Papers - NANASHIMA Atsushi
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Morinaga M., Tagawa Y., Yasutake T., Miyashita K., Sawai T., Matsumoto Y., Nanashima A., Hatano K., Uchikawa T., Fujise N.
Japanese Journal of Cancer and Chemotherapy 21 Suppl 1 75 - 81 1994.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Cancer and Chemotherapy
The authors have performed fluorescence in situ hybridization (FISH) in tissue sections of archival paraffin-embedded blocks of seven cases in adenoma and ten cases in carcinoma in order to clarify which chromosomal aberration occurred in association with multi-step carcinogenesis in colorectal carcinomas, using alpha-satellite DNA probes to chromosome 11 and 17, D11Z1 and D17Z1, respectively. Monosomy of chromosome 11 was most frequented (5/7, 71.4%) in adenoma, and trisomy of chromosome 17 was predominant (9/10, 90.0%) in carcinoma. The numerical chromosomal aberrations can be already detected at the stage of adenoma, and monosomy of chromosome 11 was mainly observed in adenoma. Furthermore, malignant transformation arising from adenoma accounted for most of the trisomic change in chromosome 17. Consequently, applying the FISH technique to tissue sections from archival paraffin embedded specimen, it would be possible to distinguish between the cancerous and non-cancerous regions in view of chromosomal numerical aberrations. The authors emphasized that intratumoral heterogeneity could be elucidated at the chromosomal level.
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Shimoyama T., Kusano H., Miyashita K., Matsumoto Y., Hatano K., Nanashima A., Uchikawa T., Fujise N., Taniguchi Y., Itoyanagi N., Shimizu T., Nakagoe T., Miura T., Tomita M., Makiyama K.
GASTROENTEROLOGICAL ENDOSCOPY 35 ( 2 ) 1993
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：GASTROENTEROLOGICAL ENDOSCOPY
Our case is a 73 year-old man. Barium enema and colonoscopy showed a nodular tumor like ha around the appendiceal orifice. Histologically, biopy specimens revealed a tubular adenoma with severe atypia. Ileocecal resection was done. Macroscopically, the lesion was a well demarcated falt tumor 35×60mm in size with nodular-aggregated surface around the appendiceal orifice. Histological examination revealed carcinoma in adenoma. In microangiography, the stalk vessels was noted in the nodular area, and the vascular patterns in the flat elevated lesion were similar to the mucosal vessels. This is a rare case in the location of the tumor, and the multiple hyperplastic polyps in the stomach were associated. © 1993, Japan Gastroenterological Endoscopy Society. All rights reserved.
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Shimoyama T., Azuma K., Shinkai K., Hayashida K., Kida H., Shimizu T., Kusano H., Terada R., Taniguchi Y., Nanashima A., Uchikawa T., Nakamura A., Nakagoe T., Miura T., Tomita M., Kawaguchi A.
Journal of the Japan Society of Colo-Proctology 46 ( 7 ) 878 - 885 1993
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of the Japan Society of Colo-Proctology