Papers - NANASHIMA Atsushi
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Photodynamic therapy using talaporfin sodium (Laserphyrin®) for bile duct carcinoma: a preliminary clinical trial.
Nanashima A, Abo T, Nonaka T, Nonaka Y, Morisaki T, Uehara R, Ohnita K, Fukuda D, Murakami G, Tou K, Kunizaki M, Hidaka S, Tsuchiya T, Takeshita H, Nakao K, Nagayasu T
Anticancer research 32 ( 11 ) 4931 - 8 2012.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Abo T., Nonaka T., Nonaka Y., Morisaki T., Uehara R., Ohnita K., Fukuda D., Murakami G., Tou K., Kunizaki M., Hidaka S., Tsuchiya T., Takeshita H., Nakao K., Nagayasu T.
Anticancer Research 32 ( 11 ) 4931 - 4938 2012.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research
The efficacy of adjuvant photodynamic therapy (PDT) using the new photosensitizer, talaporfin sodium (TPS), was assessed in 7 patients with bile duct carcinoma (BDC). The 664-nm semiconductor laser (100 J/ cm 2 ) was applied through endoscopy to the tumor lesion within 6 h after injection of TPS. Cases included three nonresectable and 4 resected BDC with remnant cancer cells at the bile duct stump. Radiated lesions exhibited mild inflammatory responses. Locally advanced tumor occluding bile duct was relieved by PDT and patency was maintained for 16 months. Two patients developed mild photodermatitis but no severe morbidity. One patient died of other disease, and two patients died of liver metastasis within 6 months, but local recurrence was not observed. Three patients maintained cancer-free survival for 6-13 months. One patient survived with good status for 24 months. Adjuvant TPS-PDT is a safe and useful treatment for local control of BDC. Compared to the conventional PDT, the patient's quality of life is remarkably improved.
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Evaluation of surgical resection for gallbladder carcinoma at a Japanese cancer institute.
Nanashima A, Tobinaga S, Abo T, Morisaki T, Uehara R, Takeshita H, Nonaka T, Hidaka S, Takeshima F, Ohnita K, Isomoto H, Kunizaki M, Sawai T, Nakao K, Nagayasu T
Hepato-gastroenterology 59 ( 118 ) 1717 - 21 2012.9
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Three-dimensional fusion images of hepatic vasculature and bile duct used for preoperative simulation before hepatic surgery.
Nanashima A, Abo T, Sakamoto I, Hayashi H, Fukuda T, Tobinaga S, Araki M, Sawai T, Nagayasu T
Hepato-gastroenterology 59 ( 118 ) 1748 - 57 2012.9
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Safety of hepatectomy accompanying combined resection of other organs.
Nanashima A, Abo T, Takeshita H, Yamasaki N, Sawai T, Nagayasu T
Hepato-gastroenterology 59 ( 118 ) 1915 - 20 2012.9
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Relationship between microvessel count and clinicopathological characteristics and postoperative survival in patients with pancreatic carcinoma.
Nanashima A, Shibata K, Nakayama T, Abo T, Nonaka T, Fukuda D, Fukuoka H, Hidaka S, Takeshita H, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 59 ( 118 ) 1964 - 9 2012.9
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Single-incision laparoscopy-assisted subtotal gastrectomy for intractable gastric ulcer: a case report.
Nonaka T, Hidaka S, Takafumi A, Fukuoka H, Takeshita H, Atsushi N, Sawai T, Yasutake T, Nagayasu T
Surgical laparoscopy, endoscopy & percutaneous techniques 22 ( 4 ) e210 - 3 2012.8
Language：Japanese Publishing type：Research paper (scientific journal)
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Extended right hepatectomy for hilar bile duct carcinoma using the modified liver hanging maneuver.
Nanashima A, Tobinaga S, Abo T, Nonaka T, Hidaka S, Takeshita H, Sawai T, Nagayasu T
Hepato-gastroenterology 59 ( 117 ) 1583 - 5 2012.7
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Does fibrin glue prevent biliary and pancreatic fistula after surgical resection?
Nanashima A, Tobinaga S, Kunizaki M, Nonaka T, Takeshita H, Hidaka S, Sawai T, Nagayasu T
Hepato-gastroenterology 59 ( 117 ) 1544 - 7 2012.7
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Distal pancreatectomy with en bloc celiac resection for locally advanced pancreas carcinoma.
Nanashima A, Abo T, Tomonaga T, Fukuda A, Kunizaki M, To K, Takeshita H, Hidaka S, Nagayasu T, Sakamoto I
Hepato-gastroenterology 59 ( 117 ) 1341 - 4 2012.7
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Comparison of postoperative morbidity in elderly patients who underwent pancreatic resection. Reviewed
Nanashima A, Abo T, Nonaka T, Hidaka S, Takeshita H, Morisaki T, Uehara R, Ohnita K, Takeshima F, Isomoto H, Sawai T, Nakao K, Nagayasu T
Hepato-gastroenterology 59 ( 116 ) 1141 - 1146 2012.6
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.5754/hge10777
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Portal vein anastomosis with parachute method in hepatectomy and pancreatectomy.
Nanashima A, Abo T, Kunizaki M, Takeshita H, Hidaka S, Sawai T, Nagayasu T
Hepato-gastroenterology 59 ( 116 ) 1000 - 2 2012.6
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Evaluation of surgical resection for pancreatic carcinoma at a Japanese single cancer institute.
Nanashima A, Tobinaga S, Abo T, Hatano K, Takeshita H, Nonaka T, Hidaka S, Tanaka K, Kunizaki M, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 59 ( 115 ) 911 - 5 2012.5
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Usefulness of omental wrapping to prevent biliary leakage and delayed gastric emptying in left hepatectomy.
Nanashima A, Tobinaga S, Abo T, Nonaka T, Kunizaki M, Takeshita H, Hidaka S, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 59 ( 115 ) 847 - 50 2012.5
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Experience of surgical resection for hilar cholangiocarcinomas at a Japanese single cancer institute.
Nanashima A, Tobinaga S, Abo T, Machino R, Takeshita H, Nonaka T, Hidaka S, Tanaka K, Kunizaki M, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 59 ( 114 ) 347 - 50 2012.3
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Diagnosis of small-bowel metastasis of hepatocellular carcinoma by double-balloon enteroscopy.
Kunizaki M, Hidaka S, Isomoto H, Takeshita H, Nanashima A, Sawai T, Yasutake T, Nagayasu T
International journal of surgery case reports 3 ( 7 ) 263 - 5 2012
Language：Japanese Publishing type：Research paper (scientific journal)
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Perioperative non-tumorous factors associated with survival in HCC patients who underwent hepatectomy.
Nanashima A, Abo T, Hamasaki K, Wakata K, Tominaga T, Hidaka S, Takeshita H, Nagayasu T
Anticancer research 31 ( 12 ) 4545 - 51 2011.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Abo T., Hamasaki K., Wakata K., Tominaga T., Hidaka S., Takeshita H., Nagayasu T.
Anticancer Research 31 ( 12 ) 4545 - 4551 2011.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research
Aim: To clarify perioperative factors associated with poor survival following hepatectomy. Patients and Methods: Clinical parameters and stress score, including surgical stress score (SSS) and comprehensive risk score (CRS) were examined from 183 hepatocellular carcinoma patients who underwent hepatectomy. Results: Factors associated with tumor relapse were increased blood loss/weight, uncontrolled ascites and grade B liver damage (p < 0.05). Ascites was identified as an independent risk factor by multivariate logistic regression analysis. Increased blood loss/weight, transfusion, high SSS, high CRS, ascites, and grade B liver damage were associated with poor disease-free survival (p < 0.05). Increased blood loss/weight, transfusion, ascites, and grade B liver damage were associated with poor overall survival (p < 0.05), and ascites, transfusion, male sex and grade B liver damage were identified as independent risk factors. Conclusion: Reducing blood loss and avoiding transfusion appear important for improving prognosis. Maintenance of liver function is necessary in cases showing poor liver function and uncontrolled ascites.
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Nanashima A., Abo T., Tobinaga S., Nonaka T., Nakao K., Hidaka S., Takeshita H., Fukuoka H., Sawai T., Yasutake T., Nagayasu T.
Acta Medica Nagasakiensia 56 ( 3 ) 93 - 97 2011.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Acta Medica Nagasakiensia
Laparoscopic surgery is a less invasive treatment option for tumors in the intraabdominal organs; however, the safety and indication of laparoscopic or laparoscopy assisted pancreaticoduodenectomy (LPD) is still controversial. We attempted LPD in four cases for intraductal papillary mucinous neoplasm (IPMN) located in the pancreatic head and we report the surgical records and short-term outcome. LPD was carried out in four patients including three patients with the combined type IPMN and one with the branch type, based on the International Consensus Guidelines. None of the patients had invasive carcinoma based on preoperative imaging diagnosis. Laparoscopic procedures were performed until isolation of the pancreas head and duodenum, and final resection of PD and intestinal reconstruction were performed using small incision laparotomy (7-8cm). The mean total operating time was 882 minutes (820-932 minutes), mean blood loss was 925ml (610-1550ml) and red cell transfusion was not required in any patients. One patient underwent reoperation for bleeding at the pancreaticojejunostomy site at day 1. Mean duration until patients were able to walk was 3.5 days (2-6 days) and duration of use of analgesia was limited to within 7 days. Grade B pancreatic fistula was observed in one patient and jejunal ileus was observed in one patient. There were no deaths. LPD was safely performed and blood loss was limited, although the operating time was long. Postoperative recovery in patients without complications might be better than the conventional PD under laparotomy. Future study is necessary.
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Predictive factor for photodynamic therapy effects on oral squamous cell carcinoma and oral epithelial dysplasia.
Uehara M, Ikeda H, Nonaka M, Sumita Y, Nanashima A, Nonaka T, Asahina I
Archives of oral biology 56 ( 11 ) 1366 - 72 2011.11
Language：Japanese Publishing type：Research paper (scientific journal)