Papers - NANASHIMA Atsushi
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Relationship between microvessel count and postoperative survival in patients with intrahepatic cholangiocarcinoma. Reviewed
Nanashima A, Shibata K, Nakayama T, Tobinaga S, Araki M, Kunizaki M, Takeshita H, Hidaka S, Sawai T, Nagayasu T, Tagawa T
Annals of surgical oncology 16 ( 8 ) 2123 - 2129 2009.8
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Clinical significance of microvessel count in patients with metastatic liver cancer originating from colorectal carcinoma.
Nanashima A, Shibata K, Nakayama T, Tobinaga S, Araki M, Kunizaki M, Takeshita H, Hidaka S, Sawai T, Nagayasu T, Yasutake T
Annals of surgical oncology 16 ( 8 ) 2130 - 7 2009.8
Language：Japanese Publishing type：Research paper (scientific journal)
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Evaluation of new prognostic staging systems (SLiDe score) for hepatocellular carcinoma patients who underwent hepatectomy.
Nanashima A, Omagari K, Sumida Y, Abo T, Fukuoha H, Takeshita H, Hidaka S, Tanaka K, Sawai T, Yasutake T, Nagayasu T, Mizuta Y, Ohba K, Ohnita K, Kadokawa Y
Hepato-gastroenterology 56 ( 93 ) 1137 - 40 2009.7
Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Omagari K., Sumida Y., Abo T., Fukuoka H., Takeshita H., Hidaka S., Tanaka K., Sawai T., Yasutake T., Nagayasu T., Mizuta Y., Ohba K., Ohnita K., Kadokawa Y.
Hepato-Gastroenterology 56 ( 93 ) 1137 - 1140 2009.7
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Hepato-Gastroenterology
Background/Aims: A new prognostic staging system, the SLiDe (S, stage; Li, liver damage; De, des-gamma-carboxy prothrombin) score was recently proposed. We examined 207 HCC patients following hepatic resection to determine the usefulness of this staging system for HCC patients after surgery. Methodology: Disease-free and overall survival rates were calculated according to the Kaplan-Meier method, and differences between groups were tested for significance using the log-rank test. Results: Regarding disease-free survival, there were no significant differences in survival between SLiDe score 0 vs 1, between score 2 vs 3, and between score 4 vs 5. There were significant differences between 0-1 vs 2-3 (p < 0.01) and between 2-3 vs 4-5 (p < 0.01). Regarding overall survival, there were no significant differences in survival between score 0 vs 1, between score 2 vs 3, and between score 4 vs 5. There were significant differences between 0-1 vs 2-3 (p < 0.05) and between 2-3 vs 4-5 (p < 0.01). Conclusions: The SLiDe score, a staging system that combines tumor factors, a tumor marker and hepatic function, might be a better predictor of prognosis in HCC patients who have undergone hepatic resection. © H.G.E. Update Medical Publishing S.A.
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Characteristics of bile duct carcinoma with superficial extension in the epithelium.
Nanashima A, Sumida Y, Tobinaga S, Abo T, Takeshita H, Sawai T, Hidaka S, Fukuoka H, Nagayasu T
World journal of surgery 33 ( 6 ) 1255 - 8 2009.6
Language：Japanese Publishing type：Research paper (scientific journal)
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Clinical significance of portal vein embolization before right hepatectomy.
Nanashima A, Sumida Y, Abo T, Nonaka T, Takeshita H, Hidaka S, Sawai T, Yasutake T, Sakamoto I, Nagayasu T
Hepato-gastroenterology 56 ( 91-92 ) 773 - 7 2009.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Treatment of concomitant gastric varices in patients with hepatocellular carcinoma at a single Japanese institute.
Nanashima A, Sumida Y, Abo T, Shibata K, Tomoshige K, Takeshita H, Hidaka S, Fukuoka H, Mochinaga K, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 56 ( 91-92 ) 857 - 60 2009.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Three-dimensional cholangiography applying C-arm computed tomography in bile duct carcinoma: a new radiological technique.
Nanashima A, Abo T, Sakamoto I, Makino K, Sumida Y, Sawai T, Nagayasu T
Hepato-gastroenterology 56 ( 91-92 ) 615 - 8 2009.5
Language：Japanese Publishing type：Research paper (scientific journal)
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Nanashima A., Araki M., Tobinaga S., Kunizaki M., Hidaka S., Shibata K., Mochinaga K., Sawai T., Isomoto H., Ohnita K., Uehara M., Nagayasu T.
European Journal of Surgical Oncology 35 ( 5 ) 504 - 509 2009.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：European Journal of Surgical Oncology
Aim: Cancer death in the early period after hepatectomy still occurs in patients with colorectal liver metastasis (CLM). We examined the relationship between clinicopathological parameters and survival periods in 130 CLM patients who underwent hepatectomy. Patients/methods: Patients were divided into four groups: Group 1 (5-year survivors without tumor relapse), Group 2 (survivors at 2-5 years), Group 3 (cancer death at 2-5 years), and Group 4 (cancer death within 2 years). Results: A short surgical margin was frequent in Group 4 compared to Group 1 (31 vs. 78%, P < 0.05). Primary node-positive status, absence of fibrous pseudo-capsular formation, higher Clinical Risk Score, and tumor recurrence within 12 months were frequent in Group 4 (P < 0.05). Multivariate analysis revealed a short surgical margin (HR; 3.5) and early tumor relapse (HR; 5.9) as independently significant related parameters (P < 0.05). Conclusions: Sufficient surgical margins and careful follow-up for early tumor relapse may be important for improving postoperative outcomes for CLM patients. © 2009 Elsevier Ltd. All rights reserved.
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Clinical significance of measuring urinary sulfated bile acids in adult patients with hepatobiliary diseases.
Nanashima A, Obatake M, Sumida Y, Abo T, Yamane Y, Nomura M, Yuhio I, Sawai T, Takeshita H, Hidaka S, Yasutake T, Nagayasu T
Hepato-gastroenterology 56 ( 90 ) 299 - 302 2009.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Vascular transection using endovascular stapling in hepatic resection.
Nanashima A, Sumida Y, Oikawa M, Murakami G, Abo T, Hidaka S, Takeshita H, Sawai T, Nagayasu T
Hepato-gastroenterology 56 ( 90 ) 498 - 500 2009.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Usefulness and limitation of laparoscopic assisted hepatic resections: a preliminary report.
Nanashima A, Sumida Y, Oikawa M, Nonaka T, Abo T, Takeshita H, Hidaka S, Fukuoka H, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 56 ( 90 ) 447 - 51 2009.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Trisectionectomy for large hepatocellular carcinoma using the liver hanging maneuver
Nanashima A., Sumida Y., Abo T., Takeshita H., Hidaka S., Sawai T., Yasutake T., Nagayasu T.
European Journal of Surgical Oncology 35 ( 3 ) 326 - 330 2009.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：European Journal of Surgical Oncology
Background/Purpose: Large liver tumors often expand and severely compress intrahepatic vessels. In cases of the trisectionectomy for such tumors, however, it is difficult to adequately expose the transection planes. The liver hanging maneuver (LHM) is a useful technique for hemihepatectomy and an adequate transection plane might be also required in trisectionectomy. Methods: LHM procedure is basically followed by the Belghiti's method. A nasogastric tube was used for hanging. At the hepatic hilum, the tube was placed between the liver and Glisson's pedicle. Results: We report here the application of LHM for right and left trisectionectomy in patients with a large hepatoma in two cases. In case of a right trisectionectomy for a large tumor compressing the umbilical Glisson's pedicle, an adequate transection plane was obtained using the LHM because the resected and remnant livers rotated to the other side upon lifting the tube during transection. In case of a left trisectionectomy for a large hepatic tumor compressing the right hepatic vein, an adequate transection plane along the right hepatic vein was obtained using LHM as well. Conclusions: LHM is a useful surgical application for right and left trisectionectomy in patients with large liver tumors compressing the cut plane. © 2008 Elsevier Ltd. All rights reserved.
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An experience of treatment of postoperative biliary stricture at a single Japanese institute.
Nanashima A, Abo T, Sumida Y, Nonaka T, Tanaka K, Hidaka S, Sawai T, Yasutake T, Nagayasu T
Hepato-gastroenterology 56 ( 89 ) 43 - 6 2009.1
Language：Japanese Publishing type：Research paper (scientific journal)
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Usefulness of measuring hepatic functional volume using Technetium-99m galactosyl serum albumin scintigraphy in bile duct carcinoma: report of two cases.
Nanashima A, Sumida Y, Abo T, Sakamoto I, Ogawa Y, Sawai T, Takeshita H, Hidaka S, Nagayasu T
Journal of hepato-biliary-pancreatic surgery 16 ( 3 ) 386 - 93 2009
Language：Japanese Publishing type：Research paper (scientific journal)
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Relationship between pattern of tumor enhancement and clinicopathologic characteristics in intrahepatic cholangiocarcinoma.
Nanashima A, Sumida Y, Abo T, Oikawa M, Murakami G, Takeshita H, Fukuoka H, Hidaka S, Nagayasu T, Sakamoto I, Sawai T
Journal of surgical oncology 98 ( 7 ) 535 - 9 2008.12
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Mihara Y., Nakayama T., Nanashima A., Kuroki T., Onizuka S., Ito M., Naruke Y., Hayashi T., Sanefuji H., Sekine I.
Acta Medica Nagasakiensia 53 ( 4 ) 89 - 95 2008.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Acta Medica Nagasakiensia
Extrahepatic bile duct cancer is a high mortal malignancy. Angiopoietin (Ang) and its receptor Tie, which are known to contribute to angiogenesis, have recently been reported to participate in the proliferation and differentiation of malignant tumor cells. The aim of this study is to investigate the expression and the significance of Ang-1, 2 and Tie-2 in extrahepatic bile duct carcinoma cells. We used immunohistochemistry to study 119 cases of surgically resected human extrahepatic bile duct carcinoma, and Reverse Transcription-Polymerase Chain Reaction (RT-PCR) to confirm the expression of Ang-1, 2 and Tie-2 mRNA. Among these 119 cases, 52 (43.7%), 50 (42.0%) and 89 (74.8%) cases showed positive staining for Ang-1, 2 and Tie-2, respectively, in bile duct carcinoma cells. In 38 cases of normal mucosa, 6 (15.8%), 10 (26.3%) and 9 (23.7%) cases were positive for Ang-1, 2 and Tie-2, respectively. The positivity for Ang-1 and Tie-2 in normal mucosa was significantly different from all carcinomas (p < 0.01 and p < 0.001, respectively). We found no significant correlation between Ang-1 and Ang-2 expression and other clinicopathological factors such as histological differentiation, grade of tumor invasion or survival rate after surgery. In contrast, Tie-2 expression correlated significantly with degree of desmoplasia, cancer stage and survival of patients. RT-PCR analyses of five surgically resected tumor samples and three human bile duct cancer cell lines all showed positive expression of Ang-1, 2 and Tie-2 mRNAs. High expressions of Ang-1, 2 and Tie-2 in human extrahepatic bile duct carcinoma cells suggested that Ang-Tie system may be involved in the progression of human bile duct cancer.
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Surgical experiences of intraductal papillary mucinous neoplasms of the pancreas at a single Japanese institute: characteristics of malignant histology.
Nanashima A, Sumida Y, Abo T, Oikawa M, Takeshita H, Hidaka S, Sawai T, Yasutake T, Kinoshita N, Hayashi T, Nagayasu T
Hepato-gastroenterology 55 ( 88 ) 2238 - 41 2008.11
Language：Japanese Publishing type：Research paper (scientific journal)
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A modified grading system for post-hepatectomy metastatic liver cancer originating from colorectal carcinoma.
Nanashima A, Sumida Y, Abo T, Tobinaga S, Takeshita H, Hidaka S, Yasutake T, Nagayasu T, Mine M, Sawai T
Journal of surgical oncology 98 ( 5 ) 363 - 70 2008.10
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Nanashima A., Sumida Y., Abo T., Nagasaki T., Tabinaga S., Fukuoka H., Takeshita H., Hidaka S., Tanaka K., Sawai T., Yasutake T., Nagayasu T.
Acta Chirurgica Belgica 108 ( 5 ) 532 - 537 2008.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Acta Chirurgica Belgica
Aims : Anatomic resection, i.e., systematic removal of a liver segment confined by portal branches, is theoretically effective in eradicating intrahepatic metastasis of hepatocellular carcinoma (HCC). The procedure may reduce tumour recurrence and enhance survival of HCC patients. To determine the significance of anatomic resection for HCC patients, we retrospectively conducted a comparative analysis between anatomic (AR) and non-anatomic liver resection (NAR) in 113 Japanese HCC pa tients with a solitary tumour, a tumour located within one segment, absence or invasion of distal to second order branches of the portal vein, and absence or invasion of peripheral branches of the hepatic vein. Methods : Patients were divided into two groups, AR group (n = 49) and NAR group (n = 64). Results : The prevalence of liver damage Grade B in the NAR group was significantly greater than in the AR group (p < 0.05). Tumour-free and overall survival following liver resection was not significantly different between AR and NAR groups. In the NAR group, tumour-free and overall survival in patients with tumour exposure at the surgical margin was significantly lower than with a surgical margin greater than 0 mm (not exposed) (p < 0.05). Survival between the AR and NAR groups without tumour exposure at the surgical margin was similar. Conclusions : Anatomic resection is the theoretical aim. In HCC patients with impaired liver functions, limited liver resection without tumour exposure may provide longer tumour-free and overall survival.