic tool with eCT. © H.G.E. Update Medical Publishing S.A., Athens-Stuttgart.
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Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma.
Nanashima A, Nakayama T, Sumida Y, Abo T, Takeshita H, Shibata K, Hidaka S, Sawai T, Yasutake T, Nagayasu T
World journal of gastroenterology 14 ( 31 ) 4915 - 22 2008.8
Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Nakayama T., Sumida Y., Abo T., Takeshita H., Shibata K., Hidaka S., Sawai T., Yasutake T., Nagayasu T.
World Journal of Gastroenterology 14 ( 31 ) 4915 - 4922 2008.8
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：World Journal of Gastroenterology
Aim: To elucidate the relationship between the microvessel count (MVC) by CD34 analyzed by immunohistochemical method and prognosis in hepatocel lular carcinoma (HCC) pat ients who underwent hepatectomy based on our preliminary study. Methods: We examined relationships between MVC and clinicopathological factors in 128 HCC patients. The modified Japan Integrated Staging score (mJIS) was applied to examine subsets of HCC patients. Results: Median MVC was 178/mm2, which was used as a cut-off value. MVC was not significantly associated with any clinicopathologic factors or postoperative recurrent rate. Lower MVC was associated with poor disease-free and overall survivals by univariate analysis (P = 0.039 and P = 0.087, respectively) and lower MVC represented an independent poor prognostic factor in disease-free survival by Cox's multivariate analysis (risk ratio, 1.64; P = 0.024), in addition to tumor size, vascular invasion, macroscopic finding and hepatic dysfunction. Significant differences in disease-free and overall survivals by MVC were observed in HCC patients with mJIS 2 (P = 0.046 and P = 0.0014, respectively), but not in those with other scores. Conclusion: Tumor MVC appears to offer a useful prognostic marker of HCC patient survival, particularly in HCC patients with mJIS 2. © 2008 The WJG Press. All rights reserved.
DOI： 10.3748/wjg.14.4915
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Clinicopathological features of "intraductal papillary neoplasm of the bile duct" and patient outcome after surgical resection.
Nanashima A, Kinoshita N, Nakanuma Y, Zen Y, Sumida Y, Abo T, Hidaka S, Takeshita H, Yasutake T, Hayashi T, Nagayasu T
Hepato-gastroenterology 55 ( 85 ) 1167 - 73 2008.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Anatomic resection of segments 5, 6 and 7 of liver for hepatocellular carcinoma: prior control of right paramedian Glisson.
Nanashima A, Sumida Y, Abo T, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 55 ( 84 ) 1077 - 80 2008.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Hepatectomy and pancreatectomy with combined vascular resection in patients with hepato-biliary and pancreas diseases at a single cancer institute.
Nanashima A, Yamaguchi H, Sumida Y, Abo T, Tobinaga S, Tanaka K, Takeshita H, Hidaka S, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 55 ( 84 ) 873 - 8 2008.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Yamaguchi H., Sumida Y., Abo T., Tobinaga S., Tanaka K., Takeshita H., Hidaka S., Sawai T., Yasutake T., Nagayasu T.
Hepato-Gastroenterology 55 ( 84 ) 873 - 878 2008.5
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Hepato-Gastroenterology
Background/Aims: In advanced cancers of hepatobiliary and pancreatic lesions, major vascular resection and reconstruction are necessary to accomplish curative resection, which may provide better patient outcomes. Methodology: Surgical records, morbidity and mortality, and prognosis were examined in patients with combined vascular resection. Thirty-six patients underwent 18 hepatectomies and 18 pancreatectomies. Results: In 18 patients who underwent hepatic resection, the resected vessels were the portal vein (PV) in 10, vena cava or hepatic vein in 9 and right hepatic artery (RHA) in 3. An artificial graft was used in 2 to replace the vena cava. Vascular bypass was performed in 5 patients. Morbidity was due to biliary stricture in 1 patient and adult respiratory distress syndrome in another who died during hospital stay. Fourteen (82%) had cancer recurrence, of whom 12 died of cancer, one died of other disease, and 2 survived cancer-free. The 5-year survival was 28%. In 18 patients who underwent pancreatectomy, resected vessels were PV in 18 and RHA in 1. An artificial graft was used in 3 and vascular passive bypass was performed in 6. One patient died of sepsis after total pancreatectomy during hospital stay. Eleven (64%) had cancer recurrence, of whom 11 died of cancer, 2 died of other disease, and 4 survived cancer-free. The 3-year survival was 27%. Conclusions: Complete surgical resection (R0) combined with main vascular resection could be safely performed in many patients with disease of the hepatobiliary and pancreas, which achieved longer survival in some patients even in the advanced stage. © H.G.E. Update Medical Publishing S.A.
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Resection of segments 4, 5 and 8 for a cystic liver tumor using the double liver hanging maneuver. Reviewed
Nanashima A, Sumida Y, Abo T, Nonaka T, Sengyoku H, Sawai T, Yasutake T, Nagayasu T
Case Reports in Gastroenterology 2 ( 1 ) 60 - 66 2008.3
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Clinicopathology and prognosis of mucinous gastric carcinoma.
Hidaka S, Tanaka K, Takeshita H, Sumida Y, Fukuoka H, Abo T, Yano H, Nanashima A, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 55 ( 82-83 ) 791 - 4 2008.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Surgical treatment and adjuvant chemotherapy in hepatocellular carcinoma patients with advanced vascular involvement.
Nanashima A, Sumida Y, Abo T, Nagasaki T, Ohba K, Kinoshita H, Tobinaga S, Kenji T, Takeshita H, Hidaka S, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 55 ( 82-83 ) 627 - 32 2008.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Principle of perioperative management for hepatic resection and education for young surgeons.
Nanashima A, Sumida Y, Abo T, Tanaka K, Takeshita H, Hidaka S, Yano H, Sawai T, Obatake M, Yasutake T, Nagayasu T
Hepato-gastroenterology 55 ( 82-83 ) 587 - 91 2008.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Principle of perioperative management for hepatic resection and education for young surgeons
Nanashima A., Sumida Y., Abo T., Tanaka K., Takeshita H., Hidaka S., Yano H., Sawai T., Obatake M., Yasutake T., Nagayasu T.
Hepato-Gastroenterology 55 ( 82-83 ) 587 - 591 2008.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Hepato-Gastroenterology
Background/Aims: An expert technique and special anatomical or physiological knowledge are needed in the field of hepatic surgery compared to other abdominal surgeries. The establishment of basic policy and operative techniques for hepatectomy and stepwise training for young hepatic surgeons are necessary. Methodology: We scheduled hepatic resection based on the indocyanine green retention rate at 15 minutes and volumetric analysis. Limited resection or preoperative portal vein embolization was often performed. Results: Between 1994 and December 2005, 338 hepatectomies were performed. Operative procedures included limited or segmental resection in 215 and hemihepatectomy or more extended hepatectomy in 123. Hyperbilirubinemia or hepatic failure after hepatectomy was observed in 15 (4%) and hospital death in 10 (3%). Although death from hepatic failure was observed in 9 of 152 (6%) between 1994 and 1999, the mortality rate has been improved since 2000 (1 of 186 [0.5%]). Senior residents start training with step by step hepatectomy from partial resection to sectionectomy. Hemi-hepatectomy for normal liver is finally permitted after technical consolidation. More complicated hepatectomy must be performed by experienced teaching surgeons. Conclusions: Competent operative techniques under experienced surgeons and the achievement of safe resection at each stage are the educational policy for hepatectomy. © H.G.E. Update Medical Publishing S.A.
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Selection of treatment modality for hepatocellular carcinoma according to the modified Japan Integrated Staging score.
Nanashima A, Masuda J, Miuma S, Sumida Y, Nonaka T, Tanaka K, Hidaka S, Sawai T, Nagayasu T
World journal of gastroenterology 14 ( 1 ) 58 - 63 2008.1
Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Masuda J., Miuma S., Sumida Y., Nonaka T., Tanaka K., Hidaka S., Sawai T., Nagayasu T.
World Journal of Gastroenterology 14 ( 1 ) 58 - 63 2008.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：World Journal of Gastroenterology
Aim: To compare the prognosis of patients who underwent hepatectomy and ablation using the modified Japan Integrated Staging score (mJIS). Methods: We examined the clinicopathologic records and patient outcomes in 278 HCC patients including 226 undergoing hepatectomy and 52 undergoing ablation therapy. Results: Cirrhosis was more frequent in the ablation group. Tumor size, number and presence of vascular invasion were significantly higher in the operation group compared to the ablation group. The local recurrence rate adjacent to treated lesions was significantly higher in the ablation group compared to the operation group (P < 0.05). The 3- and 5-year survival rates in the ablation and the operation group were 66% and 78%, and 50% and 63%, respectively, but not significantly different. Over 50% survival rates were observed in patients with a mJIS score of 0-2 in both groups. However, survival rates with a score of 3-5 in both groups were significantly lower. Conclusion: According to the mJIS system, both local treatments could be selected for patients with a score of 0-2. However, for patients with a score more than 3, liver transplantation might be a better option in patients with HCC. © 2008 WJG. All rights reserved.
DOI： 10.3748/wjg.14.58
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Patient outcome and prognostic factors in intrahepatic cholangiocarcinoma after hepatectomy.
Nanashima A, Sumida Y, Abo T, Nagasaki T, Takeshita H, Fukuoka H, Sawai T, Tanaka K, Yasutake T, Nagayasu T
Hepato-gastroenterology 54 ( 80 ) 2337 - 42 2007.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Patient outcome and prognostic factors in intrahepatic cholangiocarcinoma after hepatectomy
Nanashima A., Sumida Y., Abo T., Nagasaki T., Takeshita H., Fukuoka H., Sawai T., Tanaka K., Yasutake T., Nagayasu T.
Hepato-Gastroenterology 54 ( 80 ) 2337 - 2342 2007.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Hepato-Gastroenterology
Background/Aims: The present study was designed to provide a systematic analysis of prognosis of patients who underwent hepatic resection for intrahepatic cholangiocarcinoma (ICC). Methodology: Subjects were 36 consecutive ICC patients who had undergone hepatic resection between 1994 and 2005. The analyzed factors included various clinicopathological and surgical parameters, counts of microvessel stained for CD34 and expression of proliferative cell nuclear antigen. Results: The 1, 2, 3-year disease-free survival rates after surgery were 33, 18, and 0% and the 1, 3 and 5-year overall survival rates were 45, 29, and 8%. High CEA levels (≥10ng/mL), excessive intraoperative blood loss (≥1000mL) and presence of neighboring peritoneal dissemination were significantly associated with shorter disease-free survival (p < 0.05). High CEA levels, periductal invasion type, excessive intraoperative blood loss and non-fibrotic liver were significant factors associated with shorter overall survival (p < 0.05). Multivariate Cox proportional hazards regression model identified high CEA values, periductal invasive type, excessive intraoperative blood loss and non-fibrotic liver as significant and independent determinants of poor prognosis. Conclusions: Hepatic resection with minimal blood loss followed by close follow-up is a suitable strategy for management of ICC patients with poor prognostic factors. © H.G.E. Update Medical Publishing S.A.
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Clinicopathological characteristics of patients with hepatocellular carcinoma after hepatectomy: relationship with status of viral hepatitis.
Nanashima A, Abo T, Sumida Y, Takeshita H, Hidaka S, Furukawa K, Sawai T, Yasutake T, Masuda J, Morisaki T, Nagayasu T
Journal of surgical oncology 96 ( 6 ) 487 - 92 2007.11
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Laparotomy wound and anastomotic recurrences after resection for cecum cancer: A case report
Nakagoe T., Sawai T., Tsuji T., Tanaka K., Nanashima A., Shibasaki S., Yamaguchi H., Yasutake T., Ayabe Y.
Hepato-Gastroenterology 54 ( 79 ) 2037 - 2039 2007.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Hepato-Gastroenterology
We report herein the case of a 46-year-old man who developed recurrences in both the incisional laparotomy wound of the abdominal wall and the stapled anastomotic site following ileo-colonic resection for cecum cancer. The patient had initially undergone laparoscopic surgery but had converted to conventional open surgery. Intestinal reconstruction had been performed by stapled functional end-to-end anastomosis between the ileum and ascending colon. The implantation of exfoliated cancer cells during the operation may have caused recurrence. © H.G.E. Update Medical Publishing S.A.
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Ets-1 proto-oncogene as a potential predictor for poor prognosis of lung adenocarcinoma.
Yamaguchi E, Nakayama T, Nanashima A, Matsumoto K, Yasutake T, Sekine I, Nagayasu T
The Tohoku journal of experimental medicine 213 ( 1 ) 41 - 50 2007.9
Language：Japanese Publishing type：Research paper (scientific journal)
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Right paramedian sectoriectomy using the double liver hanging maneuver.
Nanashima A, Sumida Y, Abo T, Yasutake T, Nagayasu T
Surgery 142 ( 3 ) 430 - 1 2007.9
Language：Japanese Publishing type：Research paper (scientific journal)