Papers - NANASHIMA Atsushi
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Intratracheal Administration of Recombinant Human Keratinocyte Growth Factor Promotes Alveolar Epithelial Cell Proliferation during Compensatory Lung Growth in Rat.
Furukawa K, Matsumoto K, Nagayasu T, Yamamoto-Fukuda T, Tobinaga S, Abo T, Yamasaki N, Tsuchiya T, Miyazaki T, Kamohara R, Nanashima A, Obatake M, Koji T
Acta histochemica et cytochemica 46 ( 6 ) 179 - 85 2013.12
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Murakami G., Nanashima A., Nonaka T., Isomoto H., Takagi K., Arai J., Hatachi G., Abo T., Nagayasu T.
Acta Medica Nagasakiensia 58 ( 3 ) 73 - 77 2013.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Acta Medica Nagasakiensia
Background: Photodynamic therapy (PDT) is an effective laser treatment for locally advanced carcinoma and is promising as neoadjuvant chemotherapy before surgery. The aim of this study was to clarify the adverse effects of PDT using a photosensitizer, talaporfin sodium (Laserphyrin®), for wound healing. Methodology: For PDT, a laser light with a wavelength of 660 nm and a frequency of 10 Hz with a total energy fluency of 60 J/cm 2 was used. Macroscopic and histological findings of wound healing after PDT were examined in vivo (4-week-old male BALB/c mice). Results: In Model 1, in which skin was cut at 0, 3, 7 days after PDT (n=3, each), wounds were similarly healed 7 days after cutting in all groups, and regenerating epithelium and the number of fibroblasts on histological findings were not different. In Model 2, in which skin defects were created before or after PDT, the size of the defects was larger at day 7 in the groups with skin defects before or after PDT in comparison with groups with no PDT. However, macroscopic wound healing at day 14 was complete in all groups and there were no significant differences among the groups by this point. Histological findings of skin defects at day 14 showed no significant difference in terms of regenerating epithelium and number of fibroblasts in each group with or without PDT. Conclusions: PDT did not influence wound healing and can be safely applied before surgical therapy. © 2006-2012 Nagasaki University Library.
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Functional liver reserve parameters predictive for posthepatectomy complications.
Nanashima A, Abo T, Arai J, Matsumoto H, Kudo T, Nagayasu T
The Journal of surgical research 185 ( 1 ) 127 - 35 2013.11
Language：Japanese Publishing type：Research paper (scientific journal)
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High expression of trimethylated histone H3 at lysine 27 predicts better prognosis in non-small cell lung cancer.
Chen X, Song N, Matsumoto K, Nanashima A, Nagayasu T, Hayashi T, Ying M, Endo D, Wu Z, Koji T
International journal of oncology 43 ( 5 ) 1467 - 80 2013.11
Language：Japanese Publishing type：Research paper (scientific journal)
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A case of perianal desmoplastic small round cell tumor
Tominaga T., Takeshita H., Takagi K., To K., Kunizaki M., Abo T., Hidaka S., Nanashima A., Nagayasu T., Sawai T.
Japanese Journal of Gastroenterological Surgery 46 ( 9 ) 700 - 707 2013.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japanese Journal of Gastroenterological Surgery
Desmoplastic small round cell tumor (DSRCT) is an uncommon, poor prognostic tumor which is found mainly in young adults. A 23-year-old woman was admitted to our hospital with a complaint of anal pain. Pelvic CT revealed a 50-mm tumor in the anal and swollen lymph nodes in the bilateral inguinal region. DSRCT was diagnosed by biopsy, and Mile's operation with bilateral inguinal lymph nodes dissection was performed. Though adjuvant radiation was performed to prevent recurrence of the disease, 6 months later, she experienced multiple distant metastasis. She was treated with multiagent chemotherapy (18 courses of VDC-IE, 13 courses of gemcitabine/docetaxel) which inhibited tumor growth for long periods. Here, we report a case of perianal DSRCT. © 2013 The Japanese Society of Gastroenterological Surgery.
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Intrahepatic cholangiocarcinoma: relationship between tumor imaging enhancement by measuring attenuation and clinicopathologic characteristics.
Nanashima A, Abo T, Murakami G, Matsumoto A, Tou K, Takeshita H, Kunizaki M, Hidaka S, Sakamoto I, Hayashi H, Fukuda T, Kudo T, Nagayasu T
Abdominal imaging 38 ( 4 ) 785 - 92 2013.8
Language：Japanese Publishing type：Research paper (scientific journal)
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Comparison of results between pylorus-preserving pancreaticoduodenectomy and subtotal stomach-preserving pancreaticoduodenectomy: report at a single cancer institute.
Nanashima A, Abo T, Sumida Y, Tobinaga S, Nonaka T, Takeshita H, Hidaka S, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 60 ( 125 ) 1182 - 8 2013.7
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Predictive parameters of intraoperative blood loss in patients who underwent pancreatectomy.
Nanashima A, Abo T, Hamasaki K, Wakata K, Kunizaki M, Nakao K, Tanaka K, Fukuda D, Nagasaki T, Tou K, Takeshita H, Hidaka S, Sawai T
Hepato-gastroenterology 60 ( 125 ) 1217 - 21 2013.7
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Does the placement of a cystic duct tube after a hepatic resection help reduce the incidence of post-operative bile leak?
Nanashima A, Abo T, Shibuya A, Tominaga T, Matsumoto A, Tou K, Kunizaki M, Takeshita H, Hidaka S, Tsuchiya T, Yamasaki N, Nagayasu T
HPB : the official journal of the International Hepato Pancreato Biliary Association 15 ( 7 ) 517 - 22 2013.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Correlation between morphological and functional liver volume in each sector using integrated SPECT/CT imaging by computed tomography and technetium-99m galactosyl serum albumin scintigraphy in patients with various diseases who had undergone hepatectomy.
Nanashima A, Abo T, Tobinaga S, Murakami G, Kido Y, Fukuda T, Tsuchiya T, Matsumoto H, Nagayasu T, Kudo T
Nuclear medicine communications 34 ( 7 ) 652 - 9 2013.7
Language：Japanese Publishing type：Research paper (scientific journal)
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A case of acinar cell carcinoma of the pancreas
Tominaga T., Nanashima A., Abo T., Wakata K., Hamasaki K., Kunizaki M., To K., Hidaka S., Takeshita H., Kinoshita N., Kudo T., Nagayasu T.
Acta Medica Nagasakiensia 58 ( 1 ) 25 - 28 2013.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Acta Medica Nagasakiensia
Background Acinar cell carcinoma (ACC) is a very rare malignancy and represents only 1% to 2% of pancreatic exocrine carcinomas. At the time of diagnosis, 75% of ACC are resectable. Reliable data concerning effective adjuvant chemotherapy has not been established. Case presentation A 30-mm tumor in the pancreatic tail was incidentally discovered by computed tomography in a 71-yearold man. Several swollen lymph nodes were seen around the main tumor. Endoscopic retrograde cholangiopancreatography (ERCP) revealed disruption of the main pancreatic duct. The patient underwent curative resection (R0) with distal pancreatectomy and node dissection. Histopathological examination revealed ACC with lymph node metastases; adjuvant chemotherapy was performed with gemcitabine after surgery. Twelve months later, the patient showed no sign of recurrence. Conclusion The prognosis of ACC is dismal, although compared to ductal adenocarcinoma, the mean survival appears to be longer. Patients with advanced-stage ACC might benefit from gemcitabine-based adjuvant chemotherapy.
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NX-PVKA levels before and after hepatectomy of hepatocellular carcinoma as predictors of patient survival: a preliminary evaluation of an improved assay for PIVKA-II.
Nanashima A, Abo T, Taura N, Shibata H, Ichikawa T, Takagi K, Arai J, Oyama S, Nagayasu T
Anticancer research 33 ( 6 ) 2689 - 97 2013.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Recent advances and significance of intra-arterial infusion chemotherapy in non-resectable colorectal liver metastasis.
Nanashima A, Takeshita H, Abo T, Tou K, Tanaka K, Fukuda D, Kunizaki M, Hidaka S, Sawai T
Journal of gastrointestinal oncology 4 ( 2 ) 164 - 72 2013.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Abo T., Taura N., Shibata H., Ichikawa T., Takagi K., Arai J., Oyama S., Nagayasu T.
Anticancer Research 33 ( 6 ) 2689 - 2698 2013.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Anticancer Research
Although the protein-induced vitamin K absence or antagonist-II (PIVKA-II) is used as a prognostic marker in hepatocellular carcinoma (HCC), a newly-improved assay, NX-PVKA (PIVKA-II measured using P-11 and P-16 antibodies) and NX-PVKA-R (ratio of PIVKA-II and NXPVKA), are more accurate markers of PIVKA-II. We conducted a prospectively preliminary analysis of the relationship between NX-PVKA-R and clinicopathological parameters and prognosis in 22 patients with HCC who underwent hepatectomy and measured changes of this marker's levels after treatment. Median value of PIVKA-II (80 mAU/ml), NX-PVKA (60 mAU/ml), NX-PVKA-R (1.5) and NX-PVKA-D (difference of markers, 15 mAU/ml) were determined. Tumor relapse was observed in six patients, and the one year relapse-free survival rate was 88%. Correlation between PIVKA-II or alpha-fetoprotein levels and NX-PVKA, NX-PVKA-R or -D levels was significant (p < 0.001). NXPVKA- R was significantly correlated with tumor size (p < 0.05). In patients who underwent pre-treatment before hepatectomy, PIVKA-II, NX-PVKA and NX-PVKA-R tended to be higher than in patients without pre-treatment, but this difference was not significant (p > 0.10). For macroscopic findings, NX-PVKA-R for the confluent-nodular type was significantly higher than that for the simple-nodular type (p < 0.05). The tumor-free survival rate in the group with a high NX-PVKA-R was significantly lower than that in the group with a low NX-PVKA-R group (p < 0.05). In patients with tumor recurrence, postoperative NX-PVKA-R increased again. We conclude that a high value of NX-PVKA-R after hepatectomy for HCC reflects malignant potential and predicts early recur rence in patients with HCC.
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Clinical significances of cancer stem cells markers in patients with intrahepatic cholangiocarcinoma who underwent hepatectomy.
Nanashima A, Hatachi G, Tsuchiya T, Matsumoto H, Arai J, Abo T, Murakami G, Tominaga T, Takagi K, Nagayasu T
Anticancer research 33 ( 5 ) 2107 - 14 2013.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma.
Nanashima A, Abo T, Kudo T, Sakamoto I, Hayashi H, Murakami G, Takeshita H, Hidaka S, Kido Y, Nagayasu T
Nuclear medicine communications 34 ( 5 ) 478 - 88 2013.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Synergic effect of photodynamic therapy using talaporfin sodium with conventional anticancer chemotherapy for the treatment of bile duct carcinoma.
Nonaka Y, Nanashima A, Nonaka T, Uehara M, Isomoto H, Abo T, Nagayasu T
The Journal of surgical research 181 ( 2 ) 234 - 41 2013.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Predictors of intraoperative blood loss in patients undergoing hepatectomy.
Nanashima A, Abo T, Hamasaki K, Wakata K, Kunizaki M, Tou K, Takeshita H, Hidaka S, Sawai T, Tsuchiya T, Nagayasu T
Surgery today 43 ( 5 ) 485 - 93 2013.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Novel powdered anti-adhesion material: preventing postoperative intra-abdominal adhesions in a rat model.
Takagi K, Araki M, Fukuoka H, Takeshita H, Hidaka S, Nanashima A, Sawai T, Nagayasu T, Hyon SH, Nakajima N
International journal of medical sciences 10 ( 4 ) 467 - 74 2013
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Usefulness of vessel-sealing devices combined with crush clamping method for hepatectomy: a retrospective cohort study.
Nanashima A, Abo T, Arai J, Takagi K, Matsumoto H, Takeshita H, Tsuchiya T, Nagayasu T
International journal of surgery (London, England) 11 ( 9 ) 891 - 7 2013
Language：Japanese Publishing type：Research paper (scientific journal)